Angizaar-H Tablet: Complete Guide to Uses, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of face, lips, throat, or tongue
- Difficulty breathing or swallowing
- Severe dizziness or fainting
- Decreased urine output or swelling in legs
- Irregular heartbeat or palpitations
- Severe abdominal pain
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is bpcure-h tablet used for?
This medicine is a combination of Losartan and Hydrochlorothiazide used to treat high blood pressure. It works by relaxing blood vessels and removing excess fluid from the body.
- Generic Name: Losartan + Hydrochlorothiazide
- Manufacturer: HBC Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bpcure-h tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें लोसार्टन और हाइड्रोक्लोरोथियाजाइड दो सक्रिय तत्व होते हैं जो रक्त वाहिकाओं को आराम देकर और शरीर से अतिरिक्त नमक और पानी निकालकर रक्तचाप को कम करते हैं। यह दवा उन रोगियों के लिए है जिनका रक्तचाप अकेले एक दवा से नियंत्रित नहीं होता। यह स्ट्रोक, दिल के दौरे और गुर्दे की समस्याओं का खतरा कम करने में मदद करती है।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, सिरदर्द, थकान, और कम रक्तचाप शामिल हैं। कुछ रोगियों को पेशाब में वृद्धि, प्यास, या इलेक्ट्रोलाइट असंतुलन (जैसे पोटेशियम या सोडियम की कमी) हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं लेकिन इनमें एलर्जी प्रतिक्रिया (चेहरे, होंठ, गले में सूजन), गुर्दे की समस्या, और गंभीर इलेक्ट्रोलाइट असंतुलन शामिल हैं। यदि आपको लगातार चक्कर आना, मांसपेशियों में कमजोरी, या अनियमित दिल की धड़कन महसूस हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। बिना सलाह के दवा बंद या मात्रा न बदलें। नियमित रूप से अपना रक्तचाप जांचें और रिकॉर्ड रखें। पर्याप्त पानी पिएं, खासकर गर्म मौसम या व्यायाम के दौरान। शराब से बचें क्योंकि इससे रक्तचाप और कम हो सकता है। यदि आपको गुर्दे या लीवर की बीमारी, मधुमेह, या गाउट है तो डॉक्टर को बताएं। पोटेशियम सप्लीमेंट या नमक के विकल्प बिना डॉक्टर की सलाह के न लें। यदि आप गर्भवती हैं तो यह दवा तुरंत बंद करें और डॉक्टर से मिलें।
💊 bpcure-h tablet Uses & Benefits
- [{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure in adults when monotherapy is insufficient.
- It reduces both systolic and diastolic blood pressure.","evidence":"Well-established"},{"condition":"Hypertensive patients with left ventricular hypertrophy","description":"Losartan component may help reduce cardiovascular risk and regression of left ventricular hypertrophy.","evidence":"Established"},{"condition":"Diabetic nephropathy","description":"Losartan is known to slow the progression of kidney disease in patients with type 2 diabetes and hypertension.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Heart failure with reduced ejection fraction","description":"Sometimes used off-label as part of heart failure management when ACE inhibitors are not tolerated.","evidence":"Limited"},{"condition":"Post-myocardial infarction","description":"May be used off-label to reduce cardiovascular events after a heart attack.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Diabetic nephropathy, Left ventricular hypertrophy, Heart failure (off-label)
📋 Drug Information
| Generic Name(s) | Losartan + Hydrochlorothiazide |
| Brand Name | Angizaar-H Tablet |
| Manufacturer | HBC Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin II Receptor Blocker + Thiazide Diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Losartan selectively blocks the angiotensin II type 1 (AT1) receptor, preventing angiotensin II from causing vasoconstriction and aldosterone release, which lowers blood pressure and reduces sodium retention. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, thereby reducing plasma volume and cardiac output initially, and later reducing peripheral vascular resistance.
Mechanism Steps
💡 How to Take bpcure-h tablet
Strength: Tablet containing Losartan 50 mg and Hydrochlorothiazide 12.5 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet (Losartan 50 mg + Hydrochlorothiazide 12.5 mg) taken orally once daily, with or without food. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood pressure response. Some patients may require a higher dose (Losartan 100 mg + Hydrochlorothiazide 25 mg) as prescribed by the doctor. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the blood pressure-lowering effects. Start with a lower dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with mild to moderate renal impairment, no dose adjustment is usually needed. In severe renal impairment (creatinine clearance <30 mL/min), this medicine is contraindicated. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with mild to moderate hepatic impairment, no dose adjustment is usually needed. In severe hepatic impairment, this medicine is contraindicated. Dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum recommended daily dose is Losartan 100 mg + Hydrochlorothiazide 25 mg once daily. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bpcure-h tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Potassium supplements | Major | |
| Lithium | Major | |
| NSAIDs | Major | |
| Corticosteroids | Moderate | |
| Oral hypoglycemics | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Digoxin | Minor |
🚨 Major Interactions
- Potassium supplements or potassium-sparing diuretics
- Lithium
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
⚡ Moderate Interactions
- Corticosteroids
- Oral hypoglycemics
- Cholestyramine
🍷 Alcohol Interaction
Alcohol may potentiate the blood pressure-lowering effects of this medicine, leading to dizziness, fainting, or orthostatic hypotension. It is advisable to avoid or limit alcohol consumption while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Pregnancy (second and third trimesters)","Anuria","Hypersensitivity to losartan, hydrochlorothiazide, or sulfonamide-derived drugs","Severe renal impairment (creatinine clearance
⚠️ Warnings & Precautions
["May cause symptomatic hypotension, especially in volume-depleted patients.","Monitor renal function and electrolytes periodically.","Avoid in patients with a history of angioedema related to ARBs.","May exacerbate gout or hyperuricemia.","Can cause photosensitivity; advise sun protection.","May impair glucose tolerance; monitor diabetic patients.","Not recommended during breastfeeding."]
