Clomipramine 50mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Irregular heartbeat or palpitations
- Severe dizziness or fainting
- Seizures
- Difficulty breathing or swallowing
- Swelling of face, lips, or tongue
- Yellowing of skin or eyes
- Unusual bleeding or bruising
- High fever with muscle rigidity
If experiencing severe symptoms, call emergency services immediately.
What is omifram 50mg tablet used for?
Clomipramine 50 mg is a tricyclic antidepressant used to treat obsessive-compulsive disorder (OCD) and depression. It works by increasing serotonin and norepinephrine in the brain. It is taken orally, usually 1-3 times daily, and may take several weeks to work. Common side effects include dry mouth, drowsiness, and constipation.
- Generic Name: Clomipramine (50mg)
- Manufacturer: Zeelab Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 omifram 50mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिप्रामाइन हाइड्रोक्लोराइड 50 मिलीग्राम की गोली है, जिसका उपयोग मुख्य रूप से ऑब्सेसिव-कंपल्सिव डिसऑर्डर (ओसीडी) और अवसाद के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर काम करती है, जिससे मूड बेहतर होता है और बार-बार आने वाले विचार कम होते हैं। यह दवा डॉक्टर के परामर्श से ही लेनी चाहिए और इसके पूरे फायदे दिखने में कुछ सप्ताह लग सकते हैं।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, कब्ज, धुंधली दृष्टि और वजन बढ़ना शामिल हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, दौरे और एलर्जी की प्रतिक्रिया हो सकती है। यदि आपको कोई भी असामान्य लक्षण महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, इससे withdrawal symptoms हो सकते हैं। शरूर न करें और वाहन चलाने या मशीन चलाने से बचें जब तक आपको इसका असर पता न चल जाए। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं, विशेष रूप से MAO inhibitors। नियमित जांच कराते रहें।
💊 omifram 50mg tablet Uses & Benefits
[{"condition":"Obsessive-Compulsive Disorder (OCD)","description":"Reduces the frequency and intensity of obsessive thoughts and compulsive behaviors.","evidence":"Well-established"},{"condition":"Major Depressive Disorder","description":"Helps relieve symptoms of depression such as sadness, hopelessness, and loss of interest.","evidence":"Well-established"},{"condition":"Panic Disorder","description":"Reduces the frequency and severity of panic attacks.","evidence":"Moderate"},{"condition":"Chronic Pain Syndromes","description":"May help with neuropathic pain and certain chronic pain conditions.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature Ejaculation","description":"Sometimes prescribed off-label to delay ejaculation.","evidence":"Limited"},{"condition":"Cataplexy","description":"May be used off-label to reduce cataplectic attacks in narcolepsy.","evidence":"Limited"}]
Primary treatment for: Obsessive-Compulsive Disorder
Also treats: Major Depressive Disorder, Panic Disorder, Chronic Pain
📋 Drug Information
| Generic Name(s) | Clomipramine (50mg) |
| Brand Name | omifram 50mg tablet |
| Manufacturer | Zeelab Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Clomipramine is a tricyclic antidepressant that inhibits the reuptake of serotonin and norepinephrine in the brain. It also has anticholinergic, antihistaminic, and alpha-adrenergic blocking properties. By blocking the serotonin transporter, it increases serotonin levels in the synaptic cleft, which helps regulate mood and anxiety. Its metabolite, desmethylclomipramine, primarily inhibits norepinephrine reuptake. This dual action contributes to its effectiveness in OCD and depression.
Mechanism Steps
💡 How to Take omifram 50mg tablet
Strength: 50 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose for adults is 25 mg once daily, gradually increased to 100-150 mg per day in divided doses, with a maximum of 250 mg per day. For OCD, doses up to 250 mg per day may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should start at a lower dose (e.g., 10-25 mg daily) and titrate slowly due to increased sensitivity to side effects. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in renal impairment. Dose adjustment may be necessary. Consult a clinician. |
| Hepatic Impairment | Use with caution in hepatic impairment. Dose reduction may be required. Consult a clinician. |
| Maximum Daily Dose | 250 mg per day (in divided doses) for adults; lower in elderly. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of omifram 50mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| SSRIs | Major | |
| CYP2D6 inhibitors | Major | |
| Alcohol | Moderate | |
| Anticholinergics | Moderate | |
| CNS depressants | Moderate | |
| Sympathomimetics | Moderate | |
| Grapefruit juice | Minor | |
| Caffeine | Minor | |
| Warfarin | Moderate |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- SSRIs (e.g., fluoxetine, paroxetine)
- Other tricyclic antidepressants
- CYP2D6 inhibitors (e.g., quinidine, terbinafine)
⚡ Moderate Interactions
- Alcohol
- Anticholinergic drugs (e.g., benztropine)
- CNS depressants (e.g., benzodiazepines)
- Sympathomimetic drugs (e.g., pseudoephedrine)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine as it can increase sedation, dizziness, and impair judgment. It may also worsen depression.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clomipramine or other tricyclic antidepressants","Concurrent use with MAO inhibitors","Acute recovery phase after myocardial infarction","Uncontrolled glaucoma","Urinary retention","Severe liver disease"]
⚠️ Warnings & Precautions
["May increase risk of suicidal thoughts in children, adolescents, and young adults.","Avoid abrupt discontinuation to prevent withdrawal symptoms.","Use with caution in patients with seizures, hyperthyroidism, or pheochromocytoma.","May impair ability to drive or operate machinery.","Avoid alcohol.","Use with caution in elderly due to increased risk of falls and confusion."]
