Azofen T 200 mg/1 mg Tablet: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Severe palpitations or irregular heartbeat
- Seizures or convulsions
- Difficulty breathing or chest tightness that worsens
- Severe nausea, vomiting, or abdominal pain
- Yellowing of skin or eyes (jaundice)
- Swelling of face, lips, or throat
- Unusual bleeding or bruising
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is azofen t 200 mg/1 mg tablet used for?
This medicine is a combination of theophylline (200 mg) and ketotifen (1 mg) used for maintenance treatment of bronchial asthma and allergic bronchitis. It works by relaxing airway muscles and reducing allergic inflammation. It is not a rescue inhaler for acute attacks.
- Generic Name: Theophylline + Ketotifen
- Manufacturer: Lark Laboratories Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 azofen t 200 mg/1 mg tablet के बारे में (Hindi Summary)
उपयोग: यह दवा थियोफिलिन (200 मिलीग्राम) और कीटोटिफेन (1 मिलीग्राम) का संयोजन है। इसका उपयोग अस्थमा और एलर्जी से होने वाली ब्रोंकाइटिस के इलाज में किया जाता है। यह श्वास नलियों को फैलाकर सांस लेने में आसानी प्रदान करती है और एलर्जी के लक्षणों जैसे छींक, खुजली और नाक बहना को कम करती है। यह दवा तुरंत अस्थमा के दौरे के लिए नहीं है, बल्कि नियमित रूप से लेने पर यह लंबे समय तक नियंत्रण बनाए रखती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, पेट में परेशानी, सिरदर्द, बेचैनी, नींद न आना, धड़कन बढ़ना और मुँह सूखना शामिल हैं। कुछ लोगों को नींद आ सकती है। गंभीर दुष्प्रभावों में अनियमित धड़कन, दौरे, गंभीर एलर्जी प्रतिक्रिया और लीवर एंजाइम बढ़ना शामिल हैं। यदि आपको धड़कन तेज होना, बेहोशी, दौरा या गंभीर पेट दर्द हो, तो तुरंत डॉक्टर से मिलें।
सुरक्षा सलाह: इस दवा को डॉक्टर के बताए अनुसार ही लें। इसे चबाएं या तोड़ें नहीं। शराब न पिएं क्योंकि इससे नींद और दुष्प्रभाव बढ़ सकते हैं। बिना डॉक्टर की सलाह के कोई अन्य दवा शुरू या बंद न करें। नियमित रूप से थियोफिलिन स्तर और लीवर फंक्शन की जांच कराएं। जब तक आपको पता न चले कि यह दवा आप पर कैसे असर करती है, वाहन न चलाएं। गर्भावस्था या स्तनपान के दौरान डॉक्टर से सलाह लें।
💊 azofen t 200 mg/1 mg tablet Uses & Benefits
[{"condition":"Bronchial asthma with allergic component","description":"Used for maintenance treatment to reduce bronchospasm and allergic airway inflammation in patients with chronic asthma.","evidence":"Well-established for theophylline; combination use supported by clinical practice."},{"condition":"Allergic bronchitis","description":"Helps relieve wheezing, cough, and allergic symptoms associated with chronic bronchitis.","evidence":"Moderate evidence for combination therapy."},{"condition":"Chronic obstructive pulmonary disease (COPD) with reversible airway component","description":"May be used as add-on therapy in selected patients with reversible airflow limitation.","evidence":"Limited; theophylline has a role but combination with ketotifen is not standard."}]
Off-label uses: [{"condition":"Apnea of prematurity","description":"Theophylline has been used off-label in neonates, but this combination product is not intended for that use.","evidence":"Limited; not applicable to this formulation."},{"condition":"Mastocytosis","description":"Ketotifen may be used off-label for mast cell activation symptoms, but theophylline is not typically combined for this indication.","evidence":"Limited."}]
Primary treatment for: Bronchial asthma with allergic component
Also treats: Allergic bronchitis, COPD with reversible airway component
📋 Drug Information
| Generic Name(s) | Theophylline + Ketotifen |
| Brand Name | Azofen T 200 mg/1 mg Tablet |
| Manufacturer | Lark Laboratories Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | RESPIRATORY |
| Action Class | Respiratory |
| Route of Administration | Oral |
| Storage | Store at room temperature (15–30°C) in a dry place, away from direct sunlight and moisture. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture, or as printed on the packaging. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works through two complementary mechanisms. Theophylline inhibits phosphodiesterase enzymes, leading to increased cyclic AMP levels in bronchial smooth muscle, which causes relaxation and bronchodilation. It also blocks adenosine receptors, reducing bronchoconstriction and mast cell mediator release. Ketotifen acts as a selective histamine H1 receptor antagonist and stabilises mast cells, preventing the release of histamine, leukotrienes, and other inflammatory mediators from sensitised mast cells. Together, they reduce both immediate bronchospasm and allergic inflammatory responses in the airways.
Mechanism Steps
💡 How to Take azofen t 200 mg/1 mg tablet
Strength: Each tablet contains theophylline 200 mg and ketotifen 1 mg.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is one tablet taken orally once or twice daily, or as directed by your doctor. The exact dose and frequency depend on the indication, severity of symptoms, and individual response. Dose must be individualised by a qualified clinician based on indication, age, weight, renal and hepatic function, and theophylline plasma levels. Do not adjust the dose without medical advice. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | Elderly patients may require lower doses because of reduced clearance of theophylline and increased sensitivity to side effects. Dose must be individualised by a qualified clinician based on renal and hepatic function and theophylline plasma levels. |
| Renal Impairment | Dose adjustment may be required in patients with renal impairment. Consult your doctor for individualised dosing. |
| Hepatic Impairment | Dose reduction is recommended in patients with hepatic impairment because theophylline and ketotifen are metabolised in the liver. Consult your doctor for individualised dosing. |
| Maximum Daily Dose | The maximum daily dose must be determined by a qualified clinician based on theophylline plasma levels and individual tolerance. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of azofen t 200 mg/1 mg tablet
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Ciprofloxacin | Major | |
| Erythromycin | Major | |
| Propranolol | Major | |
| Phenytoin | Moderate | |
| Rifampicin | Moderate | |
| Cimetidine | Moderate | |
| Oral contraceptives | Minor | |
| Furosemide | Minor | |
| Alcohol | Moderate | |
| Caffeine | Moderate |
🚨 Major Interactions
- Ciprofloxacin
- Erythromycin
- Propranolol
⚡ Moderate Interactions
- Phenytoin
- Rifampicin
- Cimetidine
🍷 Alcohol Interaction
Alcohol should be avoided while taking this medicine. Alcohol can increase drowsiness caused by ketotifen and may affect theophylline metabolism, potentially leading to increased side effects or reduced efficacy.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Hypersensitivity to theophylline, ketotifen, or any component of the formulation","Active peptic ulcer disease","Severe liver disease","Uncontrolled cardiac arrhythmias","History of seizures (relative contraindication)","Children under 12 years (unless specifically prescribed by a pediatrician)"]
⚠️ Warnings & Precautions
["Theophylline has a narrow therapeutic index; dose must be individualised and plasma levels monitored.","Avoid concurrent use with drugs that inhibit or induce theophylline metabolism.","Use with caution in patients with heart disease, hypertension, or seizure disorders.","Ketotifen may cause drowsiness; avoid driving or operating machinery until effects are known.","Do not use this medicine to treat acute bronchospasm; it is not a rescue medication.","Avoid alcohol and caffeine-containing products while taking this medicine.","Consult your doctor before taking any new medicine, including over-the-counter products."]
🤱 Lactation Safety
Theophylline and ketotifen are excreted in breast milk. Breastfeeding is not recommended while taking this medicine unless advised by a doctor. Consult your healthcare provider.
💊 Overdose Management
Overdose of this medicine can cause severe nausea, vomiting, restlessness, palpitations, seizures, and cardiac arrhythmias. If you suspect an overdose, seek emergency medical care immediately. Treatment is supportive and may include activated charcoal, antiarrhythmics, and management of seizures. Do not induce vomiting unless instructed by a healthcare professional.
