cinadil d 15 mg/25 mg tablet - Domperidone (15mg) + Cinnarizine (25mg) medicine

Cinadil D 15 Mg/25 Mg Tablet: Complete Medicine Guide

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🏭 Psychotropics India Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 26, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate
Reviewed by
SaathiMed Expert Panel | Oct 26, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Blood in vomit or stool
  • Severe abdominal pain
  • Chest pain or palpitations
  • Difficulty breathing or swelling of face/lips/throat
  • Uncontrollable muscle movements or tremors
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is cinadil d 15 mg/25 mg tablet used for?

This medicine is a combination of Domperidone and Cinnarizine used to treat vertigo, nausea, and vomiting. It works by blocking dopamine and calcium channels to reduce dizziness and stomach upset. Take it exactly as prescribed by your doctor.

  • Generic Name: Domperidone + Cinnarizine
  • Manufacturer: Psychotropics India Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 cinadil d 15 mg/25 mg tablet के बारे में (Hindi Summary)

उपयोग: यह दवा डोम्पेरिडोन और सिनारिज़ीन का संयोजन है, जिसका उपयोग चक्कर आना, उल्टी और मतली के इलाज के लिए किया जाता है। यह वर्टिगो, मोशन सिकनेस और मेनियर रोग में लाभकारी है। यह दवा मस्तिष्क में संतुलन बनाए रखने और पेट की गतिविधि को सुधारने में मदद करती है।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मुँह सूखना, नींद आना, थकान, सिरदर्द और पेट में हल्की परेशानी शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन मांसपेशियों में अकड़न, कंपन, अनियमित दिल की धड़कन या एलर्जी हो सकती है। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। दवा लेने के बाद गाड़ी चलाने या मशीन चलाने से बचें क्योंकि इससे नींद आ सकती है। शराब का सेवन न करें। यदि आपको हृदय, यकृत या गुर्दे की बीमारी है तो डॉक्टर को बताएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर की सलाह लें। दवा को बच्चों से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 cinadil d 15 mg/25 mg tablet Uses & Benefits

[{"condition":"Vertigo","description":"Relieves spinning sensation and imbalance associated with vestibular disorders.","evidence":"Well-established"},{"condition":"Nausea and vomiting","description":"Controls nausea and vomiting of various origins, including motion sickness and drug-induced emesis.","evidence":"Well-established"},{"condition":"Motion sickness","description":"Prevents and treats nausea, vomiting, and dizziness caused by motion.","evidence":"Well-established"},{"condition":"Meniere's disease","description":"Helps manage vertigo, tinnitus, and hearing loss associated with Meniere's disease.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Migraine-associated vertigo","description":"Sometimes used to alleviate vertigo during migraine attacks.","evidence":"Limited"},{"condition":"Gastroparesis","description":"Domperidone component may be used off-label to improve gastric emptying in diabetic gastroparesis.","evidence":"Limited"}]

