carbotero 450 mg injection

4.7 (16 reviews)

Carboplatin (450mg)

🏭 Hetero Drugs Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 23, 2026

⚠️ Hepatotoxicity Risk 📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 23, 2026

What is carbotero 450 mg injection used for?

Adcarb 450mg Injection (Carboplatin) is used to treat ANTI NEOPLASTICS. It contains Carboplatin (450mg), which Platinum compound forms DNA cross-links, inhibiting DNA replication and transcri. Always consult your doctor before use. Take as prescribed.

Generic Name: Carboplatin
Manufacturer: Hetero Drugs Ltd
Form: Allopathy
Pregnancy Category: D
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 carbotero 450 mg injection Uses & Benefits

Ovarian carcinoma, lung cancer, head and neck cancers, testicular cancer, bladder cancer.

Off-label uses: Endometrial cancer, cervical cancer, osteosarcoma.

📋 Drug Information

Generic Name(s)	Carboplatin
Brand Name	Adcarb 450mg Injection
Manufacturer	Hetero Drugs Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Platinum compounds-Anticancer
Route of Administration	Intravenous infusion.
Storage	Store at 20-25°C (68-77°F), protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionNot well absorbed orally; administered intravenously for complete bioavailability.

DistributionDistributes into extracellular fluid; low penetration into CNS.

Protein BindingLow, approximately 0% (carboplatin is not significantly protein bound).

MetabolismMinimal hepatic metabolism; primarily undergoes hydrolysis to active species.

Half-Life2-6 hours (initial), 22-40 hours (terminal) in patients with normal renal function.

ExcretionPrimarily renal (60-90% unchanged in urine within 24 hours).

Bioavailability100% (intravenous administration).

Onset of ActionRapid, within minutes of infusion.

Peak Plasma TimeImmediately after infusion.

Duration of ActionVariable, depends on dose and renal function.

How It Works

Platinum compound forms DNA cross-links, inhibiting DNA replication and transcription.

Mechanism Steps

1Carboplatin enters cells via passive diffusion or active transport.

2Undergoes hydrolysis to form reactive platinum species.

3Platinum species bind to DNA, forming intrastrand and interstrand cross-links.

💡 How to Take carbotero 450 mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of carbotero 450 mg injection

✅ Common Side Effects

Nausea
vomiting
myelosuppression (thrombocytopenia, neutropenia, anemia)
fatigue

🚨 Serious Side Effects

Severe myelosuppression
nephrotoxicity
ototoxicity
hypersensitivity reactions
hemolytic uremic syndrome

⚠️ Rare Side Effects

Secondary malignancies
interstitial pneumonitis
hepatic veno-occlusive disease

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Aminoglycosides	Major	Increased nephrotoxicity and ototoxicity
Warfarin	Moderate	Increased anticoagulant effect
Phenytoin	Moderate	Decreased phenytoin levels
Live vaccines	Minor	Risk of disseminated infection

🚨 Major Interactions

Nephrotoxic drugs (e.g., aminoglycosides)
Other myelosuppressive agents

⚡ Moderate Interactions

Warfarin
Phenytoin

ℹ️ Minor Interactions

Live vaccines

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

Avoid alcohol due to increased risk of hepatotoxicity and GI side effects.

🛡️ Safety & Warnings

🚫 Contraindications

Severe renal impairment (CrCl < 20 mL/min), severe myelosuppression, hypersensitivity to platinum compounds, pregnancy.

📊 Monitoring Parameters

Complete blood count (CBC), renal function (serum creatinine, BUN), liver function tests, audiometry.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care, monitor bone marrow function, consider hematopoietic growth factors.

⏰ Missed Dose

Do not double dose; contact healthcare provider for rescheduling.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

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🔄 Substitutes for carbotero 450 mg injection

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Alternative brands with exact same active ingredient (Carboplatin (450mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.