Canfree Kit: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, or throat, or difficulty breathing.
- Severe skin rash, blisters, or peeling skin.
- Yellowing of skin or eyes, dark urine, or severe abdominal pain.
- Unusual bruising or bleeding.
- Persistent fever, sore throat, or mouth ulcers.
- Palpitations, fainting, or irregular heartbeat.
- Severe nausea, vomiting, or headache after alcohol consumption.
If experiencing severe symptoms, call emergency services immediately.
What is cans 150mg/750mg kit used for?
This medicine is a prescription combination of fluconazole (an antifungal) and ornidazole (an antiprotozoal/antibiotic) used to treat mixed infections caused by fungi, protozoa, and anaerobic bacteria, such as vaginal infections. It works by breaking down the cell membranes of fungi and damaging the DNA of protozoa and bacteria. It must be taken exactly as prescribed, and alcohol must be avoided during treatment.
- Generic Name: Fluconazole + Ornidazole
- Manufacturer: Ravenbhel Pharmaceuticals Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cans 150mg/750mg kit के बारे में (Hindi Summary)
उपयोग: यह दवा फ्लुकोनाज़ोल और ओर्निडाज़ोल का संयोजन है, जिसका उपयोग योनि संक्रमण, अमीबियासिस, जिआर्डियासिस और ट्राइकोमोनियासिस जैसे मिश्रित संक्रमणों के इलाज के लिए किया जाता है। यह फंगल, प्रोटोज़ोआ और एनारोबिक बैक्टीरिया को मारती है। इसे डॉक्टर के निर्देशानुसार ही लें और शराब का सेवन बिल्कुल न करें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट दर्द, सिरदर्द, चक्कर आना और मुँह में धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, लिवर की समस्या, रक्त विकार या हृदय की धड़कन में गड़बड़ी हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। शराब का सेवन बिल्कुल न करें और दवा खत्म होने के 48 घंटे बाद तक भी न करें। गर्भवती महिलाएं या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा का पूरा कोर्स पूरा करें, बीच में न छोड़ें। चक्कर आने पर वाहन न चलाएं। दवा को ठंडी और सूखी जगह पर रखें।
💊 cans 150mg/750mg kit Uses & Benefits
[{"condition":"Vaginal candidiasis with bacterial vaginosis","description":"This kit is used to treat mixed vaginal infections where both Candida yeast and anaerobic bacteria are present, providing broad coverage with a single course.","evidence":"Well-established"},{"condition":"Gastrointestinal amoebiasis","description":"Ornidazole component targets Entamoeba histolytica, while fluconazole may cover concurrent fungal overgrowth in immunocompromised patients.","evidence":"Moderate"},{"condition":"Giardiasis","description":"Ornidazole is effective against Giardia lamblia; fluconazole is added when fungal co-infection is suspected or confirmed.","evidence":"Moderate"},{"condition":"Trichomoniasis","description":"Ornidazole treats Trichomonas vaginalis; fluconazole may be included for mixed vaginal infections.","evidence":"Moderate"},{"condition":"Anaerobic bacterial infections","description":"Ornidazole covers anaerobic bacteria such as Bacteroides and Clostridium species; fluconazole adds antifungal coverage when needed.","evidence":"Moderate"}]
Off-label uses: [{"condition":"Prophylaxis in immunocompromised patients","description":"Sometimes used to prevent fungal and anaerobic infections in patients with prolonged neutropenia or after certain transplant procedures.","evidence":"Limited"},{"condition":"Refractory oral thrush","description":"Fluconazole component may be used for oral candidiasis that has not responded to topical treatments, though the combination with ornidazole is not standard.","evidence":"Limited"}]
Primary treatment for: Mixed vaginal infections (candidiasis and bacterial vaginosis)
Also treats: Amoebiasis, Giardiasis, Trichomoniasis, Anaerobic bacterial infections
📋 Drug Information
| Generic Name(s) | Fluconazole + Ornidazole |
| Brand Name | Canfree Kit |
| Manufacturer | Ravenbhel Pharmaceuticals Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Antifungal + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F) in a dry place, away from direct sunlight and moisture. Keep the medicine in its original packaging to protect it from light and contamination. Do not refrigerate unless specifically instructed. Keep out of reach of children and pets. |
| Shelf Life | The shelf life of this medicine is typically 24 months from the date of manufacture, but refer to the expiry date printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with distinct mechanisms. Fluconazole selectively inhibits fungal cytochrome P450-dependent 14-alpha-demethylase, blocking the conversion of lanosterol to ergosterol, which is essential for fungal cell membrane integrity. This leads to increased membrane permeability and leakage of cellular contents, resulting in fungal cell death. Ornidazole is a nitroimidazole that enters susceptible anaerobic microorganisms and protozoa, where its nitro group is reduced to reactive intermediates that bind to DNA, causing strand breakage and inhibiting nucleic acid synthesis, ultimately leading to cell death. Together, they provide antifungal and antiprotozoal/anaerobic antibacterial coverage.
