cardine 20mg tablet - Uses, Price, Side Effects & Substitutes
What is cardine 20mg tablet used for?
Accardi MR Tablet MR (Trimetazidine) is used to treat CARDIAC. It contains Trimetazidine (20mg), which Inhibits long-chain 3-ketoacyl-CoA thiolase, shifting myocardial energy metaboli. Always consult your doctor before use. Take as prescribed.
- Generic Name: Trimetazidine
- Manufacturer: Diacardus Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ cardine 20mg tablet Uses & Benefits
Adjunctive therapy for stable angina pectoris; also used for vertigo and tinnitus (off-label in some regions).
Off-label uses: Vertigo, Tinnitus, Diabetic cardiomyopathy
๐ Drug Information
| Generic Name(s) | Trimetazidine |
| Brand Name | Accardi MR Tablet MR |
| Manufacturer | Diacardus Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Fatty acid modulator & Sodium channel blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from moisture and light. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits long-chain 3-ketoacyl-CoA thiolase, shifting myocardial energy metabolism from fatty acid oxidation to glucose oxidation, thereby improving cardiac efficiency under ischemic conditions.
Mechanism Steps
๐ก How to Take cardine 20mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of cardine 20mg tablet
โ Common Side Effects
- Dizziness
- Headache
- Gastrointestinal disturbances (nausea, vomiting, diarrhea)
- Asthenia
๐จ Serious Side Effects
- Parkinsonism
- Tremor
- Gait instability
- Restless leg syndrome
- Severe bradycardia
โ ๏ธ Rare Side Effects
- Allergic reactions (rash, urticaria)
- Hepatitis
- Thrombocytopenia
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Paroxetine | Major | Increased trimetazidine plasma concentration due to CYP2D6 inhibition |
| Ketoconazole | Major | Increased trimetazidine plasma concentration due to CYP3A4 inhibition |
| Warfarin | Moderate | Possible increased anticoagulant effect; monitor INR |
| Metoprolol | Moderate | Additive bradycardia and hypotension |
๐จ Major Interactions
- CYP2D6 inhibitors (e.g., paroxetine, fluoxetine)
- CYP3A4 inhibitors (e.g., ketoconazole, ritonavir)
โก Moderate Interactions
- Antihypertensives (additive hypotensive effect)
- Beta-blockers
- Calcium channel blockers
โน๏ธ Minor Interactions
- Antacids
- Food (delayed absorption)
๐ฝ๏ธ Food Interactions
Food may delay absorption but does not significantly affect overall bioavailability.
๐ท Alcohol Interaction
No significant interaction reported; however, alcohol may exacerbate angina symptoms.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to trimetazidine or excipients; Parkinson's disease, parkinsonian symptoms, tremors, restless leg syndrome; severe renal impairment (CrCl <30 mL/min).
๐ Monitoring Parameters
Blood pressure, heart rate, ECG, renal function, liver function tests.
๐คฑ Lactation Safety
Excreted in breast milk; avoid use or discontinue breastfeeding.
๐ Overdose Management
No specific antidote; symptomatic and supportive treatment. Gastric lavage if recent ingestion.
โฐ Missed Dose
Take as soon as remembered unless almost time for next dose; do not double dose.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for cardine 20mg tablet
View AllAlternative brands with exact same active ingredient (Trimetazidine (20mg)):
-
davaindia trimetazidine 20mg tabletDavaindia Generic Pharmacy โน10.00 69.2% CHEAPER
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Trimedor 20mg TabletAvinash Health Products Pvt Ltd โน12.66 61% CHEAPER
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tricard 20mg tabletBiogenetic Pharmaceuticals โน30.00 7.5% CHEAPER
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themidon tabletThemis Medicare Ltd โน32.00 1.4% CHEAPER
-
prodium 20mg tabletMacleods Pharmaceuticals Pvt Ltd โน32.03 1.3% CHEAPER
-
triadin 20mg tabletMedley Pharmaceuticals โน32.72 0.9% COSTLIER
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TRIZIDINE 20MG TABLETAbbott โน32.81 1.1% COSTLIER
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mayosest 20mg tabletAristo Pharmaceuticals Pvt Ltd โน33.03 1.8% COSTLIER
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TETAZ 20MG TABLETKopran Ltd โน33.28 2.6% COSTLIER
-
guard 20mg tabletAdmac Pharma Ltd โน33.75 4% COSTLIER
Medical Note: Always consult your doctor before switching medications.