⏰ Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double the dose to catch up. Consult your doctor if you are unsure.
Additional Safety Advice
Take this medicine exactly as prescribed by your doctor. Do not crush, chew, or break the tablet unless your doctor advises otherwise. Avoid alcohol because it can increase drowsiness and affect theophylline levels. Do not start or stop any other medicine without informing your doctor, especially antibiotics, antifungals, or heart medicines. Keep your scheduled blood tests for theophylline levels and liver function. Avoid driving or operating heavy machinery until you know how this medicine affects you, as it may cause drowsiness. If you are pregnant, planning pregnancy, or breastfeeding, talk to your doctor before taking this medicine. Store it in a cool, dry place away from direct sunlight and out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more sensitive to theophylline side effects and may require lower doses. Regular monitoring of theophylline levels, heart rhythm, and liver function is recommended. Falls risk may increase if drowsiness occurs.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, consult your doctor before taking this medicine. Theophylline and ketotifen should be used during pregnancy only if clearly needed. Your doctor may adjust the dose or switch to a safer alternative.
🏥 Post-Surgery Considerations
Inform your surgeon and anesthesiologist that you are taking this medicine. Theophylline can interact with some anesthetic agents and may affect heart rhythm. Your doctor may advise temporary dose adjustments around surgery.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine. Ketotifen can cause dry mouth, which may increase the risk of dental caries. Maintain good oral hygiene and stay hydrated.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
Moderate exercise is generally safe, but avoid strenuous activity in cold, dry air as it can trigger bronchospasm. Warm up before exercise and carry your rescue inhaler if prescribed. Consult your doctor before starting a new exercise regimen.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness, especially when starting treatment. Avoid driving or operating heavy machinery until you know how it affects you. It may also cause restlessness or insomnia, which can affect work performance. Discuss with your doctor if side effects interfere with your daily activities.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. If you experience serious side effects such as severe palpitations, seizures, or allergic reactions, seek immediate medical attention and follow your doctor's advice on discontinuation.
📅 Long-Term Use Effects
Long-term use of this medicine requires periodic monitoring of theophylline plasma levels, liver function, and heart rhythm. Prolonged use may lead to tolerance or cumulative side effects. Regular follow-up with your doctor is essential to adjust the dose and assess continued need.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
First-line controller therapy for persistent asthma, reducing airway inflammation.
Evidence: Well-establishedOral medications like montelukast for allergic asthma.
Evidence: Well-establishedReducing exposure to triggers can decrease symptoms.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, if you have asthma, it is especially important to stay up to date with influenza and pneumococcal vaccinations as advised by your doctor.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
Carry this medicine in its original packaging with a copy of your prescription. Keep it in your hand luggage to avoid temperature extremes. If travelling across time zones, consult your doctor about adjusting the dosing schedule. Store at room temperature and avoid leaving it in a hot car. Check customs regulations for carrying prescription medicines.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: Theophylline starts working within 30 minutes to 2 hours, but full benefits for asthma control may take several days to weeks of regular use.
A: Yes, taking it with food or milk is recommended to reduce stomach upset.
A: If you remember within a few hours, take it. If it is almost time for the next dose, skip the missed dose and continue your regular schedule. Do not double dose.
A: No, do not stop without consulting your doctor. Stopping suddenly can worsen your condition.
A: Pediatric dosing is not established for this combination. Consult a pediatrician.
🤔 Common Patient Concerns
🛑 Myths vs. Facts
- Myth: This medicine can be used to treat sudden asthma attacks.
Fact: This medicine is for maintenance therapy only and is not a rescue medication for acute bronchospasm. - Myth: It is safe to take extra doses if symptoms worsen.
Fact: Taking extra doses can lead to serious theophylline toxicity. Always follow your doctor's prescription. - Myth: This medicine is habit-forming.
Fact: This medicine is not habit-forming, but it must be taken regularly as prescribed for best results.
🔄 Alternative Options
Generic Alternatives
- Theophylline 200 mg + Ketotifen 1 mg tablet (generic)
Brand Alternatives
- Azofen T 200 mg/1 mg tablet