cletus 50mg tablet - Cilostazol (50mg) medicine

cletus 50mg tablet

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🏭 Novartis India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Reviewed by
SaathiMed Expert Panel | Oct 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

What is cletus 50mg tablet used for?

This medicine contains Cilostazol (50mg) and is used to treat CARDIAC. Inhibits phosphodiesterase type 3 (PDE3), leading to increased cAMP levels in platelets and vascular. Always consult your doctor before use.

  • Generic Name: Cilostazol
  • Manufacturer: Novartis India Ltd
  • Form: Allopathy
  • Pregnancy Category: Category A
  • Prescription Required: Yes
💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cletus 50mg tablet Uses & Benefits

Intermittent claudication due to peripheral arterial disease.

Off-label uses: Prevention of stroke (not FDA approved), prevention of restenosis after coronary stenting (limited evidence).

📋 Drug Information

Generic Name(s)Cilostazol
Brand NameCilodoc 50 Tablet
ManufacturerNovartis India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassPhosphodiesterase III Inhibiotrs (PVD)
Route of AdministrationOral
StorageStore at 20-25°C (68-77°F); protect from light and moisture.
Shelf LifeAs per manufacturer

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; absolute bioavailability is not determined.
DistributionDistributes widely; volume of distribution is approximately 2.5 L/kg.
Protein Binding95-98% bound to plasma proteins, mainly albumin.
MetabolismExtensively metabolized in the liver via CYP3A4 and CYP2C19, and to a lesser extent by CYP1A2 and CYP2D6.
Half-Life11-13 hours
ExcretionPrimarily excreted in urine (74%) as metabolites; 20% in feces.
BioavailabilityNot determined; absorption is rapid.
Onset of ActionWithin 2-4 weeks for symptomatic improvement in intermittent claudication.
Peak Plasma Time3-4 hours
Duration of ActionNot well defined; effects persist with continued dosing.

How It Works

Inhibits phosphodiesterase type 3 (PDE3), leading to increased cAMP levels in platelets and vascular smooth muscle, resulting in antiplatelet and vasodilatory effects.

Mechanism Steps

1Cilostazol is absorbed orally and reaches peak plasma concentration in 3-4 hours.
2It binds to PDE3 enzyme in platelets and vascular smooth muscle cells.
3Inhibition of PDE3 prevents breakdown of cAMP, leading to increased intracellular cAMP levels.
4Elevated cAMP activates protein kinase A (PKA), which phosphorylates target proteins.
5In platelets, PKA activation inhibits calcium mobilization and granule release, reducing platelet aggregation.
6In vascular smooth muscle, PKA activation leads to relaxation and vasodilation.
7The combined antiplatelet and vasodilatory effects improve blood flow and reduce symptoms of intermittent claudication.

💡 How to Take cletus 50mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cletus 50mg tablet

✅ Common Side Effects

Headache
Diarrhea
Abnormal stools
Palpitations
Dizziness

🚨 Serious Side Effects

Bleeding (e.g., intracranial hemorrhage, GI bleeding)
Thrombocytopenia
Ventricular tachycardia
Heart failure exacerbation

⚠️ Rare Side Effects

Hepatitis
Agranulocytosis
Stevens-Johnson syndrome
Anaphylaxis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major Increased cilostazol levels; avoid coadministration.
Omeprazole Major Increased cilostazol levels; consider dose adjustment.
Warfarin Moderate Increased bleeding risk; monitor INR.
Aspirin Moderate Increased bleeding risk; monitor for signs of bleeding.
Grapefruit juice Minor May increase cilostazol levels; avoid.

🚨 Major Interactions

  • CYP3A4 inhibitors (e.g., ketoconazole, itraconazole, erythromycin)
  • CYP2C19 inhibitors (e.g., omeprazole, ticlopidine)

⚡ Moderate Interactions

  • Anticoagulants (e.g., warfarin)
  • Antiplatelet agents (e.g., aspirin, clopidogrel)
  • CYP3A4 inducers (e.g., rifampin, carbamazepine)

🍷 Alcohol Interaction

No specific interaction; however, alcohol may increase bleeding risk in combination with antiplatelet effects.

🛡️ Safety & Warnings

🚫 Contraindications

Congestive heart failure, history of hemorrhagic stroke, active bleeding, severe hepatic impairment, hypersensitivity.

🤱 Lactation Safety

Not recommended; unknown if excreted in human milk.

💊 Overdose Management

Symptomatic and supportive; no specific antidote. Monitor for severe headache, diarrhea, hypotension, and tachycardia.

⏰ Missed Dose

Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.

🔄 Substitutes for cletus 50mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

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