axioff tz 50mg/150mg suspension - Uses, Price, Side Effects & Substitutes
What is axioff tz 50mg/150mg suspension used for?
Aflox TZ 200mg/600mg Tablet (Ofloxacin + Tinidazole) is used to treat GASTRO INTESTINAL. It contains Ofloxacin (50mg) + Tinidazole (150mg), which Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA rep. Always consult your doctor before use. Take as prescribed.
- Generic Name: Ofloxacin + Tinidazole
- Manufacturer: Axis Life Science Pvt Ltd
- Form: Allopathy
- Pregnancy Category: A
- Prescription Required: Yes
๐ axioff tz 50mg/150mg suspension Uses & Benefits
Gastrointestinal infections (diarrhea, dysentery, giardiasis, amebiasis), intra-abdominal infections, mixed infections
Off-label uses: Helicobacter pylori eradication (in combination), pelvic inflammatory disease
๐ Drug Information
| Generic Name(s) | Ofloxacin + Tinidazole |
| Brand Name | Aflox TZ 200mg/600mg Tablet |
| Manufacturer | Axis Life Science Pvt Ltd |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GASTRO INTESTINAL |
| Action Class | Antibiotic + Antiprotozoal |
| Route of Administration | Oral |
| Storage | Store at room temperature (20-25ยฐC), protect from light and moisture |
| Shelf Life | As per manufacturer |
๐ฌ Pharmacology (PK/PD)
Pharmacokinetics
How It Works
Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication; Tinidazole enters cells and causes DNA damage via nitro radical formation
Mechanism Steps
๐ก How to Take axioff tz 50mg/150mg suspension
Follow your doctor's prescription exactly.
โ ๏ธ Side Effects of axioff tz 50mg/150mg suspension
โ Common Side Effects
- Nausea
- Vomiting
- Diarrhea
- Headache
- Dizziness
- Metallic taste
- Abdominal pain
๐จ Serious Side Effects
- Tendon rupture
- Peripheral neuropathy
- QT prolongation
- Seizures
- Clostridium difficile colitis
- Severe hypersensitivity reactions
โ ๏ธ Rare Side Effects
- Blood dyscrasias
- Hepatotoxicity
- Stevens-Johnson syndrome
- Anaphylaxis
- Pseudomembranous colitis
Consult your doctor if you experience any unusual symptoms.
๐ฌ Drug Interactions
| โ ๏ธ Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | Increased INR and bleeding risk |
| Antidiabetic agents | Major | Hypoglycemia |
| QT prolonging drugs | Major | Increased risk of arrhythmias |
| NSAIDs | Major | Increased CNS stimulation and seizure risk |
| Theophylline | Moderate | Increased theophylline levels |
| Caffeine | Moderate | Reduced caffeine clearance |
| Cyclosporine | Moderate | Increased nephrotoxicity |
| Methotrexate | Moderate | Increased methotrexate toxicity |
| Antacids | Minor | Reduced absorption of ofloxacin |
| Sucralfate | Minor | Reduced absorption of ofloxacin |
| Iron supplements | Minor | Reduced absorption of ofloxacin |
| Zinc | Minor | Reduced absorption of ofloxacin |
๐จ Major Interactions
- Warfarin
- Antidiabetic agents
- QT prolonging drugs
- NSAIDs
โก Moderate Interactions
- Theophylline
- Caffeine
- Cyclosporine
- Methotrexate
โน๏ธ Minor Interactions
- Antacids
- Sucralfate
- Iron supplements
- Zinc
๐ฝ๏ธ Food Interactions
Avoid dairy products, calcium-fortified juices, and antacids within 2-4 hours; food delays absorption but does not affect extent
๐ท Alcohol Interaction
Avoid alcohol during and for 3 days after therapy due to disulfiram-like reaction with tinidazole
๐ก๏ธ Safety & Warnings
๐ซ Contraindications
Hypersensitivity to fluoroquinolones or nitroimidazoles, pregnancy, lactation, history of tendon disorders with quinolones, epilepsy, blood dyscrasias
๐ Monitoring Parameters
Renal function, hepatic function, blood glucose (in diabetics), ECG (if risk factors for QT prolongation), signs of tendonitis or neuropathy
๐คฑ Lactation Safety
Contraindicated; excreted in breast milk
๐ Overdose Management
Symptomatic and supportive; no specific antidote; hemodialysis may remove tinidazole
โฐ Missed Dose
Take as soon as remembered; if near next dose, skip missed dose; do not double dose