chemofit 250mg tablet - Uses, Price, Side Effects & Substitutes
What is chemofit 250mg tablet used for?
Adgef 250 Tablet (Gefitinib) is used to treat ANTI NEOPLASTICS. It contains Gefitinib (250mg), which Inhibits epidermal growth factor receptor (EGFR) tyrosine kinase, blocking downs. Always consult your doctor before use. Take as prescribed.
- Generic Name: Gefitinib
- Manufacturer: RPG Life Sciences Ltd
- Form: Allopathy
- Pregnancy Category: D
- Prescription Required: Yes
๐ chemofit 250mg tablet Uses & Benefits
First-line treatment of metastatic non-small cell lung cancer (NSCLC) with EGFR exon 19 deletions or exon 21 L858R mutations.
Off-label uses: Other EGFR-mutated cancers (e.g., head and neck, colorectal) with limited evidence.
๐ Drug Information
| Generic Name(s) | Gefitinib |
| Brand Name | Adgef 250 Tablet |
| Manufacturer | RPG Life Sciences Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Tyrosine kinase inhibitors |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits epidermal growth factor receptor (EGFR) tyrosine kinase, blocking downstream signaling pathways involved in cell proliferation and survival.
Mechanism Steps
๐ก How to Take chemofit 250mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of chemofit 250mg tablet
โ Common Side Effects
- Diarrhea
- Rash
- Dry skin
- Nausea
- Vomiting
- Anorexia
- Stomatitis
- Paronychia
๐จ Serious Side Effects
- Interstitial lung disease (ILD)
- Severe hepatotoxicity
- Gastrointestinal perforation
- Severe diarrhea leading to dehydration
- Bullous skin reactions
- Ocular toxicity (e.g., keratitis)
โ ๏ธ Rare Side Effects
- Pancreatitis
- Hemorrhagic cystitis
- Nail disorders
- Hair changes
- Taste alteration
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Ketoconazole | Major | Increased gefitinib plasma concentration |
| Rifampin | Major | Decreased gefitinib plasma concentration |
| Metoprolol | Major | Increased metoprolol levels |
| Antacids | Moderate | Reduced gefitinib absorption |
| Omeprazole | Moderate | Reduced gefitinib absorption |
๐จ Major Interactions
- CYP3A4 inducers (e.g., rifampin, phenytoin)
- CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
- Warfarin
- Metoprolol
โก Moderate Interactions
- CYP2D6 substrates (e.g., tricyclic antidepressants)
- Antacids
- H2 receptor antagonists
- Proton pump inhibitors
โน๏ธ Minor Interactions
- CYP2D6 inhibitors (e.g., fluoxetine)
- CYP3A4 substrates with narrow therapeutic index
๐ฝ๏ธ Food Interactions
High-fat meals may reduce absorption; take on an empty stomach.
๐ท Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to gefitinib or excipients; severe hepatic impairment.
๐ Monitoring Parameters
Liver function tests, renal function, pulmonary symptoms, skin reactions, diarrhea, and ECG for QT prolongation.
๐คฑ Lactation Safety
Not recommended; excreted in animal milk, unknown in humans.
๐ Overdose Management
No specific antidote; symptomatic and supportive care.
โฐ Missed Dose
Take as soon as remembered if within 12 hours; skip if less than 12 hours to next dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for chemofit 250mg tablet
View AllAlternative brands with exact same active ingredient (Gefitinib (250mg)):
-
gefires 250mg tabletResonance Laboratories Pvt Ltd โน318.75 90.6% CHEAPER
-
fitnib 250mg tabletZen Pharma Pvt Ltd โน450.00 86.7% CHEAPER
-
chemogef 250mg tabletNeon Laboratories Ltd โน1,102.00 67.5% CHEAPER
-
unigef 250mg tabletSamarth Life Sciences Pvt Ltd โน1,341.00 60.4% CHEAPER
-
gefimipsa 250mg capsuleArk Life Sciences Pvt Ltd โน1,396.88 58.8% CHEAPER
-
geftistar 250mg tabletLupin Ltd โน1,465.00 56.8% CHEAPER
-
meftinib 250mg tabletInd Swift Laboratories Ltd โน1,871.63 44.8% CHEAPER
-
kabigef 250mg tabletFresenius Kabi India Pvt Ltd โน2,139.63 36.9% CHEAPER
-
geftiwel 250mg tabletGetwell Oncology Pvt Ltd โน2,500.00 26.2% CHEAPER
-
gefitero tabletHetero Drugs Ltd โน2,532.75 25.3% CHEAPER
Medical Note: Always consult your doctor before switching medications.