belic 10 mg/325 mg tablet - Uses, Price, Side Effects & Substitutes
What is belic 10 mg/325 mg tablet used for?
Buscopan Plus (Hyoscine butylbromide + Paracetamol) is used to treat GASTRO INTESTINAL. It contains Hyoscine butylbromide (10mg) + Paracetamol (325mg), which Hyoscine butylbromide: competitive antagonist of acetylcholine at muscarinic rec. Always consult your doctor before use. Take as prescribed.
- Generic Name: Hyoscine butylbromide + Paracetamol
- Manufacturer: Alchem Phytoceuticals Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ belic 10 mg/325 mg tablet Uses & Benefits
Symptomatic relief of abdominal cramps and pain associated with GI disorders (e.g., irritable bowel syndrome, gastroenteritis)
Off-label uses: Dysmenorrhea, renal colic (adjunct)
๐ Drug Information
| Generic Name(s) | Hyoscine butylbromide + Paracetamol |
| Brand Name | Buscopan Plus |
| Manufacturer | Alchem Phytoceuticals Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antispasmodic + Analgesic/Antipyretic |
| Route of Administration | Oral |
| Storage | Store at room temperature (15-30ยฐC), protect from moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Hyoscine butylbromide: competitive antagonist of acetylcholine at muscarinic receptors in smooth muscle; Paracetamol: inhibits cyclooxygenase (COX) in CNS, reducing prostaglandin synthesis
Mechanism Steps
๐ก How to Take belic 10 mg/325 mg tablet
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of belic 10 mg/325 mg tablet
โ Common Side Effects
- Dry mouth
- Drowsiness
- Blurred vision
- Constipation
- Nausea
- Rash
๐จ Serious Side Effects
- Hepatotoxicity (paracetamol overdose)
- Severe allergic reactions
- Urinary retention
- Tachycardia
โ ๏ธ Rare Side Effects
- Blood dyscrasias (paracetamol)
- Pancreatitis
- Acute generalized exanthematous pustulosis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk with high doses of paracetamol |
| Alcohol (chronic) | Major | Increased hepatotoxicity risk |
| Isoniazid | Major | Increased hepatotoxicity risk |
| Rifampin | Major | Decreased paracetamol efficacy, increased hepatotoxicity |
| Carbamazepine | Major | Decreased paracetamol efficacy, increased hepatotoxicity |
| Phenytoin | Major | Decreased paracetamol efficacy, increased hepatotoxicity |
| Barbiturates | Major | Decreased paracetamol efficacy, increased hepatotoxicity |
| Anticholinergics | Moderate | Additive anticholinergic effects |
| Tricyclic antidepressants | Moderate | Additive anticholinergic effects |
| MAOIs | Moderate | Possible hypertensive crisis (theoretical) |
| Cholinesterase inhibitors | Moderate | Reduced anticholinergic effect |
| Oral contraceptives | Minor | Decreased paracetamol efficacy |
| Chloramphenicol | Minor | Increased chloramphenicol half-life |
| Probenecid | Minor | Decreased paracetamol clearance |
๐จ Major Interactions
- Warfarin
- Alcohol (chronic heavy use)
- Isoniazid
- Rifampin
- Carbamazepine
- Phenytoin
- Barbiturates
โก Moderate Interactions
- Anticholinergics
- Tricyclic antidepressants
- MAOIs
- Cholinesterase inhibitors
โน๏ธ Minor Interactions
- Oral contraceptives
- Chloramphenicol
- Probenecid
๐ฝ๏ธ Food Interactions
Food may delay absorption of paracetamol; no significant food interactions with hyoscine butylbromide
๐ท Alcohol Interaction
Chronic heavy alcohol use increases risk of hepatotoxicity with paracetamol
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to any component, severe hepatic impairment, narrow-angle glaucoma, myasthenia gravis, megacolon, paralytic ileus, obstructive uropathy
๐ Monitoring Parameters
Liver function tests (paracetamol), anticholinergic symptoms (hyoscine butylbromide)
๐คฑ Lactation Safety
Paracetamol: safe in usual doses; hyoscine butylbromide: excreted in small amounts, likely safe
๐ Overdose Management
Paracetamol: N-acetylcysteine within 8-10 hours; Hyoscine butylbromide: supportive care, physostigmine for severe anticholinergic symptoms
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose. Do not double dose.