Anafranil 25mg Tablet: Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Irregular or fast heartbeat
- Severe dizziness or fainting
- Seizures
- Difficulty breathing or swallowing
- Swelling of face, lips, or throat
- Yellowing of skin or eyes
- Unusual bruising or bleeding
- Severe confusion or agitation
If experiencing severe symptoms, call emergency services immediately.
What is anafranil 25mg tablet used for?
This medicine is a tricyclic antidepressant used to treat obsessive-compulsive disorder and depression. It works by increasing serotonin and norepinephrine in the brain. It is available as a 25 mg oral tablet and is usually taken once daily. Common side effects include dry mouth, drowsiness, and dizziness. It should not be stopped suddenly.
- Generic Name: Clomipramine
- Manufacturer: Novartis India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 anafranil 25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोमिप्रामाइन हाइड्रोक्लोराइड नामक सक्रिय तत्व से बनी एक ट्राइसाइक्लिक एंटीडिप्रेसेंट है, जिसका उपयोग मुख्य रूप से ऑब्सेसिव-कंपल्सिव डिसऑर्डर (ओसीडी) और अवसाद के इलाज के लिए किया जाता है। यह मस्तिष्क में सेरोटोनिन और नॉरएपिनेफ्रिन के स्तर को बढ़ाकर काम करती है, जिससे मूड में सुधार होता है और बार-बार आने वाले विचारों तथा दोहराव वाले व्यवहार में कमी आती है। यह 25 मिलीग्राम की गोली के रूप में उपलब्ध है और आमतौर पर दिन में एक बार ली जाती है। इस दवा को डॉक्टर की सलाह के बिना अचानक बंद नहीं करना चाहिए।
साइड इफेक्ट्स: आम दुष्प्रभावों में मुँह सूखना, नींद आना, चक्कर आना, कब्ज, धुंधली दृष्टि और पसीना आना शामिल हैं। ये आमतौर पर हल्के होते हैं और शरीर के सामान्य होने पर कम हो जाते हैं। गंभीर दुष्प्रभावों में अनियमित दिल की धड़कन, बेहोशी, दौरे, एलर्जी प्रतिक्रिया और यकृत की समस्या शामिल हो सकती है। यदि आपको कोई गंभीर लक्षण महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे निकासी के लक्षण जैसे मतली, सिरदर्द और चिड़चिड़ापन हो सकता है। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन चलाने या मशीनरी चलाने से बचें। इस दवा के साथ शराब न पिएँ। अपने डॉक्टर को अन्य सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। नियमित जांच के लिए अपॉइंटमेंट लें।
💊 anafranil 25mg tablet Uses & Benefits
- [{"condition":"Obsessive-compulsive disorder (OCD)","description":"This medicine is FDA-approved for the treatment of obsessive-compulsive disorder in adults and children aged 10 years and older.
- It helps reduce the frequency and intensity of intrusive thoughts and repetitive behaviors.","evidence":"Well-established"},{"condition":"Major depressive disorder","description":"This medicine is used to treat depression, particularly when other antidepressants have not been effective.
- It helps improve mood, sleep, and energy levels.","evidence":"Well-established"},{"condition":"Panic disorder","description":"This medicine may be prescribed to reduce the frequency and severity of panic attacks.","evidence":"Moderate"},{"condition":"Chronic pain syndromes","description":"This medicine can be used off-label for certain chronic pain conditions, such as neuropathic pain, due to its effects on serotonin and norepinephrine.","evidence":"Limited"}]
Off-label uses: [{"condition":"Premature ejaculation","description":"This medicine may be used off-label to delay ejaculation, but it is not a first-line treatment.","evidence":"Limited"},{"condition":"Cataplexy associated with narcolepsy","description":"This medicine may help reduce cataplexy attacks in some patients.","evidence":"Limited"}]
Primary treatment for: Obsessive-compulsive disorder
Also treats: Major depressive disorder, Panic disorder, Chronic pain syndromes
📋 Drug Information
| Generic Name(s) | Clomipramine |
| Brand Name | Anafranil |
| Manufacturer | Novartis India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Tricyclic antidepressants |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep away from moisture and heat. Keep in the original container. |
| Shelf Life | Not established from the available information. Refer to the packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by inhibiting the reuptake of serotonin and norepinephrine in the brain, which increases their availability in the synaptic cleft. This leads to enhanced neurotransmission and helps regulate mood and behavior. It also has effects on other neurotransmitter systems, including dopamine and histamine, which contribute to its side effect profile.
