Biophenicol 500mg Capsule: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe allergic reaction (swelling of face, lips, throat, difficulty breathing)
- Signs of blood disorder (unusual tiredness, pale skin, easy bruising, frequent infections)
- Severe skin irritation, blistering, or peeling
- New fungal or bacterial infection at the application site
- No improvement or worsening of the condition after a few days of use
If experiencing severe symptoms, call emergency services immediately.
What is comyetin 500mg capsule used for?
This medicine is a topical antibiotic containing chloramphenicol 500mg, used to treat bacterial skin infections. It works by stopping bacterial protein synthesis. Apply as directed by your doctor, usually 1-4 times daily. Do not use for prolonged periods without medical supervision.
- Generic Name: Chloramphenicol
- Manufacturer: Modern Laboratories
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 comyetin 500mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा क्लोरैम्फेनिकॉल 500mg युक्त एक टॉपिकल एंटीबायोटिक है, जिसका उपयोग त्वचा के बैक्टीरियल संक्रमणों के इलाज के लिए किया जाता है। यह संक्रमित घावों, जलन और अल्सर के इलाज में मदद करती है। यह बैक्टीरिया के प्रोटीन संश्लेषण को रोककर उनकी वृद्धि को रोकती है। इसका उपयोग डॉक्टर के निर्देशानुसार ही करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में त्वचा में जलन, लालिमा, खुजली या जलन की भावना शामिल हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी प्रतिक्रिया, सूजन, या सांस लेने में कठिनाई हो सकती है। यदि कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा का उपयोग करने से पहले अपने डॉक्टर को अपनी एलर्जी और चिकित्सीय स्थिति के बारे में बताएं। इसे आंखों, नाक और मुंह से दूर रखें। बड़े घावों पर लंबे समय तक उपयोग न करें। उपयोग से पहले और बाद में हाथ धोएं। यदि स्थिति में सुधार न हो तो डॉक्टर से मिलें।
💊 comyetin 500mg capsule Uses & Benefits
[{"condition":"Bacterial skin infections","description":"Used to treat infections caused by susceptible bacteria, such as impetigo, infected wounds, and burns.","evidence":"Well-established"},{"condition":"Infected ulcers","description":"Applied to infected skin ulcers to reduce bacterial load and promote healing.","evidence":"Well-established"},{"condition":"Secondary skin infections","description":"May be used to treat secondary bacterial infections in conditions like eczema or dermatitis.","evidence":"Limited"}]
Off-label uses: [{"condition":"Acne vulgaris","description":"Sometimes used off-label for inflammatory acne due to its antibacterial properties.","evidence":"Limited"}]
Primary treatment for: Bacterial skin infections
Also treats: Infected wounds, Infected burns, Infected ulcers
📋 Drug Information
| Generic Name(s) | Chloramphenicol |
| Brand Name | Andrecin Eye Drop |
| Manufacturer | Modern Laboratories |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | OTOLOGICALS |
| Action Class | Chloramphenicol |
| Route of Administration | Topical |
| Storage | Store at room temperature (15-30°C). Protect from light and moisture. Keep the container tightly closed. |
| Shelf Life | Not established from the available information. Refer to the packaging for the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Chloramphenicol works by inhibiting bacterial protein synthesis. It binds to the 50S ribosomal subunit and blocks the peptidyl transferase activity, preventing the formation of peptide bonds between amino acids. This stops the growth and multiplication of bacteria, allowing the body's immune system to eliminate the infection.
Mechanism Steps
💡 How to Take comyetin 500mg capsule
Strength: Topical preparation containing chloramphenicol 500mg
Dosage Information
| Adult Dosage | Apply a thin layer to the affected area as directed by your doctor, usually 1-4 times daily depending on the severity of the infection. The exact dose and duration must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function. Do not use for longer than prescribed. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dosage adjustments are established for elderly patients. Use with caution and follow your doctor's instructions. |
| Renal Impairment | No specific dosage adjustments are established for topical use. However, if systemic absorption is significant, caution is advised in patients with renal impairment. |
| Hepatic Impairment | No specific dosage adjustments are established for topical use. However, if systemic absorption is significant, caution is advised in patients with hepatic impairment. |
| Maximum Daily Dose | Not established from the available information. Follow your doctor's prescription. |
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of comyetin 500mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Other topical antibiotics | Moderate |
🚨 Major Interactions
- Other topical antibiotics
🍷 Alcohol Interaction
No known interaction with alcohol when used topically. However, alcohol may worsen skin irritation if applied to the same area.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to chloramphenicol or any component","History of bone marrow suppression","Porphyria","Use on large areas of broken skin without medical supervision"]
⚠️ Warnings & Precautions
["For external use only. Do not ingest.","Avoid contact with eyes, nose, and mouth.","Do not use on large areas or for prolonged periods unless directed.","May cause allergic reactions; discontinue if reaction occurs.","Prolonged use may lead to bacterial or fungal overgrowth.","Use in pregnancy and breastfeeding only if clearly needed.","Keep out of reach of children."]
