carbasma s tablet - Doxofylline (NA) + Salbutamol (NA) medicine

Carbasma S Tablet: Comprehensive Guide to Uses, Side Effects, and Safety

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🏭 Strides shasun Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 21, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for approved indications.
Reviewed by
SaathiMed Expert Panel | Oct 21, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe chest pain or irregular heartbeat
  • Difficulty breathing or worsening of asthma symptoms
  • Seizures or convulsions
  • Severe allergic reaction (rash, swelling of face/lips/throat)
  • Muscle weakness or cramps (signs of low potassium)
  • Yellowing of eyes or skin, dark urine
  • Extreme dizziness or fainting

If experiencing severe symptoms, call emergency services immediately.

What is carbasma s tablet used for?

This medicine is a combination of doxofylline and salbutamol used to treat bronchial asthma and COPD. It works by relaxing the muscles in the airways to make breathing easier. It is not for sudden asthma attacks.

  • Generic Name: Doxofylline + Salbutamol
  • Manufacturer: Strides shasun Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 carbasma s tablet के बारे में (Hindi Summary)

उपयोग: यह दवा दोक्सोफाइलिन और सालबुटामोल का संयोजन है, जिसका उपयोग ब्रोंकियल अस्थमा और क्रॉनिक ऑब्सट्रक्टिव पल्मोनरी डिजीज (सीओपीडी) के इलाज में किया जाता है। यह श्वास नलियों की मांसपेशियों को आराम देकर सांस लेने में आसानी प्रदान करती है। यह दवा तुरंत अस्थमा के दौरे के लिए नहीं है; इसके लिए रेस्क्यू इनहेलर का उपयोग करें।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, सिरदर्द, बेचैनी, कंपन, धड़कन और हृदय गति में वृद्धि शामिल हैं। गंभीर दुष्प्रभावों में अनियमित हृदय गति, पोटेशियम की कमी, और एलर्जी प्रतिक्रियाएं हो सकती हैं। यदि कोई दुष्प्रभाव लंबे समय तक बना रहे या बिगड़ जाए तो तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। इसे चबाएं या तोड़ें नहीं, पूरा निगल लें। शराब और कैफीन युक्त पदार्थों से बचें। यदि आपको हृदय रोग, उच्च रक्तचाप, मधुमेह, थायरॉइड या गुर्दे/यकृत की समस्या है तो डॉक्टर को बताएं। तीव्र अस्थमा के दौरे के लिए इसका उपयोग न करें। नियमित जांच के लिए डॉक्टर के पास जाएं।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 carbasma s tablet Uses & Benefits

[{"condition":"Bronchial asthma","description":"Helps in the maintenance treatment of asthma by relaxing bronchial smooth muscles and reducing airway inflammation, thereby improving breathing.","evidence":"Well-established"},{"condition":"Chronic obstructive pulmonary disease (COPD)","description":"Used to relieve bronchospasm and improve airflow in patients with COPD, reducing symptoms like wheezing and shortness of breath.","evidence":"Well-established"},{"condition":"Bronchospasm associated with bronchitis","description":"Provides symptomatic relief in reversible bronchospasm due to chronic bronchitis.","evidence":"Moderate"}]

Off-label uses: []

Primary treatment for: Bronchial asthma

Also treats: Chronic obstructive pulmonary disease (COPD), Chronic bronchitis

📋 Drug Information

Generic Name(s)Doxofylline + Salbutamol
Brand NameCarbasma S Tablet
ManufacturerStrides shasun Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassBronchodilator (Xanthine derivative + Beta-2 agonist)
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with food to reduce stomach upset.
2
Do not use this medicine for sudden asthma attacks; always keep a rescue inhaler handy.
3
Avoid caffeine and alcohol as they can increase side effects like tremor and palpitations.
4
Monitor your heart rate and report any irregular heartbeat to your doctor.
5
If you have diabetes, monitor your blood sugar levels regularly as this medicine can raise them.
6
Do not stop this medicine abruptly without consulting your doctor.
7
Inform your doctor if you experience persistent nausea, headache, or restlessness.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Wheezing
This medicine is commonly prescribed for wheezing due to asthma or COPD.
Likely Use
✅
Shortness of breath
Helps relieve bronchospasm and improve breathing.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
✅
Chest tightness
May help relax airway muscles and reduce tightness.
Likely Use