🤱 Lactation Safety
Not established from the available information. Hydrochlorothiazide is excreted in breast milk and may suppress lactation. Losartan is not recommended during breastfeeding. Consult your doctor before breastfeeding.
💊 Overdose Management
Overdose may cause severe hypotension, electrolyte imbalances, and dehydration. Treatment is supportive and symptomatic. If overdose is suspected, contact emergency services immediately. Induce vomiting if recent ingestion and patient is conscious. Monitor vital signs and electrolytes closely.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop or change the dose without medical advice. Monitor your blood pressure regularly and keep a record. Stay adequately hydrated, especially during hot weather or exercise. Avoid alcohol as it may intensify blood pressure-lowering effects. Inform your doctor if you have kidney or liver disease, diabetes, or gout. Do not use potassium supplements or salt substitutes containing potassium without consulting your doctor. If you become pregnant, stop this medicine immediately and contact your doctor.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the blood pressure-lowering effects and electrolyte imbalances. Start with a lower dose and monitor closely. Regular monitoring of kidney function and electrolytes is recommended.
🤰 Pregnancy Planning (TTC)
This medicine is contraindicated during pregnancy. If you are planning pregnancy, consult your doctor to switch to a safer alternative before conception. Use effective contraception while taking this medicine.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may need to be temporarily stopped before surgery to avoid hypotension during the procedure. Follow your doctor's instructions.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or increase bleeding risk during dental procedures. Your dentist may take precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities initially as they may cause dizziness due to lowered blood pressure. Stay hydrated during exercise. If you experience dizziness, shortness of breath, or chest pain, stop and consult your doctor.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when you first start taking it. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal work routine after adjusting to the medication.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects like angioedema, severe hypotension, or kidney problems, seek immediate medical advice. Your doctor may adjust the dose or switch to another medicine.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of kidney function, electrolytes, and blood pressure. It can effectively control hypertension and reduce cardiovascular risk. However, prolonged use may lead to electrolyte imbalances, increased uric acid levels, and reduced glucose tolerance. Periodic blood tests are recommended to detect any abnormalities early.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help lower blood pressure and complement medicine.
Evidence: Well-establishedACE inhibitors, calcium channel blockers, or beta-blockers may be alternatives if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, consult your doctor before receiving any live vaccines while on this medicine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, consult your doctor about adjusting the timing. Carry enough supply for the entire trip plus extra in case of delays. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within 1-2 hours, but full effect may take 2-4 weeks of regular use.
A: It is usually taken in the morning to avoid nighttime urination. However, your doctor may advise based on your condition.
A: If you remember within 12 hours, take it. Otherwise, skip the missed dose and continue with your regular schedule. Do not double dose.
A: No, this medicine is contraindicated during pregnancy as it can harm the fetus. Consult your doctor immediately if you become pregnant.
🤔 Common Patient Concerns
🔄 Substitutes for bpcure-h tablet
View AllAlternative brands with exact same active ingredient:
-
hyplo-h 50mg/12.5mg tabletBonsai Pharma ₹18.75 66.6% CHEAPER
-
losapil h tabletPsychotropics India Ltd ₹18.75 66.6% CHEAPER
-
lospot h tabletInd Swift Laboratories Ltd ₹20.00 64.4% CHEAPER
-
loratus hz 50mg/12.5mg tabletTusker Pharma Pvt Ltd ₹22.31 60.3% CHEAPER
-
losalife h tabletTorrent Pharmaceuticals Ltd ₹28.57 49.1% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure high blood pressure permanently.
Fact: This medicine controls blood pressure but does not cure hypertension. Lifestyle changes and continued medication are often needed. - Myth: You can stop taking this medicine once your blood pressure is normal.
Fact: Stopping suddenly can cause a rebound increase in blood pressure. Always consult your doctor before stopping. - Myth: This medicine is safe to take during pregnancy.
Fact: This medicine is contraindicated during pregnancy as it can harm the fetus.
🔄 Alternative Options
Generic Alternatives
- Losartan + Hydrochlorothiazide generic tablets
Brand Alternatives
- Angizaar-H Tablet