Betazole RD 10mg/20mg Tablet - Uses, Price, Side Effects
What is betazole rd 10mg/20mg tablet used for?
Betazole RD 10mg/20mg Tablet is a combination of Domperidone (10mg) and Rabeprazole (20mg) used to treat gastroesophageal reflux disease (GERD), acidity, and heartburn. Domperidone helps control nausea and vomiting by blocking dopamine receptors, while Rabeprazole reduces stomach acid production by inhibiting the proton pump in the stomach lining.
- Generic Name: Domperidone + Rabeprazole
- Manufacturer: Betamax Remedies
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ betazole rd 10mg/20mg tablet Uses & Benefits
๐ Drug Information
| Generic Name(s) | Domperidone + Rabeprazole |
| Brand Name | Acera-D Capsule SR |
| Manufacturer | Betamax Remedies |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Prokinetic agent + Proton pump inhibitor |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Domperidone: Blocks dopamine D2 receptors in the chemoreceptor trigger zone and gastrointestinal tract, enhancing gastric motility and emptying. Rabeprazole: Irreversibly inhibits H+/K+ ATPase (proton pump) in gastric parietal cells, reducing gastric acid secretion.
Mechanism Steps
๐ก How to Take betazole rd 10mg/20mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of betazole rd 10mg/20mg tablet
โ Common Side Effects
- Headache
- Diarrhea
- Constipation
- Abdominal pain
- Nausea
- Dry mouth
๐จ Serious Side Effects
- QT prolongation
- Ventricular arrhythmias
- Torsades de pointes
- Gynecomastia
- Galactorrhea
- Liver injury
โ ๏ธ Rare Side Effects
- Extrapyramidal symptoms
- Hyperprolactinemia
- Interstitial nephritis
- Clostridium difficile infection
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Moderate | Increased risk of bleeding |
| Ketoconazole | Moderate | Increased domperidone levels |
| Digoxin | Minor | Altered digoxin absorption |
๐จ Major Interactions
- CYP3A4 inhibitors (e.g., ketoconazole, erythromycin)
- CYP2C19 inhibitors (e.g., fluconazole)
- QT-prolonging drugs (e.g., amiodarone, moxifloxacin)
โก Moderate Interactions
- Antacids
- Sucralfate
- Digoxin
- Methotrexate
โน๏ธ Minor Interactions
- Caffeine
- Theophylline
๐ฝ๏ธ Food Interactions
Food may delay absorption of domperidone; rabeprazole absorption unaffected by food.
๐ท Alcohol Interaction
Alcohol may worsen gastrointestinal irritation and reduce drug efficacy.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to domperidone or rabeprazole; gastrointestinal hemorrhage, obstruction, or perforation; prolactinoma; concomitant use with QT-prolonging drugs or strong CYP3A4 inhibitors.
๐ Monitoring Parameters
ECG for QT interval; liver function tests; renal function; serum electrolytes.
๐คฑ Lactation Safety
Domperidone: Excreted in breast milk, may cause adverse effects; Rabeprazole: Excreted in breast mil
๐ Overdose Management
Symptomatic and supportive treatment; gastric lavage; monitoring of ECG for QT prolongation.
โฐ Missed Dose
Take as soon as remembered unless near next dose; do not double dose.