Awnacef SB 1gm/500mg Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing, wheezing, or swelling of the face, lips, or throat
- Severe, watery, or bloody diarrhea with fever or abdominal cramps
- Rash that spreads rapidly or involves blistering or peeling skin
- Decreased urine output or swelling in the legs or feet
- Yellowing of the skin or eyes (jaundice)
- Severe abdominal pain radiating to the back
- Unusual bleeding or bruising
- Seizures or confusion
If experiencing severe symptoms, call emergency services immediately.
What is awnacef sb 1gm/500mg injection used for?
This medicine is a combination antibiotic injection containing ceftriaxone and sulbactam. It is used to treat serious bacterial infections such as pneumonia, urinary tract infections, and sepsis. It works by killing bacteria and blocking their defense enzymes. It must be given by a healthcare professional.
- Generic Name: Ceftriaxone (1gm) + Sulbactam (500mg)
- Manufacturer: Shawn & Co
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 awnacef sb 1gm/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्ट्रिएक्सोन और सल्बैक्टम का संयोजन है, जिसे इंजेक्शन के रूप में दिया जाता है। यह गंभीर बैक्टीरियल संक्रमणों जैसे निमोनिया, मूत्र मार्ग संक्रमण, पेट के अंदर के संक्रमण, त्वचा संक्रमण, मेनिनजाइटिस और सेप्सिस के इलाज के लिए उपयोग किया जाता है। यह बैक्टीरिया को मारता है और उनके रक्षा एंजाइमों को रोकता है। यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन स्थल पर दर्द, दस्त, मतली, उल्टी, दाने और लीवर एंजाइम में वृद्धि शामिल हैं। गंभीर दुष्प्रभावों में एलर्जी प्रतिक्रिया, गंभीर दस्त, त्वचा पर गंभीर प्रतिक्रिया और खून की समस्या हो सकती है। यदि आपको सांस लेने में कठिनाई, चेहरे पर सूजन, या गंभीर दस्त हो तो तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर की देखरेख में ही दी जानी चाहिए। इससे पहले कि आपको यह इंजेक्शन दिया जाए, अपने डॉक्टर को पेनिसिलिन या सेफलोस्पोरिन से एलर्जी के बारे में बताएं। अपने डॉक्टर को अपनी सभी दवाओं के बारे में बताएं, खासकर खून पतला करने वाली दवाएं। इलाज के दौरान शराब न पिएं। पूरा कोर्स पूरा करें भले ही आप बेहतर महसूस करें।
💊 awnacef sb 1gm/500mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used for moderate to severe community-acquired pneumonia requiring hospitalization or parenteral therapy.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Effective against many gram-negative bacteria causing pyelonephritis and complicated urinary tract infections.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used in combination with anaerobic coverage for intra-abdominal infections such as peritonitis and abscesses.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Treats severe cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Bacterial meningitis","description":"Ceftriaxone is a preferred agent for many causes of bacterial meningitis when used at appropriate high doses.","evidence":"Well-established"},{"condition":"Sepsis and bacteremia","description":"Used empirically in sepsis while awaiting culture results, with adjustment based on susceptibility.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Ceftriaxone is a first-line treatment for uncomplicated gonorrhea, though sulbactam adds no benefit for this indication.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in certain surgical procedures","description":"Sometimes used for surgical prophylaxis in patients with beta-lactam allergy or specific institutional protocols.","evidence":"Limited"},{"condition":"Lyme disease with neurologic involvement","description":"Ceftriaxone is used off-label for late Lyme disease with neurologic manifestations.","evidence":"Moderate"}]
Primary treatment for: Bacterial infections
Also treats: Pneumonia, Urinary tract infections, Intra-abdominal infections, Skin infections, Meningitis, Sepsis, Gonorrhea
📋 Drug Information
| Generic Name(s) | Ceftriaxone (1gm) + Sulbactam (500mg) |
| Brand Name | awnacef sb 1gm/500mg injection |
| Manufacturer | Shawn & Co |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | |
| Route of Administration | Parenteral (intravenous or intramuscular injection) |
| Storage | Store the unreconstituted powder at room temperature between 20°C and 25°C (68°F to 77°F). Protect from light and moisture. After reconstitution, the solution should be used within the time specified by the manufacturer, typically within 6 hours at room temperature or 24 hours if refrigerated. Do not freeze. |
| Shelf Life | The shelf life of the unreconstituted product is typically 24 to 36 months from the date of manufacture, depending on the manufacturer. Check the expiry date on the packaging before use. |
| WHO Guideline | The World Health Organization includes ceftriaxone in its Model List of Essential Medicines for the treatment of various bacterial infections, including pneumonia, meningitis, and gonorrhea. The combination with sulbactam is not specifically listed by WHO, but ceftriaxone-sulbactam is used in some regions. |
| ICMR Guideline | The Indian Council of Medical Research has published treatment guidelines for antimicrobial use in various infections. Ceftriaxone-sulbactam is included in some institutional protocols for empirical therapy of hospital-acquired infections, but specific ICMR recommendations should be consulted. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
Ceftriaxone inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins, preventing peptidoglycan cross-linking and causing bacterial lysis. Sulbactam is a beta-lactamase inhibitor that irreversibly binds to certain beta-lactamase enzymes, protecting ceftriaxone from enzymatic degradation and extending its spectrum against beta-lactamase-producing bacteria.
