breath dx syrup - Phenylpropanolamine (NA) + Chlorpheniramine Maleate (NA) medicine

Agicof Syrup: Complete Medicine Guide

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🏭 Hippo Labs Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Oct 17, 2026
📋 Prescription Required 💊 Generic Available
Medically Reviewed
11 min read
Evidence: Moderate for short-term symptomatic relief of cold and allergy symptoms.
Reviewed by
SaathiMed Expert Panel | Oct 17, 2026
🩺
Medically Fact-Checked & Clinically Verified by SaathiMed Clinical Review Board
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026

When to Call Your Doctor IMMEDIATELY

  • Severe headache, chest pain, or shortness of breath
  • Irregular or rapid heartbeat
  • Confusion, hallucinations, or unusual behavior
  • Seizures or loss of consciousness
  • Swelling of face, lips, tongue, or throat
  • Difficulty urinating or no urine output
  • Yellowing of skin or eyes, dark urine, or severe abdominal pain

If experiencing severe symptoms, call emergency services immediately.

What is breath dx syrup used for?

This medicine is a combination of phenylpropanolamine and chlorpheniramine maleate used for temporary relief of nasal congestion, sneezing, and runny nose due to colds or allergies. It works by shrinking nasal blood vessels and blocking histamine. It can cause drowsiness, so avoid driving. Do not use for more than 7 days without medical advice.

  • Generic Name: Phenylpropanolamine + Chlorpheniramine Maleate
  • Manufacturer: Hippo Labs Pvt Ltd
  • Form: Allopathy
  • Pregnancy Category: Consult doctor
  • Prescription Required: Yes

🇮🇳 breath dx syrup के बारे में (Hindi Summary)

उपयोग: यह दवा आम सर्दी, एलर्जी और नाक बंद होने के लक्षणों से राहत दिलाने के लिए इस्तेमाल की जाती है। इसमें फेनिलप्रोपेनॉलामाइन नाक की भीड़ को कम करता है और क्लोरफेनिरामाइन मेलिएट छींक, खुजली और बहती नाक को रोकता है। यह सिरप के रूप में मौखिक रूप से ली जाती है। इसका उपयोग केवल अल्पकालिक राहत के लिए किया जाना चाहिए, आमतौर पर 7 दिनों से अधिक नहीं। इसे लेने से नींद आ सकती है, इसलिए वाहन चलाने या मशीनरी चलाने से बचें। उच्च रक्तचाप, हृदय रोग, ग्लूकोमा या पेशाब में रुकावट वाले रोगियों को इसका उपयोग नहीं करना चाहिए।

साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में नींद आना, मुँह सूखना, चक्कर आना, धुंधली दृष्टि और हल्का पेट खराब होना शामिल है। कुछ लोगों को बेचैनी, घबराहट या अनिद्रा हो सकती है। दुर्लभ मामलों में दिल की धड़कन तेज होना, रक्तचाप बढ़ना या पेशाब करने में कठिनाई हो सकती है। गंभीर दुष्प्रभाव जैसे गंभीर एलर्जी प्रतिक्रिया, दौरे या मतिभ्रम बहुत दुर्लभ हैं, लेकिन तुरंत चिकित्सा सहायता की आवश्यकता होती है।

सुरक्षा सलाह: इस दवा को अपने डॉक्टर के निर्देशानुसार ही लें। अनुशंसित खुराक या अवधि से अधिक न लें। शराब और अन्य नींद लाने वाली दवाओं से बचें क्योंकि इससे नींद और चक्कर बढ़ सकते हैं। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, वाहन न चलाएं। यदि आपको उच्च रक्तचाप, हृदय रोग, मधुमेह, थायरॉइड, ग्लूकोमा या प्रोस्टेट की समस्या है तो अपने डॉक्टर को बताएं। 7 दिनों से अधिक इसका उपयोग न करें। बच्चों की पहुंच से दूर रखें।

