Bisolol H 2.5 mg/6.25 mg Tablet: Comprehensive Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe dizziness or fainting
- Heart rate below 50 beats per minute
- Difficulty breathing or wheezing
- Swelling of face, lips, tongue, or throat
- Chest pain or palpitations
- Severe abdominal pain or vomiting
- Decreased urine output or swelling in legs
- Unusual bleeding or bruising
If experiencing severe symptoms, call emergency services immediately.
What is besoloc h 2.5mg/6.25mg tablet used for?
This medicine is a combination of Bisoprolol (a beta-blocker) and Hydrochlorothiazide (a diuretic) used to treat high blood pressure. It works by slowing the heart rate and removing excess fluid from the body, thereby lowering blood pressure.
- Generic Name: Bisoprolol (2.5mg) + Hydrochlorothiazide (6.25mg)
- Manufacturer: East West Pharma
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 besoloc h 2.5mg/6.25mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा उच्च रक्तचाप (हाइपरटेंशन) के इलाज के लिए इस्तेमाल की जाती है। इसमें बिसोप्रोलोल और हाइड्रोक्लोरोथियाजाइड दो सक्रिय तत्व होते हैं। बिसोप्रोलोल दिल की धड़कन को धीमा करता है और रक्त वाहिकाओं को आराम देता है, जिससे रक्तचाप कम होता है। हाइड्रोक्लोरोथियाजाइड शरीर से अतिरिक्त नमक और पानी को बाहर निकालता है, जिससे रक्त की मात्रा कम होती है और रक्तचाप नियंत्रित रहता है। यह दवा अक्सर तब दी जाती है जब एक दवा से रक्तचाप नियंत्रित नहीं होता। यह दवा एनजाइना (सीने में दर्द) और दिल की विफलता में भी मदद कर सकती है। इसे डॉक्टर के निर्देशानुसार ही लें।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में चक्कर आना, थकान, सिरदर्द, और कम रक्तचाप शामिल हैं। कुछ लोगों को हाथ-पैर ठंडे लग सकते हैं, जी मिचलाना, या बार-बार पेशाब आना हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन इनमें धड़कन का बहुत धीमा होना, सांस लेने में कठिनाई, गंभीर इलेक्ट्रोलाइट असंतुलन, और एलर्जी प्रतिक्रियाएं शामिल हो सकती हैं। यदि आपको कोई असामान्य लक्षण दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे अचानक बंद न करें, क्योंकि इससे दिल की समस्या बढ़ सकती है। शराब का सेवन न करें क्योंकि इससे चक्कर आ सकते हैं और रक्तचाप बहुत कम हो सकता है। उठते समय धीरे-धीरे उठें। पर्याप्त पानी पिएं। अपने रक्तचाप, हृदय गति, और इलेक्ट्रोलाइट स्तर की नियमित जांच कराएं। यदि आप गर्भवती हैं या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। बिना डॉक्टर की सलाह के कोई अन्य दवा न लें।
💊 besoloc h 2.5mg/6.25mg tablet Uses & Benefits
- [{"condition":"Hypertension","description":"This medicine is used to lower high blood pressure when monotherapy is insufficient.
- It reduces cardiovascular risk and helps prevent stroke, heart attack, and kidney damage.","evidence":"Well-established"},{"condition":"Angina pectoris","description":"Bisoprolol component helps reduce the frequency and severity of angina attacks by decreasing heart rate and oxygen demand.","evidence":"Well-established"},{"condition":"Heart failure","description":"Bisoprolol is used in stable chronic heart failure to improve survival and reduce hospitalizations, but the combination with hydrochlorothiazide is not typically used for this indication.","evidence":"Well-established for bisoprolol alone"}]
Off-label uses: [{"condition":"Atrial fibrillation rate control","description":"Bisoprolol may be used off-label to control heart rate in atrial fibrillation, but the combination with hydrochlorothiazide is not standard for this purpose.","evidence":"Limited"},{"condition":"Migraine prophylaxis","description":"Beta-blockers like bisoprolol are sometimes used off-label to prevent migraines, but this combination is not typically recommended.","evidence":"Limited"}]
Primary treatment for: Hypertension
Also treats: Angina pectoris, Heart failure (stable chronic)
📋 Drug Information
| Generic Name(s) | Bisoprolol (2.5mg) + Hydrochlorothiazide (6.25mg) |
| Brand Name | besoloc h 2.5mg/6.25mg tablet |
| Manufacturer | East West Pharma |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | |
| Route of Administration | Oral |
| Storage | Store at room temperature between 15°C and 30°C (59°F to 86°F). Protect from light and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two antihypertensive agents with complementary mechanisms. Bisoprolol selectively blocks beta-1 adrenergic receptors in the heart, reducing heart rate, contractility, and cardiac output. It also suppresses renin release from the kidneys, leading to decreased angiotensin II and aldosterone production. Hydrochlorothiazide inhibits the sodium-chloride symporter in the distal convoluted tubule of the nephron, increasing excretion of sodium, chloride, and water. This reduces plasma volume and, over time, lowers peripheral vascular resistance. The combined effect results in a more pronounced reduction in blood pressure than either agent alone.