Mechanism Steps
💡 How to Take awnacef sb 1gm/500mg injection
Strength: Each vial contains ceftriaxone sodium equivalent to 1 gram of ceftriaxone and sulbactam sodium equivalent to 500 mg of sulbactam.
Dosage Information
| Adult Dosage | The usual adult dose of this medicine is 1 gram of ceftriaxone combined with 500 mg of sulbactam administered intravenously or intramuscularly every 12 hours, but dosing varies widely based on the type and severity of infection. For severe infections such as meningitis, higher doses may be used. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician for appropriate dosing in children. |
| Elderly Dosage | Elderly patients may have reduced renal function and should be monitored closely. Dose adjustment may be necessary based on creatinine clearance. No specific dose reduction is required solely based on age, but individualization by a clinician is essential. |
| Renal Impairment | In patients with renal impairment, dose adjustment may be required. For creatinine clearance less than 10 mL/min, the daily dose of ceftriaxone should not exceed 2 grams. Sulbactam dosing should also be adjusted based on renal function. Consult a clinician for specific recommendations. |
| Hepatic Impairment | In patients with hepatic impairment, no specific dose adjustment is generally required for ceftriaxone, but monitoring of liver enzymes is advised. Sulbactam pharmacokinetics may be altered; use with caution and individualize dosing. |
| Maximum Daily Dose | The maximum daily dose of ceftriaxone is generally 4 grams, but in severe infections such as meningitis, up to 4 grams per day may be used. Sulbactam maximum daily dose is typically 4 grams. Doses must be individualized by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of awnacef sb 1gm/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Calcium-containing IV solutions | Major | |
| Aminoglycosides | Major | |
| Loop diuretics | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Methotrexate | Minor | |
| Chloramphenicol | Minor |
🚨 Major Interactions
- Warfarin
- Calcium-containing intravenous solutions
- Aminoglycosides
⚡ Moderate Interactions
- Loop diuretics
- Probenecid
- Oral contraceptives
🍷 Alcohol Interaction
Alcohol should be avoided while receiving this medicine because it can increase the risk of liver toxicity and may worsen side effects such as nausea, dizziness, and gastrointestinal upset. It is best to abstain from alcohol during the entire course of treatment and for a few days after.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe hypersensitivity to ceftriaxone, sulbactam, or any beta-lactam antibiotic","History of anaphylaxis to penicillins or cephalosporins","Neonates with hyperbilirubinemia or receiving calcium-containing IV solutions","Concurrent use with calcium-containing intravenous solutions in neonates"]
⚠️ Warnings & Precautions
["Serious and occasionally fatal hypersensitivity reactions can occur. Discontinue immediately if allergic reaction develops.","Clostridioides difficile-associated diarrhea may occur during or after treatment. Do not treat with antiperistaltic agents.","Use with caution in patients with renal impairment; dose adjustment may be needed.","Use with caution in patients with hepatic impairment; monitor liver enzymes.","May cause gallbladder sludge or pseudolithiasis, especially in children; usually reversible.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi.","Do not mix with calcium-containing solutions due to risk of precipitation.","May interfere with certain laboratory tests, including urine glucose and Coombs test."]
🤱 Lactation Safety
Ceftriaxone is excreted in human milk in low concentrations and is generally considered compatible with breastfeeding. Sulbactam also passes into breast milk in small amounts. Consult your doctor before breastfeeding while receiving this medicine, and monitor the infant for diarrhea or thrush.
💊 Overdose Management
Overdose of this medicine is unlikely in clinical settings because it is administered by healthcare professionals. If accidental overdose occurs, treatment is supportive and symptomatic. Monitor vital signs, renal function, and liver function. There is no specific antidote. Ceftriaxone and sulbactam are not significantly removed by hemodialysis, though dialysis may be considered in severe cases with renal failure.