💡 Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

💊 breath dx syrup Uses & Benefits

[{"condition":"Common cold with nasal congestion","description":"Provides temporary relief of nasal stuffiness and sneezing associated with the common cold.","evidence":"Established for short-term symptomatic relief"},{"condition":"Allergic rhinitis","description":"Helps reduce runny nose, sneezing, and itchy, watery eyes due to seasonal or perennial allergies.","evidence":"Established for short-term symptomatic relief"},{"condition":"Sinusitis with congestion","description":"May alleviate nasal congestion and pressure in acute sinusitis as an adjunct to other treatments.","evidence":"Limited, used for symptomatic relief"},{"condition":"Vasomotor rhinitis","description":"Can reduce nasal congestion and rhinorrhea in non-allergic rhinitis.","evidence":"Limited"}]

Off-label uses: [{"condition":"Motion sickness","description":"Chlorpheniramine maleate may help prevent motion sickness due to its antihistamine effects.","evidence":"Limited"},{"condition":"Insomnia due to allergic symptoms","description":"The sedating effect of chlorpheniramine may help sleep in patients with allergic symptoms, but this is not a primary indication.","evidence":"Limited"}]

Primary treatment for: Common cold and allergic rhinitis

Also treats: Sinusitis, Vasomotor rhinitis

📋 Drug Information

Generic Name(s)Phenylpropanolamine + Chlorpheniramine Maleate
Brand NameAxn Syrup
ManufacturerHippo Labs Pvt Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassRESPIRATORY
Action ClassSympathomimetic + Antihistamine
Route of AdministrationOral
StorageStore at room temperature between 15°C and 30°C. Protect from light and moisture. Keep the bottle tightly closed. Do not freeze.
Shelf LifeNot established from the available information. Refer to the product packaging for the expiry date.
WHO GuidelineNot established from the available information.
ICMR GuidelineNot established from the available information.

👨‍⚕️ Doctor's Practical Tips

Evidence-based practical advice from experienced clinicians

1
Take this medicine exactly as prescribed and do not exceed the recommended dose or duration.
2
Avoid driving or operating heavy machinery until you know how this medicine affects your alertness.
3
Do not use this medicine for more than 7 days without consulting a doctor.
4
Inform your doctor about all other medications you are taking, especially MAO inhibitors, antidepressants, and blood pressure medicines.
5
Avoid alcohol and other sedating drugs while taking this medicine.
6
If you have high blood pressure, heart disease, diabetes, thyroid problems, glaucoma, or prostate enlargement, consult your doctor before use.
7
Keep this medicine out of reach of children and store it properly.

🔍 Is This Medicine Right for Your Symptom?

Educational reference. Always consult a doctor for diagnosis.

✅
Nasal congestion
This medicine is commonly used for this symptom.
Likely Use
✅
Sneezing and runny nose
This medicine helps relieve these allergic symptoms.
Likely Use
❌
Fever
This medicine is not a primary fever reducer.
Not Primary
❌
Chest pain
This medicine is not for chest pain and may worsen certain heart conditions.
Not Primary

🔬 How This Medicine Works (Pharmacology)

Pharmacokinetics

AbsorptionPhenylpropanolamine is absorbed from the gastrointestinal tract. Chlorpheniramine maleate is also absorbed from the gastrointestinal tract. Specific bioavailability data for this combination syrup are not established from the available information.
DistributionBoth components are distributed widely in body tissues. Phenylpropanolamine crosses the blood-brain barrier to a limited extent. Chlorpheniramine is highly lipophilic and enters the central nervous system, which explains its sedative effects. Protein binding data for this combination are not established from the available information.
Protein BindingNot established from the available information.
MetabolismPhenylpropanolamine undergoes limited metabolism, primarily by monoamine oxidase. Chlorpheniramine is metabolized in the liver by cytochrome P450 enzymes, including CYP2D6, to inactive metabolites.
Half-LifeThe elimination half-life of phenylpropanolamine is approximately 3 to 6 hours. The elimination half-life of chlorpheniramine is approximately 12 to 43 hours, with considerable interindividual variation.
ExcretionPhenylpropanolamine is excreted largely unchanged in the urine. Chlorpheniramine and its metabolites are excreted primarily in the urine.
BioavailabilityNot established from the available information.
Onset of ActionOnset of decongestant effect is typically within 30 to 60 minutes after oral administration. Antihistamine effects may begin within 1 hour.
Peak Plasma TimePeak plasma concentrations for phenylpropanolamine are reached in about 1 to 2 hours. For chlorpheniramine, peak levels occur in about 2 to 6 hours.
Duration of ActionThe decongestant effect of phenylpropanolamine lasts about 4 to 6 hours. The antihistamine effect of chlorpheniramine lasts about 4 to 6 hours, but sedation may persist longer.

