Bigunyl 5mg/800mg Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Muscle pain, unusual tiredness, or difficulty breathing, which may indicate lactic acidosis.
- Severe abdominal pain that may radiate to the back, with or without nausea and vomiting, which may indicate pancreatitis.
- Symptoms of severe low blood sugar such as confusion, seizures, or loss of consciousness.
- Swelling of the face, lips, tongue, or throat, or difficulty breathing, which may indicate a severe allergic reaction.
- Yellowing of the skin or eyes, dark urine, or severe itching, which may indicate liver problems.
- Decreased urine output, swelling in the legs, or sudden weight gain, which may indicate kidney problems.
- Fever, sore throat, or mouth ulcers, which may indicate a blood disorder.
- Unusual bleeding or bruising, which may indicate a blood clotting problem.
If experiencing severe symptoms, call emergency services immediately.
What is bigunyl 5mg/800mg tablet used for?
This medicine is a combination of glipizide and metformin used to treat type 2 diabetes. It lowers blood sugar by increasing insulin release and improving insulin sensitivity. It is taken orally with meals, usually once or twice daily, and the dose is individualized by a doctor.
- Generic Name: Glipizide + Metformin
- Manufacturer: Diacardus Pharmacy Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bigunyl 5mg/800mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा टाइप 2 डायबिटीज (मधुमेह) के इलाज के लिए इस्तेमाल की जाती है। इसमें ग्लिपिजाइड और मेटफॉर्मिन दो दवाएं होती हैं। ग्लिपिजाइड शरीर में इंसुलिन बनाने में मदद करती है, जबकि मेटफॉर्मिन लिवर द्वारा बनने वाली शुगर को कम करती है और शरीर की इंसुलिन के प्रति संवेदनशीलता बढ़ाती है। यह दवा खाने के साथ ली जाती है, आमतौर पर दिन में एक या दो बार। इससे ब्लड शुगर कंट्रोल में मदद मिलती है, लेकिन यह डायबिटीज का इलाज नहीं है। इसे डॉक्टर की सलाह के बिना बंद न करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में जी मिचलाना, दस्त, पेट में असहजता, और मुंह में धातु जैसा स्वाद शामिल हैं। ये आमतौर पर कुछ हफ्तों में ठीक हो जाते हैं। ग्लिपिजाइड की वजह से ब्लड शुगर कम हो सकती है, जिसे हाइपोग्लाइसीमिया कहते हैं। इसके लक्षण हैं कंपकंपी, पसीना आना, घबराहट, और भूख लगना। गंभीर लेकिन दुर्लभ दुष्प्रभावों में लैक्टिक एसिडोसिस शामिल है, जो मेटफॉर्मिन की वजह से हो सकता है। अगर आपको मांसपेशियों में दर्द, सांस लेने में तकलीफ, या पेट में तेज दर्द हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को हमेशा डॉक्टर के बताए अनुसार खाने के साथ लें। खाना न छोड़ें, क्योंकि इससे ब्लड शुगर कम हो सकती है। अपने पास हमेशा ग्लूकोज की गोलियां, कैंडी, या फलों का रस रखें ताकि ब्लड शुगर कम होने पर तुरंत इलाज कर सकें। शराब न पिएं, क्योंकि इससे ब्लड शुगर कम होने और लैक्टिक एसिडोसिस का खतरा बढ़ता है। अपने डॉक्टर को सभी दवाओं के बारे में बताएं जो आप ले रहे हैं। नियमित रूप से ब्लड शुगर, किडनी फंक्शन, और लिवर फंक्शन की जांच कराएं। डॉक्टर की सलाह के बिना दवा बंद न करें।
💊 bigunyl 5mg/800mg tablet Uses & Benefits
[{"condition":"Type 2 diabetes mellitus","description":"Used as an add-on therapy in adults whose blood sugar is not controlled by metformin alone or glipizide alone, along with diet and exercise.","evidence":"Well-established"},{"condition":"Type 2 diabetes with insulin resistance","description":"The metformin component improves insulin sensitivity, while glipizide increases insulin secretion, making this combination useful when both defects are present.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Polycystic ovary syndrome (PCOS)","description":"Metformin alone is sometimes used off-label in PCOS to improve insulin resistance and menstrual regularity, but the combination with glipizide is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Type 2 diabetes mellitus
Also treats: Insulin resistance, Metabolic syndrome, Prediabetes (in some cases)
📋 Drug Information
| Generic Name(s) | Glipizide + Metformin |
| Brand Name | Aviglip MF Tablet |
| Manufacturer | Diacardus Pharmacy Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI DIABETIC |
| Action Class | Antidiabetic |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in their original container, tightly closed. Protect from light and moisture. Do not store in the bathroom. Keep out of reach of children and pets. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. The World Health Organization does not recommend specific fixed-dose combinations for all patients. Treatment should be individualized. |
| ICMR Guideline | Not established from the available information. The Indian Council of Medical Research provides general guidance on diabetes management, but specific recommendations for this combination should be based on clinical judgment. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antidiabetic agents with complementary mechanisms. Glipizide is a second-generation sulfonylurea that binds to ATP-sensitive potassium channels on pancreatic beta cells, causing the channels to close. This closure leads to depolarization of the beta-cell membrane, opening of voltage-gated calcium channels, and an influx of calcium. The rise in intracellular calcium triggers the release of insulin from stored granules. Metformin is a biguanide that decreases hepatic glucose production by inhibiting gluconeogenesis and glycogenolysis. It also reduces intestinal absorption of glucose and improves peripheral insulin sensitivity by increasing glucose uptake and utilization in skeletal muscle and fat tissue. The combined effect is a reduction in both fasting and postprandial blood glucose levels.
