Cirohist Expectorant: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or shortness of breath
- Swelling of face, lips, tongue, or throat
- Severe skin rash or hives
- Irregular heartbeat or palpitations
- Seizures or convulsions
- Blood in vomit or stool
- Decreased urine output or swelling in legs
- Severe drowsiness or confusion
If experiencing severe symptoms, call emergency services immediately.
What is cirohist expectorant used for?
This medicine is a combination of Chlorpheniramine Maleate (an antihistamine) and Ammonium Chloride (an expectorant) used for temporary relief of cough, runny nose, and allergic symptoms. It works by blocking histamine and thinning mucus. It may cause drowsiness, so avoid driving. Do not use without a doctor's advice, especially in pregnancy, breastfeeding, or severe liver/kidney disease.
- Generic Name: Chlorpheniramine Maleate + Ammonium Chloride
- Manufacturer: Ciron Drugs & Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cirohist expectorant के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरफेनिरामाइन मेलिएट और अमोनियम क्लोराइड का संयोजन है। इसका उपयोग खांसी, नाक बहना, छींक आना और एलर्जी के लक्षणों से राहत के लिए किया जाता है। यह बलगम को पतला करके खांसी को आसान बनाती है और एलर्जी के कारण होने वाले लक्षणों को कम करती है। यह दवा नींद ला सकती है, इसलिए वाहन चलाने से बचें। गर्भवती और स्तनपान कराने वाली महिलाएं बिना डॉक्टर की सलाह के इसका सेवन न करें।
साइड इफेक्ट्स: आम दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, जी मिचलाना और पेट खराब होना शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी की प्रतिक्रिया, रक्त विकार, गुर्दे की समस्या और दौरे पड़ना शामिल हो सकते हैं। यदि सांस लेने में कठिनाई, चेहरे या गले में सूजन, या त्वचा पर गंभीर दाने हों तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। निर्धारित मात्रा से अधिक न लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, वाहन न चलाएं। शराब का सेवन न करें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। यदि आपको ग्लूकोमा, प्रोस्टेट की समस्या, दमा या थायरॉइड की बीमारी है तो डॉक्टर को बताएं। बच्चों की पहुंच से दूर रखें।
💊 cirohist expectorant Uses & Benefits
[{"condition":"Cough associated with upper respiratory tract infections","description":"Helps loosen mucus and reduce cough frequency by thinning bronchial secretions and reducing allergic components.","evidence":"Established for symptomatic relief"},{"condition":"Allergic rhinitis","description":"Reduces sneezing, runny nose, and itching through antihistamine action.","evidence":"Established for symptomatic relief"},{"condition":"Common cold with nasal congestion","description":"Provides temporary relief of runny nose, sneezing, and cough.","evidence":"Established for symptomatic relief"}]
Off-label uses: []
Primary treatment for: Cough and allergic rhinitis
Also treats: Common cold, Upper respiratory tract infection, Allergic conditions
📋 Drug Information
| Generic Name(s) | Chlorpheniramine Maleate + Ammonium Chloride |
| Brand Name | Avicof Syrup |
| Manufacturer | Ciron Drugs & Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Antihistamine + Expectorant |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Chlorpheniramine Maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing allergic symptoms such as sneezing, rhinorrhea, and itching. Ammonium Chloride acts as an expectorant by irritating the gastric mucosa, which reflexively stimulates respiratory tract secretions, thereby thinning mucus and making it easier to cough up. The combination provides symptomatic relief of cough and allergic nasal symptoms.
Mechanism Steps
💡 How to Take cirohist expectorant
Strength: Each tablet or 5 mL of syrup contains Chlorpheniramine Maleate 2 mg and Ammonium Chloride 100 mg.
