azither 150mg injection - Uses, Price, Side Effects & Substitutes
Arteether (150mg)
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Medically Reviewed
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💊 What is azither 150mg injection used for?
Artisun 150mg Injection (Arteether) is used to treat Treatment of uncomplicated and severe falciparum malaria; chloroquine-resistant malaria.. It contains Arteether (150mg), which Arteether is converted to dihydroartemisinin, which generates free radicals that. Always consult your doctor before use. Take as prescribed.
💊 Generic Name
Arteether
Arteether
🏭 Manufacturer
Azilliane Healthcare
Azilliane Healthcare
📦 Form
Allopathy
Allopathy
🤰 Pregnancy Category
Category A
Category A
🇮🇳 azither 150mg injection के बारे में संक्षिप्त जानकारी
azither 150mg injection का उपयोग मुख्य रूप से anti malarials और उससे जुड़ी समस्याओं के इलाज के लिए किया जाता है। इस दवा में मुख्य सामग्री के रूप में Arteether (150mg) मौजूद है।
💡 Did You Know? The first generic medicine was introduced in India in 1970 after the Patents Act was amended.
📋 Complete Drug Information
| Generic Name(s) | Arteether |
|---|---|
| Brand Name | Artisun 150mg Injection |
| Manufacturer | Azilliane Healthcare |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI MALARIALS |
| Action Class | Antimalarial- Artemisinin and derivatives |
| Route of Administration | Intramuscular injection only. |
| Storage | Store at 20-25°C; protect from light; do not freeze. |
🔬 Pharmacology
Pharmacokinetics
AbsorptionRapidly absorbed after intramuscular injection; peak plasma concentrations achieved within 2-3 hours.
DistributionWidely distributed in body tissues; crosses blood-brain barrier.
Protein BindingApproximately 95% bound to plasma proteins.
MetabolismMetabolized in the liver primarily by CYP2A6 to dihydroartemisinin (active metabolite).
Half-LifeApproximately 23 hours for arteether; 4-11 hours for dihydroartemisinin.
ExcretionPrimarily excreted in urine (up to 80%) and feces.
BioavailabilityNot applicable (parenteral administration); high systemic availability.
Onset of ActionRapid onset; clinical improvement within 24-48 hours.
Peak Plasma Time2-3 hours after intramuscular injection.
Duration of ActionLong-acting; single dose provides therapeutic levels for several days.
Mechanism of Action
Arteether is converted to dihydroartemisinin, which generates free radicals that damage parasite proteins and membranes.
Step-by-Step Mechanism
1
Arteether is hydrolyzed to dihydroartemisinin (DHA) in the liver.
2
DHA interacts with heme (from hemoglobin digestion) in the parasite.
3
Formation of free radicals (carbon-centered radicals) via cleavage of endoperoxide bridge.
4
Free radicals alkylate parasite proteins and membranes, causing oxidative stress.
5
Disruption of parasite's detoxification pathways and mitochondrial function.
6
Rapid parasite death and clearance from blood.
💡 How to take azither 150mg injection
Prescribed Dosage: Follow your doctor's prescription exactly.
- ✅ Take exactly as prescribed by your doctor.
- ✅ Do not exceed the recommended dose.
- ✅ Complete the full course of medication.
- ✅ Store at 20-25°C; protect from light; do not freeze.
⚠️ Side Effects of azither 150mg injection
✅ Common Side Effects
- Headache
- Dizziness
- Nausea
- Vomiting
- Abdominal pain
- Injection site pain
🚨 Serious Side Effects
- QTc prolongation
- Severe hemolysis (in G6PD deficiency)
- Hepatotoxicity
- Allergic reactions
⚠️ Rare Side Effects
- Neurotoxicity (ataxia, tremors)
- Hemolytic anemia
- Stevens-Johnson syndrome
Important: Consult your doctor if you experience any unusual symptoms or severe side effects.
🔬 Drug Interactions
| ⚠️ Drug | Severity | Effect |
|---|---|---|
| Mefloquine | Major | Increased risk of neuropsychiatric effects and QTc prolongation |
| Quinine | Major | Additive cardiotoxicity (QTc prolongation) |
| Halofantrine | Major | Increased risk of fatal cardiac arrhythmias |
| Ketoconazole | Moderate | Increased arteether levels due to CYP2A6 inhibition |
| Rifampin | Moderate | Decreased arteether efficacy due to CYP2A6 induction |
| Warfarin | Minor | Possible increased INR; monitor |
| Carbamazepine | Minor | Possible decreased arteether levels |
🚨 Major Interactions
- Mefloquine
- Quinine
- Halofantrine
⚡ Moderate Interactions
- CYP2A6 inhibitors (e.g., ketoconazole)
- CYP2A6 inducers (e.g., rifampin)
🍽️ Food Interactions
No significant food interactions.
🍷 Alcohol Interaction
Avoid alcohol; may increase hepatotoxicity risk.
🛡️ Safety & Warnings
Pregnancy
Category A
Liver Risk
Low
Kidney Risk
Low
Heart Risk
Low
🚫 Contraindications
Hypersensitivity to arteether or artemisinin derivatives; severe hepatic impairment.
📊 Monitoring Parameters
Parasite count, hemoglobin, liver function tests, ECG if co-administered with cardiotoxic drugs.
🤱 Lactation Safety
Excreted in breast milk; caution advised; discontinue breastfeeding or drug.
💊 Overdose
Symptomatic and supportive treatment; no specific antidote; monitor ECG and liver function.
⏰ Missed Dose
Administer as soon as remembered; do not double dose; maintain dosing interval.