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionBoth doxofylline and salbutamol are absorbed from the gastrointestinal tract after oral administration. Doxofylline bioavailability is approximately 60-70%, while salbutamol undergoes first-pass metabolism with oral bioavailability around 40%. Food may delay absorption of salbutamol but does not significantly affect doxofylline.
DistributionBoth drugs are widely distributed throughout the body. Doxofylline has a volume of distribution of about 1 L/kg, and salbutamol distributes into tissues including lungs, liver, and kidneys. Salbutamol crosses the placenta and is excreted in breast milk.
Protein BindingDoxofylline is approximately 30% bound to plasma proteins. Salbutamol is about 10% bound to plasma proteins.
MetabolismDoxofylline is metabolized in the liver primarily by cytochrome P450 enzymes (CYP1A2, CYP2E1, CYP3A4) to inactive metabolites. Salbutamol is metabolized in the liver by sulfation to inactive phenolic sulfate conjugates.
Half-LifeDoxofylline elimination half-life is approximately 6-8 hours. Salbutamol elimination half-life is about 4-6 hours.
ExcretionDoxofylline and its metabolites are excreted mainly in urine (about 90%) and feces (about 10%). Salbutamol and its metabolites are excreted primarily in urine (about 80%) and feces (about 20%).
BioavailabilityDoxofylline oral bioavailability is about 60-70%. Salbutamol oral bioavailability is approximately 40% due to first-pass metabolism.
Onset of ActionSalbutamol component begins to act within 15-30 minutes after oral administration. Doxofylline has a slower onset, typically within 1-2 hours.
Peak Plasma TimeDoxofylline reaches peak plasma concentration in about 1-2 hours. Salbutamol peaks in about 2-4 hours after oral intake.
Duration of ActionThe bronchodilator effect of salbutamol lasts about 4-6 hours, while doxofylline provides sustained bronchodilation for up to 12 hours. The combination is usually dosed two to three times daily.

How It Works

This medicine combines two bronchodilators with complementary mechanisms. Doxofylline, a methylxanthine, inhibits phosphodiesterase enzymes, increasing cyclic AMP levels, which leads to relaxation of bronchial smooth muscle and mild anti-inflammatory effects. Salbutamol, a selective beta-2 adrenergic agonist, stimulates beta-2 receptors on airway smooth muscle, causing rapid relaxation and bronchodilation. Together, they provide both immediate and sustained relief from bronchospasm.

Mechanism Steps

1
Doxofylline inhibits phosphodiesterase: Doxofylline blocks phosphodiesterase enzymes, leading to increased cyclic AMP in bronchial smooth muscle cells, which causes relaxation and bronchodilation.
2
Salbutamol stimulates beta-2 receptors: Salbutamol binds to beta-2 adrenergic receptors on airway smooth muscle, activating adenylate cyclase and increasing cyclic AMP, resulting in rapid muscle relaxation.
3
Synergistic bronchodilation: The combined increase in cyclic AMP from both agents produces enhanced relaxation of bronchial smooth muscle, effectively widening the airways.
4
Reduction of airway inflammation: Doxofylline additionally reduces inflammatory mediator release, contributing to decreased airway edema and mucus secretion.

💡 How to Take carbasma s tablet

Strength: Not established from the available information.

1Take this medicine orally with a glass of water.
2Swallow the tablet whole; do not crush, chew, or break it.
3Take it with food or milk to reduce stomach upset.
4Take at the same times each day to maintain consistent blood levels.
5If you miss a dose, follow the missed dose instructions.
6Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one tablet two to three times daily, or as prescribed by your doctor. The exact dose and frequency depend on the severity of the condition, your response to treatment, and other medical conditions. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the recommended dose.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of this medicine, especially cardiac and central nervous system effects. Dose adjustment may be necessary based on renal and hepatic function. Use with caution and monitor closely.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult your doctor for appropriate dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult your doctor for appropriate dosing.
Maximum Daily DoseThe maximum recommended daily dose is 3 tablets per day, but this may vary based on the prescribed strength and clinical judgment. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Reduces stomach upset and nausea.
Caffeine
Avoid or limit
May increase nervousness, tremor, and palpitations.
Grapefruit
Avoid
May increase drug levels by affecting liver enzymes.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of carbasma s tablet

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset. If nausea persists, consult your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. Avoid caffeine. Consult doctor if headache is severe or persistent.
Tremor (Common (5-10%))
Usually decreases with continued use. Avoid caffeine. If tremor interferes with daily activities, inform your doctor.
Palpitations (Common (5-10%))
Report to your doctor if you experience a racing or pounding heartbeat. Avoid stimulants like caffeine.
Restlessness (Common (5-10%))
Try relaxation techniques. If restlessness affects sleep, take the last dose earlier in the evening after consulting your doctor.

