Asunra 400mg Tablet (Deferasirox): Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in vomit or black, tarry stools
- Severe abdominal pain or persistent vomiting
- Decreased urine output or swelling in legs or feet
- Yellowing of skin or eyes, or dark urine
- Difficulty breathing or swelling of face, lips, or throat
- Unusual bruising or bleeding
- Sudden hearing loss or ringing in the ears
- Blurred vision or eye pain
- Fever with rash or skin peeling
If experiencing severe symptoms, call emergency services immediately.
What is asunra 400mg tablet used for?
This medicine contains Deferasirox 400 mg, an oral iron chelator used to treat chronic iron overload caused by repeated blood transfusions. It binds to excess iron and helps remove it from the body through the stool and urine. It requires regular blood tests to monitor kidney and liver function.
- Generic Name: Deferasirox
- Manufacturer: Novartis India Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 asunra 400mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा डेफेरासिरोक्स 400 मिलीग्राम की गोली है, जिसे मुंह से लिया जाता है। यह शरीर में अतिरिक्त लोहे (आयरन) को बांधकर बाहर निकालने में मदद करती है। यह उन रोगियों के लिए दी जाती है जिन्हें बार-बार रक्त चढ़ाने की आवश्यकता होती है, जैसे थैलेसीमिया, सिकल सेल रोग या मायलोडिस्प्लास्टिक सिंड्रोम। यह दवा लोहे की अधिकता से होने वाले अंगों के नुकसान को रोकने में मदद करती है। इसे डॉक्टर की सलाह के बिना कभी नहीं लेना चाहिए। इस दवा को लेते समय नियमित रूप से खून की जांच करानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में पेट दर्द, जी मिचलाना, उल्टी, दस्त, कब्ज, सिरदर्द और त्वचा पर चकत्ते शामिल हैं। कुछ लोगों में गुर्दे या यकृत की कार्यप्रणाली में बदलाव देखा जा सकता है। गंभीर दुष्प्रभावों में गुर्दे की चोट, यकृत की चोट, रक्तस्राव, सुनने में कमी और दृष्टि में बदलाव शामिल हैं। अगर आपको कोई भी असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। गोली को पानी के साथ पूरा निगलें, चबाएं या तोड़ें नहीं। इसे हर दिन एक ही समय पर लें, हल्के भोजन के साथ लेने से पेट की परेशानी कम हो सकती है। एल्युमिनियम युक्त एंटासिड इस दवा के साथ न लें। पर्याप्त पानी पिएं। गुर्दे और यकृत की कार्यप्रणाली की नियमित जांच कराएं। अन्य दवाओं के बारे में डॉक्टर को बताएं। दवा को बच्चों से दूर रखें।
💊 asunra 400mg tablet Uses & Benefits
[{"condition":"Chronic iron overload due to repeated blood transfusions","description":"This medicine is used to remove excess iron from the body in patients with transfusion-dependent anemias such as beta-thalassemia, sickle cell disease, and myelodysplastic syndromes.","evidence":"Well-established"},{"condition":"Iron overload in non-transfusion-dependent thalassemia","description":"This medicine may be used in patients with thalassemia who develop iron overload without regular transfusions, as determined by a specialist.","evidence":"Established in specific patient groups"}]
Off-label uses: [{"condition":"Iron overload in rare hereditary hemochromatosis","description":"This medicine is sometimes used off-label when standard treatments are not suitable, but this must be decided by a specialist.","evidence":"Limited"}]
Primary treatment for: Chronic iron overload due to repeated blood transfusions
Also treats: Beta-thalassemia, Sickle cell disease, Myelodysplastic syndromes, Non-transfusion-dependent thalassemia
📋 Drug Information
| Generic Name(s) | Deferasirox |
| Brand Name | Asunra |
| Manufacturer | Novartis India Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | BLOOD RELATED |
| Action Class | Iron chelating agents |
| Route of Administration | Oral |
| Storage | Store this medicine at room temperature between 15°C and 30°C (59°F to 86°F). Keep it in the original container, tightly closed, away from moisture and heat. Do not refrigerate unless instructed. Keep out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 2 to 3 years from the date of manufacture. Check the expiry date on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by binding to iron in the body to form a stable complex that can be removed from the body. It is a tridentate iron chelator that has a high affinity for ferric iron (Fe3+). By binding to iron, it helps prevent iron from causing damage to organs such as the heart, liver, and endocrine glands. The iron complex is then eliminated mainly through the stool and to a lesser extent through the urine.
