chemogef 250mg tablet

4.9 (9 reviews)

Gefitinib (250mg)

🏭 Neon Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is chemogef 250mg tablet used for?

Adgef 250 Tablet (Gefitinib) is used to treat ANTI NEOPLASTICS. It contains Gefitinib (250mg), which Inhibits epidermal growth factor receptor (EGFR) tyrosine kinase, blocking downs. Always consult your doctor before use. Take as prescribed.

Generic Name: Gefitinib
Manufacturer: Neon Laboratories Ltd
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 chemogef 250mg tablet Uses & Benefits

First-line treatment of metastatic non-small cell lung cancer (NSCLC) with EGFR exon 19 deletions or exon 21 L858R mutations.

Off-label uses: Other EGFR-mutated cancers (e.g., head and neck, colorectal) with limited evidence.

📋 Drug Information

Generic Name(s)	Gefitinib
Brand Name	Adgef 250 Tablet
Manufacturer	Neon Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Tyrosine kinase inhibitors
Route of Administration	Oral
Storage	Store at 20-25°C (68-77°F); protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionAbsorbed slowly after oral administration; peak plasma concentrations achieved within 3-7 hours.

DistributionExtensively distributed into tissues; volume of distribution approximately 1400 L.

Protein BindingApproximately 90% bound to plasma proteins (albumin and alpha-1-acid glycoprotein).

MetabolismMetabolized primarily by CYP3A4 and, to a lesser extent, by CYP2D6.

Half-LifeApproximately 48 hours.

ExcretionPrimarily excreted in feces (86%) and to a lesser extent in urine (4%).

BioavailabilityApproximately 60%.

Onset of ActionNot well-defined; clinical effects observed within days to weeks.

Peak Plasma Time3-7 hours post-dose.

Duration of ActionSustained inhibition of EGFR tyrosine kinase; half-life supports once-daily dosing.

How It Works

Inhibits epidermal growth factor receptor (EGFR) tyrosine kinase, blocking downstream signaling pathways involved in cell proliferation and survival.

Mechanism Steps

1Gefitinib binds to the ATP-binding site of EGFR tyrosine kinase domain.

2Inhibits autophosphorylation of EGFR.

3Blocks downstream signaling pathways (RAS/RAF/MEK/ERK and PI3K/AKT).

💡 How to Take chemogef 250mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of chemogef 250mg tablet

✅ Common Side Effects

Diarrhea
Rash
Dry skin
Nausea
Vomiting
Anorexia
Stomatitis
Paronychia

🚨 Serious Side Effects

Interstitial lung disease (ILD)
Severe hepatotoxicity
Gastrointestinal perforation
Severe diarrhea leading to dehydration
Bullous skin reactions
Ocular toxicity (e.g., keratitis)

⚠️ Rare Side Effects

Pancreatitis
Hemorrhagic cystitis
Nail disorders
Hair changes
Taste alteration

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased INR and bleeding risk
Ketoconazole	Major	Increased gefitinib plasma concentration
Rifampin	Major	Decreased gefitinib plasma concentration
Metoprolol	Major	Increased metoprolol levels
Antacids	Moderate	Reduced gefitinib absorption
Omeprazole	Moderate	Reduced gefitinib absorption

🚨 Major Interactions

CYP3A4 inducers (e.g., rifampin, phenytoin)
CYP3A4 inhibitors (e.g., ketoconazole, itraconazole)
Warfarin
Metoprolol

⚡ Moderate Interactions

CYP2D6 substrates (e.g., tricyclic antidepressants)
Antacids
H2 receptor antagonists
Proton pump inhibitors

ℹ️ Minor Interactions

CYP2D6 inhibitors (e.g., fluoxetine)
CYP3A4 substrates with narrow therapeutic index

🍽️ Food Interactions

High-fat meals may reduce absorption; take on an empty stomach.

🍷 Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to gefitinib or excipients; severe hepatic impairment.

📊 Monitoring Parameters

Liver function tests, renal function, pulmonary symptoms, skin reactions, diarrhea, and ECG for QT prolongation.

🤱 Lactation Safety

Not recommended; excreted in animal milk, unknown in humans.

💊 Overdose Management

No specific antidote; symptomatic and supportive care.

⏰ Missed Dose

Take as soon as remembered if within 12 hours; skip if less than 12 hours to next dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for chemogef 250mg tablet

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Alternative brands with exact same active ingredient (Gefitinib (250mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Regular Customer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Certified Buyer Jul 10, 2026

Found this to be a helpful product. Good results.