cinnar d 15mg/20mg tablet - Uses, Price, Side Effects & Substitutes
What is cinnar d 15mg/20mg tablet used for?
Agvert 15mg/20mg Tablet (Domperidone + Cinnarizine) is used to treat GASTRO INTESTINAL. It contains Domperidone (15mg) + Cinnarizine (20mg), which Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone; Cinn. Always consult your doctor before use. Take as prescribed.
- Generic Name: Domperidone + Cinnarizine
- Manufacturer: Excare Laboratories
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cinnar d 15mg/20mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Cinnarizine |
| Brand Name | Agvert 15mg/20mg Tablet |
| Manufacturer | Excare Laboratories |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antiemetic and Antivertigo |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone blocks dopamine D2 receptors in the chemoreceptor trigger zone; Cinnarizine blocks histamine H1 receptors and calcium channels in the vestibular system
Mechanism Steps
๐ก How to Take cinnar d 15mg/20mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cinnar d 15mg/20mg tablet
โ Common Side Effects
- Dry mouth
- Drowsiness
- Headache
- Dizziness
- Fatigue
๐จ Serious Side Effects
- QT prolongation
- Torsades de pointes
- Extrapyramidal symptoms
- Neuroleptic malignant syndrome
โ ๏ธ Rare Side Effects
- Galactorrhea
- Gynecomastia
- Amenorrhea
- Allergic reactions
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Ketoconazole | Major | Increased risk of QT prolongation |
| Erythromycin | Major | Increased risk of cardiac arrhythmias |
| Clarithromycin | Major | Increased domperidone levels and QT prolongation |
| Amiodarone | Major | Additive QT prolongation |
| Haloperidol | Major | Increased risk of extrapyramidal symptoms |
| Cimetidine | Moderate | Increased domperidone bioavailability |
| Fluoxetine | Moderate | Increased risk of serotonin syndrome |
| Paroxetine | Moderate | Increased risk of serotonin syndrome |
| Quinidine | Moderate | Additive QT prolongation |
| Ritonavir | Moderate | Increased domperidone levels |
| Alprazolam | Minor | Increased sedation |
| Diazepam | Minor | Increased sedation |
| Omeprazole | Minor | Decreased domperidone absorption |
| Ranitidine | Minor | Decreased domperidone absorption |
๐จ Major Interactions
- Ketoconazole
- Erythromycin
- Clarithromycin
- Amiodarone
- Haloperidol
โก Moderate Interactions
- Cimetidine
- Fluoxetine
- Paroxetine
- Quinidine
- Ritonavir
โน๏ธ Minor Interactions
- Alprazolam
- Diazepam
- Omeprazole
- Ranitidine
๐ฝ๏ธ Food Interactions
Food may delay absorption; avoid grapefruit juice
๐ท Alcohol Interaction
Increased sedation and dizziness
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, GI hemorrhage, mechanical obstruction, prolactinoma, QT prolongation, concurrent strong CYP3A4 inhibitors
๐ Monitoring Parameters
ECG for QT interval, liver function, renal function, extrapyramidal symptoms
๐คฑ Lactation Safety
Domperidone excreted in breast milk; cinnarizine unknown; avoid use
๐ Overdose Management
Supportive care; ECG monitoring; activated charcoal if recent ingestion; treat arrhythmias
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose