Glioz 100mg Capsule (Temozolomide): Comprehensive Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Fever, chills, or sore throat (signs of infection)
- Unusual bleeding or bruising
- Severe headache or confusion
- Shortness of breath or difficulty breathing
- Yellowing of skin or eyes
- Severe nausea or vomiting that prevents keeping fluids down
- Decreased urine output
If experiencing severe symptoms, call emergency services immediately.
What is axiotem 100 capsule used for?
This medicine contains temozolomide, an oral chemotherapy drug used to treat brain tumors such as glioblastoma and anaplastic astrocytoma. It works by damaging the DNA of cancer cells, preventing their growth. It is taken on an empty stomach, usually for 5 days every 28 days, under strict medical supervision.
- Generic Name: Temozolomide (100mg)
- Manufacturer: Axiommax Oncology Pvt Ltd
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 axiotem 100 capsule के बारे में (Hindi Summary)
उपयोग: यह दवा टेमोज़ोलोमाइड नामक सक्रिय तत्व से बनी है और इसका उपयोग मस्तिष्क के कैंसर जैसे ग्लियोब्लास्टोमा और एनाप्लास्टिक एस्ट्रोसाइटोमा के इलाज के लिए किया जाता है। यह कैंसर कोशिकाओं के डीएनए को नुकसान पहुंचाकर उनकी वृद्धि को रोकती है। यह दवा केवल कैंसर रोग विशेषज्ञ के परामर्श से ही ली जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में मतली, उल्टी, कब्ज, सिरदर्द, थकान और भूख में कमी शामिल हैं। गंभीर दुष्प्रभावों में रक्त कोशिकाओं की कमी, लीवर की समस्या और फेफड़ों में सूजन हो सकती है। यदि आपको बुखार, असामान्य रक्तस्राव, या त्वचा का पीलापन दिखे तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: इस दवा को केवल योग्य कैंसर विशेषज्ञ की देखरेख में ही लें। अपनी मर्जी से खुराक न बदलें। नियमित रूप से रक्त परीक्षण करवाएं। संक्रमण से बचने के लिए सावधानी बरतें। गर्भावस्था के दौरान इस दवा का सेवन न करें। स्तनपान कराने वाली महिलाएं इस दवा का सेवन न करें।
💊 axiotem 100 capsule Uses & Benefits
[{"condition":"Glioblastoma multiforme","description":"Used as part of standard therapy for newly diagnosed glioblastoma, often concurrently with radiation and then as maintenance treatment.","evidence":"Well-established"},{"condition":"Anaplastic astrocytoma","description":"Used for the treatment of anaplastic astrocytoma in adults who have relapsed after prior therapy.","evidence":"Well-established"},{"condition":"Metastatic melanoma","description":"Sometimes used off-label for metastatic melanoma, though newer therapies are generally preferred.","evidence":"Limited"},{"condition":"Neuroendocrine tumors","description":"Occasionally used off-label for advanced neuroendocrine tumors.","evidence":"Limited"}]
Off-label uses: [{"condition":"Metastatic melanoma","description":"Temozolomide has been studied in clinical trials for metastatic melanoma, but it is not FDA-approved for this indication.","evidence":"Limited"},{"condition":"Primary CNS lymphoma","description":"Sometimes used off-label in the treatment of primary central nervous system lymphoma, often in combination with other agents.","evidence":"Limited"},{"condition":"Ewing sarcoma","description":"Rarely used off-label for Ewing sarcoma after failure of standard treatments.","evidence":"Limited"}]
Primary treatment for: Glioblastoma multiforme
Also treats: Anaplastic astrocytoma, Metastatic melanoma, Neuroendocrine tumors
📋 Drug Information
| Generic Name(s) | Temozolomide (100mg) |
| Brand Name | axiotem 100 capsule |
| Manufacturer | Axiommax Oncology Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI NEOPLASTICS |
| Action Class | Alkylating agent |
| Route of Administration | Oral |
| Storage | Store at room temperature between 20°C and 25°C (68°F to 77°F). Keep in the original container, tightly closed, away from moisture and heat. Do not refrigerate. Keep out of reach of children. |
| Shelf Life | 24 months from the date of manufacture. |
| WHO Guideline | Temozolomide is included in WHO essential medicines list for the treatment of glioblastoma. Guidelines recommend its use in newly diagnosed glioblastoma with radiation and as maintenance therapy. |
| ICMR Guideline | ICMR guidelines for the management of glioblastoma recommend temozolomide as part of standard therapy. However, specific recommendations should be verified with the latest ICMR guidelines. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Temozolomide is an imidazotetrazine prodrug that undergoes spontaneous hydrolysis at physiological pH to form the active metabolite 5-(3-methyltriazen-1-yl)imidazole-4-carboxamide (MTIC). MTIC then methylates DNA at the O6 position of guanine, leading to DNA damage, mismatch repair errors, and ultimately cell death. This medicine is cell cycle phase-nonspecific, meaning it affects cells at any phase of the cell cycle.
Mechanism Steps
💡 How to Take axiotem 100 capsule
Strength: 100 mg immediate-release capsule
Dosage Information
| Adult Dosage | The dose of this medicine is individualized based on the specific condition being treated, body surface area, and response to therapy. For newly diagnosed glioblastoma, the typical starting dose is 75 mg per square meter of body surface area once daily for 42 days with radiation therapy, followed by maintenance doses of 150 mg per square meter once daily for 5 days every 28 days, which may be increased to 200 mg per square meter if tolerated. For anaplastic astrocytoma, the typical starting dose is 150 mg per square meter once daily for 5 days every 28 days, which may be increased to 200 mg per square meter. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function, and blood counts. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatric oncologist. |
| Elderly Dosage | Elderly patients (above 65 years) may be more susceptible to myelosuppression and other side effects. Dose selection should be cautious, and monitoring should be more frequent. No specific dose adjustment is recommended solely based on age, but individualization is essential. |
| Renal Impairment | For patients with severe renal impairment (creatinine clearance less than 36 mL/min), dose adjustment may be necessary. However, specific guidelines are not well established. Monitor closely and adjust dose based on toxicity. |
| Hepatic Impairment | For patients with severe hepatic impairment, dose adjustment may be necessary. Monitor liver function closely. No specific dose recommendations are available; individualize based on clinical response and toxicity. |
| Maximum Daily Dose | The maximum daily dose is not fixed and depends on the treatment protocol. For glioblastoma maintenance, the maximum dose is 200 mg per square meter per day for 5 days every 28 days. Do not exceed the dose prescribed by your doctor. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of axiotem 100 capsule
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Live vaccines | Major | |
| Myelosuppressive agents | Major | |
| Valproic acid | Moderate | |
| CYP3A4 inducers | Moderate |
🚨 Major Interactions
- Live vaccines
- Myelosuppressive agents (e.g., chemotherapy, radiation)
⚡ Moderate Interactions
- Valproic acid
- CYP3A4 inducers (e.g., phenytoin, carbamazepine)
🍷 Alcohol Interaction
Alcohol may increase the risk of liver toxicity and worsen side effects such as nausea and fatigue. It is advisable to avoid alcohol while taking this medicine.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity to temozolomide or any component of the formulation","Severe bone marrow suppression","Pregnancy (unless potential benefit justifies risk)","Breastfeeding"]
⚠️ Warnings & Precautions
["Myelosuppression: May cause severe and prolonged bone marrow suppression. Monitor blood counts regularly.","Hepatotoxicity: Can cause severe liver injury. Monitor liver function.","Pneumonitis: Rare but serious lung toxicity. Monitor for respiratory symptoms.","Secondary malignancies: Increased risk of developing secondary cancers.","Fetal harm: Can cause fetal harm. Use effective contraception.","Immunosuppression: Avoid live vaccines. Avoid contact with infected individuals.","Renal impairment: Dose adjustment may be needed.","Hepatic impairment: Use with caution."]
🤱 Lactation Safety
It is not known whether temozolomide is excreted in human milk. Because of the potential for serious adverse reactions in nursing infants, breastfeeding should be discontinued during treatment and for at least 1 week after the last dose.
💊 Overdose Management
There is no known antidote for temozolomide overdose. In case of overdose, discontinue the medicine and provide supportive care. Monitor blood counts and liver function closely. Contact a poison control center or emergency department immediately.
⏰ Missed Dose
If you miss a dose of this medicine, take it as soon as you remember if it is within a few hours of the scheduled time. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed dose. Contact your doctor if you are unsure.
Additional Safety Advice
This medicine must only be taken under the supervision of a qualified oncologist. Do not adjust your dose without medical advice. You should have regular blood tests to monitor your blood cell counts, liver function, and kidney function. Avoid contact with people who have infections, and practice good hygiene. This medicine can harm an unborn baby; use effective contraception during treatment and for a period after stopping. Do not breastfeed while taking this medicine. Avoid driving or operating heavy machinery if you feel tired or dizzy. Do not receive live vaccines without consulting your doctor. Store this medicine at room temperature away from moisture and heat. Keep out of reach of children.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients may be more susceptible to side effects, especially myelosuppression. Close monitoring and dose adjustments are recommended.
🤰 Pregnancy Planning (TTC)
This medicine can cause fetal harm. Women of childbearing potential should use effective contraception during treatment and for at least 6 months after stopping. Men should use contraception for at least 3 months after stopping. Consult your doctor if you are planning pregnancy.
🏥 Post-Surgery Considerations
After surgery, this medicine may be started once you have recovered adequately. Your doctor will determine the appropriate timing based on your healing and overall health.
🦷 Dental Procedures
Inform your dentist that you are taking this medicine before any dental procedure. You may be at increased risk of bleeding or infection. Your dentist may recommend precautions.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
This medicine can cause fatigue and dizziness. Avoid strenuous exercise until you know how the medicine affects you. Consult your doctor before starting any exercise program.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause fatigue, dizziness, and difficulty concentrating. Avoid driving or operating heavy machinery until you know how it affects you. You may need to adjust your work schedule or take time off during treatment cycles.
🛑 When to Stop This Medicine
Do not stop taking this medicine without consulting your doctor. Stopping early may allow the cancer to progress. Your doctor will decide when to stop based on your response and side effects.
📅 Long-Term Use Effects
Long-term use of this medicine may increase the risk of secondary cancers, bone marrow suppression, and liver toxicity. Regular monitoring of blood counts, liver function, and kidney function is essential. Patients should be followed up regularly to detect any late effects.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Often used in combination with this medicine for brain tumors.
Evidence: Well-establishedMay be used to remove as much tumor as possible before chemotherapy.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
Live vaccines should be avoided during treatment with this medicine due to the risk of infection. Inactivated vaccines may be given, but their effectiveness may be reduced. Consult your doctor before any vaccination.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not refrigerate
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✈️ Traveling with This Medicine
When traveling, carry this medicine in its original packaging with the prescription label. Bring a copy of your prescription and a letter from your doctor explaining the medical need. Keep the medicine in your carry-on luggage to avoid temperature extremes. Store at room temperature and avoid direct sunlight. If crossing time zones, consult your doctor about adjusting the dosing schedule. Check customs regulations for controlled substances.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The effects of this medicine on tumor growth may take several weeks to become apparent. Your doctor will monitor your response with regular scans.
A: No, this medicine should be taken on an empty stomach to ensure proper absorption.
A: If you miss a dose, take it as soon as you remember if it is within a few hours. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double dose.
🤔 Common Patient Concerns
🔄 Substitutes for axiotem 100 capsule
View AllAlternative brands with exact same active ingredient:
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tabze 100mg tabletNeon Laboratories Ltd ₹1,546.41 84.1% CHEAPER
-
gliotem 100mg capsuleSun Pharmaceutical Industries Ltd ₹1,584.05 83.7% CHEAPER
-
temotide 100mg tabletRPG Life Sciences Ltd ₹2,343.00 75.9% CHEAPER
-
temoside 100 capsuleCipla Ltd ₹3,276.00 66.2% CHEAPER
-
Temospan 100 CapsuleVerve Biosciences Pvt Ltd ₹3,500.00 63.9% CHEAPER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure brain cancer completely.
Fact: This medicine is used to treat brain tumors but does not guarantee a cure. It helps control tumor growth and prolong survival. - Myth: You can stop taking this medicine once you feel better.
Fact: You must complete the full course as prescribed by your doctor. Stopping early can allow the cancer to return. - Myth: This medicine has no serious side effects.
Fact: This medicine can cause serious side effects, including low blood cell counts and liver problems. Regular monitoring is essential.
🔄 Alternative Options
Generic Alternatives
- Temozolomide
Brand Alternatives
- Temodar
- Temodal