bonumrab-sl capsule sr - Uses, Price, Side Effects & Substitutes
What is bonumrab-sl capsule sr used for?
Acera-L Capsule SR (Levosulpiride + Rabeprazole) is used to treat GASTRO INTESTINAL. It contains Levosulpiride (75mg) + Rabeprazole (20mg), which Levosulpiride: Dopamine D2 receptor antagonist in GI tract, enhancing motility; . Always consult your doctor before use. Take as prescribed.
- Generic Name: Levosulpiride + Rabeprazole
- Manufacturer: Bonum Medelae Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ bonumrab-sl capsule sr Uses & Benefits
Gastroesophageal reflux disease (GERD); dyspepsia; gastroparesis; irritable bowel syndrome with constipation
Off-label uses: Diabetic gastroparesis; functional dyspepsia; cyclic vomiting syndrome
๐ Drug Information
| Generic Name(s) | Levosulpiride + Rabeprazole |
| Brand Name | Acera-L Capsule SR |
| Manufacturer | Bonum Medelae Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral (sustained release capsule) |
| Storage | Store at room temperature (20-25ยฐC); protect from moisture and light |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Levosulpiride: Dopamine D2 receptor antagonist in GI tract, enhancing motility; Rabeprazole: Irreversible inhibition of H+/K+ ATPase in gastric parietal cells, reducing acid secretion
Mechanism Steps
๐ก How to Take bonumrab-sl capsule sr
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of bonumrab-sl capsule sr
โ Common Side Effects
- Headache
- Diarrhea
- Nausea
- Abdominal pain
- Dizziness
- Constipation
๐จ Serious Side Effects
- QT prolongation
- Tardive dyskinesia
- Neuroleptic malignant syndrome
- Clostridium difficile infection
- Fractures (long-term)
โ ๏ธ Rare Side Effects
- Gynecomastia
- Galactorrhea
- Interstitial nephritis
- Lupus erythematosus
- Hepatotoxicity
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased bleeding risk |
| Clopidogrel | Major | Reduced antiplatelet effect |
| Methotrexate | Major | Increased methotrexate toxicity |
| Cilostazol | Major | Increased cilostazol levels |
| Atazanavir | Major | Reduced atazanavir absorption |
| Diazepam | Moderate | Increased diazepam levels |
| Phenytoin | Moderate | Increased phenytoin levels |
| Digoxin | Moderate | Increased digoxin levels |
| Ketoconazole | Moderate | Reduced ketoconazole absorption |
| Iron salts | Moderate | Reduced iron absorption |
| Sucralfate | Minor | Reduced absorption of levosulpiride |
| Antacids | Minor | Reduced absorption of rabeprazole |
| Vitamin B12 | Minor | Reduced B12 absorption with long-term use |
๐จ Major Interactions
- Warfarin
- Clopidogrel
- Methotrexate
- Cilostazol
- Atazanavir
โก Moderate Interactions
- Diazepam
- Phenytoin
- Digoxin
- Ketoconazole
- Iron salts
โน๏ธ Minor Interactions
- Sucralfate
- Antacids
- Vitamin B12
๐ฝ๏ธ Food Interactions
Food may delay absorption of both components; avoid high-fat meals
๐ท Alcohol Interaction
Avoid alcohol; may increase risk of GI side effects
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to components; GI hemorrhage; mechanical obstruction; perforation; pheochromocytoma; concomitant use with neuroleptics
๐ Monitoring Parameters
Liver function tests; renal function; ECG (QT interval); serum electrolytes; magnesium levels
๐คฑ Lactation Safety
Excreted in breast milk; use with caution
๐ Overdose Management
Supportive care; activated charcoal; monitor ECG for QT prolongation
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose