celdaz 500 injection - Dacarbazine (500mg) medicine

celdaz 500 injection

4.6 (15 reviews)
Dacarbazine (500mg)
๐Ÿญ Celon Laboratories Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 21, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 21, 2026

What is celdaz 500 injection used for?

Arzi 200mg Injection (Dacarbazine) is used to treat ANTI NEOPLASTICS. It contains Dacarbazine (500mg), which Alkylating agent that methylates DNA at guanine residues, causing DNA cross-link. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Dacarbazine
  • Manufacturer: Celon Laboratories Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š celdaz 500 injection Uses & Benefits

Metastatic melanoma; Hodgkin lymphoma (as part of ABVD regimen); soft tissue sarcoma.

Off-label uses: Pancreatic neuroendocrine tumors; glioblastoma multiforme.

๐Ÿ“‹ Drug Information

Generic Name(s)Dacarbazine
Brand NameArzi 200mg Injection
ManufacturerCelon Laboratories Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassAlkylating agent
Route of AdministrationIntravenous injection or infusion.
StorageStore at 2-8ยฐC; protect from light; reconstituted solution stable for 8 hours at room temperature.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration ensures complete bioavailability; not administered orally due to erratic absorption.
DistributionWidely distributed throughout the body; crosses blood-brain barrier to a limited extent.
Protein BindingApproximately 20-30% bound to plasma proteins.
MetabolismHepatic metabolism via N-demethylation by cytochrome P450 enzymes (CYP1A2, CYP2E1) to active metabolite MTIC.
Half-LifeBiphasic: initial half-life ~19 minutes, terminal half-life ~5 hours.
ExcretionRenal excretion: ~40% as unchanged drug and metabolites within 6 hours.
Bioavailability100% (intravenous administration).
Onset of ActionRapid; within minutes of infusion.
Peak Plasma TimeAt end of intravenous infusion.
Duration of ActionVariable; effects persist for days to weeks depending on tumor response.

How It Works

Alkylating agent that methylates DNA at guanine residues, causing DNA cross-linking and strand breaks, inhibiting DNA replication and transcription.

Mechanism Steps

1Dacarbazine undergoes hepatic N-demethylation to form MTIC (5-(3-methyltriazen-1-yl)imidazole-4-carboxamide).
2MTIC spontaneously decomposes to generate a methyldiazonium ion.
3Methyldiazonium ion methylates DNA at the O6 and N7 positions of guanine.

๐Ÿ’ก How to Take celdaz 500 injection

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of celdaz 500 injection

โœ… Common Side Effects

  • Nausea
  • Vomiting
  • Anorexia
  • Myelosuppression (leukopenia, thrombocytopenia)
  • Alopecia
  • Injection site reactions

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • Hepatotoxicity
  • Anaphylaxis
  • Hemolytic uremic syndrome
  • Secondary malignancies

โš ๏ธ Rare Side Effects

  • Photosensitivity
  • Renal failure
  • Pulmonary fibrosis
  • Neurotoxicity

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk due to enhanced anticoagulant effect.
Phenytoin Major Decreased phenytoin levels; monitor phenytoin concentrations.
Fluvoxamine Major Increased dacarbazine toxicity due to CYP1A2 inhibition.
Disulfiram Major Increased dacarbazine toxicity due to CYP2E1 inhibition.
Live vaccines Moderate Risk of disseminated infection; avoid live vaccines.
Anticoagulants Moderate Increased bleeding risk; monitor INR.

๐Ÿšจ Major Interactions

  • Warfarin
  • Phenytoin
  • CYP1A2 inhibitors (e.g., fluvoxamine)
  • CYP2E1 inhibitors (e.g., disulfiram)

โšก Moderate Interactions

  • Other myelosuppressive agents
  • Live vaccines
  • Anticoagulants

โ„น๏ธ Minor Interactions

  • Corticosteroids
  • Antiemetics

๐Ÿฝ๏ธ Food Interactions

No significant food interactions; administered intravenously.

๐Ÿท Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to dacarbazine; severe myelosuppression; pregnancy.

๐Ÿ“Š Monitoring Parameters

Complete blood count (CBC), liver function tests (LFTs), renal function tests, serum electrolytes.

๐Ÿคฑ Lactation Safety

Contraindicated; discontinue breastfeeding during therapy.

๐Ÿ’Š Overdose Management

Supportive care; monitor for myelosuppression, hepatic toxicity; no specific antidote.

โฐ Missed Dose

Administer as soon as possible; do not double dose; consult physician.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for celdaz 500 injection

View All

Alternative brands with exact same active ingredient (Dacarbazine (500mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Regular Customer Jul 10, 2026

Found this to be a helpful product. Good results.

Certified Buyer Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

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