Mechanism Steps
💡 How to Take anafranil 25mg tablet
Strength: 25 mg immediate-release tablet
Dosage Information
| Adult Dosage | The usual starting dose for adults is 25 mg once daily, which may be gradually increased to a maximum of 250 mg per day in divided doses, depending on the condition being treated and your response. For obsessive-compulsive disorder, doses typically range from 100 mg to 250 mg per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients should start at a lower dose, typically 10 mg to 25 mg daily, and increase gradually. Close monitoring is required due to increased risk of side effects. |
| Renal Impairment | Use with caution in patients with renal impairment. Dose adjustment may be necessary. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | 250 mg per day in divided doses for adults, but individual maximum may vary based on indication and tolerability. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of anafranil 25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAOIs | Major | |
| SSRIs | Major | |
| Antiarrhythmics | Major | |
| Anticholinergics | Major | |
| CYP2D6 inhibitors | Moderate | |
| CYP1A2 inhibitors | Moderate | |
| CNS depressants | Moderate | |
| Sympathomimetics | Moderate | |
| Antacids | Minor | |
| Grapefruit juice | Minor |
🚨 Major Interactions
- Monoamine oxidase inhibitors (MAOIs)
- Other antidepressants (SSRIs, SNRIs, TCAs)
- Antiarrhythmic drugs (e.g., quinidine, flecainide)
- Anticholinergic drugs (e.g., benztropine, diphenhydramine)
⚡ Moderate Interactions
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, bupropion)
- CYP1A2 inhibitors (e.g., fluvoxamine, ciprofloxacin)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids)
- Sympathomimetic drugs (e.g., pseudoephedrine, amphetamines)
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impair your ability to think clearly. It may also worsen the side effects of this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to clomipramine or other tricyclic antidepressants","Concurrent use with monoamine oxidase inhibitors (MAOIs) or within 14 days of stopping an MAOI","Acute recovery phase after myocardial infarction","Severe liver disease","Narrow-angle glaucoma","Urinary retention","Concomitant use with cisapride"]
⚠️ Warnings & Precautions
["May increase the risk of suicidal thoughts and behaviors, especially in children, adolescents, and young adults. Monitor closely.","May cause drowsiness and impair ability to drive or operate machinery.","May cause orthostatic hypotension. Rise slowly from sitting or lying positions.","May cause anticholinergic effects such as dry mouth, constipation, and blurred vision.","May lower seizure threshold. Use with caution in patients with a history of seizures.","May cause QT prolongation. Use with caution in patients with cardiac disease.","Do not stop abruptly; taper gradually to avoid withdrawal symptoms.","Use with caution in elderly patients due to increased risk of side effects."]
🤱 Lactation Safety
This medicine is excreted in breast milk. Because of the potential for serious adverse reactions in nursing infants, a decision should be made whether to discontinue nursing or to discontinue the medicine, taking into account the importance of the medicine to the mother.