Mechanism Steps
💡 How to Take bigunyl 5mg/800mg tablet
Strength: Each tablet contains Glipizide 5 mg and Metformin 800 mg. The tablet is intended for oral administration.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on your blood sugar levels, kidney function, liver function, and other medicines you take. A common starting dose is one tablet once daily with a meal, and the dose may be increased gradually based on your response. The maximum recommended dose is usually two tablets per day, taken with meals. Do not adjust the dose without consulting your doctor. Always take this medicine with food to reduce stomach upset and the risk of low blood sugar. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients, especially those above 65 years, may be more sensitive to the effects of this medicine. Kidney function declines with age, which increases the risk of lactic acidosis from metformin and hypoglycemia from glipizide. The dose should be started at the lower end of the range and adjusted carefully based on kidney function and blood sugar levels. Regular monitoring of kidney function and blood sugar is essential. |
| Renal Impairment | This medicine is contraindicated in patients with severe kidney impairment (eGFR less than 30 mL/min/1.73 m2). In patients with mild to moderate kidney impairment, the dose may need to be reduced, and kidney function should be monitored closely. Metformin should not be started in patients with eGFR between 30 and 45 mL/min/1.73 m2 unless the benefits outweigh the risks, and the dose should be adjusted. Always consult your doctor for dose adjustments based on your kidney function. |
| Hepatic Impairment | This medicine should be used with caution in patients with liver impairment. Glipizide is metabolized in the liver, and liver disease can increase its levels and the risk of hypoglycemia. Metformin can increase the risk of lactic acidosis in liver disease. Dose adjustment or alternative therapy may be needed. Consult your doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose of this medicine is usually two tablets per day, providing a total of 10 mg glipizide and 1600 mg metformin. However, the exact maximum dose must be determined by your doctor based on your individual needs and kidney function. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bigunyl 5mg/800mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Contrast media | Major | |
| Alcohol | Major | |
| Beta-blockers | Major | |
| MAOIs | Major | |
| Other antidiabetics | Major | |
| Corticosteroids | Moderate | |
| Thiazide diuretics | Moderate | |
| ACE inhibitors | Moderate | |
| Fluconazole | Moderate | |
| Warfarin | Moderate |
🚨 Major Interactions
- Contrast media (iodinated)
- Alcohol
- Beta-blockers
- Monoamine oxidase inhibitors (MAOIs)
- Other antidiabetic drugs (insulin, sulfonylureas, meglitinides)
⚡ Moderate Interactions
- Corticosteroids
- Thiazide diuretics
- Loop diuretics
- ACE inhibitors
- Fluconazole
- Warfarin
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol increases the risk of low blood sugar caused by glipizide and also increases the risk of lactic acidosis caused by metformin. If you drink alcohol, talk to your doctor about safe limits and never drink on an empty stomach.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Type 1 diabetes mellitus","Diabetic ketoacidosis","Severe kidney impairment (eGFR less than 30 mL/min/1.73 m2)","Acute or chronic metabolic acidosis, including lactic acidosis","Severe liver disease","Known hypersensitivity to glipizide, metformin, or any component of the tablet","Acute conditions that may alter kidney function, such as dehydration, severe infection, or shock","Use of iodinated contrast media within 48 hours"]
⚠️ Warnings & Precautions
["Risk of lactic acidosis: Metformin can cause a rare but serious condition called lactic acidosis. Seek immediate medical help if you experience muscle pain, unusual tiredness, difficulty breathing, stomach pain, or a slow or irregular heartbeat.","Risk of hypoglycemia: Glipizide can cause low blood sugar. Learn to recognize the symptoms and carry a fast-acting sugar source. Avoid skipping meals.","Kidney function: Your kidney function will be checked before and during treatment. Dose adjustments may be needed.","Liver function: Use with caution in liver disease. Regular monitoring may be advised.","Alcohol: Avoid alcohol as it increases the risk of hypoglycemia and lactic acidosis.","Surgery and procedures: Inform your doctor before any surgery or procedure using contrast dye. This medicine may need to be temporarily stopped.","Vitamin B12: Long-term use of metformin may cause vitamin B12 deficiency. Your doctor may monitor your levels.","Pregnancy and breastfeeding: Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Elderly patients: Use with caution due to increased risk of kidney impairment and hypoglycemia.","Do not share this medicine with others, even if they have similar symptoms."]
