Bisobis H 2.5mg/6.25mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Difficulty breathing or wheezing
- Irregular or very slow heartbeat
- Severe allergic reaction (rash, swelling, difficulty breathing)
- Muscle cramps or weakness
- Decreased urine output
- Yellowing of skin or eyes
If experiencing severe symptoms, call emergency services immediately.
What is bisocar ht 2.5 mg/6.25 mg tablet used for?
This medicine is a combination of bisoprolol and hydrochlorothiazide used to treat high blood pressure. It works by slowing the heart rate and removing excess fluid from the body.
- Generic Name: Bisoprolol + Hydrochlorothiazide
- Manufacturer: Rusan Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 bisocar ht 2.5 mg/6.25 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें बिसोप्रोलोल और हाइड्रोक्लोरोथियाजाइड दो सक्रिय तत्व हैं। बिसोप्रोलोल दिल की धड़कन को धीमा करता है और रक्तचाप को कम करता है, जबकि हाइड्रोक्लोरोथियाजाइड शरीर से अतिरिक्त नमक और पानी को बाहर निकालता है। यह दवा उन रोगियों के लिए है जिनका रक्तचाप एक दवा से नियंत्रित नहीं होता। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: आम दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द और बार-बार पेशाब आना शामिल हैं। कुछ लोगों को कम रक्तचाप, धीमी हृदय गति या हल्की मतली हो सकती है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन यदि सांस लेने में कठिनाई, त्वचा पर चकत्ते, या बेहोशी हो तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। अचानक बंद न करें, क्योंकि इससे हृदय की समस्या बढ़ सकती है। शराब से बचें क्योंकि इससे चक्कर और कम रक्तचाप हो सकता है। उठते समय धीरे-धीरे उठें। पर्याप्त पानी पिएं जब तक डॉक्टर ने तरल पदार्थ प्रतिबंधित न किया हो। नियमित रूप से रक्तचाप, हृदय गति और गुर्दे की जांच कराएं।
💊 bisocar ht 2.5 mg/6.25 mg tablet Uses & Benefits
[{"condition":"Hypertension","description":"Used to lower high blood pressure when a single agent is insufficient, reducing the risk of stroke, heart attack, and kidney damage.","evidence":"Well-established"},{"condition":"Heart failure with reduced ejection fraction","description":"Bisoprolol component may be used as part of heart failure therapy, but the combination with hydrochlorothiazide is not typically first-line for this indication.","evidence":"Limited for combination"}]
Off-label uses: [{"condition":"Angina prophylaxis","description":"Bisoprolol alone may be used to prevent angina, but the combination with hydrochlorothiazide is not standard for this purpose.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Heart failure, Angina
📋 Drug Information
| Generic Name(s) | Bisoprolol + Hydrochlorothiazide |
| Brand Name | Bisobis H |
| Manufacturer | Rusan Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Beta-blocker + Thiazide diuretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients with complementary blood pressure-lowering actions. Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and cardiac output. It also decreases renin release from the kidneys. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, which reduces blood volume and peripheral resistance.
Mechanism Steps
💡 How to Take bisocar ht 2.5 mg/6.25 mg tablet
Strength: Bisoprolol 2.5 mg + Hydrochlorothiazide 6.25 mg immediate-release tablet.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine. Start with a lower dose and monitor closely for dizziness, falls, and electrolyte imbalances. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Hydrochlorothiazide may not be effective when creatinine clearance is below 30 mL/min. Dose adjustment may be required. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Bisoprolol is metabolized in the liver; dose reduction may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet (bisoprolol 2.5 mg + hydrochlorothiazide 6.25 mg) once daily, but your doctor may prescribe a different strength or frequency based on your condition. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of bisocar ht 2.5 mg/6.25 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Clonidine | Major | |
| Digoxin | Major | |
| Lithium | Major | |
| NSAIDs | Moderate | |
| Corticosteroids | Moderate | |
| Antidiabetics | Moderate | |
| Antacids | Minor | |
| Cholestyramine | Minor |
🚨 Major Interactions
- Calcium channel blockers (verapamil, diltiazem)
- Clonidine
- Digoxin
- Lithium
⚡ Moderate Interactions
- NSAIDs (ibuprofen, naproxen)
- Corticosteroids
- Antidiabetic drugs
🍷 Alcohol Interaction
Alcohol may increase the blood pressure-lowering effect of this medicine, leading to dizziness, fainting, or falls. It is best to avoid alcohol or limit intake while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe asthma or COPD","Anuria","Allergy to bisoprolol, hydrochlorothiazide, or sulfonamides"]
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly; taper gradually under medical supervision.","Use with caution in patients with asthma or COPD; may cause bronchospasm.","May mask symptoms of hypoglycemia in diabetic patients.","Can cause electrolyte imbalances; monitor potassium levels.","May increase blood glucose and uric acid levels.","Avoid in pregnancy unless clearly needed; consult doctor.","Use with caution in elderly patients; increased risk of falls.","May cause photosensitivity; use sunscreen."]
