calcigo max softgel capsule - Calcitriol (0.25mcg) + Eicosapentaenoic Acid (180mg) medicine

Calcitriol + Eicosapentaenoic Acid Softgel Capsule: Comprehensive Guide

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🏭 Resolute Healthcare 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 31, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate to well-established for individual components.
Reviewed by
SaathiMed Expert Panel | Oct 31, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe nausea, vomiting, or abdominal pain
  • Confusion, drowsiness, or irregular heartbeat
  • Excessive thirst and frequent urination
  • Blood in urine or severe flank pain
  • Swelling of face, lips, or throat
  • Yellowing of skin or eyes
  • Decreased urine output

If experiencing severe symptoms, call emergency services immediately.

What is calcigo max softgel capsule used for?

This medicine is a combination of Calcitriol and Eicosapentaenoic Acid used to support bone health and reduce inflammation. It is taken orally once daily with food.

  • Generic Name: Calcitriol + Eicosapentaenoic Acid
  • Manufacturer: Resolute Healthcare
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 calcigo max softgel capsule के बारे में (Hindi Summary)

उपयोग: यह दवा कैल्सिट्रियोल और ईकोसापेंटेनोइक एसिड का संयोजन है, जिसका उपयोग हड्डियों की मजबूती के लिए और सूजन कम करने के लिए किया जाता है। यह ऑस्टियोपोरोसिस, क्रोनिक किडनी रोग और कैल्शियम की कमी में मदद करती है।

साइड इफेक्ट्स: आम दुष्प्रभावों में मतली, कब्ज, सिरदर्द और धातु जैसा स्वाद शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन उच्च कैल्शियम स्तर, गुर्दे की पथरी या एलर्जी प्रतिक्रिया हो सकती है।

सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। कैल्शियम और किडनी फंक्शन की नियमित जांच कराएं। बिना सलाह के अन्य विटामिन डी या कैल्शियम सप्लीमेंट न लें। पर्याप्त पानी पिएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें।

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 calcigo max softgel capsule Uses & Benefits

[{"condition":"Osteoporosis","description":"Helps maintain bone density and reduces fracture risk by improving calcium absorption.","evidence":"Well-established"},{"condition":"Chronic kidney disease-associated mineral bone disorder","description":"Used to manage low calcium levels and bone disease in patients with kidney disease.","evidence":"Well-established"},{"condition":"Hypocalcemia","description":"Treats low blood calcium levels, especially in patients with hypoparathyroidism.","evidence":"Well-established"},{"condition":"Inflammatory conditions","description":"Eicosapentaenoic Acid may help reduce inflammation in conditions like rheumatoid arthritis.","evidence":"Moderate"}]

Off-label uses: [{"condition":"Cardiovascular risk reduction","description":"Omega-3 fatty acids may be used off-label to support heart health.","evidence":"Limited"},{"condition":"Depression","description":"Some evidence suggests omega-3s may help with mood disorders, but not standard.","evidence":"Limited"}]

Primary treatment for: Osteoporosis

Also treats: Chronic kidney disease, Hypocalcemia, Rheumatoid arthritis

📋 Drug Information

Generic Name(s)Calcitriol + Eicosapentaenoic Acid
Brand NameCalcigo Max Softgel Capsule
ManufacturerResolute Healthcare
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassVITAMINS MINERALS NUTRIENTS
Action ClassVitamin D Analog + Omega-3 Fatty Acid
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a dry place, away from direct sunlight. Keep in the original container.
Shelf Life24 months from the date of manufacture.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine with a meal to improve absorption and reduce stomach upset.
2
Regularly monitor your calcium and phosphate levels as advised by your doctor.
3
Avoid taking extra calcium or vitamin D supplements without consulting your doctor.
4
Stay well hydrated to support kidney function.
5
Inform your doctor if you experience symptoms of high calcium such as confusion or excessive thirst.
6
Do not stop this medicine abruptly without medical advice.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Bone pain
This medicine is commonly prescribed for bone health.
Likely Use
✅
Muscle cramps
May help if due to low calcium.
Likely Use
❌
Fever
This medicine is not a fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionCalcitriol is rapidly absorbed from the intestine. Eicosapentaenoic Acid is absorbed in the small intestine with the help of bile acids.
DistributionCalcitriol is distributed widely in the body, with highest concentrations in the liver, kidney, and intestine. Eicosapentaenoic Acid is incorporated into cell membranes and transported in the blood bound to lipoproteins.
Protein BindingCalcitriol is approximately 99.9% bound to vitamin D-binding protein and albumin. Eicosapentaenoic Acid is highly bound to plasma proteins, mainly albumin.
MetabolismCalcitriol is metabolized in the liver and intestine via CYP24A1 to inactive metabolites. Eicosapentaenoic Acid is metabolized by beta-oxidation and lipoxygenase/cyclooxygenase pathways.
Half-LifeCalcitriol half-life is about 5-8 hours. Eicosapentaenoic Acid half-life is approximately 20-40 hours.
ExcretionCalcitriol metabolites are excreted mainly in bile and feces, with a small amount in urine. Eicosapentaenoic Acid metabolites are excreted in urine and feces.
BioavailabilityCalcitriol bioavailability is about 70-80%. Eicosapentaenoic Acid bioavailability from softgel capsules is approximately 60-80% when taken with food.
Onset of ActionCalcitriol effects on calcium absorption begin within hours; EPA anti-inflammatory effects may take weeks.
Peak Plasma TimeCalcitriol peak plasma levels occur at 2-6 hours. EPA peak levels occur at 4-6 hours after ingestion.
Duration of ActionCalcitriol effects last about 24-48 hours. EPA effects persist as long as tissue levels are maintained.