Primary treatment for: Vertigo

Also treats: Nausea and vomiting, Motion sickness, Meniere's disease

📋 Drug Information

Generic Name(s)Domperidone + Cinnarizine
Brand NameAgvert 15mg/20mg Tablet
ManufacturerPsychotropics India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassAntiemetic and Antivertigo
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Avoid driving or operating machinery until you know how this medicine affects you.
3
Do not consume alcohol while taking this medicine.
4
Take the tablet at the same time each day for best results.
5
If you miss a dose, take it as soon as you remember, but do not double the dose.
6
Consult your doctor if symptoms persist beyond 7 days.
7
Report any unusual muscle movements or heart palpitations immediately.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Vertigo
This medicine is commonly prescribed for vertigo.
Likely Use
✅
Nausea
This medicine helps control nausea.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionDomperidone is rapidly absorbed from the gastrointestinal tract after oral administration, with peak plasma concentrations occurring within 30 to 60 minutes. Cinnarizine is also well absorbed orally, with peak plasma levels reached in 1 to 4 hours. Food may slightly delay the absorption of both components.
DistributionDomperidone is widely distributed in body tissues but does not readily cross the blood-brain barrier. Cinnarizine is highly lipophilic and distributes extensively into tissues, including the central nervous system.
Protein BindingDomperidone is approximately 91-93% bound to plasma proteins. Cinnarizine is about 91% bound to plasma proteins.
MetabolismDomperidone undergoes extensive first-pass metabolism in the liver and intestinal wall via CYP3A4 and CYP1A2 enzymes. Cinnarizine is metabolized in the liver, primarily by CYP2D6 and CYP3A4.
Half-LifeThe elimination half-life of Domperidone is approximately 7-9 hours in healthy individuals. Cinnarizine has a half-life of about 3-6 hours.
ExcretionDomperidone is excreted mainly in the feces (about 66%) and urine (about 33%) as metabolites. Cinnarizine is excreted primarily in the feces as metabolites, with a small amount in urine.
BioavailabilityThe oral bioavailability of Domperidone is about 13-17% due to extensive first-pass metabolism. Cinnarizine has a bioavailability of approximately 60-70%.
Onset of ActionThe onset of action for Domperidone is within 30-60 minutes, while Cinnarizine begins to act within 1-2 hours.
Peak Plasma TimeDomperidone: 0.5-1 hour; Cinnarizine: 1-4 hours.
Duration of ActionThe duration of action for Domperidone is about 4-6 hours, and for Cinnarizine, it is about 6-8 hours.

How It Works

This medicine combines two active ingredients with complementary mechanisms. Domperidone is a peripheral dopamine D2 receptor antagonist that blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) and gastrointestinal tract, thereby reducing nausea and vomiting and enhancing gastric motility. Cinnarizine is a calcium channel blocker that inhibits calcium influx into vestibular hair cells, reducing their excitability. It also has antihistamine (H1) and anticholinergic properties, which contribute to its antivertigo effects. Together, they suppress vertigo and nausea through central and peripheral actions.

Mechanism Steps

1
Domperidone blocks dopamine D2 receptors: Domperidone antagonizes dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, reducing nausea and vomiting and promoting gastric emptying.
2
Cinnarizine blocks calcium channels: Cinnarizine inhibits calcium influx into vestibular hair cells, decreasing their excitability and suppressing vertigo.
3
Cinnarizine antagonizes histamine H1 receptors: Cinnarizine blocks histamine H1 receptors in the vestibular nuclei, adding to its antivertigo effect.
4
Combined effect: The combined actions of Domperidone and Cinnarizine provide rapid relief from vertigo, nausea, and vomiting.

💡 How to Take cinadil d 15 mg/25 mg tablet

Strength: Tablet containing Domperidone 15 mg and Cinnarizine 25 mg.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush or chew.
3Take with or without food, but with food if it upsets your stomach.
4Take at the same time each day to maintain consistent levels.
5Do not exceed the prescribed dose.
6If you miss a dose, follow the missed dose instructions.

Dosage Information

Adult DosageThe usual adult dose of this medicine is one tablet taken orally one to three times daily, depending on the condition being treated and the severity of symptoms. For vertigo, it is often taken twice daily. For nausea and vomiting, it may be taken up to three times daily. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the maximum recommended dose. Take with or without food, but taking with food may reduce stomach upset.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the side effects of this medicine, especially drowsiness and extrapyramidal symptoms. Use with caution and consider lower doses. Dose must be individualized by a qualified clinician.
Renal ImpairmentIn patients with severe renal impairment, the dose may need to be reduced. Consult your doctor for appropriate dosing.
Hepatic ImpairmentIn patients with severe hepatic impairment, this medicine is contraindicated. In mild to moderate hepatic impairment, use with caution and consider dose reduction. Consult your doctor.
Maximum Daily DoseThe maximum recommended daily dose is 3 tablets (45 mg Domperidone and 75 mg Cinnarizine). Do not exceed this dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset.
Grapefruit
Avoid
May increase drug levels.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of cinadil d 15 mg/25 mg tablet