How It Works

This medicine combines two active ingredients with complementary actions. Phenylpropanolamine is a sympathomimetic amine that directly and indirectly stimulates alpha-adrenergic receptors, causing vasoconstriction of nasal mucosal blood vessels and reducing congestion. Chlorpheniramine maleate is a first-generation antihistamine that competitively blocks histamine H1 receptors, reducing sneezing, itching, and rhinorrhea. Additionally, chlorpheniramine has anticholinergic properties that contribute to drying of secretions.

Mechanism Steps

1
Alpha-adrenergic stimulation: Phenylpropanolamine stimulates alpha-adrenergic receptors on nasal blood vessels, causing vasoconstriction and reduced swelling.
2
Histamine H1 receptor blockade: Chlorpheniramine maleate competitively blocks histamine at H1 receptors, preventing sneezing, itching, and increased vascular permeability.
3
Anticholinergic effect: Chlorpheniramine also blocks muscarinic receptors, reducing nasal secretions and causing dryness.
4
Central nervous system depression: Chlorpheniramine crosses the blood-brain barrier and causes drowsiness by blocking histamine in the central nervous system.

💡 How to Take breath dx syrup

Strength: Not established from the available information.

1Shake the bottle well before each use.
2Use a calibrated measuring cup or spoon to measure the dose accurately.
3Take the medicine orally, with or without food.
4If stomach upset occurs, take with food or milk.
5Do not exceed the recommended dose or frequency.
6After taking, avoid driving or operating machinery until you know how it affects you.

Dosage Information

Adult DosageThe usual adult dose of this medicine is 5 to 10 mL orally every 4 to 6 hours as needed for symptoms, not to exceed 6 doses in 24 hours. However, the exact dose must be individualized by a qualified clinician based on the indication, age, weight, renal and hepatic function, and other medications being taken. Do not self-medicate beyond the recommended duration.
Pediatric DosagePediatric dosing is not established from available information. Consult a pediatrician.
Elderly DosageElderly patients are more sensitive to the sedative and anticholinergic effects of chlorpheniramine and the cardiovascular effects of phenylpropanolamine. Use with caution and lower doses may be appropriate. Dose must be individualized by a qualified clinician.
Renal ImpairmentDose adjustment may be required in patients with renal impairment. Consult a clinician for individualized dosing.
Hepatic ImpairmentDose adjustment may be required in patients with hepatic impairment. Consult a clinician for individualized dosing.
Maximum Daily DoseThe maximum daily dose is not established from the available information. Do not exceed the dose recommended by your doctor.

Dosage Timeline

🌅 Morning ❌ ☀️ Afternoon ❌ 🌆 Evening ❌ 🌙 Night ❌

🍽️ Food Timing Guide

With food
Take with meals if stomach upset occurs
Reduces gastrointestinal discomfort.
Alcohol
Avoid
Increases drowsiness and impairs coordination.
Caffeine
Limit
May increase nervousness and insomnia.

⏰ What to Do If You Miss a Dose

📌 Less than half the dosing interval has passed
→ Take the missed dose as soon as you remember.
💡 Continue with the regular schedule.
📌 More than half the dosing interval has passed
→ Skip the missed dose.
💡 Do not double dose to catch up.