How It Works

Calcitriol binds to vitamin D receptors in the intestine, bone, kidney, and parathyroid glands, increasing calcium absorption and regulating bone mineralization. Eicosapentaenoic Acid is incorporated into cell membranes and competes with arachidonic acid for cyclooxygenase and lipoxygenase enzymes, reducing the production of pro-inflammatory eicosanoids.

Mechanism Steps

1
Calcitriol binding to VDR: Calcitriol binds to the vitamin D receptor in target tissues, forming a heterodimer with the retinoid X receptor.
2
Gene transcription modulation: The complex enters the nucleus and regulates gene expression, increasing calcium-binding proteins like calbindin.
3
Increased calcium absorption: This leads to enhanced active transport of calcium across the intestinal epithelium.
4
EPA incorporation into membranes: Eicosapentaenoic Acid is incorporated into cell membrane phospholipids, altering membrane fluidity and signaling.
5
Reduced eicosanoid production: EPA competes with arachidonic acid for COX and LOX enzymes, decreasing pro-inflammatory prostaglandins and leukotrienes.

💡 How to Take calcigo max softgel capsule

Strength: Each softgel capsule contains Calcitriol 0.25 mcg and Eicosapentaenoic Acid 180 mg.

1Take the softgel capsule whole with a glass of water.
2Take it with a meal to enhance absorption and reduce stomach upset.
3Do not crush, chew, or break the capsule.
4Follow your doctor's instructions exactly.
5Do not take more than the prescribed dose.

Dosage Information

Adult DosageThe usual adult dose is one softgel capsule once daily or as directed by your physician. The dose may be adjusted based on your calcium levels, kidney function, and the condition being treated. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients may be more sensitive to the effects of calcitriol. Dose adjustment may be necessary based on renal function and calcium levels. Consult your doctor.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be required. Monitor calcium and phosphate levels closely.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Monitor liver function and calcium levels.
Maximum Daily DoseThe maximum daily dose should not exceed one capsule unless prescribed otherwise by your doctor. Do not exceed the recommended dose.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals
Enhances absorption of EPA and reduces stomach upset.
Grapefruit
Avoid excessive intake
May affect calcitriol metabolism.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of calcigo max softgel capsule

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food to reduce nausea. Consult doctor if persistent.
Constipation (Common (5-10%))
Increase fiber and fluid intake. Consult doctor if severe.
Headache (Common (5-10%))
Usually resolves. Consult doctor if severe or persistent.
Metallic taste (Uncommon (1-5%))
Usually temporary. Consult doctor if bothersome.

🚨 Serious Side Effects

Hypercalcemia (Rare (<0.1%))
Seek immediate medical attention if you experience confusion, excessive thirst, frequent urination, or irregular heartbeat.
Kidney stones (Rare (<0.1%))
Report severe flank pain or blood in urine to your doctor immediately.
Severe allergic reaction (Rare (<0.1%))
Seek emergency care if you develop rash, swelling, or difficulty breathing.

⚠️ Rare Side Effects

Hyperphosphatemia
Monitor phosphate levels; consult doctor if levels rise.
Nephrocalcinosis
Regular kidney function tests; report any changes in urination.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Thiazide diuretics Major
Digoxin Major
Warfarin Major
Corticosteroids Moderate
Orlistat Moderate
Bile acid sequestrants Moderate
Antacids (magnesium) Minor
Ketoconazole Minor

🚨 Major Interactions

  • Thiazide diuretics
  • Digoxin
  • Warfarin

⚡ Moderate Interactions

  • Corticosteroids
  • Orlistat
  • Bile acid sequestrants

🍷 Alcohol Interaction

Alcohol may impair calcium absorption and increase risk of bone loss. It is advisable to limit or avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypercalcemia","Hypervitaminosis D","Hypersensitivity to calcitriol, eicosapentaenoic acid, or any component","Severe renal impairment without monitoring","Hyperphosphatemia"]

⚠️ Warnings & Precautions

["Monitor calcium levels regularly to avoid hypercalcemia.","Avoid concurrent use of other vitamin D supplements without medical advice.","Use cautiously in patients with kidney stones or renal impairment.","May increase risk of bleeding when taken with anticoagulants.","Not recommended for children without pediatrician guidance.","Inform your doctor if you are pregnant or breastfeeding."]

