cans 3 vaginal suppository - Clindamycin (100mg) + Clotrimazole (200mg) medicine

cans 3 vaginal suppository

4.8 (14 reviews)
๐Ÿญ Ravenbhel Pharmaceuticals Pvt Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Aug 22, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Aug 22, 2026

What is cans 3 vaginal suppository used for?

Applygen Soft Gelatin Vaginal Suppositories (Clindamycin + Clotrimazole) is used to treat ANTI INFECTIVES. It contains Clindamycin (100mg) + Clotrimazole (200mg), which Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal sub. Always consult your doctor before use. Take as prescribed.

  • Generic Name: Clindamycin + Clotrimazole
  • Manufacturer: Ravenbhel Pharmaceuticals Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

๐Ÿ’Š cans 3 vaginal suppository Uses & Benefits

Bacterial vaginosis, vulvovaginal candidiasis, mixed vaginal infections

Off-label uses: Prevention of post-surgical vaginal infections

๐Ÿ“‹ Drug Information

Generic Name(s)Clindamycin + Clotrimazole
Brand NameApplygen Soft Gelatin Vaginal Suppositories
ManufacturerRavenbhel Pharmaceuticals Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassANTI INFECTIVES
Action ClassAntibiotic + Antifungal
Route of AdministrationVaginal
StorageStore at 20-25ยฐC (68-77ยฐF); protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionMinimal systemic absorption via vaginal mucosa
DistributionLocal distribution in vaginal tissues
Protein BindingClindamycin: 90-94%; Clotrimazole: 90%
MetabolismClindamycin: Hepatic via CYP3A4; Clotrimazole: Hepatic
Half-LifeClindamycin: 2-3 hours; Clotrimazole: 3-6 hours
ExcretionClindamycin: Renal and biliary; Clotrimazole: Feces
BioavailabilityLow systemic bioavailability due to local application
Onset of ActionWithin 24-48 hours
Peak Plasma TimeNot applicable (local action)
Duration of ActionUp to 7 days

How It Works

Clindamycin inhibits bacterial protein synthesis by binding to 50S ribosomal subunit; Clotrimazole inhibits fungal ergosterol synthesis by inhibiting 14ฮฑ-demethylase

Mechanism Steps

1Clindamycin binds to 50S ribosomal subunit of bacteria, inhibiting peptide bond formation and protein synthesis
2Clotrimazole inhibits fungal cytochrome P450 14ฮฑ-demethylase, blocking conversion of lanosterol to ergosterol
3Ergosterol depletion disrupts fungal cell membrane integrity, leading to cell death

๐Ÿ’ก How to Take cans 3 vaginal suppository

Follow your doctor's prescription exactly.

โš ๏ธ Side Effects of cans 3 vaginal suppository

โœ… Common Side Effects

  • Vaginal burning
  • itching
  • irritation
  • abdominal cramps

๐Ÿšจ Serious Side Effects

  • Pseudomembranous colitis
  • severe allergic reactions

โš ๏ธ Rare Side Effects

  • Hepatotoxicity
  • Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Major Increased bleeding risk
Neuromuscular blockers Major Enhanced neuromuscular blockade

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Warfarin

โšก Moderate Interactions

  • CYP3A4 inhibitors
  • CYP3A4 inducers

โ„น๏ธ Minor Interactions

  • Oral contraceptives

๐Ÿฝ๏ธ Food Interactions

No significant food interactions

๐Ÿท Alcohol Interaction

No known interaction

๐Ÿ›ก๏ธ Safety & Warnings

๐Ÿšซ Contraindications

Hypersensitivity to clindamycin, clotrimazole, or any component; history of pseudomembranous colitis

๐Ÿ“Š Monitoring Parameters

Clinical response, signs of superinfection, hypersensitivity reactions

๐Ÿคฑ Lactation Safety

Use with caution; minimal systemic absorption

๐Ÿ’Š Overdose Management

Unlikely due to local use; symptomatic treatment if ingested

โฐ Missed Dose

Insert as soon as remembered; skip if near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

๐Ÿ”— View Profile

โญ User Reviews

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Trusted Reviewer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Regular Customer Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

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