briopan-d capsule pr - Domperidone (30mg) + Pantoprazole (40mg) medicine

Briopan-D Capsule PR - Uses, Price, Side Effects

4.6 (13 reviews)

Domperidone (30mg) Pantoprazole (40mg)

🏭 Halberd Pharmaceuticals 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is briopan-d capsule pr used for?

Briopan-D Capsule PR is a combination medicine containing Domperidone (30mg) and Pantoprazole (40mg). It is used to treat gastroesophageal reflux disease (GERD), acidity, and heartburn. Pantoprazole reduces stomach acid production, while Domperidone helps prevent nausea and vomiting by improving gastric motility. It is typically taken before meals.

Generic Name: Domperidone + Pantoprazole
Manufacturer: Halberd Pharmaceuticals
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.

💊 briopan-d capsule pr Uses & Benefits

Gastroesophageal reflux disease (GERD), dyspepsia, gastroparesis, peptic ulcer disease, Zollinger-Ellison syndrome (pantoprazole component).

Off-label uses: Domperidone: Lactation stimulation (not approved in many countries); Pantoprazole: Prevention of stress ulcers, eosinophilic esophagitis.

📋 Drug Information

Generic Name(s)	Domperidone + Pantoprazole
Brand Name	Anleo-DSR Capsule
Manufacturer	Halberd Pharmaceuticals
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	GASTRO INTESTINAL
Action Class	Prokinetic agent + Proton pump inhibitor
Route of Administration	Oral
Storage	Store at room temperature (20-25°C), protect from moisture and light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionDomperidone: Rapidly absorbed after oral administration; Pantoprazole: Rapidly absorbed, delayed-release formulation.

DistributionDomperidone: Widely distributed, crosses blood-brain barrier minimally; Pantoprazole: Volume of distribution about 0.15 L/kg, highly protein bound.

Protein BindingDomperidone: 91-93%; Pantoprazole: 98%

MetabolismDomperidone: Extensive hepatic metabolism via CYP3A4; Pantoprazole: Hepatic metabolism via CYP2C19 and CYP3A4.

Half-LifeDomperidone: 7-9 hours; Pantoprazole: 1-2 hours

ExcretionDomperidone: 31% urine, 66% feces; Pantoprazole: 80% urine (as metabolites), 20% feces.

BioavailabilityDomperidone: 13-17%; Pantoprazole: 77%

Onset of ActionDomperidone: 30-60 minutes; Pantoprazole: 2-4 hours (max acid suppression)

Peak Plasma TimeDomperidone: 0.5-1 hour; Pantoprazole: 2-4 hours

Duration of ActionDomperidone: 4-6 hours; Pantoprazole: 24 hours (acid suppression)

How It Works

Domperidone is a dopamine D2 receptor antagonist that enhances gastric motility and accelerates gastric emptying. Pantoprazole is a proton pump inhibitor that irreversibly inhibits H+/K+ ATPase in gastric parietal cells, reducing gastric acid secretion.

Mechanism Steps

1Domperidone blocks D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, increasing acetylcholine release and enhancing gastric motility.

2Domperidone increases lower esophageal sphincter tone and accelerates gastric emptying.

3Pantoprazole accumulates in the acidic canaliculi of parietal cells and is protonated to its active form.

💡 How to Take briopan-d capsule pr

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of briopan-d capsule pr

✅ Common Side Effects

Headache
Diarrhea
Nausea
Abdominal pain
Flatulence
Dry mouth
Dizziness

🚨 Serious Side Effects

QT prolongation
Ventricular arrhythmias
Extrapyramidal symptoms (domperidone)
Clostridium difficile infection
Bone fracture (long-term)
Hypomagnesemia
Interstitial nephritis

⚠️ Rare Side Effects

Gynecomastia
Galactorrhea
Jaundice
Hepatitis
Anaphylaxis
Stevens-Johnson syndrome
Agranulocytosis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Ketoconazole	Moderate	Increased risk of QT prolongation
Digoxin	Moderate	Increased digoxin levels

🚨 Major Interactions

Ketoconazole
Itraconazole
Voriconazole
Clarithromycin
Erythromycin
Ritonavir
Saquinavir
Amiodarone
Quinidine
Methotrexate

⚡ Moderate Interactions

Warfarin
Cilostazol
Citalopram
Escitalopram
Fluoxetine
Paroxetine
Sertraline
Tacrolimus
Cyclosporine
Digoxin

ℹ️ Minor Interactions

Sucralfate
Antacids
Iron supplements
Calcium carbonate

🍽️ Food Interactions

Food delays absorption of domperidone; pantoprazole should be taken before meals for optimal effect.

🍷 Alcohol Interaction

Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.

🛡️ Safety & Warnings

Liver

Low

Kidney

Low

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Hypersensitivity to any component; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concurrent use with strong CYP3A4 inhibitors (e.g., ketoconazole) causing QT prolongation; severe hepatic impairment.

📊 Monitoring Parameters

Liver function tests, ECG (QT interval), serum electrolytes, magnesium levels (long-term use), renal function.

🤱 Lactation Safety

Domperidone is excreted in breast milk; pantoprazole is excreted in small amounts. Caution advised.

💊 Overdose Management

Supportive care; domperidone overdose may cause extrapyramidal symptoms; pantoprazole overdose unlikely to cause serious effects.

⏰ Missed Dose

Take as soon as remembered unless near next dose; skip missed dose if close to next dose; do not double dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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⭐ User Reviews

Happy Patient Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Certified Buyer Jul 10, 2026

Helpful and effective medicine as per my experience. Always consult a doctor.

Trusted Reviewer Jul 10, 2026

Found this to be a helpful product. Good results.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.