calfin 25mg/500mg tablet - Uses, Price, Side Effects & Substitutes
What is calfin 25mg/500mg tablet used for?
Calfin (Pyrimethamine + Sulfamethoxazole) is used to treat ANTI MALARIALS. It contains Pyrimethamine (25mg) + Sulfamethoxazole (500mg), which Pyrimethamine inhibits dihydrofolate reductase; Sulfamethoxazole inhibits dihydr. Always consult your doctor before use. Take as prescribed.
- Generic Name: Pyrimethamine + Sulfamethoxazole
- Manufacturer: Redson Laboratories Pvt Ltd
- Form: Allopathy
- Pregnancy Category: C
- Prescription Required: Yes
๐ calfin 25mg/500mg tablet Uses & Benefits
Treatment of chloroquine-resistant falciparum malaria; toxoplasmosis (in combination with other agents).
Off-label uses: Treatment of Pneumocystis jirovecii pneumonia (PCP) in combination with other agents.
๐ Drug Information
| Generic Name(s) | Pyrimethamine + Sulfamethoxazole |
| Brand Name | Calfin |
| Manufacturer | Redson Laboratories Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial combination |
| Route of Administration | Oral |
| Storage | Store at 20-25ยฐC (68-77ยฐF), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Pyrimethamine inhibits dihydrofolate reductase; Sulfamethoxazole inhibits dihydropteroate synthase, sequentially blocking folate synthesis in Plasmodium.
Mechanism Steps
๐ก How to Take calfin 25mg/500mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of calfin 25mg/500mg tablet
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Rash
- Headache
๐จ Serious Side Effects
- Stevens-Johnson syndrome
- Toxic epidermal necrolysis
- Agranulocytosis
- Aplastic anemia
- Hepatotoxicity
โ ๏ธ Rare Side Effects
- Megaloblastic anemia
- Pancreatitis
- Interstitial nephritis
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Methotrexate | Major | Increased methotrexate toxicity |
| Phenytoin | Major | Increased phenytoin levels |
| Sulfonylureas | Major | Increased hypoglycemic effect |
| Oral contraceptives | Moderate | Reduced contraceptive efficacy |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Digoxin | Moderate | Increased digoxin levels |
| Antacids | Minor | Reduced absorption |
| Vitamin K | Minor | Antagonizes anticoagulant effect |
๐จ Major Interactions
- Warfarin
- Methotrexate
- Phenytoin
- Sulfonylureas
โก Moderate Interactions
- Oral contraceptives
- Cyclosporine
- Digoxin
โน๏ธ Minor Interactions
- Antacids
- Vitamin K
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
Avoid alcohol due to increased hepatotoxicity risk.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to sulfonamides or pyrimethamine; severe hepatic or renal impairment; megaloblastic anemia; pregnancy (especially first trimester); lactation; infants <2 months.
๐ Monitoring Parameters
CBC, renal and hepatic function, folate levels, signs of hypersensitivity.
๐คฑ Lactation Safety
Contraindicated (excreted in milk, risk of kernicterus in infants)
๐ Overdose Management
Gastric lavage, supportive care, folinic acid (leucovorin) to counteract folate deficiency.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.