bricarex expectorant - Guaifenesin (66.65mg) + Terbutaline (1.5mg) medicine

Bricarex Expectorant: Complete Medicine Guide

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🏭 AstraZeneca 📦 Varies by brand 💊 Allopathy 📅 Updated: Sep 25, 2026
⚠️ Nephrotoxicity Risk 📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Limited for the combination; individual components have varying levels of evidence.
Reviewed by
SaathiMed Expert Panel | Sep 25, 2026

When to Call Your Doctor IMMEDIATELY

  • Difficulty breathing or shortness of breath
  • Chest pain or irregular heartbeat
  • Severe allergic reaction (swelling of face, lips, throat)
  • Seizures or convulsions
  • Blood in sputum or vomit
  • Severe dizziness or fainting
  • Persistent vomiting or inability to keep fluids down

If experiencing severe symptoms, call emergency services immediately.

What is bricarex expectorant used for?

This medicine is a combination expectorant and bronchodilator used to relieve productive cough and mild breathing difficulty by thinning mucus and opening airways.

  • Generic Name: Guaifenesin (66.65mg) + Terbutaline (1.5mg)
  • Manufacturer: AstraZeneca
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 bricarex expectorant के बारे में (Hindi Summary)

उपयोग: यह दवा गुआइफेनेसिन और टर्ब्यूटलाइन का संयोजन है। यह कफ को पतला करके बाहर निकालने में मदद करती है और श्वास नलियों को फैलाकर सांस लेने में आसानी प्रदान करती है। इसका उपयोग मुख्य रूप से बलगम वाली खांसी और हल्की सांस की तकलीफ में किया जाता है। यह दवा डॉक्टर की सलाह पर ही लेनी चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में जी मिचलाना, उल्टी, सिरदर्द, चक्कर आना, घबराहट, कंपन और धड़कन तेज होना शामिल हैं। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन एलर्जी, सांस लेने में कठिनाई, अनियमित धड़कन या दौरे पड़ने पर तुरंत डॉक्टर से संपर्क करें।

सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। खुराक न बढ़ाएं और न घटाएं। इस दवा के साथ शराब न पिएं। यदि आपको हृदय रोग, उच्च रक्तचाप, मधुमेह, थायरॉइड या गुर्दे/यकृत की समस्या है तो डॉक्टर को बताएं। गर्भवती या स्तनपान कराने वाली महिलाएं डॉक्टर से सलाह लें। दवा को बच्चों से दूर रखें।

💡 Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

💊 bricarex expectorant Uses & Benefits

[{"condition":"Productive cough with thick mucus","description":"Helps loosen and thin mucus, making it easier to cough out.","evidence":"Well-established for guaifenesin; terbutaline adds bronchodilation."},{"condition":"Acute bronchitis","description":"Provides symptomatic relief of cough and mild bronchospasm.","evidence":"Commonly used, but evidence for combination is limited."},{"condition":"Chronic obstructive pulmonary disease (COPD) exacerbation","description":"May help relieve bronchospasm and mucus plugging in mild exacerbations.","evidence":"Terbutaline is effective as a bronchodilator; guaifenesin may aid mucus clearance."}]

Off-label uses: [{"condition":"Asthma with mucus hypersecretion","description":"Sometimes used off-label for short-term relief of wheezing and mucus in asthma, but not a preferred treatment.","evidence":"Limited; inhaled therapy is preferred."}]