Mechanism Steps
💡 How to Take cans 150mg/750mg kit
Strength: This kit contains fluconazole 150 mg and ornidazole 750 mg, both as immediate-release oral tablets.
Dosage Information
| Adult Dosage | The dosage of this medicine must be individualized by a qualified clinician based on the specific infection, its severity, the patient's age, weight, renal and hepatic function, and other medications being taken. A common regimen for mixed vaginal infections is one fluconazole 150 mg tablet and one ornidazole 750 mg tablet taken together as a single dose, or ornidazole 750 mg once daily for 5 to 7 days with a single fluconazole 150 mg dose. However, this is only an example; do not self-medicate. Always follow your doctor's prescription exactly. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Elderly patients may require dose adjustments based on renal and hepatic function. Fluconazole is primarily excreted by the kidneys, and renal function declines with age. Monitor closely for side effects and adjust doses as needed. Ornidazole does not require specific adjustment in the elderly unless renal or hepatic impairment is present. |
| Renal Impairment | In patients with renal impairment, fluconazole dose should be reduced according to creatinine clearance. For ornidazole, no specific dose adjustment is generally required, but caution is advised in severe renal failure. Consult your doctor for personalized dosing. |
| Hepatic Impairment | In patients with hepatic impairment, both fluconazole and ornidazole should be used with caution. Dose reduction may be necessary, and liver function should be monitored closely. Consult your doctor for personalized dosing. |
| Maximum Daily Dose | The maximum daily dose depends on the indication and patient factors. For fluconazole, the maximum recommended daily dose is 400 mg for most indications, though higher doses may be used in certain serious infections under medical supervision. For ornidazole, the maximum daily dose is typically 1.5 g (1500 mg). Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cans 150mg/750mg kit
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Phenytoin | Major | |
| Cyclosporine | Major | |
| Oral hypoglycemics | Major | |
| Amiodarone | Major | |
| Rifampicin | Moderate | |
| Cimetidine | Moderate | |
| Lithium | Moderate | |
| Theophylline | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Warfarin
- Oral hypoglycemics (e.g., glipizide, glyburide)
- Phenytoin
- Cyclosporine
- QT-prolonging drugs (e.g., amiodarone, sotalol)
⚡ Moderate Interactions
- Rifampicin
- Cimetidine
- Lithium
- Theophylline
🍷 Alcohol Interaction
Alcohol must be strictly avoided while taking this medicine and for at least 48 hours after the last dose. Ornidazole can cause a disulfiram-like reaction characterized by severe nausea, vomiting, flushing, headache, and rapid heartbeat. Additionally, alcohol may increase the risk of liver toxicity and worsen side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to fluconazole, ornidazole, or other azole or nitroimidazole drugs.","Concurrent use with disulfiram.","Alcohol consumption during treatment and for 48 hours after.","Severe liver disease or active liver failure.","Pregnancy, especially in the first trimester, unless clearly necessary.","Breastfeeding without medical advice.","Use with caution in patients with QT prolongation or taking QT-prolonging drugs."]
⚠️ Warnings & Precautions
["Do not consume alcohol during treatment and for at least 48 hours after the last dose due to the risk of a disulfiram-like reaction.","Use effective contraception during treatment if you are of childbearing age.","Inform your doctor if you have liver, kidney, or heart disease before taking this medicine.","Avoid driving or operating machinery if you experience dizziness or drowsiness.","Complete the full course as prescribed, even if symptoms improve, to prevent recurrence and resistance.","Report any signs of allergic reaction, liver problems, or blood disorders immediately.","Do not share this medicine with others."]