⚠️ Side Effects of breath dx syrup

✅ Common Side Effects

Drowsiness (Common (up to 20%))
Avoid driving or operating machinery. If persistent or bothersome, consult your doctor.
Dry mouth (Common (10-15%))
Sip water, chew sugar-free gum, or use saliva substitutes. Consult doctor if severe.
Dizziness (Common (5-10%))
Rise slowly from sitting or lying positions. Avoid alcohol. Consult doctor if persistent.
Blurred vision (Uncommon (1-5%))
Avoid driving until vision clears. Consult doctor if persistent.
Nausea or stomach upset (Uncommon (1-5%))
Take with food or milk. Consult doctor if severe or persistent.

🚨 Serious Side Effects

Severe hypertensive crisis (Rare (<0.1%))
Seek immediate medical attention if you experience severe headache, chest pain, or shortness of breath.
Cardiac arrhythmias (Rare (<0.1%))
Go to the emergency room if you notice palpitations, fainting, or irregular heartbeat.
Hallucinations or psychosis (Rare (<0.1%))
Discontinue and seek immediate medical help if you experience confusion, hallucinations, or unusual behavior.
Seizures (Rare (<0.1%))
Call emergency services if a seizure occurs.
Severe allergic reaction (anaphylaxis) (Rare (<0.1%))
Seek emergency care immediately for swelling of face, lips, throat, or difficulty breathing.

⚠️ Rare Side Effects

Blood dyscrasias (e.g., agranulocytosis, thrombocytopenia)
Report unusual bruising, bleeding, or signs of infection to your doctor promptly.
Hepatotoxicity
Seek medical attention if you notice yellowing of skin or eyes, dark urine, or right upper abdominal pain.
Urinary retention
Consult your doctor if you have difficulty passing urine.

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

Drug Severity Effect
MAOIs Major
Other sympathomimetics Major
Tricyclic antidepressants Major
Alcohol Moderate
CNS depressants Moderate
Anticholinergics Moderate
Beta-blockers Moderate
Caffeine Minor
Antacids Minor

🚨 Major Interactions

  • Monoamine oxidase inhibitors (MAOIs)
  • Other sympathomimetics (e.g., pseudoephedrine, phenylephrine)
  • Tricyclic antidepressants

⚡ Moderate Interactions

  • Alcohol and CNS depressants (e.g., benzodiazepines, opioids)
  • Anticholinergic drugs (e.g., atropine, oxybutynin)
  • Beta-blockers

🍷 Alcohol Interaction

Alcohol should be avoided while taking this medicine because it can increase drowsiness, dizziness, and impairment of judgment and motor skills. It may also enhance the central nervous system depressant effects of chlorpheniramine.

🔎 Check Your Other Medicines

Educational tool. Always confirm with your doctor or pharmacist.

🛡️ Safety & Warnings

🚫 Contraindications

["Hypersensitivity to phenylpropanolamine, chlorpheniramine, or any component of the formulation","Uncontrolled hypertension","Severe coronary artery disease","Hyperthyroidism","Narrow-angle glaucoma","Urinary retention or prostatic hypertrophy","Use within 14 days of MAO inhibitor therapy","Newborns and premature infants"]

⚠️ Warnings & Precautions

["May cause drowsiness; avoid driving or operating machinery until effects are known.","Use with caution in patients with cardiovascular disease, hypertension, diabetes, or thyroid disorders.","Do not exceed recommended dose or duration of use.","Avoid alcohol and other CNS depressants.","Consult a doctor before use in pregnancy, breastfeeding, or in children under 12 years.","May cause anticholinergic effects such as dry mouth, constipation, and blurred vision.","Do not use for persistent or chronic symptoms without medical evaluation."]

🤱 Lactation Safety

Not established from the available information. Both phenylpropanolamine and chlorpheniramine may pass into breast milk. Consult a doctor before use during breastfeeding.

💊 Overdose Management

Overdose may cause severe hypertension, tachycardia, arrhythmias, hallucinations, seizures, and respiratory depression. Treatment is supportive and symptomatic. There is no specific antidote. Gastric lavage may be considered if ingestion is recent. Monitor vital signs and provide symptomatic care. Seek immediate medical attention.