Primary treatment for: Productive cough with bronchospasm

Also treats: Acute bronchitis, COPD exacerbation, Asthma with mucus

📋 Drug Information

Generic Name(s)Guaifenesin (66.65mg) + Terbutaline (1.5mg)
Brand Namebricarex expectorant
ManufacturerAstraZeneca
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action Class
Route of AdministrationOral
StorageStore at room temperature (15-30°C) in a cool, dry place away from direct sunlight. Keep in the original container.
Shelf LifeNot established from the available information. Refer to the product packaging for expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Always take this medicine with food to reduce stomach upset.
2
Stay well hydrated to help thin mucus and ease coughing.
3
Avoid alcohol while taking this medicine as it can increase drowsiness and heart rate.
4
Do not exceed the prescribed dose; follow your doctor's instructions strictly.
5
Consult your doctor if symptoms persist beyond 7 days or worsen.
6
Report any unusual heart palpitations, tremor, or nervousness to your doctor.
7
Do not use this medicine for a dry cough; it is meant for productive cough with mucus.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Productive cough with thick mucus
This medicine is commonly prescribed for this.
Likely Use
✅
Wheezing
Terbutaline helps relieve mild bronchospasm.
Likely Use
❌
Dry cough
This medicine is not for dry cough; it is for productive cough.
Not Primary
❌
Fever
This medicine is not a primary fever reducer.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionGuaifenesin is rapidly absorbed from the gastrointestinal tract after oral administration. Terbutaline is also well absorbed orally, but undergoes some first-pass metabolism. Exact bioavailability data for this specific combination product is not established from the available information.
DistributionGuaifenesin distributes widely into body tissues and fluids. Terbutaline distributes into most body tissues, with some accumulation in the liver, kidneys, and skeletal muscle. Protein binding data for the combination is not established from the available information.
Protein BindingGuaifenesin protein binding is not well established. Terbutaline is approximately 25% bound to plasma proteins. The protein binding of the combination product is not established from the available information.
MetabolismGuaifenesin is metabolized in the liver, primarily by oxidation and conjugation. Terbutaline undergoes extensive first-pass metabolism in the liver, mainly by conjugation with sulfate. The exact metabolic pathways for the combination are not fully established from the available information.
Half-LifeThe elimination half-life of guaifenesin is approximately 1 hour. Terbutaline has an elimination half-life of about 3 to 4 hours. The half-life of the combination product is not established from the available information.
ExcretionGuaifenesin and its metabolites are excreted primarily in the urine. Terbutaline is excreted mainly in the urine as unchanged drug and conjugates. The excretion profile of the combination product is not established from the available information.
BioavailabilityThe oral bioavailability of guaifenesin is approximately 50% due to first-pass metabolism. Terbutaline oral bioavailability is about 15% due to extensive first-pass metabolism. The bioavailability of this specific combination product is not established from the available information.
Onset of ActionTerbutaline begins to act within 30 minutes after oral administration. Guaifenesin's expectorant effect may take a few hours to become noticeable. The onset of the combination product is not established from the available information.
Peak Plasma TimePeak plasma concentrations of terbutaline are reached in about 2 to 4 hours after oral administration. Guaifenesin peaks within 1 hour. The peak time for the combination product is not established from the available information.
Duration of ActionTerbutaline's bronchodilator effect lasts about 4 to 6 hours. Guaifenesin's effect lasts several hours. The duration of action of the combination product is not established from the available information.

How It Works

This medicine combines two active ingredients with complementary actions. Guaifenesin is an expectorant that works by increasing the volume and reducing the viscosity of bronchial secretions, likely through reflex stimulation of gastric mucosa and subsequent parasympathetic action. This makes cough more productive. Terbutaline is a selective beta-2 adrenergic receptor agonist that stimulates beta-2 receptors on bronchial smooth muscle, leading to relaxation and bronchodilation. It also inhibits release of mediators from mast cells and improves mucociliary clearance. Together, they help relieve cough and mild breathing difficulty associated with thick mucus and bronchospasm.

Mechanism Steps

1
Guaifenesin stimulates gastric mucosa: Guaifenesin acts on the stomach lining to reflexively increase respiratory tract secretions, thinning mucus.
2
Terbutaline binds beta-2 receptors: Terbutaline selectively binds to beta-2 adrenergic receptors on bronchial smooth muscle cells.
3
Bronchial smooth muscle relaxation: This binding activates cyclic AMP, leading to relaxation of bronchial muscles and widening of airways.
4
Enhanced mucociliary clearance: Terbutaline also improves ciliary beat frequency, helping move thinned mucus upward for expulsion.

💡 How to Take bricarex expectorant

Strength: Each 5 mL of expectorant syrup contains Guaifenesin 66.65 mg and Terbutaline 1.5 mg.

1Shake the bottle well before use.
2Measure the dose accurately using the measuring cup or spoon provided.
3Take the medicine with food or milk to reduce stomach upset.
4Swallow the medicine; do not chew or crush.
5Follow the prescribed schedule and do not exceed the recommended dose.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5-10 mL (or as directed by the physician) taken orally every 4-6 hours, not exceeding the recommended daily dose. However, the exact dose and frequency must be individualized by a qualified clinician based on the indication, severity of symptoms, age, weight, renal and hepatic function, and response to therapy. Do not self-medicate. Always follow your doctor's prescription.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children.
Elderly DosageElderly patients may be more sensitive to the cardiovascular effects of terbutaline. Use with caution and lower doses may be considered. Dose must be individualized by a qualified clinician.
Renal ImpairmentUse with caution in patients with renal impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Hepatic ImpairmentUse with caution in patients with hepatic impairment. Dose adjustment may be necessary. Consult a doctor for individualized dosing.
Maximum Daily DoseThe maximum daily dose of this medicine is not established from the available information. Do not exceed the dose prescribed by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals or snacks
Reduces stomach upset.
Caffeine
Limit
May increase nervousness and tremor.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of bricarex expectorant