Mechanism Steps
💡 How to Take besoloc h 2.5mg/6.25mg tablet
Strength: Tablet containing Bisoprolol 2.5 mg and Hydrochlorothiazide 6.25 mg.
Dosage Information
| Adult Dosage | The usual adult dose is one tablet of Bisoprolol 2.5 mg and Hydrochlorothiazide 6.25 mg taken orally once daily, preferably in the morning. The dose may be adjusted by your doctor based on your blood pressure response and tolerance. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not exceed the prescribed dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may be more sensitive to the effects of this medicine, especially dizziness and electrolyte imbalances. Start with a low dose and monitor closely. Dose must be individualized by a qualified clinician. |
| Renal Impairment | Use with caution in patients with renal impairment. Hydrochlorothiazide may accumulate and cause electrolyte disturbances. Dose adjustment may be required based on creatinine clearance. Consult your doctor. |
| Hepatic Impairment | Use with caution in patients with hepatic impairment. Bisoprolol metabolism may be affected. Dose adjustment may be necessary. Consult your doctor. |
| Maximum Daily Dose | The maximum recommended daily dose is one tablet of Bisoprolol 2.5 mg and Hydrochlorothiazide 6.25 mg. Do not exceed without medical advice. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of besoloc h 2.5mg/6.25mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Verapamil | Major | |
| Clonidine | Major | |
| Lithium | Major | |
| NSAIDs | Moderate | |
| Digoxin | Moderate | |
| Corticosteroids | Moderate | |
| Antidiabetics | Moderate | |
| Cholestyramine | Moderate | |
| Antacids | Minor | |
| Cimetidine | Minor |
🚨 Major Interactions
- Calcium channel blockers (verapamil, diltiazem)
- Clonidine
- Monoamine oxidase inhibitors (MAOIs)
- Lithium
- Nonsteroidal anti-inflammatory drugs (NSAIDs)
⚡ Moderate Interactions
- Digoxin
- Corticosteroids
- Antidiabetic drugs
- Cholestyramine
🍷 Alcohol Interaction
Alcohol may enhance the blood pressure-lowering effects of this medicine, leading to dizziness, lightheadedness, and fainting. It is advisable to avoid alcohol or limit intake while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Severe bradycardia","Second or third-degree heart block","Cardiogenic shock","Decompensated heart failure","Severe asthma or COPD","Anuria","Severe renal impairment (eGFR
⚠️ Warnings & Precautions
["Do not stop this medicine abruptly; taper gradually under medical supervision.","May mask symptoms of hypoglycemia in diabetic patients.","May worsen symptoms of peripheral arterial disease.","Can cause electrolyte imbalances; monitor regularly.","May increase blood sugar and uric acid levels.","Use with caution in patients with psoriasis or a history of psoriasis.","Avoid in patients with a history of bronchospasm.","May cause photosensitivity; use sun protection."]
🤱 Lactation Safety
Bisoprolol and hydrochlorothiazide are excreted in breast milk. Breastfeeding is not recommended while taking this medicine. Consult your doctor for alternative options.