✅ Common Side Effects

Dry mouth (Common (5-10%))
Sip water frequently or chew sugar-free gum. Consult doctor if persistent.
Drowsiness (Common (5-10%))
Avoid driving or operating machinery. Consult doctor if severe.
Fatigue (Common (5-10%))
Get adequate rest. Consult doctor if it interferes with daily activities.
Headache (Common (5-10%))
Take rest and stay hydrated. Consult doctor if headache persists.
Gastrointestinal discomfort (Common (5-10%))
Take with food to minimize stomach upset. Consult doctor if symptoms worsen.

🚨 Serious Side Effects

Extrapyramidal symptoms (Rare (<0.1%))
Seek immediate medical attention if you experience muscle stiffness, tremors, or involuntary movements.
Cardiac arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you experience palpitations, chest pain, or fainting.
Severe allergic reactions (Rare (<0.1%))
Seek emergency help if you notice rash, swelling of face/lips/throat, or difficulty breathing.

⚠️ Rare Side Effects

Neuroleptic malignant syndrome
Seek emergency care if you develop high fever, muscle rigidity, confusion, or irregular pulse.
QT prolongation
Consult doctor if you have a history of heart disease or are taking other QT-prolonging drugs.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Ketoconazole Major
Erythromycin Major
Amiodarone Major
Anticholinergics Moderate
CNS depressants Moderate
Levodopa Moderate
Grapefruit juice Minor
Antacids Minor

🚨 Major Interactions

  • Ketoconazole
  • Erythromycin
  • Amiodarone

⚡ Moderate Interactions

  • Anticholinergic drugs
  • CNS depressants
  • Levodopa

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can increase drowsiness and impair your ability to drive or operate machinery. It may also worsen dizziness and increase the risk of falls.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Known hypersensitivity to Domperidone or Cinnarizine","Severe hepatic impairment","Cardiac conduction disorders, including QT prolongation","Concomitant use with QT-prolonging drugs or potent CYP3A4 inhibitors","Prolactin-secreting pituitary tumors","Gastrointestinal bleeding, obstruction, or perforation","Parkinson's disease (Domperidone may worsen symptoms)"]

⚠️ Warnings & Precautions

["Use with caution in patients with heart disease, liver disease, or kidney disease.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Avoid alcohol while taking this medicine.","Do not exceed the recommended dose or duration of treatment.","Use with caution in elderly patients due to increased risk of side effects.","Consult your doctor if symptoms persist or worsen.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding."]

🤱 Lactation Safety

Domperidone is excreted in breast milk and may cause side effects in the infant. Cinnarizine may also pass into breast milk. This medicine is not recommended during breastfeeding unless clearly needed and advised by a doctor.

💊 Overdose Management

Overdose may cause drowsiness, extrapyramidal symptoms, and cardiac arrhythmias. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if taken recently. Monitor ECG and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose or duration of treatment. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. Avoid alcohol consumption while taking this medicine, as it can increase drowsiness and impair your ability to perform tasks. Inform your doctor if you have a history of heart problems, liver disease, kidney disease, or Parkinson's disease. Do not take this medicine if you are pregnant or breastfeeding without consulting your doctor. Keep this medicine out of reach of children. Store it at room temperature, away from moisture and direct sunlight. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for your next dose. Do not double the dose.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to side effects such as drowsiness, confusion, and extrapyramidal symptoms. Use with caution and lower doses may be required. Regular monitoring is advised.

🤰 Pregnancy Planning (TTC)

If you are planning to become pregnant, consult your doctor before taking this medicine. It is not recommended during pregnancy unless clearly needed.

🏥 Post-Surgery Considerations

Consult your doctor before taking this medicine after surgery, as it may affect gastric motility and interact with other medications.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine, as it may cause dry mouth and increase the risk of dental problems. Maintain good oral hygiene.