✅ Common Side Effects

Nausea (Common (5-10%))
Take with food or milk to reduce stomach upset. If persistent, consult your doctor.
Headache (Common (5-10%))
Rest and stay hydrated. Consult doctor if severe or persistent.
Tremor (Common (5-10%))
Usually decreases with continued use. Avoid caffeine. Consult doctor if bothersome.
Nervousness (Common (5-10%))
Try relaxation techniques. If severe, consult doctor.
Palpitations (Uncommon (1-5%))
Report to doctor if persistent or accompanied by chest pain.

🚨 Serious Side Effects

Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency medical help immediately if you experience swelling of face, lips, throat, or difficulty breathing.
Irregular heartbeat (arrhythmia) (Rare (<0.1%))
Seek immediate medical attention if you feel palpitations, dizziness, or fainting.
Chest pain (Rare (<0.1%))
Stop the medicine and seek emergency care.
Seizures (Very rare (<0.01%))
Seek emergency medical help immediately.

⚠️ Rare Side Effects

Kidney stones (with high doses of guaifenesin)
Report flank pain or blood in urine to doctor.
Severe skin reactions (Stevens-Johnson syndrome)
Seek immediate medical attention if you develop rash, blisters, or peeling skin.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
Propranolol Major
MAOIs Major
Tricyclic antidepressants Major
Furosemide Moderate
Corticosteroids Moderate
Digoxin Moderate
Antacids Minor
Caffeine Minor

🚨 Major Interactions

  • Beta-blockers (e.g., propranolol)
  • Monoamine oxidase inhibitors (MAOIs)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Diuretics (e.g., furosemide)
  • Corticosteroids
  • Digoxin

🍷 Alcohol Interaction

Alcohol may increase drowsiness, dizziness, and heart rate when taken with this medicine. It is advisable to avoid alcohol while taking this medicine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to guaifenesin, terbutaline, or any component of the formulation","Severe cardiac disease, including arrhythmias","Uncontrolled hypertension","Hyperthyroidism","Severe hepatic or renal impairment","Children below the age recommended by the manufacturer (consult doctor)"]

⚠️ Warnings & Precautions

["Use with caution in patients with cardiovascular disease, including coronary insufficiency, arrhythmias, and hypertension.","Use with caution in patients with diabetes mellitus, as terbutaline may increase blood glucose levels.","Use with caution in patients with hyperthyroidism.","Use with caution in patients with a history of seizures.","Do not exceed the recommended dose.","Avoid concomitant use with beta-blockers.","May cause dizziness; avoid driving or operating machinery until you know how it affects you."]

🤱 Lactation Safety

Guaifenesin and terbutaline may pass into breast milk. Terbutaline may cause tremors or increased heart rate in the infant. Consult your doctor before breastfeeding while taking this medicine.

💊 Overdose Management

Overdose may cause severe tachycardia, palpitations, tremor, nervousness, seizures, and cardiac arrest. Seek emergency medical attention immediately. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if within 1-2 hours of ingestion. Monitor cardiac rhythm and vital signs.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as prescribed by your doctor. Do not increase or decrease the dose without medical advice. Avoid drinking alcohol while taking this medicine as it can increase drowsiness and heart rate. Inform your doctor if you have heart disease, high blood pressure, diabetes, thyroid problems, or kidney or liver disease. Do not use this medicine for a prolonged period without consulting your doctor. If you are pregnant or breastfeeding, consult your doctor before using this medicine. Keep this medicine out of reach of children. Do not drive or operate heavy machinery if you feel dizzy or shaky after taking this medicine. Store in a cool, dry place away from direct sunlight.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more sensitive to the cardiovascular effects of terbutaline, such as increased heart rate and palpitations. Lower doses may be appropriate. Monitor for dizziness and falls. Consult a doctor for individualized dosing.

🤰 Pregnancy Planning (TTC)

If you are planning pregnancy or are pregnant, consult your doctor before taking this medicine. The safety of this combination during pregnancy is not well established. Your doctor will weigh the benefits and risks.