Dosage Information
| Adult Dosage | The usual adult dose is 1 to 2 tablets or 5 to 10 mL of syrup every 4 to 6 hours as needed, not to exceed 6 doses in 24 hours. However, dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-medicate. Follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. This medicine is contraindicated in newborns and premature infants. For children over 2 years, dosing must be determined by a pediatrician based on weight and clinical condition. |
| Elderly Dosage | Elderly patients are more sensitive to the sedative and anticholinergic effects of Chlorpheniramine Maleate. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Ammonium chloride may worsen acidosis and electrolyte imbalance. Dose adjustment may be required. Consult a doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Chlorpheniramine is metabolized in the liver; reduced liver function may increase its effects. Dose adjustment may be required. Consult a doctor. |
| Maximum Daily Dose | The maximum daily dose for adults is 6 doses of the standard dose in 24 hours. Do not exceed the recommended dose. For children, follow pediatrician's advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cirohist expectorant
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| MAO inhibitors | Major | |
| CNS depressants | Major | |
| Anticholinergics | Moderate | |
| CYP2D6 inhibitors | Moderate | |
| Diuretics | Moderate | |
| Antihypertensives | Minor | |
| Levodopa | Minor |
🚨 Major Interactions
- MAO inhibitors (e.g., phenelzine, tranylcypromine)
- CNS depressants (e.g., alcohol, benzodiazepines, opioids, sleep aids)
⚡ Moderate Interactions
- Anticholinergic drugs (e.g., atropine, benztropine, tricyclic antidepressants)
- CYP2D6 inhibitors (e.g., fluoxetine, paroxetine, quinidine)
- Diuretics, corticosteroids, or other drugs causing electrolyte imbalance
🍷 Alcohol Interaction
Alcohol increases the sedative and impairing effects of Chlorpheniramine Maleate. Avoid drinking alcohol while taking this medicine because it can cause excessive drowsiness, dizziness, and difficulty concentrating.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to Chlorpheniramine Maleate, Ammonium Chloride, or any component of the formulation","Newborns and premature infants","Nursing mothers","Patients with severe liver disease","Patients with severe kidney disease","Patients with narrow-angle glaucoma","Patients with symptomatic prostate enlargement or bladder neck obstruction","Patients with asthma attack"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol and other CNS depressants.","Use with caution in patients with glaucoma, prostate enlargement, or urinary retention.","Use with caution in patients with cardiovascular disease, hypertension, or thyroid disorders.","Do not use for chronic cough or cough with excessive secretions unless directed by a doctor.","Do not exceed recommended dose.","Keep out of reach of children.","Consult a doctor if symptoms persist beyond 7 days or are accompanied by fever, rash, or persistent headache."]
🤱 Lactation Safety
Not recommended. Chlorpheniramine may pass into breast milk and cause drowsiness in the infant. Ammonium chloride may also affect the nursing infant. Consult your doctor for safer alternatives.
💊 Overdose Management
Overdose may cause severe drowsiness, dizziness, confusion, seizures, respiratory depression, or coma. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Avoid driving or operating heavy machinery until you know how this medicine affects you. Do not drink alcohol while taking this medicine because it can increase drowsiness and dizziness. Inform your doctor if you have glaucoma, prostate enlargement, asthma, or thyroid problems. Do not use this medicine for longer than directed without medical advice. Keep out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the sedative and anticholinergic effects of Chlorpheniramine Maleate. Use with caution and consider lower doses. Monitor for confusion, dizziness, and falls.
🤰 Pregnancy Planning (TTC)
Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant, or breastfeeding. Safety in pregnancy is not well established.
🏥 Post-Surgery Considerations
Consult your doctor before using this medicine after surgery, as it may interact with anesthetics and other medications. It may also increase the risk of urinary retention.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine, as it may cause dry mouth and increase the risk of dental problems. It may also interact with sedatives used during dental procedures.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or activities requiring alertness until you know how this medicine affects you, as it may cause drowsiness and dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness and impair your ability to drive or operate machinery. Avoid these activities until you know how it affects you. It may also reduce your concentration, so take caution with tasks requiring mental alertness.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects. Do not stop abruptly if you have been taking it for a long time without medical advice.
📅 Long-Term Use Effects
Long-term use of this medicine is not recommended without medical supervision. Prolonged use may lead to tolerance, dependence, and increased risk of side effects such as sedation, dry mouth, and kidney problems. Regular monitoring of renal function and electrolytes may be needed if used for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps relieve nasal congestion without medication.
Evidence: Well-establishedCan help loosen mucus and ease breathing.
Evidence: Commonly usedSoothes throat and reduces cough frequency.
Evidence: Some evidence💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Not established from the available information. This medicine does not interact with vaccines. However, if you are acutely ill, consult your doctor before vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from light and moisture. If traveling across time zones, continue your regular dosing schedule as prescribed. Check customs regulations for carrying medicines. Keep it in your carry-on luggage if flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts working within 30 to 60 minutes after oral administration.
A: Do not take with other antihistamines or cough medicines without consulting your doctor, as it may increase side effects.
A: Pediatric dosing is not established from available information. Consult a pediatrician. It is contraindicated in newborns and premature infants.
A: Seek immediate medical attention. Overdose may cause severe drowsiness, seizures, or breathing difficulty.
🤔 Common Patient Concerns
🔄 Substitutes for cirohist expectorant
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any type of cough.
Fact: This medicine is for symptomatic relief of cough due to cold or allergies. It does not treat infections or chronic cough. Consult a doctor for persistent cough. - Myth: It is safe to take this medicine for a long time.
Fact: Prolonged use without medical supervision can cause side effects. Use only for short-term relief as directed. - Myth: This medicine is safe during pregnancy.
Fact: Safety in pregnancy is not well established. Consult your doctor before use.
🔄 Alternative Options
Generic Alternatives
- Chlorpheniramine Maleate + Ammonium Chloride combination (generic)