Bruzen MR 400mg/2mg Tablet: Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Blood in stool or vomit
- Severe abdominal pain
- Chest pain or difficulty breathing
- Severe headache with visual changes
- Sudden swelling of face, lips, or throat
- Yellowing of skin or eyes
- Decreased urine output
- Unusual bruising or bleeding
If experiencing severe symptoms, call emergency services immediately.
What is brutiz 400mg/2mg capsule used for?
This medicine is a combination of ibuprofen (an NSAID) and tizanidine (a muscle relaxant) used for short-term relief of painful musculoskeletal conditions. It reduces pain, inflammation, and muscle spasm. Take it with food, avoid alcohol, and do not drive until you know how it affects you.
- Generic Name: Ibuprofen + Tizanidine
- Manufacturer: Quixotic Pharma Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 brutiz 400mg/2mg capsule के बारे में (Hindi Summary)
उपयोग: यह दवा इबुप्रोफेन और टिज़ानिडीन का संयोजन है, जिसका उपयोग मांसपेशियों में दर्द, सूजन और ऐंठन के अल्पकालिक उपचार के लिए किया जाता है। यह पीठ दर्द, गर्दन दर्द, और मांसपेशियों की ऐंठन में राहत देती है। इसे भोजन के साथ लें और शराब से बचें।
साइड इफेक्ट्स: सामान्य दुष्प्रभावों में नींद आना, चक्कर आना, मुंह सूखना, जी मिचलाना और पेट खराब होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें पेट में रक्तस्राव, दिल का दौरा, स्ट्रोक, लीवर और किडनी की समस्या शामिल हो सकती है। कोई भी गंभीर लक्षण होने पर तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के निर्देशानुसार ही लें। खुराक से अधिक न लें। इसे भोजन के साथ लें ताकि पेट में जलन न हो। शराब का सेवन बिल्कुल न करें। जब तक आपको पता न चले कि यह दवा आप पर कैसे असर करती है, तब तक वाहन न चलाएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर से सलाह लें।
💊 brutiz 400mg/2mg capsule Uses & Benefits
[{"condition":"Acute musculoskeletal pain with muscle spasm","description":"Short-term relief of pain and spasm associated with back pain, neck pain, and sports injuries.","evidence":"Well-established"},{"condition":"Tension headache with muscle tightness","description":"May help relieve tension-type headaches when muscle spasm is a component.","evidence":"Limited"},{"condition":"Post-operative pain with spasm","description":"Sometimes used for short-term management of post-surgical pain and muscle spasm.","evidence":"Limited"}]
Off-label uses: [{"condition":"Fibromyalgia","description":"Occasionally prescribed off-label for pain and muscle stiffness, but evidence is limited.","evidence":"Limited"},{"condition":"Chronic neck pain","description":"May be used off-label for chronic neck pain with muscle spasm, but long-term safety is not established.","evidence":"Limited"}]
Primary treatment for: Musculoskeletal pain with muscle spasm
Also treats: Back pain, Neck pain, Tension headache, Post-operative pain
📋 Drug Information
| Generic Name(s) | Ibuprofen + Tizanidine |
| Brand Name | Bruzen MR 400mg/2mg Tablet |
| Manufacturer | Quixotic Pharma Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | PAIN ANALGESICS |
| Action Class | Nonsteroidal Anti-inflammatory Drug (NSAID) + Alpha-2 Adrenergic Agonist |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from moisture and direct sunlight. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary actions. Ibuprofen is a nonsteroidal anti-inflammatory drug that reversibly inhibits cyclooxygenase enzymes (COX-1 and COX-2), reducing the production of prostaglandins, which are mediators of pain, inflammation, and fever. Tizanidine is a centrally acting alpha-2 adrenergic agonist that reduces the release of excitatory neurotransmitters from spinal interneurons, leading to muscle relaxation. Together, they provide both anti-inflammatory and muscle relaxant effects.
