Benipack Trio 12.5mg Tablet - Uses, Price, Side Effects
What is benipack trio 12.5mg tablet used for?
Benipack Trio 12.5mg Tablet is a combination of Benidipine (a calcium channel blocker) and Telmisartan (an ARB) used to treat hypertension. It works by relaxing blood vessels, lowering blood pressure, and reducing strain on the heart.
- Generic Name: Benidipine + Telmisartan
- Manufacturer: Koye Pharmaceuticals Pvt ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ benipack trio 12.5mg tablet Uses & Benefits
Hypertension, chronic stable angina (benidipine component).
Off-label uses: Heart failure (telmisartan), diabetic nephropathy (telmisartan).
๐ Drug Information
| Generic Name(s) | Benidipine + Telmisartan |
| Brand Name | Benitowa-TM Tablet |
| Manufacturer | Koye Pharmaceuticals Pvt ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | CARDIAC |
| Action Class | Calcium channel blocker + Angiotensin II receptor blocker |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Benidipine inhibits calcium influx into vascular smooth muscle, causing vasodilation; Telmisartan blocks angiotensin II AT1 receptors, reducing vasoconstriction and aldosterone secretion.
Mechanism Steps
๐ก How to Take benipack trio 12.5mg tablet
Follow your doctor's prescription exactly.
Dosage Timeline
โ ๏ธ Side Effects of benipack trio 12.5mg tablet
โ Common Side Effects
- Dizziness
- Headache
- Flushing
- Peripheral edema
- Cough
- Diarrhea
- Fatigue
๐จ Serious Side Effects
- Angioedema
- Hyperkalemia
- Renal impairment
- Hypotension
- Syncope
โ ๏ธ Rare Side Effects
- Hepatotoxicity
- Thrombocytopenia
- Leukopenia
- Stevens-Johnson syndrome
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Lithium | Moderate | Increased lithium levels and toxicity risk |
| NSAIDs | Moderate | Reduced antihypertensive effect, increased renal impairment risk |
| Potassium-sparing diuretics | Major | Increased risk of hyperkalemia |
๐จ Major Interactions
- Lithium
- Potassium-sparing diuretics
- ACE inhibitors
- CYP3A4 inhibitors (e.g., ketoconazole)
- CYP3A4 inducers (e.g., rifampin)
โก Moderate Interactions
- NSAIDs
- Antidiabetic agents
- Digoxin
- Warfarin
โน๏ธ Minor Interactions
- Antacids
- Cimetidine
๐ฝ๏ธ Food Interactions
Grapefruit juice (may increase benidipine levels), High-fat meal may reduce telmisartan absorption
๐ท Alcohol Interaction
May potentiate hypotensive effects; avoid excessive alcohol.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity, pregnancy, bilateral renal artery stenosis, severe hypotension, cardiogenic shock, history of angioedema with ARBs.
๐ Monitoring Parameters
Blood pressure, heart rate, serum potassium, renal function, liver function.
๐คฑ Lactation Safety
Not recommended; avoid breastfeeding.
๐ Overdose Management
Symptomatic treatment; monitor blood pressure, heart rate; consider gastric lavage, activated charcoal; IV fluids and vasopressors if needed.
โฐ Missed Dose
Take as soon as remembered; skip if near next dose; do not double dose.