🤱 Lactation Safety
Clomipramine is excreted in breast milk. Breastfeeding is not recommended while taking this medicine due to potential serious adverse effects in the infant. Consult your doctor.
💊 Overdose Management
Overdose can be life-threatening. Symptoms include irregular heartbeat, severe drowsiness, confusion, agitation, hallucinations, seizures, and coma. Seek emergency medical help immediately. Treatment is supportive and may include activated charcoal, sodium bicarbonate for cardiac toxicity, and management of seizures.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop suddenly as it can cause withdrawal symptoms. Avoid alcohol and be cautious when driving or operating machinery until you know how it affects you. Inform your doctor about all other medicines you are taking, especially MAOIs, as dangerous interactions can occur. Regular monitoring of heart function, blood counts, and mood changes is important. Keep all appointments with your healthcare provider.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to side effects such as confusion, falls, and cardiac effects. Start at a lower dose and titrate slowly. Regular monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor. Clomipramine may pose risks to the fetus. Alternative treatments may be considered. Do not stop suddenly without medical advice.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthetic agents and affect blood pressure and heart rate. Your doctor may advise temporary discontinuation.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it can cause dry mouth and may interact with certain anesthetics or sedatives used in dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause drowsiness and dizziness. Avoid strenuous exercise or activities requiring alertness until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and impair concentration, affecting your ability to drive or operate machinery. It may also affect your work performance initially. Discuss with your doctor about adjusting the dose or timing to minimize impact.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects or need to discontinue, your doctor will gradually reduce the dose to prevent withdrawal symptoms and relapse.
📅 Long-Term Use Effects
Long-term use may require periodic monitoring of heart function, liver function, and blood counts. Weight gain and sexual dysfunction may persist. Regular follow-up with your doctor is essential to adjust the dose and manage side effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can be used alone or with medication for OCD and depression.
Evidence: Well-establishedAlternative antidepressants with different side effect profiles.
Evidence: Well-establishedComplementary therapies to reduce anxiety.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage. For long flights, adjust dosing times gradually to the new time zone. Store at room temperature and avoid extreme heat or moisture. Check local customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: It may take 2 to 4 weeks to notice improvement in depression, and up to 10 weeks for full benefit in OCD.
A: Take it as soon as you remember, but if it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, stopping suddenly can cause withdrawal symptoms. Always consult your doctor before stopping, and taper gradually.
🤔 Common Patient Concerns
🔄 Substitutes for omifram 50mg tablet
View AllAlternative brands with exact same active ingredient:
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clominex 50 tabletNext Labs Pvt Ltd ₹42.19 40.6% COSTLIER
-
imi-ci 50mg tabletSunrise Remedies Pvt Ltd ₹51.56 71.9% COSTLIER
-
ecmin 50mg tabletElite Pharma Pvt Ltd ₹56.25 87.5% COSTLIER
-
lodep 50mg tabletExcare Laboratories ₹56.25 87.5% COSTLIER
-
klomin 50mg tabletRKG Pharma ₹56.31 87.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Clomipramine is addictive.
Fact: Clomipramine is not addictive, but it can cause withdrawal symptoms if stopped abruptly. It should be tapered gradually. - Myth: You can stop taking clomipramine once you feel better.
Fact: You should continue taking it as prescribed to prevent relapse. Stopping suddenly can cause withdrawal and return of symptoms. - Myth: Clomipramine works immediately.
Fact: It may take 2-4 weeks or longer to see full benefits.
🔄 Alternative Options
Generic Alternatives
- Clomipramine hydrochloride
Brand Alternatives
- Anafranil