acebit-h 50mg/12.5mg tablet - Uses, Price, Side Effects & Substitutes
What is acebit-h 50mg/12.5mg tablet used for?
Angizaar-H Tablet (Losartan + Hydrochlorothiazide) is used to treat CARDIAC. It contains Losartan (50mg) + Hydrochlorothiazide (12.5mg), which Losartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldo. Always consult your doctor before use. Take as prescribed.
- Generic Name: Losartan + Hydrochlorothiazide
- Manufacturer: Diacardus Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ acebit-h 50mg/12.5mg tablet Uses & Benefits
Hypertension (first-line), especially in patients with left ventricular hypertrophy.
Off-label uses: Diabetic nephropathy, Heart failure (with caution)
๐ Drug Information
| Generic Name(s) | Losartan + Hydrochlorothiazide |
| Brand Name | Angizaar-H Tablet |
| Manufacturer | Diacardus Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin II Receptor Blocker + Thiazide Diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Losartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldosterone secretion; hydrochlorothiazide inhibits sodium reabsorption in distal tubule, reducing plasma volume.
Mechanism Steps
๐ก How to Take acebit-h 50mg/12.5mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of acebit-h 50mg/12.5mg tablet
โ Common Side Effects
- Dizziness
- Headache
- Fatigue
- Cough
- Hyperglycemia
- Hypokalemia
- Hyperuricemia
๐จ Serious Side Effects
- Angioedema
- Renal failure
- Hepatotoxicity
- Severe hypotension
- Electrolyte imbalance
โ ๏ธ Rare Side Effects
- Pancreatitis
- Blood dyscrasias
- Anaphylaxis
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | Increased lithium toxicity risk |
| ACE inhibitors | Major | Increased risk of hypotension and renal impairment |
| Aliskiren | Major | Increased risk of renal impairment, hypotension, and hyperkalemia |
| Potassium-sparing diuretics | Major | Increased risk of hyperkalemia |
| NSAIDs | Major | Reduced antihypertensive effect and increased renal risk |
| Alcohol | Moderate | Increased orthostatic hypotension |
| Barbiturates | Moderate | Increased orthostatic hypotension |
| Corticosteroids | Moderate | Increased hypokalemia risk |
| Insulin | Moderate | Altered glucose control |
| Oral hypoglycemics | Moderate | Altered glucose control |
| Cholestyramine | Minor | Reduced absorption of hydrochlorothiazide |
| Colestipol | Minor | Reduced absorption of hydrochlorothiazide |
| Dofetilide | Minor | Increased risk of torsades de pointes |
๐จ Major Interactions
- Lithium
- ACE inhibitors
- Aliskiren
- Potassium-sparing diuretics
- NSAIDs
โก Moderate Interactions
- Alcohol
- Barbiturates
- Corticosteroids
- Insulin
- Oral hypoglycemics
โน๏ธ Minor Interactions
- Cholestyramine
- Colestipol
- Dofetilide
๐ฝ๏ธ Food Interactions
Avoid potassium-rich foods; high salt intake may reduce efficacy.
๐ท Alcohol Interaction
May potentiate orthostatic hypotension.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Anuria, hypersensitivity to sulfonamides, severe renal impairment (CrCl <30 mL/min), pregnancy (second and third trimesters).
๐ Monitoring Parameters
Blood pressure, serum potassium, renal function, blood glucose, uric acid.
๐คฑ Lactation Safety
Avoid; hydrochlorothiazide may suppress lactation.
๐ Overdose Management
Symptomatic and supportive; monitor electrolytes, blood pressure, and renal function. Induce emesis or gastric lavage if recent.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.