🤱 Lactation Safety
Metformin is excreted in breast milk in small amounts. Glipizide is also excreted in breast milk. The effects on a nursing infant are not fully established. Consult your doctor before breastfeeding while taking this medicine. Monitoring the infant's blood sugar may be advised.
💊 Overdose Management
Overdose of this medicine can cause severe hypoglycemia due to glipizide and lactic acidosis due to metformin. Symptoms of severe hypoglycemia include confusion, seizures, and loss of consciousness. Lactic acidosis may cause muscle pain, difficulty breathing, and stomach pain. If you suspect an overdose, seek emergency medical care immediately. Treatment may include intravenous glucose for hypoglycemia and supportive care for lactic acidosis. Hemodialysis may be needed to remove metformin in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember, provided it is not almost time for your next dose. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you miss a dose and experience symptoms of low blood sugar, treat it with fast-acting sugar and contact your doctor.
Additional Safety Advice
Always take this medicine exactly as prescribed by your doctor, with meals to reduce stomach upset and lower the risk of low blood sugar. Never skip meals while taking this medicine, because skipping meals can cause your blood sugar to drop too low. Carry a fast-acting source of sugar, such as glucose tablets, candy, or fruit juice, at all times so you can treat low blood sugar quickly if it occurs. Tell your doctor about all other medicines, supplements, and herbal products you take, because many can interact with this medicine. Avoid drinking alcohol, as it increases the risk of low blood sugar and lactic acidosis. Drink plenty of water and stay hydrated, especially during hot weather or exercise. Your doctor will check your kidney function, liver function, and vitamin B12 levels regularly, so keep all scheduled appointments and lab tests. Do not stop or change the dose of this medicine on your own, even if you feel well, because diabetes can be silent and uncontrolled blood sugar can damage your heart, kidneys, eyes, and nerves over time. If you are scheduled for a surgery, X-ray with contrast dye, or dental procedure, inform your healthcare team that you are taking this medicine, as it may need to be temporarily stopped.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine. Kidney function declines with age, increasing the risk of lactic acidosis from metformin and hypoglycemia from glipizide. Start at the lowest effective dose and monitor kidney function and blood sugar closely. Avoid skipping meals. Educate elderly patients and their caregivers about the symptoms of low blood sugar and how to treat it. Regular follow-up is essential.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before conception. This medicine is generally not recommended during pregnancy. Insulin is the preferred treatment for diabetes during pregnancy. Your doctor will adjust your treatment plan to ensure good blood sugar control before and during pregnancy to reduce the risk of complications for both you and your baby. Do not stop or change your medicine without consulting your doctor.