Mechanism Steps
💡 How to Take brutiz 400mg/2mg capsule
Strength: Each tablet contains Ibuprofen 400 mg and Tizanidine 2 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet taken orally two to three times daily as needed for pain and muscle spasm. The maximum recommended dose is 3 tablets in 24 hours. Take with food or milk to reduce stomach upset. The dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose or duration without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients (above 65 years) may be more sensitive to the effects of this medicine, especially drowsiness, dizziness, and gastrointestinal bleeding. Use the lowest effective dose for the shortest duration. Dose must be individualized by a qualified clinician based on renal and hepatic function. |
| Renal Impairment | Use with caution in patients with renal impairment. Ibuprofen may worsen kidney function. Tizanidine may accumulate. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Both ibuprofen and tizanidine are metabolized in the liver. Dose reduction may be necessary. Consult a doctor for individualized dosing. |
| Maximum Daily Dose | The maximum recommended daily dose is 3 tablets (1200 mg ibuprofen and 6 mg tizanidine) in 24 hours. Do not exceed this dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of brutiz 400mg/2mg capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Ciprofloxacin | Major | |
| Fluvoxamine | Major | |
| ACE inhibitors | Moderate | |
| Diuretics | Moderate | |
| Lithium | Moderate | |
| Methotrexate | Moderate | |
| Oral contraceptives | Moderate | |
| Antacids | Minor | |
| Food (high-fat) | Minor |
🚨 Major Interactions
- Warfarin
- Other NSAIDs (e.g., aspirin, naproxen)
- Ciprofloxacin
- Fluvoxamine
⚡ Moderate Interactions
- ACE inhibitors (e.g., lisinopril)
- Diuretics (e.g., furosemide)
- Lithium
- Methotrexate
- Oral contraceptives
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol increases the risk of gastrointestinal bleeding from ibuprofen and enhances the sedative effects of tizanidine, leading to excessive drowsiness, dizziness, and impaired coordination.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Active peptic ulcer or history of recurrent ulcers","Severe heart failure","Severe kidney disease","Severe liver disease","History of asthma, urticaria, or allergic reaction to aspirin or other NSAIDs","Concurrent use with fluvoxamine or ciprofloxacin","Pregnancy (third trimester)","Breastfeeding without medical advice"]
⚠️ Warnings & Precautions
["May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Do not take with alcohol or other central nervous system depressants.","May increase risk of serious cardiovascular events; use lowest effective dose for shortest duration.","May cause gastrointestinal bleeding, especially in the elderly or those with a history of ulcers.","Use with caution in patients with kidney or liver disease; dose adjustment may be needed.","May cause low blood pressure; rise slowly from sitting or lying position.","Do not use for more than 7-10 days without medical advice.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding."]
🤱 Lactation Safety
Ibuprofen is considered safe during breastfeeding as it passes into breast milk in very small amounts. Tizanidine also passes into breast milk; its effects on a nursing infant are not well established. Consult your doctor before using this medicine while breastfeeding.
💊 Overdose Management
Overdose symptoms may include severe drowsiness, dizziness, nausea, vomiting, stomach pain, slow or irregular heartbeat, fainting, and difficulty breathing. Seek immediate medical attention. Treatment is supportive and symptomatic. There is no specific antidote. Activated charcoal may be administered if the patient presents early. Monitor vital signs and provide supportive care.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not exceed the recommended dose or duration. Take it with food or milk to reduce stomach irritation. Avoid alcohol completely, as it increases the risk of stomach bleeding and drowsiness. Do not drive or operate machinery until you know how this medicine affects you. Inform your doctor if you have a history of stomach ulcers, kidney or liver disease, heart problems, high blood pressure, or asthma. Do not use this medicine if you are pregnant, especially in the third trimester, or breastfeeding without medical advice. Keep out of reach of children. Store at room temperature away from moisture and heat. Do not share this medicine with others, even if they have similar symptoms.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are at higher risk of gastrointestinal bleeding, kidney problems, and drowsiness. Use the lowest effective dose for the shortest duration. Monitor blood pressure, kidney function, and for signs of bleeding.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Ibuprofen may affect ovulation and is not recommended during the third trimester. Tizanidine should be used only if clearly needed.
