Bpcure-H Tablet - Uses, Price, Side Effects, and More
What is bpcure-h tablet used for?
Bpcure-H Tablet is a combination of Losartan (50mg) and Hydrochlorothiazide (12.5mg) used to treat high blood pressure. Losartan relaxes blood vessels by blocking angiotensin II, while Hydrochlorothiazide removes excess fluid and salt, lowering blood pressure. It is taken once daily in the morning.
- Generic Name: Losartan + Hydrochlorothiazide
- Manufacturer: HBC Lifesciences Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ bpcure-h tablet Uses & Benefits
Hypertension (first-line), especially in patients with left ventricular hypertrophy.
Off-label uses: Diabetic nephropathy, Heart failure (with caution)
๐ Drug Information
| Generic Name(s) | Losartan + Hydrochlorothiazide |
| Brand Name | Angizaar-H Tablet |
| Manufacturer | HBC Lifesciences Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Angiotensin II Receptor Blocker + Thiazide Diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Losartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldosterone secretion; hydrochlorothiazide inhibits sodium reabsorption in distal tubule, reducing plasma volume.
Mechanism Steps
๐ก How to Take bpcure-h tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of bpcure-h tablet
โ Common Side Effects
- Dizziness
- Headache
- Fatigue
- Cough
- Hyperglycemia
- Hypokalemia
- Hyperuricemia
๐จ Serious Side Effects
- Angioedema
- Renal failure
- Hepatotoxicity
- Severe hypotension
- Electrolyte imbalance
โ ๏ธ Rare Side Effects
- Pancreatitis
- Blood dyscrasias
- Anaphylaxis
- Photosensitivity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Lithium | Major | Increased lithium toxicity risk |
| ACE inhibitors | Major | Increased risk of hypotension and renal impairment |
| Aliskiren | Major | Increased risk of renal impairment, hypotension, and hyperkalemia |
| Potassium-sparing diuretics | Major | Increased risk of hyperkalemia |
| NSAIDs | Major | Reduced antihypertensive effect and increased renal risk |
| Alcohol | Moderate | Increased orthostatic hypotension |
| Barbiturates | Moderate | Increased orthostatic hypotension |
| Corticosteroids | Moderate | Increased hypokalemia risk |
| Insulin | Moderate | Altered glucose control |
| Oral hypoglycemics | Moderate | Altered glucose control |
| Cholestyramine | Minor | Reduced absorption of hydrochlorothiazide |
| Colestipol | Minor | Reduced absorption of hydrochlorothiazide |
| Dofetilide | Minor | Increased risk of torsades de pointes |
๐จ Major Interactions
- Lithium
- ACE inhibitors
- Aliskiren
- Potassium-sparing diuretics
- NSAIDs
โก Moderate Interactions
- Alcohol
- Barbiturates
- Corticosteroids
- Insulin
- Oral hypoglycemics
โน๏ธ Minor Interactions
- Cholestyramine
- Colestipol
- Dofetilide
๐ฝ๏ธ Food Interactions
Avoid potassium-rich foods; high salt intake may reduce efficacy.
๐ท Alcohol Interaction
May potentiate orthostatic hypotension.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Anuria, hypersensitivity to sulfonamides, severe renal impairment (CrCl <30 mL/min), pregnancy (second and third trimesters).
๐ Monitoring Parameters
Blood pressure, serum potassium, renal function, blood glucose, uric acid.
๐คฑ Lactation Safety
Avoid; hydrochlorothiazide may suppress lactation.
๐ Overdose Management
Symptomatic and supportive; monitor electrolytes, blood pressure, and renal function. Induce emesis or gastric lavage if recent.
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.