celvestrant pfs injection

4.7 (13 reviews)

Fulvestrant (250mg)

🏭 Celon Laboratories Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is celvestrant pfs injection used for?

Celvestrant PFS Injection (Fulvestrant) is used to treat ANTI NEOPLASTICS. It contains Fulvestrant (250mg), which Estrogen receptor antagonist; binds to estrogen receptors and downregulates them. Always consult your doctor before use. Take as prescribed.

Generic Name: Fulvestrant
Manufacturer: Celon Laboratories Ltd
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 celvestrant pfs injection Uses & Benefits

Treatment of hormone receptor-positive metastatic breast cancer in postmenopausal women with disease progression after antiestrogen therapy.

Off-label uses: Male breast cancer, Preoperative therapy in early breast cancer

📋 Drug Information

Generic Name(s)	Fulvestrant
Brand Name	Celvestrant PFS Injection
Manufacturer	Celon Laboratories Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Estrogen receptor antagonist
Route of Administration	Intramuscular injection (gluteal).
Storage	Store at 2-8°C (refrigerate); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionSlow absorption after intramuscular injection; bioavailability is approximately 100% due to direct systemic administration.

DistributionWidely distributed; volume of distribution is large (3-5 L/kg).

Protein Binding99% bound to plasma proteins, primarily albumin.

MetabolismHepatic metabolism via CYP3A4 to inactive metabolites.

Half-LifeApproximately 40 days after multiple doses.

ExcretionPrimarily fecal (90%) and renal (<1% unchanged).

Bioavailability100% (intramuscular injection).

Onset of ActionWithin 1-2 weeks.

Peak Plasma Time7-14 days after a single dose.

Duration of ActionApproximately 1 month.

How It Works

Estrogen receptor antagonist; binds to estrogen receptors and downregulates them.

Mechanism Steps

1Fulvestrant binds to estrogen receptors (ER) with high affinity.

2Receptor dimerization is inhibited.

3ER degradation is accelerated via ubiquitin-proteasome pathway.

💡 How to Take celvestrant pfs injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of celvestrant pfs injection

✅ Common Side Effects

Injection site pain
Nausea
Fatigue
Arthralgia
Headache

🚨 Serious Side Effects

Venous thromboembolism
Severe injection site reaction
Hepatotoxicity

⚠️ Rare Side Effects

Anaphylaxis
Interstitial lung disease

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Rifampin	Major	Decreased fulvestrant exposure
Ketoconazole	Major	Increased fulvestrant exposure
Warfarin	Moderate	Increased INR
Tamoxifen	Moderate	Reduced efficacy of fulvestrant

🚨 Major Interactions

CYP3A4 inducers (e.g., rifampin, carbamazepine)
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

⚡ Moderate Interactions

Anticoagulants (e.g., warfarin)
Tamoxifen

ℹ️ Minor Interactions

Grapefruit juice

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No known interaction.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to fulvestrant or any excipients; pregnancy.

📊 Monitoring Parameters

Liver function tests, tumor response, signs of bleeding.

🤱 Lactation Safety

Not recommended; discontinue breastfeeding during treatment.

💊 Overdose Management

No specific antidote; supportive care.

⏰ Missed Dose

Administer as soon as possible; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

🔗 View Profile

🔄 Substitutes for celvestrant pfs injection

View All

Alternative brands with exact same active ingredient (Fulvestrant (250mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Happy Patient Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.