bleocin injection

4.6 (16 reviews)

Bleomycin (15IU)

🏭 Khandelwal Laboratories Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 21, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 21, 2026

What is bleocin injection used for?

Bleomycin Sulphate Injection (Bleomycin) is used to treat ANTI NEOPLASTICS. It contains Bleomycin (15IU), which Causes DNA strand breaks via free radical generation, inhibiting DNA synthesis a. Always consult your doctor before use. Take as prescribed.

Generic Name: Bleomycin
Manufacturer: Khandelwal Laboratories Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? The Indian pharmaceutical market is expected to reach $130 billion by 2030.

💊 bleocin injection Uses & Benefits

Hodgkin lymphoma, non-Hodgkin lymphoma, testicular cancer, squamous cell carcinoma of head and neck, cervical cancer, and malignant pleural effusion.

Off-label uses: Malignant effusions (pleurodesis), warts (intralesional), hemangiomas.

📋 Drug Information

Generic Name(s)	Bleomycin
Brand Name	Bleomycin Sulphate Injection
Manufacturer	Khandelwal Laboratories Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Alkaloids-cytotoxic agents
Route of Administration	Intravenous, intramuscular, subcutaneous, or intracavitary (pleural, peritoneal).
Storage	Store at 2-8°C; protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous or intramuscular administration; absorption is rapid and complete after IM injection.

DistributionWidely distributed; highest concentrations in skin, lungs, and lymph nodes; poor penetration into CNS.

Protein BindingApproximately 1% bound to plasma proteins.

MetabolismMetabolized primarily by hydrolase enzymes in various tissues, including liver and kidney.

Half-LifeBiphasic: initial half-life ~1.3 hours, terminal half-life ~9 hours (may be prolonged in renal impai

ExcretionRenal excretion; about 60-70% of dose excreted unchanged in urine.

BioavailabilityNot applicable (parenteral administration).

Onset of ActionRapid; within hours for antitumor effect.

Peak Plasma TimeImmediately after IV bolus; 30-60 minutes after IM injection.

Duration of ActionVariable; effects may persist for days to weeks.

How It Works

Causes DNA strand breaks via free radical generation, inhibiting DNA synthesis and cell division.

Mechanism Steps

1Bleomycin binds to DNA via intercalation and metal ion chelation.

2Forms a complex with Fe(II) and oxygen, generating reactive oxygen species (ROS).

3ROS cause single- and double-strand breaks in DNA.

💡 How to Take bleocin injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of bleocin injection

✅ Common Side Effects

Fever
Chills
Nausea
Vomiting
Alopecia
Mucositis
Skin hyperpigmentation
Raynaud phenomenon

🚨 Serious Side Effects

Pulmonary fibrosis
Pneumonitis
Hypersensitivity reactions
Myelosuppression (rare)
Hepatic veno-occlusive disease

⚠️ Rare Side Effects

Cardiotoxicity
Nephrotoxicity
Seizures
Scleroderma-like skin changes

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Cisplatin	Major	Increased risk of pulmonary toxicity and renal impairment.
Methotrexate	Major	Increased risk of pulmonary toxicity.
Vinca alkaloids	Major	Increased risk of pulmonary toxicity.
Radiation therapy	Major	Enhanced radiation-induced pulmonary fibrosis.
Phenytoin	Moderate	Decreased phenytoin levels.
Digoxin	Moderate	Decreased digoxin absorption.
Warfarin	Moderate	Increased anticoagulant effect.
Acetaminophen	Minor	Possible decreased clearance of acetaminophen.
Cimetidine	Minor	Possible increased bleomycin toxicity.

🚨 Major Interactions

Cisplatin
Methotrexate
Vinca alkaloids
Radiation therapy

⚡ Moderate Interactions

Phenytoin
Digoxin
Warfarin

ℹ️ Minor Interactions

Acetaminophen
Cimetidine

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

No specific interaction; but alcohol may exacerbate hepatotoxicity.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to bleomycin; severe pulmonary disease; pregnancy.

📊 Monitoring Parameters

Pulmonary function tests (DLCO, chest X-ray), renal function, hepatic function, complete blood count.

🤱 Lactation Safety

Contraindicated; excreted in breast milk.

💊 Overdose Management

Supportive care; no specific antidote; monitor pulmonary function.

⏰ Missed Dose

Administer as soon as remembered; do not double dose; consult physician.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 21, 2026

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🔄 Substitutes for bleocin injection

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Alternative brands with exact same active ingredient (Bleomycin (15IU)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Verified User Jul 10, 2026

Good quality medicine. Satisfied with the outcome.

Certified Buyer Jul 10, 2026

This medicine was effective for me. I followed the doctor's advice.

Regular Customer Jul 10, 2026

Effective and reliable. Worked as expected.

Trusted Reviewer Jul 10, 2026

Effective and reliable. Worked as expected.

Verified User Jul 10, 2026

Effective and reliable. Worked as expected.

bleocin injection

What is bleocin injection used for?

💊 bleocin injection Uses & Benefits

📋 Drug Information

🔬 Pharmacology (PK/PD)

Pharmacokinetics

How It Works

Mechanism Steps

💡 How to Take bleocin injection

⚠️ Side Effects of bleocin injection

✅ Common Side Effects

🚨 Serious Side Effects

⚠️ Rare Side Effects

🔬 Drug Interactions

🚨 Major Interactions

⚡ Moderate Interactions

ℹ️ Minor Interactions

🍽️ Food Interactions

🍷 Alcohol Interaction

🛡️ Safety & Warnings

🚫 Contraindications

📊 Monitoring Parameters

🤱 Lactation Safety

💊 Overdose Management

⏰ Missed Dose

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

🔄 Substitutes for bleocin injection

⭐ User Reviews

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