Mechanism Steps
💡 How to Take asunra 400mg tablet
Strength: This medicine is available as an immediate-release tablet containing 400 mg of Deferasirox. It is taken by mouth.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 20 mg per kilogram of body weight once daily for transfusion-dependent iron overload. For non-transfusion-dependent thalassemia, the starting dose is usually 10 mg per kilogram once daily. The dose may be adjusted by your doctor based on serum ferritin levels, kidney function, liver function, and how well you tolerate the medicine. The maximum recommended dose is 40 mg per kilogram per day. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the side effects of this medicine, especially kidney and liver problems. The dose may need to be adjusted based on kidney and liver function. Regular monitoring is especially important in this age group. Dose must be individualized by a qualified clinician. |
| Renal Impairment | This medicine is not recommended in patients with severe kidney impairment or kidney failure. In patients with mild to moderate kidney impairment, the dose may need to be reduced and kidney function monitored closely. Dose must be individualized by a qualified clinician based on renal function. |
| Hepatic Impairment | This medicine is not recommended in patients with severe liver impairment. In patients with mild to moderate liver impairment, the dose may need to be reduced and liver function monitored closely. Dose must be individualized by a qualified clinician based on hepatic function. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is 40 mg per kilogram of body weight. Doses above this are not recommended. Always follow your doctor's prescription. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of asunra 400mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Aluminum-containing antacids | Major | |
| Vitamin C (high dose) | Major | |
| Other iron chelators | Major | |
| Rifampicin | Moderate | |
| Cholestyramine | Moderate | |
| Midazolam | Moderate | |
| Alcohol | Moderate |
🚨 Major Interactions
- Aluminum-containing antacids
- Vitamin C (ascorbic acid) supplements
- Other iron chelators (e.g., deferoxamine)
⚡ Moderate Interactions
- Rifampicin
- Cholestyramine
- Midazolam
🍷 Alcohol Interaction
Alcohol may increase the risk of liver problems when taken with this medicine. It is best to avoid alcohol or limit its use while taking this medicine. Discuss with your doctor if you consume alcohol regularly.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known allergy to deferasirox or any ingredient in this medicine","Severe kidney disease or kidney failure","Severe liver disease or liver failure","Low platelet count (thrombocytopenia) below a certain level","High-risk myelodysplastic syndrome or advanced cancers with very low platelet counts","Pregnancy, unless clearly needed and advised by a specialist","Breastfeeding"]
⚠️ Warnings & Precautions
["This medicine can cause serious kidney problems. Regular blood tests are mandatory.","This medicine can cause serious liver problems. Report symptoms like yellowing of eyes or skin, dark urine, or abdominal pain.","This medicine may cause bleeding, especially in the stomach or intestines. Report black stools or vomiting blood.","This medicine can cause hearing loss and vision changes. Regular check-ups are recommended.","This medicine may cause severe skin reactions. Seek immediate medical help for any rash with blisters or peeling.","Do not take this medicine with aluminum-containing antacids.","Avoid high-dose vitamin C supplements unless prescribed.","Use effective contraception during treatment if you are a woman who can become pregnant.","Do not breastfeed while taking this medicine.","Tell your doctor about all other medicines you take, including over-the-counter products and herbal supplements."]
🤱 Lactation Safety
It is not known whether this medicine passes into breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for guidance.
