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bivacs 250mg injection

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Bivalirudin (250mg)

🏭 Intas Pharmaceuticals Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jul 5, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Jul 05, 2026

What is bivacs 250mg injection used for?

Bivastat 250mg Injection (Bivalirudin) is used to treat CARDIAC. It contains Bivalirudin (250mg), which Direct thrombin inhibitor that binds reversibly to both free and clot-bound thro. Always consult your doctor before use. Take as prescribed.

Generic Name: Bivalirudin
Manufacturer: Intas Pharmaceuticals Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 bivacs 250mg injection Uses & Benefits

Anticoagulation in patients undergoing percutaneous coronary intervention (PCI), including those with heparin-induced thrombocytopenia (HIT) or at risk for HIT.

Off-label uses: Anticoagulation for cardiac surgery, treatment of deep vein thrombosis (DVT), pulmonary embolism (PE).

📋 Drug Information

Generic Name(s)	Bivalirudin
Brand Name	Bivastat 250mg Injection
Manufacturer	Intas Pharmaceuticals Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Direct thrombin inhibitor- parenteral
Route of Administration	Intravenous (IV) bolus and infusion.
Storage	Store at 20-25°C (68-77°F); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in immediate and complete bioavailability.

DistributionDistributes primarily in extracellular fluid; volume of distribution approximately 0.2 L/kg.

Protein BindingApproximately 90% bound to plasma proteins.

MetabolismMetabolized by proteolytic cleavage and hepatic metabolism.

Half-LifeApproximately 25 minutes in patients with normal renal function.

ExcretionRenal excretion (approximately 20% unchanged) and proteolytic degradation.

Bioavailability100% (intravenous administration).

Onset of ActionImmediate.

Peak Plasma TimeImmediately after bolus injection.

Duration of ActionApproximately 1 hour after discontinuation.

How It Works

Direct thrombin inhibitor that binds reversibly to both free and clot-bound thrombin.

Mechanism Steps

1Bivalirudin binds directly to the active site of thrombin (Factor IIa).

2Inhibits thrombin-mediated conversion of fibrinogen to fibrin.

3Prevents activation of Factors V, VIII, and XIII.

💡 How to Take bivacs 250mg injection

Follow your doctor's prescription exactly.

⚠️ Side Effects of bivacs 250mg injection

✅ Common Side Effects

Bleeding
Back pain
Nausea
Headache
Hypotension

🚨 Serious Side Effects

Major hemorrhage
Intracranial bleeding
Anaphylaxis
Thrombosis (if inadequate anticoagulation)

⚠️ Rare Side Effects

Allergic reactions
Thrombocytopenia
Renal impairment

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Heparin	Major	Increased bleeding risk
Aspirin	Major	Increased bleeding risk
Clopidogrel	Major	Increased bleeding risk
NSAIDs	Major	Increased bleeding risk
SSRIs	Moderate	Increased bleeding risk
Ginkgo biloba	Moderate	Increased bleeding risk

🚨 Major Interactions

Warfarin
Heparin
Enoxaparin
Fondaparinux
Rivaroxaban
Apixaban
Dabigatran
Edoxaban
Aspirin
Clopidogrel
Prasugrel
Ticagrelor
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Thrombolytics
Glycoprotein IIb/IIIa inhibitors

⚡ Moderate Interactions

Selective serotonin reuptake inhibitors (SSRIs)
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Corticosteroids
Antiplatelet herbs (e.g., ginkgo, garlic)

ℹ️ Minor Interactions

Antacids
H2 receptor antagonists
Proton pump inhibitors

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase bleeding risk; avoid excessive alcohol consumption.

🛡️ Safety & Warnings

🚫 Contraindications

Active bleeding, hypersensitivity to bivalirudin, history of heparin-induced thrombocytopenia (HIT) with bivalirudin use, severe uncontrolled hypertension.

📊 Monitoring Parameters

Activated clotting time (ACT), activated partial thromboplastin time (aPTT), prothrombin time (PT), signs of bleeding, renal function.

🤱 Lactation Safety

Unknown if excreted in breast milk; caution advised.

💊 Overdose Management

Discontinue infusion; monitor for bleeding; supportive care; no specific antidote; hemodialysis may remove bivalirudin.

⏰ Missed Dose

Not applicable (continuous IV infusion).

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Jul 05, 2026

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🔄 Substitutes for bivacs 250mg injection

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Alternative brands with exact same active ingredient (Bivalirudin (250mg)):

Medical Note: Always consult your doctor before switching medications.

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📌 Quick Facts

Storage	Store at 20-25°C (68-77°F); protect from light.
Route	Intravenous (IV) bolus and infusion.
Pregnancy	Category A
Breastfeeding	Unknown if excreted in breast milk; caution advised.
Alcohol	May increase bleeding risk; avoid excessive alcohol consumption.
Onset of Action	Immediate.
Half-Life	Approximately 25 minutes in patients with normal renal function.
Prescription	✅ Required

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