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biogesic 20mg/2ml injection - Gentamicin (20mg/2ml) medicine

Biogesic 20mg/2ml Injection - Uses, Price, Side Effects

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Gentamicin (20mg/2ml)
๐Ÿญ Biochem Pharmaceutical Industries ๐Ÿ“ฆ Varies by brand ๐Ÿ’Š Allopathy ๐Ÿ“… Updated: Jun 30, 2026
โš ๏ธ Nephrotoxicity Risk ๐Ÿ“‹ Prescription Required ๐Ÿ’Š Generic Available
Medically Reviewed
SaathiMed Expert Panel | Jun 30, 2026

What is biogesic 20mg/2ml injection used for?

Biogesic 20mg/2ml Injection contains Gentamicin, an aminoglycoside antibiotic used to treat serious bacterial infections, especially those caused by Gram-negative bacteria. It works by inhibiting bacterial protein synthesis, leading to bacterial cell death. It is commonly used for infections of the eyes, ears, and other sites. Use only under medical supervision.

  • Generic Name: Gentamicin
  • Manufacturer: Biochem Pharmaceutical Industries
  • Form: Allopathy
  • Pregnancy Category: D
  • Prescription Required: Yes
๐Ÿ’ก Did You Know? India is the largest provider of generic medicines globally, supplying over 50% of global vaccine demand.

๐Ÿ’Š biogesic 20mg/2ml injection Uses & Benefits

Serious infections caused by susceptible Gram-negative bacteria: septicemia, respiratory tract infections, urinary tract infections, intra-abdominal infections, skin and soft tissue infections, bone and joint infections, ophthalmic and otic infections.

Off-label uses: Brucellosis, Tularemia, Plague, Neonatal sepsis (with ampicillin)

๐Ÿ“‹ Drug Information

Generic Name(s)Gentamicin
Brand NameAlpagen 40mg Injection
ManufacturerBiochem Pharmaceutical Industries
Packaging / FormVaries by brand (Allopathy)
Therapeutic ClassOPHTHAL OTOLOGICALS
Action ClassAminoglycosides
Route of AdministrationIntramuscular, intravenous (slow infusion)
StorageStore at 20-25ยฐC; protect from freezing; use within 24 hours after opening.
Shelf LifeAs per manufacturer

๐Ÿ”ฌ Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionGentamicin is poorly absorbed from the gastrointestinal tract; after intramuscular injection, absorption is rapid and complete.
DistributionDistributes primarily into extracellular fluid; crosses the placenta; low protein binding; penetrates poorly into cerebrospinal fluid unless meninges are inflamed.
Protein Binding0-30%
MetabolismMinimal hepatic metabolism; primarily excreted unchanged.
Half-Life2-4 hours (adults); prolonged in renal impairment.
ExcretionPrimarily renal (glomerular filtration) as unchanged drug.
BioavailabilityIntramuscular: nearly 100%
Onset of ActionRapid (within 1 hour after IM injection)
Peak Plasma Time30-90 minutes after IM injection
Duration of ActionApproximately 8-12 hours

How It Works

Binds to the 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis.

Mechanism Steps

1Gentamicin binds to the 30S ribosomal subunit of bacteria.
2This causes misreading of mRNA codons during translation.
3Incorrect amino acids are incorporated into the growing peptide chain.

๐Ÿ’ก How to Take biogesic 20mg/2ml injection

Follow your doctor's prescription exactly.

Dosage Timeline

๐ŸŒ… Morning โœ… โ˜€๏ธ Afternoon โŒ ๐ŸŒ† Evening โœ… ๐ŸŒ™ Night โŒ

โš ๏ธ Side Effects of biogesic 20mg/2ml injection

โœ… Common Side Effects

  • Nephrotoxicity (elevated creatinine, proteinuria)
  • Ototoxicity (vestibular and cochlear)
  • Local injection site reactions

๐Ÿšจ Serious Side Effects

  • Acute renal failure
  • Irreversible hearing loss
  • Neuromuscular blockade (respiratory paralysis)
  • Anaphylaxis

โš ๏ธ Rare Side Effects

  • Pseudomembranous colitis
  • Superinfection
  • Hypomagnesemia
  • Hypocalcemia

Consult your doctor if you experience any unusual symptoms.

๐Ÿ”ฌ Drug Interactions

โš ๏ธ DrugSeverityEffect
Warfarin Moderate Increased risk of bleeding
Furosemide Moderate Increased risk of nephrotoxicity
Cisplatin Major Increased risk of nephrotoxicity and ototoxicity

๐Ÿšจ Major Interactions

  • Neuromuscular blocking agents
  • Other aminoglycosides
  • Potent diuretics (e.g., furosemide)
  • Vancomycin
  • Cisplatin
  • Cyclosporine
  • Amphotericin B

โšก Moderate Interactions

  • Penicillins (may inactivate in vitro)
  • Cephalosporins
  • NSAIDs
  • Indomethacin

โ„น๏ธ Minor Interactions

  • Bisphosphonates
  • Botulinum toxin

๐Ÿท Alcohol Interaction

No known interaction.

๐Ÿ›ก๏ธ Safety & Warnings

Liver
Low
Kidney
Moderate
Heart
Low
Pregnancy
Category D

๐Ÿšซ Contraindications

Hypersensitivity to gentamicin or other aminoglycosides; myasthenia gravis; pre-existing severe renal impairment (unless benefit outweighs risk).

๐Ÿ“Š Monitoring Parameters

Renal function (serum creatinine, BUN), urine output, audiometry (especially with prolonged therapy), serum drug levels (peak and trough).

๐Ÿคฑ Lactation Safety

Caution; excreted in breast milk in small amounts; risk of infant gut flora alteration.

๐Ÿ’Š Overdose Management

Supportive care; hemodialysis may enhance elimination; monitor renal function and hearing.

โฐ Missed Dose

Administer as soon as remembered; if close to next dose, skip missed dose; do not double dose.

๐Ÿ‘จโ€โš•๏ธ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Reviewed: Jun 30, 2026

๐Ÿ”— View Profile

๐Ÿ”„ Substitutes for biogesic 20mg/2ml injection

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Alternative brands with exact same active ingredient (Gentamicin (20mg/2ml)):

Medical Note: Always consult your doctor before switching medications.

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