🤱 Lactation Safety
Not established from the available information. Consult your doctor before use.
💊 Overdose Management
Overdose from topical application is unlikely. If accidental ingestion occurs, seek immediate medical attention. Symptoms of systemic overdose may include nausea, vomiting, and bone marrow suppression. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a dose, apply it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not apply a double dose to make up for a missed one.
Additional Safety Advice
Before using this medicine, inform your doctor if you are allergic to chloramphenicol or any other antibiotics. Do not apply this medicine to large areas of broken skin or for prolonged periods unless directed by a doctor. Avoid contact with eyes, nose, and mouth unless specifically instructed. If the medicine gets into these areas, rinse thoroughly with water. Wash your hands before and after applying the medicine. Do not cover the treated area with airtight dressings unless told to do so. If your condition does not improve within a few days or worsens, stop using the medicine and consult your doctor. Do not share this medicine with others, even if they have similar symptoms. Keep out of reach of children. Pregnant and breastfeeding women should consult their doctor before using this medicine.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects if systemic absorption occurs. Use with caution and monitor for any unusual symptoms.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before using this medicine. Topical use is generally considered safe, but systemic absorption should be minimized.
🏥 Post-Surgery Considerations
If you have recently had surgery, consult your surgeon before applying this medicine to surgical wounds. It may be used if prescribed for infected surgical sites.
🦷 Dental Procedures
This medicine is for topical skin use and is not typically relevant to dental procedures. Inform your dentist if you are using it on your face or neck.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If the infection is on a weight-bearing area or a joint, avoid strenuous exercise that may irritate the area. Consult your doctor before resuming intense physical activity.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is applied topically and is unlikely to affect your ability to drive or operate machinery. However, if you experience any dizziness or allergic reaction, avoid these activities until you feel better.
🛑 When to Stop This Medicine
Stop using this medicine and consult your doctor if your symptoms worsen, if you develop a severe allergic reaction, or if you do not see improvement within a few days. Do not stop abruptly if you are on a prescribed course without consulting your doctor.
📅 Long-Term Use Effects
Prolonged use of topical chloramphenicol may lead to bacterial resistance, fungal overgrowth, or rare blood disorders if significant systemic absorption occurs. Use only as prescribed and for the recommended duration. Regular monitoring may be needed if used on large areas or for extended periods.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Cleaning wounds with mild soap and water can help prevent infection.
Evidence: Well-establishedMupirocin or fusidic acid may be alternatives for certain skin infections.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No known interactions with vaccines. However, if you have an active infection, consult your doctor about timing of vaccinations.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription in case of customs checks. Store at room temperature and protect from extreme heat or cold. If crossing time zones, continue your regular application schedule as prescribed. Keep it in your carry-on luggage if flying.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start seeing improvement in a few days, but complete healing may take longer depending on the infection.
A: It can be used on some open wounds, but only if prescribed by a doctor. Do not use on large open wounds without medical advice.
A: Consult your doctor before use. Topical chloramphenicol is generally considered low risk, but systemic absorption can occur.
🤔 Common Patient Concerns
🔄 Substitutes for comyetin 500mg capsule
View AllAlternative brands with exact same active ingredient:
-
labchlor 500mg capsuleLaborate Pharmaceuticals India Ltd ₹18.16 48.1% CHEAPER
-
armycetin 500mg capsuleAgron Remedies Pvt Ltd ₹18.63 46.8% CHEAPER
-
kemicetine 500mgMac Laboratories Ltd ₹18.96 45.8% CHEAPER
-
biophenicol 500mg capsuleBiochem Pharmaceutical Industries ₹23.44 33% CHEAPER
-
cadimycetin 500mg capsuleZydus Cadila ₹25.20 28% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: Topical antibiotics are always safe and can be used for any skin problem.
Fact: Topical antibiotics should only be used for bacterial infections as prescribed. Misuse can lead to resistance and side effects. - Myth: You can stop using the antibiotic as soon as the symptoms improve.
Fact: You should complete the full course as prescribed to prevent recurrence and resistance, unless your doctor advises otherwise.
🔄 Alternative Options
Generic Alternatives
- Chloramphenicol topical preparations