aprifast iv injection
What is aprifast iv injection used for?
Amitant-IV Injection (Fosaprepitant) is used to treat GASTRO INTESTINAL. It contains Fosaprepitant (150mg), which Fosaprepitant is a prodrug of aprepitant, which is a selective high-affinity ant. Always consult your doctor before use. Take as prescribed.
- Generic Name: Fosaprepitant
- Manufacturer: Axiommax Oncology Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ aprifast iv injection Uses & Benefits
Prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy; prevention of postoperative nausea and vomiting (PONV).
Off-label uses: Treatment of pruritus; prevention of nausea and vomiting in other settings (e.g., radiation therapy).
๐ Drug Information
| Generic Name(s) | Fosaprepitant |
| Brand Name | Amitant-IV Injection |
| Manufacturer | Axiommax Oncology Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | NK1 Antagonists |
| Route of Administration | Intravenous infusion over 15-30 minutes. |
| Storage | Store at 20-25ยฐC (68-77ยฐF); protect from light; reconstituted solution stable for 24 hours at room temperature. |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Fosaprepitant is a prodrug of aprepitant, which is a selective high-affinity antagonist of the human substance P/neurokinin 1 (NK1) receptor.
Mechanism Steps
๐ก How to Take aprifast iv injection
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of aprifast iv injection
โ Common Side Effects
- Fatigue
- Constipation
- Diarrhea
- Headache
- Hiccups
- Anorexia
๐จ Serious Side Effects
- Hypersensitivity reactions (anaphylaxis, urticaria)
- Stevens-Johnson syndrome
- Angioedema
โ ๏ธ Rare Side Effects
- Elevated liver enzymes
- Bradycardia
- Confusion
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Decreased INR; reduced anticoagulant effect. |
| Oral contraceptives | Major | Reduced contraceptive efficacy. |
| Midazolam | Major | Increased midazolam exposure; risk of prolonged sedation. |
| Rifampin | Major | Reduced aprepitant exposure; decreased efficacy. |
| Ketoconazole | Moderate | Increased aprepitant exposure. |
| Dexamethasone | Minor | Increased dexamethasone exposure. |
๐จ Major Interactions
- Warfarin
- Oral contraceptives
- CYP3A4 substrates (e.g., midazolam, pimozide, ergot alkaloids)
- CYP3A4 inducers (e.g., rifampin, carbamazepine, phenytoin)
โก Moderate Interactions
- CYP2C9 substrates (e.g., tolbutamide, warfarin)
- CYP2C19 substrates (e.g., omeprazole)
- CYP3A4 inhibitors (e.g., ketoconazole, clarithromycin)
โน๏ธ Minor Interactions
- Dexamethasone
- Methylprednisolone
๐ฝ๏ธ Food Interactions
No significant food interactions.
๐ท Alcohol Interaction
May increase CNS depression; avoid concurrent use.
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to fosaprepitant, aprepitant, or any component; concurrent use with pimozide.
๐ Monitoring Parameters
Monitor for signs of hypersensitivity; liver function tests if prolonged use; INR in patients on warfarin.
๐คฑ Lactation Safety
Not recommended; unknown if excreted in human milk.
๐ Overdose Management
No specific antidote; supportive care; dialysis unlikely to be effective due to high protein binding.
โฐ Missed Dose
Not applicable for single-dose IV regimen; if used in multi-day regimen, administer as soon as remembered if within 12 hours.
๐จโโ๏ธ Reviewed by Expert
๐ Substitutes for aprifast iv injection
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Medical Note: Always consult your doctor before switching medications.
โญ User Reviews
Found this to be a helpful product. Good results.
Good quality medicine. Satisfied with the outcome.
Found this to be a helpful product. Good results.
Good quality medicine. Satisfied with the outcome.
Found this to be a helpful product. Good results.