⏰ Missed Dose
If you miss a scheduled dose of this medicine, contact your healthcare provider as soon as possible. Do not attempt to self-administer a double dose. Your provider will advise whether to reschedule the missed dose or adjust the timing of the next dose. It is important to maintain the prescribed dosing schedule to ensure effective treatment.
Additional Safety Advice
This medicine must be given only under medical supervision. Inform your doctor about any allergy to penicillin or cephalosporin antibiotics before receiving this medicine. Tell your clinician about all other medicines you take, especially blood thinners, because this medicine can increase bleeding risk. Do not attempt to self-administer this injection. If you develop severe diarrhea, skin rash, facial swelling, or breathing difficulty, seek emergency care immediately. Your kidney and liver function may need monitoring during treatment, especially if you have existing kidney or liver disease. Complete the full course as prescribed even if you feel better, to prevent resistance and relapse.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Elderly patients are more likely to have reduced kidney function and may require dose adjustment. They should be monitored closely for side effects and signs of toxicity.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant, discuss with your doctor before starting this medicine. It is generally considered safe, but the need for the medicine should be clearly established.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to prevent or treat surgical site infections. Follow your surgeon's instructions regarding dosing and duration.
🦷 Dental Procedures
Inform your dentist if you are receiving this medicine, as it may interact with other medications used during dental procedures. No specific precautions are typically required.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While receiving this medicine, you may feel tired or weak. Avoid strenuous exercise until you have recovered from the infection. Light activities like walking are fine if you feel up to it. Consult your doctor before resuming intense workouts.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause dizziness or fatigue in some people. Avoid driving or operating heavy machinery if you feel unwell. You may need to take time off work to receive the injections and recover from the infection.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. Stopping early can lead to relapse and antibiotic resistance. Your doctor will determine when to stop based on your clinical response and culture results.
📅 Long-Term Use Effects
Long-term use of this medicine may lead to antibiotic resistance, fungal overgrowth, and rarely, liver or kidney problems. Prolonged therapy should be monitored with regular blood tests. It is important to use this medicine only for the prescribed duration and indication.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
For mild infections, oral antibiotics may be used instead of injections.
Evidence: Well-establishedDepending on the causative organism and susceptibility, other antibiotics like piperacillin-tazobactam or cefepime may be used.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with vaccines. However, if you are due for a vaccine, inform your doctor, as the timing may need to be adjusted if you are acutely ill.
📦 Storage Guide
✅ DO
Store at room temperature (20-25°C)
❌ DON'T
Do not freeze
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Protect from light and moisture
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Use reconstituted solution within the specified time
❌ DON'T
Do not use if solution is cloudy or contains particles
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label intact. Bring a copy of your prescription and a doctor's letter explaining the medical need. Keep the unreconstituted vials at room temperature and protect them from extreme heat or cold. If traveling across time zones, consult your doctor about adjusting the dosing schedule. Declare the medicine at customs if required and check local regulations regarding injectable antibiotics.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start feeling better within 24 to 48 hours after starting this medicine, but it is important to complete the full course as prescribed.
A: No, this medicine is available only as an injection and must be given by a healthcare professional.
A: Mild diarrhea is common. However, if it is severe, bloody, or accompanied by fever or abdominal cramps, contact your doctor immediately.
A: It is generally considered safe when clearly needed, but you should consult your doctor to weigh the benefits and risks.
🤔 Common Patient Concerns
🔄 Substitutes for awnacef sb 1gm/500mg injection
View AllAlternative brands with exact same active ingredient:
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cefinec-s injectionSolveig Lifesciences ₹58.62 45.6% CHEAPER
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marxone injectionMRG Biotech Pvt Ltd ₹103.00 4.5% CHEAPER
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cefiton-s 1gm/500mg injectionBiotrendz Medicaments ₹103.62 3.9% CHEAPER
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xetra-s 1gm/500mg injectionBaxton Pharmacia ₹142.00 31.7% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure viral infections like the flu.
Fact: This medicine is an antibiotic and only works against bacterial infections. It is ineffective against viruses. - Myth: You can stop the injection as soon as you feel better.
Fact: You must complete the full course as prescribed to prevent relapse and antibiotic resistance. - Myth: This medicine is safe to self-administer at home.
Fact: This injection must be given by a trained healthcare professional due to risks of allergic reactions and improper administration.
🔄 Alternative Options
Generic Alternatives
- Ceftriaxone and sulbactam injection (generic)
Brand Alternatives
- Monocef-SB
- Intacef-SB
- Oframax-SB
- Cefaxone-SB