caprelsa tablet
What is caprelsa tablet used for?
Caprelsa (Vandetanib) is used to treat ANTI NEOPLASTICS. It contains Vandetanib (300mg), which Inhibits multiple receptor tyrosine kinases including VEGFR-2, EGFR, and RET.. Always consult your doctor before use. Take as prescribed.
- Generic Name: Vandetanib
- Manufacturer: AstraZeneca
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ caprelsa tablet Uses & Benefits
Treatment of symptomatic or progressive medullary thyroid cancer in patients with unresectable locally advanced or metastatic disease.
Off-label uses: Non-small cell lung cancer (EGFR-mutant), Thyroid cancer (other types)
๐ Drug Information
| Generic Name(s) | Vandetanib |
| Brand Name | Caprelsa |
| Manufacturer | AstraZeneca |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Protein synthesis inhibitors |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Inhibits multiple receptor tyrosine kinases including VEGFR-2, EGFR, and RET.
Mechanism Steps
๐ก How to Take caprelsa tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of caprelsa tablet
โ Common Side Effects
- Diarrhea
- Rash
- Nausea
- Hypertension
- Headache
- Fatigue
๐จ Serious Side Effects
- QTc prolongation
- Torsades de pointes
- Hemorrhage
- Heart failure
- Interstitial lung disease
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Posterior reversible encephalopathy syndrome (PRES)
- Pancreatitis
- Thrombotic microangiopathy
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| CYP3A4 inducers (e.g., rifampin) | Major | Reduced vandetanib exposure |
| CYP3A4 inhibitors (e.g., ketoconazole) | Major | Increased vandetanib exposure |
| QTc-prolonging agents (e.g., amiodarone) | Major | Increased risk of torsades de pointes |
| Warfarin | Moderate | Increased INR and bleeding risk |
| Digoxin | Moderate | Increased digoxin levels |
๐จ Major Interactions
- CYP3A4 inducers
- CYP3A4 inhibitors
- QTc-prolonging agents
โก Moderate Interactions
- Anticoagulants
- Antiplatelet agents
- Digoxin
โน๏ธ Minor Interactions
- Grapefruit juice
- St. John's Wort
๐ฝ๏ธ Food Interactions
Avoid grapefruit juice; may increase vandetanib levels.
๐ท Alcohol Interaction
Avoid alcohol due to potential hepatotoxicity and QTc prolongation.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Congenital long QT syndrome, hypokalemia, hypomagnesemia, severe hepatic impairment.
๐ Monitoring Parameters
ECG (QTc), serum electrolytes (K+, Mg2+), liver function, renal function, blood pressure, thyroid function.
๐คฑ Lactation Safety
Not recommended; unknown if excreted in human milk.
๐ Overdose Management
No specific antidote; symptomatic and supportive care; monitor ECG and electrolytes.
โฐ Missed Dose
If missed, take as soon as remembered unless next dose is within 12 hours; do not double dose.