🏥 Post-Surgery Considerations
After surgery, your blood sugar may be unstable. This medicine may need to be temporarily stopped, especially if you are not eating or if you are undergoing procedures with contrast dye. Your doctor will monitor your blood sugar and adjust your treatment accordingly. Follow your doctor's instructions about when to restart the medicine. Keep your surgical team informed about your diabetes and medicines.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Dental procedures can cause stress and may affect your blood sugar. If you are having a procedure that requires fasting or sedation, your doctor may need to adjust your dose. Check your blood sugar before and after the procedure. Maintain good oral hygiene to prevent dental problems, which are more common in people with diabetes.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Exercise can lower blood sugar, especially when combined with this medicine. Check your blood sugar before exercising. If it is below 100 mg/dL, eat a small snack containing carbohydrates before exercising. Carry a fast-acting source of sugar with you. Avoid exercising if your blood sugar is very high or if you have ketones in your urine. Stay hydrated. If you experience symptoms of low blood sugar during exercise, stop and treat it immediately. Consult your doctor before starting a new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause low blood sugar, which can affect your ability to drive or operate machinery. Do not drive or operate heavy machinery if you feel symptoms of low blood sugar. Keep a fast-acting source of sugar in your car or at your workplace. Inform your employer about your diabetes and treatment. If your job involves shift work, consult your doctor about adjusting your dosing schedule. Regular meals and blood sugar monitoring can help you manage your work life effectively.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as lactic acidosis, severe hypoglycemia, or an allergic reaction, seek immediate medical attention and follow your doctor's advice. Your doctor may stop the medicine temporarily before surgery or contrast procedures. If your kidney function declines significantly, your doctor may switch you to a different medicine. Always consult your doctor before making any changes to your treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to vitamin B12 deficiency due to metformin, which can cause anemia and nerve damage. Regular monitoring of vitamin B12 levels is advised. Kidney function may decline over time, especially in elderly patients, requiring dose adjustments. The risk of hypoglycemia persists with long-term use, especially if meals are skipped. Weight gain may occur due to glipizide. Long-term blood sugar control is essential to prevent complications such as heart disease, kidney damage, eye problems, and nerve damage. Regular follow-up with your doctor and lifestyle modifications are important.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet and exercise are the foundation of diabetes management and can help reduce the need for medicines.
Evidence: Well-establishedDPP-4 inhibitors, SGLT2 inhibitors, and GLP-1 receptor agonists are alternatives with different side effect profiles.
Evidence: Well-establishedMay be needed if oral medicines are not enough to control blood sugar.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
People with diabetes are at higher risk of complications from infections such as influenza and pneumonia. Ensure you are up to date with recommended vaccinations, including annual influenza vaccine, pneumococcal vaccine, and hepatitis B vaccine. Discuss with your doctor about the best timing for vaccinations, especially if your blood sugar is poorly controlled.
📦 Storage Guide
✅ DO
Store at room temperature between 15°C and 30°C.
❌ DON'T
Do not refrigerate unless specified.
✅ DO
Keep in the original container, tightly closed.
❌ DON'T
Do not transfer to unmarked containers.
✅ DO
Keep away from direct sunlight and moisture.
❌ DON'T
Do not store in the bathroom cabinet.
✅ DO
Keep out of reach of children and pets.
❌ DON'T
Do not use after the expiry date.
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label clearly visible. Bring enough supply for the entire trip, plus extra in case of delays. Carry a copy of your prescription and a letter from your doctor explaining that you need this medicine for diabetes. If you are crossing time zones, consult your doctor about how to adjust your dosing schedule. Store the medicine in a cool, dry place, away from direct sunlight and moisture. Keep it in your carry-on luggage rather than checked baggage. Carry a fast-acting source of sugar and your blood glucose meter. Inform airport security that you have diabetes and are carrying medical supplies.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood sugar within 30 to 60 minutes, but the full effect may take 1 to 2 weeks of regular use. Your doctor will monitor your blood sugar and adjust the dose as needed.
A: This medicine is often used with other diabetes medicines, but the combination can increase the risk of low blood sugar. Your doctor will adjust the doses and monitor your blood sugar closely.
A: If you experience symptoms of low blood sugar such as shakiness, sweating, or confusion, take a fast-acting source of sugar immediately, such as glucose tablets, candy, or fruit juice. If symptoms do not improve or you become unconscious, seek emergency medical help.
A: No, do not stop taking this medicine without consulting your doctor. Your blood sugar is normal because of the medicine. Stopping it can cause your blood sugar to rise again and lead to complications.
A: Glipizide may cause weight gain, while metformin may cause weight loss or have a neutral effect. The overall effect varies from person to person. A healthy diet and regular exercise can help manage weight.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can cure diabetes.
Fact: This medicine helps control blood sugar but does not cure diabetes. Lifestyle changes and ongoing treatment are needed. - Myth: You can stop taking this medicine once your blood sugar is normal.
Fact: Blood sugar is normal because of the medicine. Stopping it without doctor's advice can cause blood sugar to rise again. - Myth: This medicine is safe for everyone with diabetes.
Fact: It is not safe for people with type 1 diabetes, severe kidney or liver disease, or diabetic ketoacidosis. - Myth: You can eat anything as long as you take this medicine.
Fact: Diet and exercise are essential for controlling blood sugar. The medicine works best with a healthy lifestyle. - Myth: This medicine causes weight gain in everyone.
Fact: Glipizide may cause weight gain, but metformin may cause weight loss or neutral weight. The effect varies.
🔄 Alternative Options
Generic Alternatives
- Glipizide and Metformin combination (generic)
Brand Alternatives
- Bigunyl 5mg/800mg Tablet