💊 Overdose Management
Overdose may cause severe bradycardia, hypotension, heart failure, bronchospasm, and electrolyte disturbances. Treatment is supportive and symptomatic. Gastric lavage may be considered if taken recently. Administer intravenous fluids, atropine for bradycardia, and vasopressors if needed. Monitor electrolytes and renal function. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not stop taking it suddenly, as abrupt withdrawal of bisoprolol can worsen heart conditions. Avoid alcohol while taking this medicine as it can enhance blood pressure-lowering effects and increase dizziness. Stand up slowly from a sitting or lying position to prevent dizziness due to low blood pressure. Stay well hydrated, especially during hot weather or exercise, to prevent dehydration from the diuretic effect. Regularly monitor your blood pressure, heart rate, and electrolyte levels as advised by your doctor. Inform your doctor if you have diabetes, asthma, kidney or liver disease, or if you are pregnant or planning to become pregnant. Do not take potassium supplements without consulting your doctor. Keep all appointments for follow-up and laboratory tests.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more prone to dizziness, electrolyte imbalances, and renal impairment. Start with a low dose and monitor closely. Regular assessment of renal function and electrolytes is advised. Fall risk may be increased due to dizziness.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, consult your doctor before conception. This medicine is generally avoided during pregnancy. Your doctor may switch you to a safer alternative. Use effective contraception while taking this medicine unless otherwise advised.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Beta-blockers may interact with anesthetic agents and affect heart rate and blood pressure during surgery. Do not stop the medicine unless instructed by your doctor.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. It may cause dry mouth or increase the risk of orthostatic hypotension during dental procedures. Local anesthetics with epinephrine should be used with caution due to potential interaction with beta-blockers.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but beta-blockers can reduce your maximum heart rate and cause fatigue. Avoid sudden strenuous activities. Stay hydrated, especially if exercising in hot weather. If you experience dizziness, chest pain, or shortness of breath during exercise, stop and seek medical attention.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue, especially when starting treatment or changing doses. Avoid driving or operating heavy machinery until you know how it affects you. Take caution when standing up quickly. Most people can continue their normal work activities with appropriate precautions.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Abrupt withdrawal can cause rebound hypertension, angina, or heart attack. Your doctor may gradually reduce the dose over 1-2 weeks. If you experience severe side effects, contact your doctor immediately for guidance.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to electrolyte imbalances, increased blood sugar, elevated uric acid levels, and altered lipid profile. Regular monitoring of blood pressure, heart rate, electrolytes, renal function, and blood glucose is essential. Prolonged use of beta-blockers may cause fatigue and reduced exercise tolerance. Hydrochlorothiazide can increase the risk of skin cancer with long-term use; protect your skin from sun exposure. Periodic review with your doctor is necessary to adjust the dose and assess the need for continued therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Diet, exercise, weight loss, and stress reduction can help lower blood pressure and may reduce the need for medication.
Evidence: Well-establishedACE inhibitors, ARBs, calcium channel blockers, or other combinations may be alternatives if this medicine is not suitable.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are established. However, inform your healthcare provider about this medicine before receiving any vaccine. Continue routine vaccinations as recommended.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Keep out of reach of children
❌ DON'T
Do not use after expiry date
✈️ Traveling with This Medicine
When traveling, carry your medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss. Store at room temperature and protect from extreme heat or cold. If crossing time zones, consult your doctor about adjusting the timing of your dose. Carry enough supply for the entire trip. Check local customs regulations for restricted medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The blood pressure-lowering effect may begin within a few hours, but full effect may take 1-2 weeks. It may take several weeks to achieve optimal control.
A: No, you should not stop without consulting your doctor. High blood pressure often has no symptoms, and stopping suddenly can cause a dangerous rebound increase.
A: If you remember within 12 hours, take the missed dose. If more than 12 hours have passed, skip it and continue with your regular schedule. Do not double the dose.
A: You can take this medicine with or without food. However, avoid alcohol and licorice. Maintain a balanced diet and monitor potassium intake.
A: This medicine is generally avoided during pregnancy unless clearly needed. Consult your doctor for alternative options.
🤔 Common Patient Concerns
🔄 Substitutes for besoloc h 2.5mg/6.25mg tablet
View AllAlternative brands with exact same active ingredient:
-
biselect ld 2.5 mg/6.25 mg tabletIntas Pharmaceuticals Ltd ₹18.75 55.9% CHEAPER
-
bisocar ht 2.5 mg/6.25 mg tabletRusan Pharma Ltd ₹21.90 48.5% CHEAPER
-
bisopil h 2.5 tabletPsychotropics India Ltd ₹28.13 33.9% CHEAPER
-
qualiz 2.5 mg/6.25 mg tabletMedreich Lifecare Ltd ₹37.50 11.8% CHEAPER
-
bisolol h 2.5 mg/6.25 mg tabletAventure Pharma ₹38.44 9.6% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be stopped once blood pressure is normal.
Fact: High blood pressure often has no symptoms, and stopping the medicine can cause a dangerous rebound increase. Always consult your doctor before stopping. - Myth: This medicine causes kidney damage in everyone.
Fact: While hydrochlorothiazide can affect kidney function, regular monitoring helps prevent serious issues. Not everyone experiences kidney problems. - Myth: You can eat anything while taking this medicine.
Fact: A healthy diet low in salt and rich in fruits and vegetables is important for blood pressure control. Avoid excessive alcohol and licorice.
🔄 Alternative Options
Generic Alternatives
- Bisoprolol 2.5 mg + Hydrochlorothiazide 6.25 mg tablet
Brand Alternatives
- Bisolol H 2.5 mg/6.25 mg tablet