cardine 20mg tablet

4.5 (8 reviews)

Trimetazidine (20mg)

🏭 Diacardus Pharmacy Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is cardine 20mg tablet used for?

Accardi MR Tablet MR (Trimetazidine) is used to treat CARDIAC. It contains Trimetazidine (20mg), which Inhibits long-chain 3-ketoacyl-CoA thiolase, shifting myocardial energy metaboli. Always consult your doctor before use. Take as prescribed.

Generic Name: Trimetazidine
Manufacturer: Diacardus Pharmacy Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 cardine 20mg tablet Uses & Benefits

Adjunctive therapy for stable angina pectoris; also used for vertigo and tinnitus (off-label in some regions).

Off-label uses: Vertigo, Tinnitus, Diabetic cardiomyopathy

📋 Drug Information

Generic Name(s)	Trimetazidine
Brand Name	Accardi MR Tablet MR
Manufacturer	Diacardus Pharmacy Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Fatty acid modulator & Sodium channel blocker
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly absorbed after oral administration; peak plasma concentrations achieved within 2-6 hours.

DistributionWidely distributed in body tissues; volume of distribution approximately 4.8 L/kg.

Protein BindingLow (approximately 16%)

MetabolismPrimarily metabolized in the liver via CYP450 enzymes, mainly CYP2D6 and CYP3A4.

Half-LifeApproximately 7-12 hours

ExcretionMainly excreted in urine (60-70% as unchanged drug and metabolites); small amount in feces.

BioavailabilityApproximately 90%

Onset of ActionWithin 2-4 hours

Peak Plasma Time2-6 hours

Duration of ActionUp to 24 hours

How It Works

Inhibits long-chain 3-ketoacyl-CoA thiolase, shifting myocardial energy metabolism from fatty acid oxidation to glucose oxidation, thereby improving cardiac efficiency under ischemic conditions.

Mechanism Steps

1Inhibition of long-chain 3-ketoacyl-CoA thiolase

2Reduction of fatty acid oxidation

3Increase in glucose oxidation

💡 How to Take cardine 20mg tablet

Follow your doctor's prescription exactly.

⚠️ Side Effects of cardine 20mg tablet

✅ Common Side Effects

Dizziness
Headache
Gastrointestinal disturbances (nausea, vomiting, diarrhea)
Asthenia

🚨 Serious Side Effects

Parkinsonism
Tremor
Gait instability
Restless leg syndrome
Severe bradycardia

⚠️ Rare Side Effects

Allergic reactions (rash, urticaria)
Hepatitis
Thrombocytopenia

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Paroxetine	Major	Increased trimetazidine plasma concentration due to CYP2D6 inhibition
Ketoconazole	Major	Increased trimetazidine plasma concentration due to CYP3A4 inhibition
Warfarin	Moderate	Possible increased anticoagulant effect; monitor INR
Metoprolol	Moderate	Additive bradycardia and hypotension

🚨 Major Interactions

CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)

⚡ Moderate Interactions

Antihypertensives (additive hypotensive effect)
Beta-blockers
Calcium channel blockers

ℹ️ Minor Interactions

Antacids
Food (delayed absorption)

🍽️ Food Interactions

Food may delay absorption but does not significantly affect overall bioavailability.

🍷 Alcohol Interaction

No significant interaction reported; however, alcohol may exacerbate angina symptoms.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to trimetazidine or excipients; Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome; severe renal impairment (CrCl <30 mL/min).

📊 Monitoring Parameters

Blood pressure, heart rate, ECG, renal function, liver function tests.

🤱 Lactation Safety

Excreted in breast milk; avoid use or discontinue breastfeeding.

💊 Overdose Management

No specific antidote; symptomatic and supportive treatment. Gastric lavage if recent ingestion.

⏰ Missed Dose

Take as soon as remembered unless almost time for next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for cardine 20mg tablet

View All

Alternative brands with exact same active ingredient (Trimetazidine (20mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

Found this to be a helpful product. Good results.