🤱 Lactation Safety

Calcitriol is excreted in breast milk. Eicosapentaenoic Acid is also present in breast milk. Consult your doctor before using this medicine while breastfeeding.

💊 Overdose Management

Overdose may cause hypercalcemia, nausea, vomiting, confusion, and cardiac arrhythmias. Seek immediate medical attention. Treatment includes discontinuation of the medicine, hydration, and symptomatic management. In severe cases, corticosteroids or calcitonin may be used.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not exceed the recommended dose. Regular blood tests to monitor calcium, phosphate, and kidney function are important. Avoid taking additional vitamin D or calcium supplements without consulting your doctor. Stay well hydrated. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Avoid alcohol as it may affect calcium metabolism. Do not stop this medicine abruptly without medical advice. Keep out of reach of children.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more prone to hypercalcemia and kidney issues. Regular monitoring and dose adjustments are important.

🤰 Pregnancy Planning (TTC)

Consult your doctor before planning pregnancy. Calcitriol may be continued if benefits outweigh risks, but dose adjustment may be needed.

🏥 Post-Surgery Considerations

Inform your surgeon about this medicine before any surgery. It may affect calcium levels and bleeding risk.

🦷 Dental Procedures

Inform your dentist about this medicine, especially if you have a history of bleeding or are on anticoagulants.

💚 Lifestyle Tips for Better Results

🏃
Maintain a balanced diet rich in calcium and vitamin D.
🥗
Engage in weight-bearing exercises to strengthen bones.
😴
Avoid smoking and limit alcohol intake.
💧
Stay hydrated to support kidney health.
🧘
Get regular check-ups and blood tests.

🏋️ Exercise Considerations

Moderate exercise is encouraged, but avoid high-impact activities if you have osteoporosis or joint pain. Consult your doctor before starting any new exercise regimen.

🥗 Diet Recommendations

Include dairy products, leafy greens, and fortified foods for calcium.
Consume fatty fish for omega-3s.
Limit processed foods and excess salt.
Stay well hydrated.

💼 Impact on Daily Work & Life

This medicine generally does not affect your ability to work or drive. However, if you experience dizziness or confusion due to high calcium, avoid driving or operating machinery.

🛑 When to Stop This Medicine

Do not stop this medicine without consulting your doctor. If you experience severe side effects, contact your doctor immediately for guidance.

📅 Long-Term Use Effects

Long-term use requires regular monitoring of calcium, phosphate, and kidney function. Unmonitored use can lead to hypercalcemia, kidney stones, and soft tissue calcification. Periodic dose adjustments may be needed.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Calcium and vitamin D supplements

May be used alone if EPA is not needed.

Evidence: Well-established
Dietary changes

Increasing calcium and omega-3 intake through food.

Evidence: Moderate

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

No specific vaccine interactions are known. Continue routine vaccinations as advised by your doctor.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature and avoid extreme heat. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 60-year-old woman with osteoporosis
She was prescribed this medicine along with calcium supplements. After 3 months, her bone density improved, and she experienced fewer aches. She emphasized taking it with food to avoid nausea.
💡 Lesson: Consistent use and regular monitoring lead to better outcomes.
👤 A 45-year-old man with chronic kidney disease
He started this medicine to manage low calcium levels. His doctor monitored his calcium and kidney function regularly. He noticed reduced muscle cramps and improved energy.
💡 Lesson: Regular blood tests are crucial to prevent complications.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Calcitriol starts working within hours, but improvements in bone health may take weeks to months.

Q: Can I take this with other supplements?

A: Consult your doctor before adding any supplements, especially calcium or vitamin D.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my kidney function?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for calcigo max softgel capsule

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can be taken without a prescription.
    Fact: This medicine is a prescription drug and should only be taken under medical supervision.
  • Myth: More is better for bone health.
    Fact: Taking more than prescribed can lead to dangerous high calcium levels.

🔄 Alternative Options

Generic Alternatives

  • Calcitriol + Eicosapentaenoic Acid softgel capsules

📊 Comparison with Similar Medicines

[{"medicine":"Calcitriol alone","difference":"Does not contain EPA; used primarily for calcium regulation."},{"medicine":"EPA alone","difference":"Does not contain calcitriol; used for inflammation and cardiovascular support."}]

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