Addtrex Tablet (Naltrexone 50mg): Complete Medicine Guide
When to Call Your Doctor IMMEDIATELY
- Severe vomiting, diarrhoea, or abdominal cramps after taking this medicine (may indicate opioid withdrawal).
- Yellowing of the skin or eyes, dark urine, or severe abdominal pain (signs of liver injury).
- Thoughts of self-harm or suicide.
- Difficulty breathing, chest pain, or severe dizziness.
- Signs of an allergic reaction such as rash, itching, swelling of face, lips, or throat.
- Unusual bleeding or bruising.
- Confusion or extreme drowsiness.
If experiencing severe symptoms, call emergency services immediately.
What is addtrex tablet used for?
This medicine is an opioid antagonist used to treat opioid and alcohol dependence. It works by blocking the rewarding effects of opioids and alcohol, helping patients stay abstinent. It is taken orally as a 50 mg tablet once daily, but only after the patient has been opioid-free for 7-10 days.
- Generic Name: Naltrexone
- Manufacturer: Rusan Pharma Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 addtrex tablet के बारे में (Hindi Summary)
उपयोग: यह दवा नाल्ट्रेक्सोन हाइड्रोक्लोराइड 50 मिलीग्राम की एक टैबलेट है, जिसका उपयोग ओपिओइड और शराब की लत के इलाज में किया जाता है। यह मस्तिष्क में उन रिसेप्टर्स को ब्लॉक करती है जिन पर ओपिओइड और शराब असर करते हैं, जिससे नशे का आनंद कम हो जाता है और लत छोड़ने में मदद मिलती है। यह दवा अकेले काम नहीं करती; इसके साथ काउंसलिंग और व्यवहार चिकित्सा भी जरूरी है। इसे डॉक्टर की सलाह के बिना शुरू या बंद न करें।
साइड इफेक्ट्स: इस दवा के आम दुष्प्रभावों में मतली, उल्टी, सिरदर्द, चक्कर आना, थकान, अनिद्रा, बेचैनी और पेट दर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और कुछ हफ्तों में ठीक हो जाते हैं। कभी-कभी यकृत (लिवर) को नुकसान, मूड में बदलाव या आत्महत्या के विचार जैसे गंभीर दुष्प्रभाव भी हो सकते हैं। अगर आपको पीलिया, गहरे रंग का पेशाब, या मन में अजीब विचार आएं तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को शुरू करने से पहले अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। ओपिओइड लेना बंद करने के कम से कम 7-10 दिन बाद ही यह दवा शुरू करें, वरना गंभीर विथड्रॉल हो सकता है। इस दवा के साथ शराब न पिएं। गर्भवती महिलाएं या गर्भधारण की योजना बनाने वाली महिलाएं डॉक्टर से सलाह लें। जब तक आपको पता न चले कि यह दवा आप पर कैसा असर करती है, तब तक वाहन न चलाएं। नियमित रूप से लिवर की जांच कराते रहें।
💊 addtrex tablet Uses & Benefits
[{"condition":"Opioid dependence","description":"This medicine is used to help patients who have stopped using opioids to remain abstinent by blocking the euphoric effects of opioids if they relapse.","evidence":"Well-established"},{"condition":"Alcohol dependence","description":"This medicine reduces the rewarding effects of alcohol and helps decrease heavy drinking in patients with alcohol use disorder.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Impulse control disorders","description":"Sometimes prescribed off-label for conditions such as pathological gambling, kleptomania, or compulsive sexual behaviour, based on its ability to modulate reward pathways.","evidence":"Limited"},{"condition":"Weight management","description":"Low-dose naltrexone has been studied off-label for weight loss and metabolic syndrome, but evidence is not robust.","evidence":"Limited"}]
Primary treatment for: Opioid dependence
Also treats: Alcohol dependence
📋 Drug Information
| Generic Name(s) | Naltrexone |
| Brand Name | Addtrex Tablet |
| Manufacturer | Rusan Pharma Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | NEURO CNS |
| Action Class | Opioid Antagonist |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30°C) in a dry place, away from direct sunlight and moisture. Keep in the original container. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by competitively binding to opioid receptors in the brain, particularly the mu-opioid receptors, without activating them. By occupying these receptors, it prevents opioids and alcohol from producing their rewarding and intoxicating effects. This helps reduce cravings and the desire to drink or use opioids. The blockade is reversible and dose-dependent.
Mechanism Steps
💡 How to Take addtrex tablet
Strength: Immediate-release oral tablet, 50 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 50 mg once daily. For opioid dependence, treatment should be initiated only after the patient has been opioid-free for at least 7-10 days. For alcohol dependence, 50 mg once daily is standard. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. Do not self-adjust the dose. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | No specific dose adjustment is recommended for elderly patients, but use with caution due to potential for increased sensitivity to side effects. Individualize by a qualified clinician. |
| Renal Impairment | No dose adjustment is typically needed for mild to moderate renal impairment. Use with caution in severe renal impairment; individualize by a qualified clinician. |
| Hepatic Impairment | Use with caution in mild to moderate hepatic impairment. Contraindicated in acute hepatitis or liver failure. Dose adjustment may be necessary; individualize by a qualified clinician. |
| Maximum Daily Dose | 50 mg per day for standard indications. Higher doses may be used in some settings under medical supervision. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of addtrex tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Opioid analgesics | Major | |
| Thioridazine | Major | |
| Disulfiram | Moderate | |
| Rifampicin | Moderate | |
| Carbamazepine | Moderate | |
| Antacids | Minor |
🚨 Major Interactions
- Opioid analgesics (e.g., morphine, codeine, fentanyl)
- Thioridazine
⚡ Moderate Interactions
- Disulfiram
- CYP450 inducers (e.g., rifampicin, carbamazepine)
🍷 Alcohol Interaction
Avoid alcohol while taking this medicine. Alcohol can increase the risk of liver damage and may reduce the effectiveness of this medicine. Additionally, alcohol may worsen side effects such as dizziness and drowsiness.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Current opioid use or opioid dependence not yet withdrawn","Acute hepatitis or liver failure","Hypersensitivity to naltrexone or any component","Patients receiving opioid analgesics"]
⚠️ Warnings & Precautions
["Do not start until opioid-free for 7-10 days.","May precipitate severe opioid withdrawal.","Risk of liver injury; monitor liver enzymes.","May cause mood changes or suicidal thoughts.","Avoid alcohol.","Use effective contraception during treatment.","Do not drive until you know how it affects you."]
