bisopil h 2.5 tablet - Bisoprolol (2.5mg) + Hydrochlorothiazide (6.25mg) medicine

Bisopil H 2.5 Tablet - Uses, Price, Side Effects

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๐Ÿญ Psychotropics India Ltd ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 29, 2026
๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 29, 2026

What is bisopil h 2.5 tablet used for?

Bisopil H 2.5 Tablet is a combination of Bisoprolol (a beta-blocker) and Hydrochlorothiazide (a diuretic) used to treat hypertension. Bisoprolol reduces heart rate and cardiac output, while Hydrochlorothiazide decreases fluid volume, together lowering blood pressure effectively.

  • Generic Name: Bisoprolol + Hydrochlorothiazide
  • Manufacturer: Psychotropics India Ltd
  • Form: Allopathy
  • Pregnancy Category: A
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? Over 80% of the antiretroviral drugs used globally to combat AIDS are supplied by Indian pharmaceutical companies.

๐Ÿ’Š bisopil h 2.5 tablet Uses & Benefits

Hypertension

Off-label uses: Heart failure (Bisoprolol alone), edema (Hydrochlorothiazide alone)

๐Ÿ“‹ Drug Information

Generic Name(s)Bisoprolol + Hydrochlorothiazide
Brand NameBisobis H
ManufacturerPsychotropics India Ltd
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassCARDIAC
Action ClassBeta-blocker + Thiazide diuretic
Route of AdministrationOral
StorageStore at 20-25ยฐC, protect from light and moisture
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionBisoprolol: well absorbed orally; Hydrochlorothiazide: 65-75% absorbed
DistributionBisoprolol: Vd ~3.5 L/kg; Hydrochlorothiazide: crosses placenta, enters breast milk
Protein BindingBisoprolol: ~30%; Hydrochlorothiazide: ~40-68%
MetabolismBisoprolol: hepatic via CYP2D6; Hydrochlorothiazide: minimal hepatic
Half-LifeBisoprolol: 10-12 hours; Hydrochlorothiazide: 6-15 hours
ExcretionBisoprolol: 50% renal unchanged, rest as metabolites; Hydrochlorothiazide: >95% renal
BioavailabilityBisoprolol: ~90%; Hydrochlorothiazide: ~65-75%
Onset of ActionBisoprolol: 1-2 hours; Hydrochlorothiazide: 2 hours
Peak Plasma TimeBisoprolol: 2-4 hours; Hydrochlorothiazide: 4 hours
Duration of ActionBisoprolol: 24 hours; Hydrochlorothiazide: 6-12 hours

How It Works

Bisoprolol: selective beta1-blocker reducing heart rate and contractility; Hydrochlorothiazide: inhibits Na+/Cl- reabsorption in distal tubule, reducing plasma volume

Mechanism Steps

1Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing sympathetic tone, decreasing heart rate and contractility, leading to reduced cardiac output and blood pressure.
2Hydrochlorothiazide inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, increasing excretion of sodium, chloride, and water, reducing plasma volume and blood pressure.
3Combination results in additive antihypertensive effect with lower doses of each component.

๐Ÿ’ก How to Take bisopil h 2.5 tablet

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โŒ ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of bisopil h 2.5 tablet

โœ… Common Side Effects

  • Dizziness
  • Fatigue
  • Headache
  • Hypokalemia
  • Hyperuricemia
  • Increased blood glucose
  • Orthostatic hypotension

๐Ÿšจ Serious Side Effects

  • Bradycardia
  • Heart block
  • Bronchospasm
  • Severe hypotension
  • Electrolyte imbalance
  • Acute renal failure

โš ๏ธ Rare Side Effects

  • Thrombocytopenia
  • Pancreatitis
  • Photosensitivity
  • Systemic lupus erythematosus
  • Stevens-Johnson syndrome

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Lithium Moderate Increased lithium toxicity risk
NSAIDs Moderate Reduced antihypertensive effect
Digoxin Moderate Increased risk of bradycardia

๐Ÿšจ Major Interactions

  • Other antihypertensives
  • Digitalis glycosides
  • Lithium
  • NSAIDs
  • Corticosteroids
  • MAOIs

โšก Moderate Interactions

  • Antidiabetic agents
  • Calcium channel blockers
  • Clonidine
  • Reserpine
  • Cholestyramine
  • Colestipol

โ„น๏ธ Minor Interactions

  • Alcohol
  • Barbiturates
  • Opioids

๐Ÿฝ๏ธ Food Interactions

Food may increase absorption of Hydrochlorothiazide; avoid high-sodium foods

๐Ÿท Alcohol Interaction

May potentiate orthostatic hypotension

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Moderate
Heart
Low
Pregnancy
Category A

๐Ÿšซ Contraindications

Sinus bradycardia, heart block, cardiogenic shock, severe asthma, anuria, hypersensitivity to sulfonamides

๐Ÿ“Š Monitoring Parameters

Blood pressure, heart rate, serum electrolytes (K+, Na+), renal function, blood glucose, uric acid

๐Ÿคฑ Lactation Safety

Contraindicated; both drugs excreted in breast milk

๐Ÿ’Š Overdose Management

Gastric lavage, activated charcoal, symptomatic treatment; for bradycardia: atropine; for hypotension: IV fluids, vasopressors

โฐ Missed Dose

Take as soon as remembered unless near next dose; do not double dose

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 29, 2026

๐Ÿ”— View Profile

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