💚 Lifestyle Tips for Better Results

🏃
Maintain a healthy weight to reduce the frequency of vertigo.
🥗
Avoid sudden head movements that can trigger dizziness.
😴
Get adequate sleep to reduce fatigue.
💧
Stay hydrated throughout the day.
🧘
Practice relaxation techniques to manage stress.
🌞
Avoid alcohol and caffeine if they worsen your symptoms.

🏋️ Exercise Considerations

Avoid exercises that require balance or rapid head movements, such as yoga inversions or high-intensity interval training, until your vertigo is controlled. Consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Eat small, frequent meals to prevent nausea.
Include ginger in your diet as it may help with nausea.
Avoid spicy and greasy foods that can upset your stomach.
Stay well hydrated with water and clear fluids.

💼 Impact on Daily Work & Life

This medicine may cause drowsiness, which can affect your ability to drive or operate machinery. It is advisable to avoid these activities until you know how the medicine affects you. Inform your employer if your job involves such tasks.

🛑 When to Stop This Medicine

Do not stop taking this medicine without consulting your doctor. If you experience severe side effects or your symptoms worsen, contact your doctor immediately. Your doctor will advise you on whether to stop or adjust the dose.

📅 Long-Term Use Effects

Long-term use of this medicine may increase the risk of extrapyramidal symptoms and cardiac arrhythmias. Regular monitoring by a doctor is recommended. Do not use for prolonged periods without medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Vestibular rehabilitation therapy

Exercises to improve balance and reduce vertigo.

Evidence: Well-established
Epley maneuver

A series of head movements to treat benign paroxysmal positional vertigo.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific interactions with vaccines are known. However, consult your doctor before receiving any vaccine while taking this medicine.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging along with a copy of your prescription. Store it in a cool, dry place away from direct sunlight. If crossing time zones, adjust the dosing schedule gradually. Check customs regulations for carrying prescription medicines. Do not leave it in a hot car.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 50-year-old woman with recurrent vertigo
She was prescribed this medicine for vertigo. After taking it regularly for a week, her spinning sensation reduced significantly. She was advised to avoid driving due to drowsiness and to take the tablet with food to prevent stomach upset.
💡 Lesson: Consistent use and following safety precautions lead to better outcomes.
👤 A 35-year-old man with motion sickness
He took this medicine before a long journey and experienced no nausea or dizziness. He noted that taking it 30 minutes before travel was effective.
💡 Lesson: Timing the dose before travel can prevent motion sickness.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts working within 30-60 minutes for nausea and 1-2 hours for vertigo.

Q: Can I take it on an empty stomach?

A: It can be taken with or without food, but taking it with food may reduce stomach upset.

Q: Is it safe to drive after taking this medicine?

A: This medicine may cause drowsiness. Avoid driving until you know how it affects you.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for cinadil d 15 mg/25 mg tablet

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken for any type of dizziness.
    Fact: This medicine is specifically for vertigo and nausea due to vestibular disorders. It is not effective for all types of dizziness.
  • Myth: It is safe to take this medicine long-term without monitoring.
    Fact: Long-term use requires monitoring for side effects such as extrapyramidal symptoms and cardiac effects.

🔄 Alternative Options

Generic Alternatives

  • Domperidone + Cinnarizine combination generics

Brand Alternatives

  • Cinadil D 15 mg/25 mg Tablet

📊 Comparison with Similar Medicines

[{"medicine":"Domperidone + Cinnarizine","uses":"Vertigo, nausea, vomiting","key_difference":"Combination provides both antiemetic and antivertigo effects."},{"medicine":"Domperidone alone","uses":"Nausea, vomiting","key_difference":"Lacks antivertigo effect."},{"medicine":"Cinnarizine alone","uses":"Vertigo, motion sickness","key_difference":"Lacks prokinetic antiemetic effect."}]

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