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bivamax 250mg injection - Bivalirudin (250mg) medicine

Bivamax 250mg Injection - Uses, Price, Side Effects

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Bivalirudin (250mg)

🏭 Lupin Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Jul 5, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Jul 05, 2026

What is bivamax 250mg injection used for?

Bivamax 250mg Injection contains Bivalirudin, a direct thrombin inhibitor used as an anticoagulant to prevent blood clots during percutaneous coronary intervention (PCI) and other cardiac procedures. It works by blocking thrombin, a key enzyme in blood clotting, reducing the risk of heart attack or stroke. It is often used as an alternative to heparin.

Generic Name: Bivalirudin
Manufacturer: Lupin Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

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💊 bivamax 250mg injection Uses & Benefits

Anticoagulation in patients undergoing percutaneous coronary intervention (PCI), including those with heparin-induced thrombocytopenia (HIT) or at risk for HIT.

Off-label uses: Anticoagulation for cardiac surgery, treatment of deep vein thrombosis (DVT), pulmonary embolism (PE).

📋 Drug Information

Generic Name(s)	Bivalirudin
Brand Name	Bivastat 250mg Injection
Manufacturer	Lupin Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	CARDIAC
Action Class	Direct thrombin inhibitor- parenteral
Route of Administration	Intravenous (IV) bolus and infusion.
Storage	Store at 20-25°C (68-77°F); protect from light.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionIntravenous administration results in immediate and complete bioavailability.

DistributionDistributes primarily in extracellular fluid; volume of distribution approximately 0.2 L/kg.

Protein BindingApproximately 90% bound to plasma proteins.

MetabolismMetabolized by proteolytic cleavage and hepatic metabolism.

Half-LifeApproximately 25 minutes in patients with normal renal function.

ExcretionRenal excretion (approximately 20% unchanged) and proteolytic degradation.

Bioavailability100% (intravenous administration).

Onset of ActionImmediate.

Peak Plasma TimeImmediately after bolus injection.

Duration of ActionApproximately 1 hour after discontinuation.

How It Works

Direct thrombin inhibitor that binds reversibly to both free and clot-bound thrombin.

Mechanism Steps

1Bivalirudin binds directly to the active site of thrombin (Factor IIa).

2Inhibits thrombin-mediated conversion of fibrinogen to fibrin.

3Prevents activation of Factors V, VIII, and XIII.

💡 How to Take bivamax 250mg injection

Follow your doctor's prescription exactly.

Dosage Timeline

🌅 Morning ✅ ☀️ Afternoon ❌ 🌆 Evening ✅ 🌙 Night ❌

⚠️ Side Effects of bivamax 250mg injection

✅ Common Side Effects

Bleeding
Back pain
Nausea
Headache
Hypotension

🚨 Serious Side Effects

Major hemorrhage
Intracranial bleeding
Anaphylaxis
Thrombosis (if inadequate anticoagulation)

⚠️ Rare Side Effects

Allergic reactions
Thrombocytopenia
Renal impairment

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Warfarin	Major	Increased bleeding risk
Heparin	Major	Increased bleeding risk
Aspirin	Moderate	Increased bleeding risk
Clopidogrel	Moderate	Increased bleeding risk
NSAIDs	Moderate	Increased bleeding risk

🚨 Major Interactions

Warfarin
Heparin
Enoxaparin
Fondaparinux
Rivaroxaban
Apixaban
Dabigatran
Edoxaban
Aspirin
Clopidogrel
Prasugrel
Ticagrelor
Nonsteroidal anti-inflammatory drugs (NSAIDs)
Thrombolytics
Glycoprotein IIb/IIIa inhibitors

⚡ Moderate Interactions

Selective serotonin reuptake inhibitors (SSRIs)
Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Corticosteroids
Antiplatelet herbs (e.g., ginkgo, garlic)

ℹ️ Minor Interactions

Antacids
H2 receptor antagonists
Proton pump inhibitors

🍽️ Food Interactions

No significant food interactions.

🍷 Alcohol Interaction

May increase bleeding risk; avoid excessive alcohol consumption.

🛡️ Safety & Warnings

Liver

Low

Kidney

Moderate

Heart

Low

Pregnancy

Category A

🚫 Contraindications

Active bleeding, hypersensitivity to bivalirudin, history of heparin-induced thrombocytopenia (HIT) with bivalirudin use, severe uncontrolled hypertension.

📊 Monitoring Parameters

Activated clotting time (ACT), activated partial thromboplastin time (aPTT), prothrombin time (PT), signs of bleeding, renal function.

🤱 Lactation Safety

Unknown if excreted in breast milk; caution advised.

💊 Overdose Management

Discontinue infusion; monitor for bleeding; supportive care; no specific antidote; hemodialysis may remove bivalirudin.

⏰ Missed Dose

Not applicable (continuous IV infusion).

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Jul 05, 2026

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🔄 Substitutes for bivamax 250mg injection

View All

Alternative brands with exact same active ingredient (Bivalirudin (250mg)):

Medical Note: Always consult your doctor before switching medications.

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📌 Quick Facts

Storage	Store at 20-25°C (68-77°F); protect from light.
Route	Intravenous (IV) bolus and infusion.
Pregnancy	Category A
Breastfeeding	Unknown if excreted in breast milk; caution advised.
Alcohol	May increase bleeding risk; avoid excessive alcohol consumption.
Onset of Action	Immediate.
Half-Life	Approximately 25 minutes in patients with normal renal function.
Prescription	✅ Required

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