⏰ Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.

Additional Safety Advice

General Safety

Take this medicine exactly as directed by your doctor. Do not exceed the recommended dose or duration of use. Avoid alcohol and other central nervous system depressants because they can increase drowsiness. Do not drive or operate heavy machinery until you know how this medicine affects you. Inform your doctor if you have high blood pressure, heart disease, diabetes, thyroid problems, glaucoma, or prostate enlargement. Do not use this medicine for longer than 7 days without medical advice. Keep out of reach of children. If you are pregnant, planning pregnancy, or breastfeeding, consult your doctor before use.

👴 Special Considerations for Elderly

💡 For Patients Above 65

Elderly patients are more susceptible to the sedative, anticholinergic, and cardiovascular effects of this medicine. Use with caution, and lower doses may be appropriate. Monitor blood pressure and mental status closely.

🤰 Pregnancy Planning (TTC)

Consult your doctor before using this medicine if you are pregnant, planning to become pregnant, or breastfeeding. The safety of this combination during pregnancy is not well established.

🏥 Post-Surgery Considerations

This medicine may interact with anesthetics and other medications used during surgery. Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be stopped before surgery as advised by your doctor.

🦷 Dental Procedures

This medicine can cause dry mouth, which may increase the risk of dental caries and oral discomfort. Inform your dentist that you are taking this medicine, especially if you are undergoing dental procedures.

💚 Lifestyle Tips for Better Results

🏃
Stay well hydrated to help thin nasal secretions.
🥗
Use a humidifier or steam inhalation to ease nasal congestion.
😴
Get plenty of rest to support your immune system.
💧
Avoid known allergens such as dust, pollen, and pet dander.
🧘
Wash your hands frequently to prevent the spread of cold viruses.
🌞
Avoid smoking and exposure to secondhand smoke.

🏋️ Exercise Considerations

This medicine can cause drowsiness and dizziness, which may impair your ability to exercise safely. Avoid strenuous exercise or activities requiring balance until you know how the medicine affects you.

🥗 Diet Recommendations

Drink warm fluids like soups and herbal teas to soothe your throat and loosen mucus.
Include vitamin C-rich fruits and vegetables to support immune health.
Avoid alcohol and caffeine, which can worsen dehydration and increase side effects.
Eat light, easily digestible meals if you have a reduced appetite.

💼 Impact on Daily Work & Life

This medicine can cause drowsiness and impair concentration, which may affect your ability to work, drive, or operate machinery. It is best to avoid these activities until you know how the medicine affects you. Consider taking it at bedtime if your symptoms allow.

🛑 When to Stop This Medicine

Stop taking this medicine and consult your doctor if your symptoms do not improve within 7 days, if they worsen, or if you experience any serious side effects such as severe headache, chest pain, palpitations, or difficulty urinating.

📅 Long-Term Use Effects

Long-term use of this medicine is not recommended. Prolonged use of decongestants like phenylpropanolamine can lead to rebound congestion, and antihistamines like chlorpheniramine may cause tolerance to sedative effects. Regular monitoring of blood pressure and heart rate is advised if used for extended periods under medical supervision.

🌿 Non-Medicine Approaches

These can complement medicine but do not replace prescribed treatment.

Saline nasal irrigation

Using saline sprays or rinses can help relieve nasal congestion without medication.

Evidence: Well-established
Steam inhalation

Inhaling steam from a hot shower or bowl of hot water can temporarily ease nasal stuffiness.

Evidence: Limited
Antihistamine nasal sprays

Prescription nasal antihistamines may be an alternative for allergic rhinitis.

Evidence: Well-established

💉 Vaccination Considerations

💉 If You're Getting Vaccinated

Not established from the available information. This medicine does not interact with vaccines, but if you are acutely ill with a fever, consult your doctor about timing of vaccination.