🤱 Lactation Safety
Both fluconazole and ornidazole are excreted in breast milk. Fluconazole is generally considered compatible with breastfeeding at low doses, but ornidazole may pose risks to the infant. It is advisable to avoid breastfeeding while taking this medicine or to pump and discard milk during treatment and for at least 48 hours after the last dose. Consult your doctor for personalized advice.
💊 Overdose Management
Overdose of this medicine may cause severe nausea, vomiting, abdominal pain, dizziness, and potentially liver or blood toxicity. If you suspect an overdose, seek emergency medical attention immediately. Treatment is supportive and symptomatic, with monitoring of vital signs, liver and kidney function, and blood counts. There is no specific antidote. Gastric lavage may be considered if the overdose is recent and the patient is stable. Hemodialysis may help remove fluconazole in severe cases.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, consult your doctor or pharmacist.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not share it with others, even if they have similar symptoms. Avoid alcohol completely while taking this medicine and for at least 48 hours after the last dose, because ornidazole can cause a disulfiram-like reaction with severe nausea, vomiting, flushing, and rapid heartbeat. Inform your doctor about all other medicines you are taking, especially blood thinners, diabetes medicines, seizure medicines, and certain antibiotics. Use effective contraception during treatment if you are of childbearing age, as this medicine may harm a developing baby. Do not drive or operate heavy machinery if you feel dizzy or drowsy. Complete the full course even if you feel better after a few doses. Keep all follow-up appointments and lab tests as advised. Store the kit in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects such as dizziness, liver toxicity, and blood disorders. Renal function should be assessed before dosing, and fluconazole dose may need adjustment. Monitor closely for any signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before taking this medicine. It is not recommended during pregnancy, especially in the first trimester. Use effective contraception during treatment and for at least 48 hours after the last dose.
🏥 Post-Surgery Considerations
If you have recently undergone surgery, inform your surgeon and anesthesiologist about this medicine. It may interact with other medications used during surgery and can affect liver function. Your doctor will determine if it is safe to continue.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure. It may interact with medications used for sedation or pain relief, and there is a risk of bleeding if you are also on blood thinners.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
If you experience dizziness or fatigue while taking this medicine, avoid strenuous exercise or activities that require mental alertness. Listen to your body and rest when needed.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness in some people. Avoid driving or operating heavy machinery until you know how it affects you. It is advisable to take it when you can rest if side effects occur. Most people can continue their normal daily activities with caution.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Complete the full course as prescribed, even if you feel better. If you experience severe side effects, contact your doctor immediately; they may advise you to stop or change the treatment.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of liver toxicity, blood disorders, and fungal resistance. It should only be used for the prescribed duration. Regular monitoring of liver function, kidney function, and blood counts may be required for prolonged therapy. Do not use for longer than recommended without medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For uncomplicated vaginal candidiasis, topical azoles like clotrimazole may be used instead of oral fluconazole.
Evidence: Well-establishedFor anaerobic infections and protozoal infections, these alternatives may be prescribed based on sensitivity and patient factors.
Evidence: Well-establishedMay help restore healthy vaginal flora and prevent recurrence, but not a substitute for antimicrobial treatment.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no specific vaccine interactions reported with this medicine. However, if you are due for any live vaccines, inform your doctor, as certain infections or medications may affect vaccine timing.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid temperature extremes in checked baggage. Store at room temperature and protect from direct sunlight. If crossing time zones, continue your dosing schedule as close to the prescribed times as possible; consult your doctor for specific advice. Check local customs regulations regarding prescription medicines before travel.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours, but it is important to complete the full course as prescribed.
A: Yes, taking it with food can reduce stomach upset. However, avoid alcohol and grapefruit juice.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
A: This medicine is not recommended during pregnancy, especially in the first trimester, unless clearly necessary. Consult your doctor.
A: No, you must complete the full course as prescribed to prevent recurrence and resistance.
🤔 Common Patient Concerns
🔄 Substitutes for cans 150mg/750mg kit
View AllAlternative brands with exact same active ingredient:
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only treats specific fungal, protozoal, and anaerobic bacterial infections. It is not effective against viruses or other types of bacteria. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed to prevent recurrence and resistance, even if symptoms improve. - Myth: It is safe to drink alcohol while taking this medicine.
Fact: Alcohol must be strictly avoided because it can cause a severe disulfiram-like reaction with nausea, vomiting, and rapid heartbeat.
🔄 Alternative Options
Generic Alternatives
- Fluconazole 150 mg tablet
- Ornidazole 750 mg tablet