🚨 Serious Side Effects

Cardiac arrhythmias (Rare (<0.1%))
Seek immediate medical attention if you experience irregular heartbeat, chest pain, or fainting.
Severe hypokalemia (Rare (<0.1%))
Report muscle weakness, cramps, or palpitations to your doctor immediately. Blood tests may be needed.
Hyperglycemia (Uncommon (0.1-1%))
Monitor blood sugar if diabetic. Report increased thirst, frequent urination, or blurred vision to your doctor.
Severe allergic reactions (Rare (<0.1%))
Seek emergency help if you develop rash, swelling of face/lips/throat, or difficulty breathing.
Seizures (Rare (<0.1%))
Discontinue and seek immediate medical attention if seizures occur.

⚠️ Rare Side Effects

Severe skin reactions (Stevens-Johnson syndrome)
Stop the medicine and seek emergency care if you notice skin rash, blisters, or peeling.
Hepatotoxicity
Report yellowing of eyes or skin, dark urine, or abdominal pain to your doctor immediately.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
MAOIs Major
Tricyclic antidepressants Major
Furosemide Major
Corticosteroids Moderate
Theophylline Moderate
Digoxin Moderate
Ciprofloxacin Moderate
Ketoconazole Moderate
Antacids Minor

🚨 Major Interactions

  • Non-selective beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants
  • Diuretics (e.g., furosemide, thiazides)
  • Corticosteroids

⚡ Moderate Interactions

  • Xanthine derivatives (e.g., theophylline)
  • Digoxin
  • CYP1A2 inhibitors (e.g., ciprofloxacin, fluvoxamine)
  • CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)

🍷 Alcohol Interaction

Alcohol may increase the risk of dizziness, drowsiness, and cardiovascular side effects such as palpitations and low blood pressure. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to doxofylline, salbutamol, or any component of the formulation","Severe cardiac disorders (e.g., severe arrhythmias, hypertrophic obstructive cardiomyopathy)","Acute porphyria","Severe hepatic impairment","Severe renal impairment","Children under 12 years (safety not established)"]

⚠️ Warnings & Precautions

["Not for acute asthma attacks; use a rapid-acting inhaler for immediate relief.","Use with caution in patients with cardiovascular diseases, hypertension, or arrhythmias.","May cause hypokalemia; monitor potassium levels, especially with concomitant diuretics or corticosteroids.","May cause hyperglycemia; monitor blood glucose in diabetic patients.","Use with caution in patients with hyperthyroidism, epilepsy, or prostatic hypertrophy.","Avoid abrupt discontinuation; taper dose gradually under medical supervision.","May impair ability to drive or operate machinery due to dizziness or tremor."]

🤱 Lactation Safety

Salbutamol is excreted in breast milk and may cause tachycardia or tremor in the infant. Doxofylline is also likely to be excreted in breast milk. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose may cause severe tachycardia, arrhythmias, hypokalemia, hyperglycemia, and seizures. Seek immediate medical attention. Treatment is supportive and symptomatic, including monitoring of vital signs, electrolytes, and cardiac rhythm. There is no specific antidote. Activated charcoal may be considered if ingestion is recent. Hemodialysis is not effective for salbutamol but may be considered for doxofylline in severe cases.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet; swallow it whole with water. Avoid alcohol and caffeine-containing products as they may increase side effects. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid disorders, or liver/kidney problems. Do not use this medicine for acute asthma attacks; use your rescue inhaler instead. Keep regular follow-up appointments for monitoring of heart rate, blood pressure, and blood potassium levels. Store at room temperature away from moisture and heat. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to cardiac side effects, hypokalemia, and central nervous system effects. Dose adjustment may be needed based on renal and hepatic function. Regular monitoring is advised.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy, consult your doctor to review your asthma medications. Uncontrolled asthma can harm both mother and baby. Your doctor may adjust or switch medications to safer alternatives.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist about this medicine before surgery. It may interact with anesthetic agents and affect heart rate and blood pressure. Your doctor may advise temporary discontinuation or dose adjustment.

🦷 Dental Procedures

Inform your dentist about this medicine before any dental procedure. It may cause dry mouth or interact with local anesthetics containing epinephrine, increasing cardiovascular effects.

💚 Lifestyle Tips for Better Results

🏃
Avoid known asthma triggers such as dust, smoke, and pollen.
🥗
Maintain a healthy weight to reduce strain on breathing.
😴
Practice breathing exercises like pursed-lip breathing.
💧
Stay up to date with vaccinations (flu, pneumonia).
🧘
Get adequate rest and manage stress.
🌞
Use a peak flow meter to monitor lung function.