📦 Storage Guide

✅ DO

Store at room temperature (15-30°C)

❌ DON'T

Do not refrigerate unless specified

✅ DO

Keep in original container

❌ DON'T

Do not transfer to unmarked containers

✅ DO

Keep away from direct sunlight

❌ DON'T

Do not store in bathroom cabinet

✅ DO

Keep out of reach of children

❌ DON'T

Do not use after expiry date

✈️ Traveling with This Medicine

When traveling, carry this medicine in its original packaging with the prescription label intact. Bring a copy of your prescription or a letter from your doctor, especially for international travel. Store it at room temperature and protect it from extreme heat or cold. If crossing time zones, adjust dosing intervals as advised by your doctor. Check local customs regulations regarding carrying medications.

💰 Cost Analysis & Savings

👥 Real Patient Stories

Educational, anonymized scenarios. Individual results may vary.

👤 A 35-year-old woman with seasonal allergies
She was prescribed this medicine for sneezing and runny nose. She took it as directed and found relief within an hour. However, she experienced drowsiness and was advised not to drive. She learned to take it at bedtime to manage symptoms without daytime sedation.
💡 Lesson: This medicine can cause significant drowsiness; timing the dose at bedtime can help manage symptoms while minimizing daytime impairment.
👤 A 50-year-old man with high blood pressure and a cold
He took this medicine without consulting his doctor and experienced a severe headache and a spike in blood pressure. He was advised to avoid decongestants like phenylpropanolamine and use alternative treatments.
💡 Lesson: Patients with high blood pressure should avoid this medicine unless specifically approved by their doctor, as it can raise blood pressure.

💬 Questions Patients Often Ask

Q: How long does it take to work?

A: This medicine usually starts relieving nasal congestion within 30 to 60 minutes after taking a dose.

Q: How long does the effect last?

A: The effects typically last about 4 to 6 hours, so it may need to be taken every 4 to 6 hours as directed.

Q: Can I take this medicine if I have high blood pressure?

A: You should avoid this medicine if you have uncontrolled high blood pressure unless your doctor specifically approves it, as it can raise blood pressure.

Q: Is this medicine safe for children?

A: Pediatric dosing is not established from available information. Consult a pediatrician before giving this medicine to a child.

Q: What should I do if I miss a dose?

A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.

🤔 Common Patient Concerns

💭 These are the concerns patients most commonly raise

  • Can I take this medicine long-term?
  • Will it affect my blood pressure?
  • Can I drive after taking this medicine?
  • Does it interact with my blood pressure medicine?
  • What if I miss a dose?
  • Can I drink alcohol while taking this?
  • Is it safe for my child?
  • Can I take it during pregnancy?

🔄 Substitutes for breath dx syrup

View All

Alternative brands with exact same active ingredient:

Medical Note: Always consult your doctor before switching medications.

🛑 Myths vs. Facts

  • Myth: This medicine can cure the common cold.
    Fact: This medicine only relieves symptoms; it does not cure the underlying viral infection.
  • Myth: It is safe to take this medicine for weeks.
    Fact: It should only be used for short-term relief, typically not more than 7 days, unless directed by a doctor.
  • Myth: This medicine is safe for everyone.
    Fact: It is not safe for people with certain conditions like uncontrolled hypertension, heart disease, or glaucoma.

📊 Comparison with Similar Medicines

[{"medicine":"This medicine","active_ingredients":"Phenylpropanolamine + Chlorpheniramine maleate","primary_use":"Nasal congestion and allergic symptoms","sedation":"Moderate to high","hypertension_risk":"Moderate"},{"medicine":"Chlorpheniramine alone","active_ingredients":"Chlorpheniramine maleate","primary_use":"Allergic symptoms","sedation":"High","hypertension_risk":"Low"},{"medicine":"Phenylephrine + chlorpheniramine","active_ingredients":"Phenylephrine + Chlorpheniramine maleate","primary_use":"Nasal congestion and allergic symptoms","sedation":"Moderate to high","hypertension_risk":"Low to moderate"}]

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