🤱 Lactation Safety
This medicine is excreted in breast milk. Consult your doctor before breastfeeding; alternative feeding options may be recommended.
💊 Overdose Management
Overdose of this medicine alone has not been associated with serious toxicity. However, if someone takes too much, seek immediate medical attention. Treatment is supportive and symptomatic. Naltrexone is an opioid antagonist, so it may block the effects of opioid painkillers used in emergency treatment.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.
Additional Safety Advice
Before starting this medicine, tell your doctor if you have any liver or kidney problems, depression, or a history of suicidal thoughts. You must be completely free of opioids for at least 7 to 10 days before taking the first dose, otherwise you may experience sudden and severe withdrawal. Do not take any opioid painkillers while on this medicine, as they will not work and could be dangerous. Avoid alcohol while taking this medicine, as it can increase the risk of liver damage and reduce the medicine's effectiveness. Use reliable contraception if you are a woman of childbearing age, as this medicine may harm an unborn baby. Do not drive or operate heavy machinery until you know how this medicine affects you, as it can cause dizziness or drowsiness. Keep all appointments with your doctor for regular liver function tests and monitoring. Never share this medicine with anyone else, even if they have the same condition. Store this medicine in a safe place out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more sensitive to the side effects of this medicine, especially dizziness and fatigue. Use with caution and monitor closely. No specific dose adjustment is recommended, but individualization is advised.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting or continuing this medicine. Effective contraception is recommended during treatment. The safety of this medicine in pregnancy is not well established.
🏥 Post-Surgery Considerations
Inform your surgeon and anaesthesiologist that you are taking this medicine, as it may interact with opioid painkillers used during and after surgery. You may need alternative pain management.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine, especially if you need pain relief. Opioid painkillers may not work effectively while you are on this medicine.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine may cause dizziness or fatigue. Avoid strenuous exercise until you know how it affects you. Stay hydrated during exercise.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or drowsiness, which can affect your ability to drive or operate machinery. Avoid these activities until you know how the medicine affects you. It is important to inform your employer if your job involves safety-sensitive tasks.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as liver problems or suicidal thoughts, seek immediate medical attention. Your doctor will decide if and when to stop the medicine based on your progress and overall health.
📅 Long-Term Use Effects
Long-term use of this medicine is generally safe when monitored appropriately. Regular liver function tests are recommended because of the potential for liver injury. Some patients may experience persistent nausea, fatigue, or mood changes. It is important to have periodic reviews with your doctor to assess ongoing need and effectiveness. Do not stop suddenly without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Helps patients develop coping strategies and change thought patterns related to substance use.
Evidence: Well-establishedProvides peer support and accountability.
Evidence: Well-establishedAnother medication for alcohol dependence with a different mechanism.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
No specific vaccine interactions are known. However, patients with substance use disorders may be at higher risk for certain infections; discuss appropriate vaccinations with your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When travelling, carry this medicine in its original packaging along with a copy of your prescription. Keep it in your carry-on luggage to avoid loss or temperature extremes. If crossing time zones, continue taking your dose at the same time each day according to your home schedule, or adjust gradually as advised by your doctor. Store away from direct sunlight and moisture. Check customs regulations for controlled substances before travelling internationally.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: This medicine starts blocking opioid receptors within 1 hour of taking a dose. However, its full benefits in reducing cravings and supporting abstinence may take several weeks to become apparent.
A: Consult your doctor before taking this medicine if you are pregnant or planning to become pregnant. The safety in pregnancy is not well established, and your doctor will weigh the benefits and risks.
A: This medicine blocks the effects of opioids, so you will not feel the euphoria. However, taking high doses of opioids to overcome the blockade can lead to serious overdose and death. Always inform emergency personnel that you are on this medicine.
🤔 Common Patient Concerns
🔄 Substitutes for addtrex tablet
View AllAlternative brands with exact same active ingredient:
-
naltrex 50mg tabletSynmedic Laboratories ₹328.13 50.5% CHEAPER
-
nalcon 50mg tabletConsern Pharma Limited ₹735.94 11% COSTLIER
-
naltreat tabletPsychocare Health Pvt Ltd ₹750.00 13.1% COSTLIER
-
gigadict tabletRyon Pharma ₹787.50 18.8% COSTLIER
-
naltox 50mg tabletDD Pharmaceuticals Pvt. Ltd. ₹884.80 33.5% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine is a substitute for opioids.
Fact: This medicine is not an opioid and does not produce euphoria. It blocks opioid effects and helps in recovery. - Myth: You can start this medicine immediately after stopping opioids.
Fact: You must be opioid-free for 7-10 days to avoid severe withdrawal. - Myth: This medicine cures addiction on its own.
Fact: It is most effective when combined with counselling and behavioural therapy.
🔄 Alternative Options
Generic Alternatives
- Naltrexone hydrochloride 50 mg tablet
Brand Alternatives
- Addtrex Tablet