adcarb 450mg injection - Carboplatin (450mg) medicine

Adcarb 450mg Injection - Uses, Price, Side Effects

4.6 (9 reviews)
Carboplatin (450mg)
๐Ÿญ Adley Formulations ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 23, 2026
โš ๏ธ Hepatotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 23, 2026

What is adcarb 450mg injection used for?

Adcarb 450mg Injection contains Carboplatin, a platinum-based chemotherapy drug used to treat ovarian cancer, lung cancer, and other solid tumors. It works by interfering with DNA replication in cancer cells, preventing their growth and division.

  • Generic Name: Carboplatin
  • Manufacturer: Adley Formulations
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

๐Ÿ’Š adcarb 450mg injection Uses & Benefits

Ovarian carcinoma, lung cancer, head and neck cancers, testicular cancer, bladder cancer.

Off-label uses: Endometrial cancer, cervical cancer, osteosarcoma.

๐Ÿ“‹ Drug Information

Generic Name(s)Carboplatin
Brand NameAdcarb 450mg Injection
ManufacturerAdley Formulations
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI NEOPLASTICS
Action ClassPlatinum compounds-Anticancer
Route of AdministrationIntravenous infusion.
StorageStore at 20-25ยฐC (68-77ยฐF), protect from light.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionNot well absorbed orally; administered intravenously for complete bioavailability.
DistributionDistributes into extracellular fluid; low penetration into CNS.
Protein BindingLow, approximately 0% (carboplatin is not significantly protein bound).
MetabolismMinimal hepatic metabolism; primarily undergoes hydrolysis to active species.
Half-Life2-6 hours (initial), 22-40 hours (terminal) in patients with normal renal function.
ExcretionPrimarily renal (60-90% unchanged in urine within 24 hours).
Bioavailability100% (intravenous administration).
Onset of ActionRapid, within minutes of infusion.
Peak Plasma TimeImmediately after infusion.
Duration of ActionVariable, depends on dose and renal function.

How It Works

Platinum compound forms DNA cross-links, inhibiting DNA replication and transcription.

Mechanism Steps

1Carboplatin enters cells via passive diffusion or active transport.
2Undergoes hydrolysis to form reactive platinum species.
3Platinum species bind to DNA, forming intrastrand and interstrand cross-links.

๐Ÿ’ก How to Take adcarb 450mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โŒ ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of adcarb 450mg injection

โœ… Common Side Effects

  • Nausea
  • vomiting
  • myelosuppression (thrombocytopenia, neutropenia, anemia)
  • fatigue

๐Ÿšจ Serious Side Effects

  • Severe myelosuppression
  • nephrotoxicity
  • ototoxicity
  • hypersensitivity reactions
  • hemolytic uremic syndrome

โš ๏ธ Rare Side Effects

  • Secondary malignancies
  • interstitial pneumonitis
  • hepatic veno-occlusive disease

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Paclitaxel Moderate Increased myelosuppression
Aminoglycosides Moderate Increased nephrotoxicity

๐Ÿšจ Major Interactions

  • Nephrotoxic drugs (e.g., aminoglycosides)
  • Other myelosuppressive agents

โšก Moderate Interactions

  • Warfarin
  • Phenytoin

โ„น๏ธ Minor Interactions

  • Live vaccines

๐Ÿฝ๏ธ Food Interactions

No significant food interactions.

๐Ÿท Alcohol Interaction

Avoid alcohol due to increased risk of hepatotoxicity and GI side effects.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Moderate
Kidney
High
Heart
Low
Pregnancy
Category D

๐Ÿšซ Contraindications

Severe renal impairment (CrCl < 20 mL/min), severe myelosuppression, hypersensitivity to platinum compounds, pregnancy.

๐Ÿ“Š Monitoring Parameters

Complete blood count (CBC), renal function (serum creatinine, BUN), liver function tests, audiometry.

๐Ÿคฑ Lactation Safety

Contraindicated; excreted in breast milk.

๐Ÿ’Š Overdose Management

Supportive care, monitor bone marrow function, consider hematopoietic growth factors.

โฐ Missed Dose

Do not double dose; contact healthcare provider for rescheduling.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 23, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for adcarb 450mg injection

View All

Alternative brands with exact same active ingredient (Carboplatin (450mg)):

Medical Note: Always consult your doctor before switching medications.

โญ User Reviews

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Certified Buyer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

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