🏋️ Exercise Considerations

Exercise may trigger bronchospasm. Use your rescue inhaler before exercise if advised. Warm up gradually and avoid exercising in cold, dry air. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Eat a balanced diet rich in fruits and vegetables.
Include omega-3 fatty acids from fish or flaxseed.
Limit processed foods and added sugars.
Stay well hydrated to keep airways moist.
Avoid foods that trigger allergies.

💼 Impact on Daily Work & Life

This medicine may cause dizziness, tremor, or palpitations, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It should not interfere with most desk jobs, but inform your employer if your work involves heavy machinery.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects or your condition worsens, contact your doctor immediately. Your doctor will decide if dose adjustment or discontinuation is needed.

📅 Long-Term Use Effects

Long-term use may lead to tolerance, increased cardiac effects, and electrolyte imbalances. Regular monitoring of heart function, potassium levels, and blood glucose is recommended. Periodic review of the need for continued therapy is advised.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Inhaled bronchodilators

Inhaled salbutamol or combination inhalers may provide targeted relief with fewer systemic side effects.

Evidence: Well-established
Inhaled corticosteroids

Used as controller therapy for asthma to reduce airway inflammation.

Evidence: Well-established
Leukotriene receptor antagonists

Oral medications like montelukast can help control asthma symptoms.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Patients with chronic respiratory diseases should receive annual influenza and pneumococcal vaccinations. These vaccines do not interact with this medicine but help prevent respiratory infections that can worsen asthma or COPD.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and protect from moisture. If traveling across time zones, adjust dosing times gradually under medical advice. Check customs regulations for carrying prescription medicines. Keep a rescue inhaler accessible at all times.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 55-year-old man with chronic asthma
He was prescribed this medicine for maintenance therapy. He initially experienced mild tremors and palpitations, which decreased after a week. He learned to avoid coffee and take the tablet with breakfast. His breathing improved significantly, and he could walk without getting breathless.
💡 Lesson: Taking the medicine with food and avoiding caffeine helps reduce side effects. Consistency is key for asthma control.
👤 A 62-year-old woman with COPD
She started this medicine along with her regular inhaler. She noticed better symptom control and fewer exacerbations. She was advised to monitor her blood potassium levels due to concomitant diuretic use. She regularly follows up with her doctor.
💡 Lesson: Regular monitoring of electrolytes is important when taking this medicine with diuretics. Combination therapy with inhalers may be needed for optimal control.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: The salbutamol component starts working within 15-30 minutes, while doxofylline takes about 1-2 hours. Full benefits may take a few days of regular use.

Q: Can I take this medicine if I have high blood pressure?

A: Consult your doctor. This medicine can increase heart rate and blood pressure, so it should be used with caution in patients with hypertension.

Q: Is it safe to take during pregnancy?

A: Use only if prescribed by your doctor. The benefits must outweigh the risks. Inform your doctor if you are pregnant or planning to become pregnant.

Q: Can I stop taking this medicine when I feel better?

A: Do not stop without consulting your doctor. Abrupt discontinuation may worsen symptoms. Your doctor will advise on tapering.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🛑 Myths vs. Facts

  • Myth: This medicine can be used for immediate relief of an asthma attack.
    Fact: This medicine is for maintenance therapy and is not a rescue inhaler. For acute attacks, use a rapid-acting bronchodilator inhaler.
  • Myth: It is safe to take extra doses if breathing difficulty worsens.
    Fact: Taking more than the prescribed dose can cause serious cardiac and metabolic side effects. Follow your doctor's instructions strictly.
  • Myth: This medicine can cure asthma permanently.
    Fact: It helps control symptoms but does not cure asthma. Long-term management includes avoiding triggers and using controller medications.

📊 Comparison with Similar Medicines

[{"medicine":"This medicine (Doxofylline + Salbutamol)","composition":"Doxofylline + Salbutamol","onset":"15-30 minutes (salbutamol), 1-2 hours (doxofylline)","duration":"4-12 hours","common_side_effects":"Nausea, headache, tremor, palpitations"},{"medicine":"Doxofylline alone","composition":"Doxofylline","onset":"1-2 hours","duration":"12 hours","common_side_effects":"Nausea, headache, restlessness"},{"medicine":"Salbutamol alone","composition":"Salbutamol","onset":"15-30 minutes","duration":"4-6 hours","common_side_effects":"Tremor, palpitations, nervousness"}]

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