axiotem 20 capsule

4.5 (17 reviews)

Temozolomide (20mg)

🏭 Axiommax Oncology Pvt Ltd 📦 Varies by brand 💊 Allopathy 📅 Updated: Aug 22, 2026

📋 Prescription Required 💊 Generic Available

Medically Reviewed

SaathiMed Expert Panel | Aug 22, 2026

What is axiotem 20 capsule used for?

Axiotem 20 Capsule (Temozolomide) is used to treat ANTI NEOPLASTICS. It contains Temozolomide (20mg), which Temozolomide is a prodrug that undergoes hydrolysis to MTIC, which methylates DN. Always consult your doctor before use. Take as prescribed.

Generic Name: Temozolomide
Manufacturer: Axiommax Oncology Pvt Ltd
Form: Allopathy
Pregnancy Category: A
Prescription Required: Yes

💡 Did You Know? India has the highest number of USFDA-compliant plants outside the USA.

💊 axiotem 20 capsule Uses & Benefits

Glioblastoma multiforme; anaplastic astrocytoma; other malignant gliomas.

Off-label uses: Metastatic melanoma; soft tissue sarcoma; CNS lymphoma.

📋 Drug Information

Generic Name(s)	Temozolomide
Brand Name	Axiotem 20 Capsule
Manufacturer	Axiommax Oncology Pvt Ltd
Packaging / Form	Varies by brand (Allopathy)
Therapeutic Class	ANTI NEOPLASTICS
Action Class	Alkylating agent
Route of Administration	Oral.
Storage	Store at 20-25°C (68-77°F); protect from light and moisture.
Shelf Life	As per manufacturer

🔬 Pharmacology (PK/PD)

Pharmacokinetics

AbsorptionRapidly and completely absorbed after oral administration; bioavailability approximately 100%.

DistributionDistributes widely into tissues, including brain; crosses blood-brain barrier.

Protein BindingApproximately 15% bound to plasma proteins.

MetabolismUndergoes rapid non-enzymatic hydrolysis at physiologic pH to the active metabolite MTIC; further metabolized to inactive metabolites.

Half-LifeApproximately 1.8 hours (parent drug); active metabolite half-life ~1.8 hours.

ExcretionPrimarily renal excretion (about 38% of total radioactivity as parent drug and metabolites).

Bioavailability~100% (oral).

Onset of ActionNot well defined; therapeutic effect observed after several cycles.

Peak Plasma Time1 hour (range 0.5-1.5 hours).

Duration of ActionNot well defined; dosing typically 5 days per 28-day cycle.

How It Works

Temozolomide is a prodrug that undergoes hydrolysis to MTIC, which methylates DNA at O6-guanine and N7-guanine positions, leading to DNA damage and apoptosis.

Mechanism Steps

1Temozolomide is converted to MTIC by non-enzymatic hydrolysis at physiologic pH.

2MTIC methylates DNA at O6-guanine and N7-guanine positions.

3O6-methylguanine mispairs with thymine during DNA replication.

💡 How to Take axiotem 20 capsule

Follow your doctor's prescription exactly.

⚠️ Side Effects of axiotem 20 capsule

✅ Common Side Effects

Nausea
Vomiting
Constipation
Fatigue
Headache
Alopecia

🚨 Serious Side Effects

Myelosuppression (neutropenia, thrombocytopenia)
Pneumocystis jirovecii pneumonia
Secondary malignancies

⚠️ Rare Side Effects

Hepatotoxicity
Stevens-Johnson syndrome
Interstitial pneumonitis

Consult your doctor if you experience any unusual symptoms.

🔬 Drug Interactions

⚠️ Drug	Severity	Effect
Valproic acid	Major	Increased risk of myelosuppression
Warfarin	Moderate	Increased INR and bleeding risk
Phenytoin	Moderate	Decreased phenytoin levels
Acetaminophen	Minor	Possible increased hepatotoxicity

🚨 Major Interactions

Valproic acid
Other myelosuppressive agents

⚡ Moderate Interactions

Warfarin
Phenytoin
Corticosteroids

ℹ️ Minor Interactions

Acetaminophen
Antiemetics

🍽️ Food Interactions

High-fat meal reduces peak concentration and delays absorption; take on empty stomach.

🍷 Alcohol Interaction

Avoid alcohol; may increase hepatotoxicity risk.

🛡️ Safety & Warnings

🚫 Contraindications

Hypersensitivity to temozolomide or dacarbazine; severe myelosuppression.

📊 Monitoring Parameters

Complete blood count (CBC) before each cycle; liver function tests.

🤱 Lactation Safety

Not recommended; excreted in breast milk.

💊 Overdose Management

Supportive care; monitor for myelosuppression; no specific antidote.

⏰ Missed Dose

Do not take missed dose; wait until next scheduled dose.

👨‍⚕️ Reviewed by Expert

SaathiMed Expert Panel

MD, PhD - Pharmacology

Last reviewed on: Aug 22, 2026

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🔄 Substitutes for axiotem 20 capsule

View All

Alternative brands with exact same active ingredient (Temozolomide (20mg)):

Medical Note: Always consult your doctor before switching medications.

⭐ User Reviews

Happy Patient Jul 10, 2026

Effective and reliable. Worked as expected.

Regular Customer Jul 10, 2026