🏥 Post-Surgery Considerations
This medicine may be used for short-term post-operative pain and muscle spasm, but it can increase the risk of bleeding. Inform your surgeon if you are taking this medicine before surgery.
🦷 Dental Procedures
Inform your dentist if you are taking this medicine before any dental procedure, as it may increase the risk of bleeding and interact with other medications.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Avoid strenuous exercise or heavy lifting while taking this medicine, as it can cause drowsiness and dizziness. Gentle stretching and low-impact activities may be beneficial, but consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine can cause drowsiness and dizziness, which may affect your ability to drive, operate machinery, or perform tasks requiring alertness. Avoid these activities until you know how the medicine affects you. It may also cause dry mouth and stomach upset, which can be managed by drinking water and taking with food.
🛑 When to Stop This Medicine
Stop taking this medicine and consult your doctor if you experience severe side effects such as stomach bleeding, chest pain, difficulty breathing, or signs of an allergic reaction. Do not stop abruptly if you have been taking it for a long time without consulting your doctor.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of gastrointestinal bleeding, kidney problems, liver damage, and cardiovascular events. It is not recommended for extended use without medical supervision. Regular monitoring of kidney and liver function may be required. Consult your doctor if you need to use this medicine for more than 7-10 days.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Can complement medicine for chronic pain and improve muscle strength and flexibility.
Evidence: Well-establishedApplying heat or cold packs can help relieve muscle spasm and pain.
Evidence: ModerateMay provide pain relief for some musculoskeletal conditions.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are scheduled for vaccination, inform your healthcare provider about all medicines you are taking.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Store at room temperature, away from direct sunlight and moisture. If traveling across time zones, adjust dosing times gradually as advised by your doctor. Check customs regulations for carrying prescription medicines. Do not pack in checked luggage; keep it in your carry-on bag.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine usually starts relieving pain and muscle spasm within 30 to 60 minutes after taking it.
A: It is best to take this medicine with food or milk to reduce the risk of stomach upset.
A: This medicine can cause drowsiness and dizziness. Avoid driving or operating machinery until you know how it affects you.
A: No, alcohol increases the risk of stomach bleeding and drowsiness. Avoid alcohol completely.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for brutiz 400mg/2mg capsule
View AllAlternative brands with exact same active ingredient:
-
lumbril tabletYash Pharma Laboratories Pvt Ltd ₹19.29 67.9% CHEAPER
-
brufen mr soft gelatin capsuleAbbott ₹20.96 65.1% CHEAPER
-
Treza MR 400mg/2mg CapsuleDestin Laboratories Pvt Ltd ₹36.56 39.1% CHEAPER
-
bruzen mr 400mg/2mg tabletAbbott ₹39.38 34.4% CHEAPER
-
Tidifen 400mg/2mg TabletRedson Laboratories Pvt Ltd ₹42.19 29.7% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken long-term for chronic pain.
Fact: This medicine is intended for short-term use only. Prolonged use increases the risk of serious side effects. - Myth: It is safe to take this medicine without food.
Fact: Taking it with food reduces the risk of stomach upset and bleeding. - Myth: This medicine is safe to take with alcohol.
Fact: Alcohol increases the risk of stomach bleeding and drowsiness. Avoid alcohol. - Myth: This medicine is a cure for arthritis.
Fact: It provides symptomatic relief but does not cure underlying joint disease.
🔄 Alternative Options
Generic Alternatives
- Ibuprofen 400 mg + Tizanidine 2 mg tablet
Brand Alternatives
- Bruzen MR 400mg/2mg Tablet