🏥 Post-Surgery Considerations

Inform your surgeon and anesthesiologist if you are taking this medicine before surgery. Terbutaline may interact with anesthetic agents and affect heart rate. Your doctor may advise you to stop it temporarily.

🦷 Dental Procedures

Inform your dentist if you are taking this medicine. It may cause dry mouth or interact with local anesthetics containing epinephrine. Your dentist may take precautions.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin mucus.
🥗
Use a humidifier to keep airways moist.
😴
Avoid smoking and exposure to secondhand smoke.
💧
Practice good hand hygiene to prevent respiratory infections.
🧘
Get adequate rest to support recovery.
🌞
Use saline nasal rinses if you have nasal congestion.

🏋️ Exercise Considerations

Avoid strenuous exercise if you experience dizziness, tremor, or palpitations after taking this medicine. Light activity is generally safe, but consult your doctor before starting any exercise program.

🥗 Diet Recommendations

Drink plenty of fluids, especially warm liquids.
Include honey and ginger in your diet to soothe the throat.
Avoid cold and processed foods that may worsen cough.
Eat a balanced diet rich in vitamins and minerals.

💼 Impact on Daily Work & Life

This medicine may cause dizziness or tremor, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is generally safe to continue desk work, but take breaks if you feel shaky.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as chest pain, palpitations, or allergic reactions. Do not stop abruptly if you have been taking it regularly for a long time without medical advice.

📅 Long-Term Use Effects

Long-term use of this medicine without medical supervision may lead to tolerance to terbutaline, reduced effectiveness, and potential cardiac side effects. Regular monitoring of heart rate, blood pressure, and potassium levels may be required. It should only be used for the duration prescribed by your doctor.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Steam inhalation

Helps loosen mucus and soothe airways.

Evidence: Commonly used, supportive care.
Saline nasal irrigation

Helps clear nasal congestion and postnasal drip.

Evidence: Well-established for nasal symptoms.
Honey and warm fluids

Soothes throat and may reduce cough frequency.

Evidence: Some evidence for cough relief.

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

There are no known interactions between this medicine and vaccines. However, if you are due for a vaccination, inform your healthcare provider about all medicines you are taking.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✈️ Traveling with This Medicine

Carry this medicine in its original packaging with a copy of your prescription. Store it at room temperature and protect it from direct sunlight. If traveling across time zones, adjust dosing intervals as advised by your doctor. Check customs regulations for carrying prescription medicines. Keep enough supply for your trip and carry it in your hand luggage if flying.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old man with acute bronchitis
He was prescribed this medicine for a productive cough with thick mucus. After taking it as directed with food, he noticed his cough became more productive and easier to clear within two days. He also experienced mild tremor initially, which subsided after a few doses.
💡 Lesson: Taking the medicine with food and staying hydrated helps improve tolerability and effectiveness.
👤 A 60-year-old woman with COPD exacerbation
She used this medicine as part of her treatment for a mild COPD flare-up. It helped relieve her wheezing and made coughing up mucus easier. She was advised to monitor her heart rate and report any palpitations.
💡 Lesson: This medicine can be helpful for COPD exacerbations but requires monitoring for cardiac side effects, especially in older adults.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: Terbutaline starts working within 30 minutes, while guaifenesin may take a few hours to show its full effect.

Q: Can I take this medicine for a dry cough?

A: No, this medicine is for productive cough with mucus. It is not effective for dry cough.

Q: Is it safe to take with other cold medicines?

A: Consult your doctor before combining with other cold medicines to avoid interactions.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my heart?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?

🔄 Substitutes for bricarex expectorant

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure any cough.
    Fact: It is only for productive cough with mucus and mild bronchospasm; it does not treat dry cough or infections.
  • Myth: It is safe to take this medicine for a long time without doctor's advice.
    Fact: Prolonged use without medical supervision can lead to side effects and mask underlying conditions.

🔄 Alternative Options

Generic Alternatives

  • Guaifenesin + Terbutaline (generic versions may be available)

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","composition":"Guaifenesin 66.65 mg + Terbutaline 1.5 mg","uses":"Productive cough with bronchospasm","notes":"Combination product"},{"medicine":"Guaifenesin + Salbutamol","composition":"Guaifenesin + Salbutamol","uses":"Productive cough with bronchospasm","notes":"Salbutamol is another beta-2 agonist"}]

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