chepatron 0.25mg injection - Palonosetron (0.25mg) medicine

chepatron 0.25mg injection - Uses, Price, Side Effects & Substitutes

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๐Ÿญ Torrent Pharmaceuticals Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is chepatron 0.25mg injection used for?

Cepatron (Palonosetron) is used to treat GASTRO INTESTINAL. It contains Palonosetron (0.25mg), which Selective serotonin 5-HT3 receptor antagonist, blocking serotonin binding in the. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Palonosetron
  • Manufacturer: Torrent Pharmaceuticals Ltd
  • Form: Allopathy
  • Pregnancy Category: B
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š chepatron 0.25mg injection Uses & Benefits

Prevention of acute and delayed nausea and vomiting associated with moderately and highly emetogenic cancer chemotherapy; prevention of postoperative nausea and vomiting.

Off-label uses: Prevention of nausea and vomiting due to radiation therapy, Treatment of hyperemesis gravidarum

๐Ÿ“‹ Drug Information

Generic Name(s)Palonosetron
Brand NameCepatron
ManufacturerTorrent Pharmaceuticals Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassGASTRO INTESTINAL
Action ClassSerotonin antagonists (5-HT3 antagonists)
Route of AdministrationIntravenous (IV) or oral.
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionWell absorbed after oral administration; IV administration provides rapid systemic availability.
DistributionDistributes widely; volume of distribution approximately 8.3 L/kg.
Protein BindingApproximately 62% bound to plasma proteins.
MetabolismPrimarily metabolized by CYP2D6, with minor contributions from CYP3A4 and CYP1A2.
Half-LifeApproximately 40 hours.
ExcretionAbout 80% excreted in urine, with 50% as unchanged drug; remainder in feces.
BioavailabilityNot applicable for IV; oral bioavailability is about 97%.
Onset of ActionRapid; within minutes after IV administration.
Peak Plasma TimeImmediately after IV administration; oral: 5-6 hours.
Duration of ActionUp to 24 hours for prevention of nausea and vomiting.

How It Works

Selective serotonin 5-HT3 receptor antagonist, blocking serotonin binding in the chemoreceptor trigger zone and gastrointestinal tract.

Mechanism Steps

1Palonosetron binds to 5-HT3 receptors on vagal afferent neurons in the gastrointestinal tract and in the chemoreceptor trigger zone of the area postrema.
2Blockade of 5-HT3 receptors prevents serotonin-mediated activation of these neurons.
3Inhibition of the vomiting reflex reduces nausea and vomiting.

๐Ÿ’ก How to Take chepatron 0.25mg injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of chepatron 0.25mg injection

โœ… Common Side Effects

  • Headache
  • Constipation
  • Diarrhea
  • Dizziness
  • Fatigue

๐Ÿšจ Serious Side Effects

  • Serotonin syndrome
  • Hypersensitivity reactions
  • Bradycardia
  • Hypotension

โš ๏ธ Rare Side Effects

  • QT prolongation
  • Seizures
  • Extrapyramidal symptoms

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Apomorphine Major Increased risk of hypotension and loss of consciousness
MAOIs Major Increased risk of serotonin syndrome
SSRIs Moderate Increased risk of serotonin syndrome
CYP2D6 inhibitors Moderate Increased palonosetron exposure
CYP2D6 inducers Moderate Decreased palonosetron exposure

๐Ÿšจ Major Interactions

  • Apomorphine
  • MAOIs
  • Serotonergic drugs (e.g., SSRIs, SNRIs)

โšก Moderate Interactions

  • CYP2D6 inhibitors (e.g., fluoxetine, paroxetine)
  • CYP2D6 inducers (e.g., rifampin)

โ„น๏ธ Minor Interactions

  • Anticholinergics
  • Corticosteroids

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

May increase sedative effects; avoid concurrent use.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to palonosetron or any component.

๐Ÿ“Š Monitoring Parameters

Monitor for signs of serotonin syndrome when used with serotonergic drugs; ECG in patients with risk factors for QT prolongation.

๐Ÿคฑ Lactation Safety

Not recommended; unknown if excreted in breast milk.

๐Ÿ’Š Overdose Management

Symptomatic and supportive treatment; no specific antidote.

โฐ Missed Dose

Administer as soon as remembered; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for chepatron 0.25mg injection

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Alternative brands with exact same active ingredient (Palonosetron (0.25mg)):

Medical Note: Always consult your doctor before switching medications.

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