💊 Overdose Management
Overdose of this medicine can be life-threatening. Symptoms include irregular heartbeat, severe drowsiness, confusion, seizures, and coma. Seek immediate medical attention. Treatment is supportive and may include gastric lavage, activated charcoal, and management of cardiac arrhythmias. There is no specific antidote.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as this can cause withdrawal symptoms such as nausea, headache, and irritability. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine, as it can increase drowsiness and impair your ability to think clearly. Inform your doctor about all other medicines you are taking, especially monoamine oxidase inhibitors, other antidepressants, and medicines for heart rhythm problems. Keep all appointments for monitoring, including blood tests and heart checks if recommended. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the side effects of this medicine, especially drowsiness, dizziness, and anticholinergic effects. Start at a lower dose and monitor closely. Regular monitoring of heart, liver, and kidney function is recommended.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before taking this medicine. The safety of this medicine during pregnancy is not fully established. Your doctor will weigh the benefits and risks and may consider alternative treatments.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may interact with anesthetic agents and affect blood pressure and heart rhythm. Your doctor may advise you to stop the medicine temporarily before surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. This medicine can cause dry mouth, which may increase the risk of dental problems. It may also interact with certain local anesthetics or sedatives used during dental work.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause drowsiness and dizziness, so avoid strenuous exercise or activities that require alertness until you know how it affects you. Stay hydrated during exercise, as this medicine can cause sweating and affect temperature regulation.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness, dizziness, and blurred vision, which may affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. You may need to adjust your work schedule if you experience significant drowsiness. Discuss any work-related concerns with your doctor.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor will gradually reduce the dose to prevent withdrawal symptoms. If you experience severe side effects, contact your doctor immediately for advice.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of heart function, liver function, and blood counts. Some patients may experience weight gain, sexual dysfunction, or dental problems due to dry mouth. It is important to attend regular follow-up appointments and report any new or worsening symptoms. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
CBT is a first-line treatment for OCD and can be used alone or in combination with medication.
Evidence: Well-establishedSSRIs are often preferred over tricyclic antidepressants due to a better safety profile.
Evidence: Well-establishedTechniques such as yoga and meditation can help reduce anxiety and stress.
Evidence: Moderate💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. Consult your doctor before receiving any vaccinations while taking this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. If crossing time zones, adjust the timing of your dose gradually to match your new schedule, but do not take a double dose. Store it in a cool, dry place away from direct sunlight. Check customs regulations for carrying prescription medicines. Always carry enough supply for your trip.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine may take 2 to 4 weeks to start working for depression, and up to 10 weeks for full benefit in OCD. It is important to continue taking it as prescribed.
A: No, you should not stop taking this medicine without consulting your doctor. Stopping abruptly can cause withdrawal symptoms and may lead to a relapse. Your doctor will gradually reduce the dose.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.
A: No, you should avoid alcohol while taking this medicine as it can increase drowsiness, dizziness, and impair your ability to think clearly.
A: Weight gain is a possible side effect of this medicine. If you notice significant weight gain, consult your doctor for advice on diet and exercise.
🤔 Common Patient Concerns
🔄 Substitutes for anafranil 25mg tablet
View AllAlternative brands with exact same active ingredient:
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clomine 25mg tabletPsychotropics India Ltd ₹18.77 59.9% CHEAPER
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clomizil 25mg capsuleGufic Bioscience Ltd ₹22.03 52.9% CHEAPER
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clopic 25mg tabletAlpic Remedies Ltd ₹27.19 41.9% CHEAPER
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clomifril 25mg tabletTorrent Pharmaceuticals Ltd ₹29.05 37.9% CHEAPER
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clomijet 25mg tabletDagon Pharmaceuticals Pvt Ltd ₹29.06 37.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is addictive.
Fact: This medicine is not addictive in the traditional sense, but it can cause withdrawal symptoms if stopped abruptly. It should be tapered gradually under medical supervision. - Myth: This medicine works immediately.
Fact: This medicine takes several weeks to show its full effects. It is important to continue taking it as prescribed. - Myth: You can stop taking this medicine once you feel better.
Fact: You should not stop taking this medicine without consulting your doctor, as it may cause withdrawal symptoms or a relapse of your condition.
🔄 Alternative Options
Generic Alternatives
- Clomipramine hydrochloride
Brand Alternatives
- Anafranil