🤱 Lactation Safety
Bisoprolol and hydrochlorothiazide are excreted in breast milk. Hydrochlorothiazide may reduce milk production. Consult your doctor before breastfeeding while taking this medicine.
💊 Overdose Management
Overdose may cause severe bradycardia, hypotension, electrolyte imbalance, and heart failure. Seek immediate medical attention. Treatment is supportive and symptomatic, including gastric lavage, activated charcoal, and monitoring of vital signs. Hemodialysis may be considered for hydrochlorothiazide removal.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed. Do not stop suddenly without consulting your doctor, as abrupt withdrawal of bisoprolol can worsen heart conditions. Avoid alcohol as it may increase dizziness and low blood pressure. Stand up slowly to prevent falls if you feel dizzy. Drink enough water unless your doctor has restricted fluids. Have your blood pressure, heart rate, and kidney function checked regularly. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Do not use potassium supplements or salt substitutes without medical advice.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a lower dose and monitor closely. Regular check-ups for kidney function and electrolytes are recommended.
🤰 Pregnancy Planning (TTC)
Consult your doctor before planning pregnancy. This medicine is not recommended during pregnancy unless clearly needed. Your doctor may switch you to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. It may interact with anesthesia and affect heart rate and blood pressure during surgery. Your doctor may advise temporary discontinuation.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, as it may cause dry mouth or interact with certain dental anesthetics. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activities initially as this medicine may cause dizziness or fatigue. Stay hydrated and avoid exercising in extreme heat. Consult your doctor before starting any new exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or tiredness, especially when you start treatment. Avoid driving or operating heavy machinery until you know how it affects you. Most people can continue their normal activities with dose adjustment.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. If you experience severe side effects, your doctor may adjust the dose or switch to another medicine. Abrupt withdrawal can worsen heart conditions.
📅 Long-Term Use Effects
Long-term use of this medicine may require regular monitoring of blood pressure, heart rate, kidney function, and electrolyte levels. It can increase blood glucose and uric acid levels, so diabetic and gout patients need monitoring. Do not stop suddenly; taper under medical supervision.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, and stress reduction can help lower blood pressure and complement medicine.
Evidence: Well-establishedACE inhibitors, ARBs, or calcium channel blockers may be alternatives if this combination is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your doctor about this medicine before receiving any vaccine, especially if you have allergies.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid loss. Store at room temperature and protect from extreme heat or moisture. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Carry enough supply for the entire trip plus extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts lowering blood pressure within a few hours, but the full effect may take 1-2 weeks. Continue taking it regularly as prescribed.
A: No, do not stop without consulting your doctor. High blood pressure often requires long-term treatment, and stopping suddenly can cause rebound hypertension.
A: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose.
🤔 Common Patient Concerns
🔄 Substitutes for bisocar ht 2.5 mg/6.25 mg tablet
View AllAlternative brands with exact same active ingredient:
-
biselect ld 2.5 mg/6.25 mg tabletIntas Pharmaceuticals Ltd ₹18.75 14.4% CHEAPER
-
bisopil h 2.5 tabletPsychotropics India Ltd ₹28.13 28.4% COSTLIER
-
qualiz 2.5 mg/6.25 mg tabletMedreich Lifecare Ltd ₹37.50 71.2% COSTLIER
-
bisolol h 2.5 mg/6.25 mg tabletAventure Pharma ₹38.44 75.5% COSTLIER
-
besoloc h 2.5mg/6.25mg tabletEast West Pharma ₹42.53 94.2% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often requires long-term treatment. Stopping suddenly can cause rebound hypertension or heart problems. - Myth: This medicine can be taken without a prescription.
Fact: This is a prescription medicine. It should only be taken under a doctor's supervision.
🔄 Alternative Options
Generic Alternatives
- Bisoprolol 2.5 mg + Hydrochlorothiazide 6.25 mg tablet
Brand Alternatives
- Bisobis H 2.5mg/6.25mg Tablet