💊 Overdose Management
If you suspect an overdose of this medicine, seek emergency medical care immediately. Symptoms of overdose may include severe nausea, vomiting, abdominal pain, and worsening of side effects. Treatment is supportive and may include activated charcoal if taken soon after ingestion. There is no specific antidote. Contact your doctor or a poison control center right away.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is less than 12 hours since the missed dose. If it is more than 12 hours, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. If you are unsure, contact your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not change the dose or stop taking it without medical advice. Swallow the tablet whole with water; do not crush, chew, or break it. Take it at the same time each day, preferably with a light meal to reduce stomach upset. Avoid taking antacids containing aluminum within a few hours of this medicine. Drink plenty of fluids unless your doctor tells you otherwise. Keep all scheduled blood tests for kidney function, liver function, and iron levels. Tell your doctor about all other medicines, supplements, and herbal products you take. Do not share this medicine with anyone else. If you miss a dose, follow your doctor's instructions; do not double the dose. Store this medicine at room temperature away from moisture and heat. Keep it out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially kidney and liver problems. Regular monitoring of kidney and liver function is particularly important. The dose may need to be adjusted based on kidney and liver function. Falls and bleeding risks should be assessed. Always follow your doctor's instructions carefully.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing this medicine. This medicine may harm the developing baby. Effective contraception is recommended for women who can become pregnant while taking this medicine. If you become pregnant while taking this medicine, contact your doctor immediately.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine before any surgery. It may affect kidney and liver function and increase bleeding risk. Your doctor may recommend monitoring before and after surgery. Do not stop the medicine without your doctor's advice.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. It may increase the risk of bleeding and affect healing. Your dentist may take precautions or consult your doctor. Maintain good oral hygiene to prevent dental problems.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe while taking this medicine, but you should avoid strenuous activities if you feel fatigued or have any bleeding. If you have heart problems related to iron overload, consult your doctor before starting any exercise program. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is usually taken once daily and is unlikely to affect your ability to drive or operate machinery. However, if you experience dizziness, fatigue, or vision changes, avoid driving or operating heavy machinery until you feel better. You can continue your normal work and daily activities, but keep your doctor informed about your job and any specific risks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Your doctor may decide to stop or change the dose based on your response, side effects, or changes in your condition. If you experience serious side effects such as kidney or liver problems, bleeding, or severe allergic reactions, seek immediate medical attention and follow your doctor's advice about stopping the medicine.
📅 Long-Term Use Effects
Long-term use of this medicine is often necessary for managing chronic iron overload. With regular monitoring, it can be used safely for many years. However, it can cause kidney and liver problems, hearing loss, and vision changes over time. Regular blood tests, hearing tests, and eye exams are important to detect these early. Your doctor will adjust the dose based on your response and any side effects. Do not stop the medicine without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Another iron chelator given by injection or infusion, often used when oral therapy is not suitable.
Evidence: Well-establishedAnother oral iron chelator, used in specific patients, especially those with heart iron overload.
Evidence: Well-established in specific groupsRemoval of blood to reduce iron levels, used in some patients with iron overload who do not have anemia.
Evidence: Well-established for certain conditions💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, because it can affect the immune system indirectly, discuss with your doctor before receiving any live vaccines. Keep your vaccinations up to date as advised by your healthcare provider.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless instructed.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss or temperature extremes. Store it at room temperature, away from direct sunlight and moisture. If crossing time zones, continue taking your dose at the same local time as advised by your doctor. Carry enough supply for your entire trip. Check customs regulations for carrying prescription medicines. Inform airport security if you carry liquid forms or needles, though this medicine is a tablet.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts working within hours to bind iron, but it may take several weeks to months to see a noticeable reduction in serum ferritin levels. Regular monitoring is needed to track progress.
A: Yes, you can take this medicine with a light meal to reduce stomach upset. However, avoid taking it with aluminum-containing antacids or high-dose vitamin C supplements.
A: Watch for signs of kidney problems (decreased urine, swelling), liver problems (yellowing of eyes or skin, dark urine), bleeding (black stools, vomiting blood), and changes in hearing or vision. Report these to your doctor immediately.
A: Yes, regular blood tests for kidney function, liver function, and serum ferritin are essential. Your doctor will advise how often you need them.
A: No, do not stop this medicine without your doctor's advice. Iron overload can return if treatment is stopped. Always consult your doctor before making any changes.
🤔 Common Patient Concerns
🔄 Substitutes for asunra 400mg tablet
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken without regular blood tests.
Fact: Regular blood tests for kidney function, liver function, and iron levels are essential while taking this medicine. - Myth: This medicine is a cure for thalassemia.
Fact: This medicine does not cure thalassemia. It only helps manage iron overload caused by transfusions. - Myth: You can stop this medicine once you feel better.
Fact: You should never stop this medicine without your doctor's advice. Iron overload can return if treatment is stopped. - Myth: This medicine can be taken with any antacid.
Fact: Aluminum-containing antacids can reduce the absorption of this medicine and should be avoided within a few hours of taking it.
🔄 Alternative Options
Generic Alternatives
- Deferasirox 400 mg tablet
Brand Alternatives
- Asunra 400mg Tablet