Cefinec-S Injection: Complete Medicine Guide
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Swelling of the face, lips, or throat, or difficulty breathing
- Widespread rash, skin blisters, or peeling skin
- Watery or bloody diarrhea, fever, or severe stomach cramps
- Yellowing of the eyes or skin, dark urine, or severe abdominal pain
- Decreased urine output or swelling of the legs
- Seizure or unusual confusion
- Severe pain, redness, or swelling at the injection site
- Persistent high fever that does not improve after 48 to 72 hours of treatment
If experiencing severe symptoms, call emergency services immediately.
What is cefiton-s 1gm/500mg injection used for?
This medicine is an intravenous antibiotic combining ceftriaxone and sulbactam. It is used to treat moderate to severe bacterial infections, including pneumonia, urinary tract infections, and skin infections. It works by killing bacteria and protecting ceftriaxone from resistance enzymes. It must be given by a healthcare professional and should not be used for viral infections.
- Generic Name: Ceftriaxone + Sulbactam
- Manufacturer: Biotrendz Medicaments
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 cefiton-s 1gm/500mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा सेफ्ट्रिएक्सोन और सल्बैक्टम का संयोजन है, जो एक इंजेक्शन के रूप में नस के माध्यम से दी जाती है। यह मध्यम से गंभीर बैक्टीरियल संक्रमणों के इलाज के लिए उपयोग की जाती है, जैसे निमोनिया, मूत्र मार्ग का संक्रमण, पेट के अंदर का संक्रमण, त्वचा का संक्रमण, और खून का संक्रमण। यह दवा बैक्टीरिया की कोशिका भित्ति को तोड़कर उन्हें मार देती है, और सल्बैक्टम उन एंजाइमों को रोकता है जो सेफ्ट्रिएक्सोन को नष्ट कर सकते हैं। यह दवा वायरल संक्रमण जैसे सर्दी-जुकाम या फ्लू के लिए नहीं है। यह केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। अपने डॉक्टर को अपनी सभी एलर्जी और दवाओं के बारे में बताएं।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन की जगह पर दर्द, लालिमा या सूजन, दस्त, जी मिचलाना, उल्टी, हल्का दाना, और सिरदर्द शामिल हैं। ये आमतौर पर हल्के होते हैं और इलाज जारी रखने पर ठीक हो जाते हैं। गंभीर दुष्प्रभाव कम होते हैं लेकिन तुरंत ध्यान देने योग्य हैं, जैसे चेहरे, होंठ या गले में सूजन, सांस लेने में कठिनाई, त्वचा पर छाले या परत उतरना, खूनी दस्त, पीलिया, पेशाब कम आना, या दौरे पड़ना। अगर आपको इनमें से कोई भी लक्षण दिखे तो तुरंत डॉक्टर को बताएं।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या नर्स द्वारा अस्पताल या क्लिनिक में ही दी जानी चाहिए। इसे घर पर खुद न लगाएं। पहली खुराक से पहले अपने डॉक्टर को अपनी सभी एलर्जी, खासकर पेनिसिलिन या सेफलोस्पोरिन से एलर्जी, और पहले हुए किसी भी इंजेक्शन रिएक्शन के बारे में बताएं। अगर आप गर्भवती हैं, गर्भधारण की योजना बना रही हैं, या स्तनपान करा रही हैं, तो डॉक्टर को बताएं। अपनी सभी दवाओं के बारे में जानकारी दें, खासकर खून पतला करने वाली दवाएं, दर्द निवारक, और पानी की गोलियां। इस दवा को कैल्शियम युक्त इंट्रावेनस तरल पदार्थों के साथ एक ही लाइन में न मिलाएं। अगर आपको किडनी या लीवर की बीमारी है या दौरे पड़ते हैं, तो डॉक्टर को बताएं। पूरा कोर्स पूरा करें, भले ही आप बेहतर महसूस करें। कोई भी नया दस्त, दाना, सूजन या सांस लेने में तकलीफ हो तो तुरंत बताएं।
💊 cefiton-s 1gm/500mg injection Uses & Benefits
[{"condition":"Community-acquired pneumonia","description":"Used to treat moderate to severe pneumonia caused by susceptible bacteria, often when patients need hospital care or injectable therapy.","evidence":"Well-established"},{"condition":"Complicated urinary tract infections","description":"Used for kidney and complicated bladder infections caused by susceptible bacteria, especially when oral therapy is not suitable.","evidence":"Well-established"},{"condition":"Intra-abdominal infections","description":"Used as part of treatment for infections such as peritonitis and intra-abdominal abscesses, often combined with surgical drainage.","evidence":"Well-established"},{"condition":"Skin and soft tissue infections","description":"Used for serious cellulitis, abscesses, and wound infections caused by susceptible organisms.","evidence":"Well-established"},{"condition":"Bloodstream infections","description":"Used for bacteremia and sepsis caused by susceptible bacteria, usually in hospital settings with close monitoring.","evidence":"Well-established"},{"condition":"Bone and joint infections","description":"Used for osteomyelitis and septic arthritis caused by susceptible bacteria, often as part of a longer treatment plan.","evidence":"Well-established"},{"condition":"Meningitis","description":"Used for bacterial meningitis caused by susceptible organisms, with dose and duration determined by the clinical team.","evidence":"Well-established"},{"condition":"Gonorrhea","description":"Ceftriaxone is a recommended treatment for uncomplicated gonorrhea; sulbactam is added in this product for broader beta-lactamase coverage in some settings.","evidence":"Well-established"}]
Off-label uses: [{"condition":"Prophylaxis in certain surgical procedures","description":"Sometimes used before surgery to prevent infection when standard agents are not suitable, based on local guidelines and patient factors.","evidence":"Limited"},{"condition":"Lyme disease with neurological involvement","description":"Ceftriaxone may be used in selected patients with Lyme neuroborreliosis when other options are not appropriate.","evidence":"Limited"}]
Primary treatment for: Bacterial infections caused by susceptible organisms
Also treats: Community-acquired pneumonia, Complicated urinary tract infections, Intra-abdominal infections, Skin and soft tissue infections, Bloodstream infections, Bone and joint infections, Meningitis, Gonorrhea
📋 Drug Information
| Generic Name(s) | Ceftriaxone + Sulbactam |
| Brand Name | Accuzon Plus 1.5gm Injection |
| Manufacturer | Biotrendz Medicaments |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | ANTI INFECTIVES |
| Action Class | Cephalosporin + Beta-lactamase inhibitor |
| Route of Administration | Intravenous (into a vein) after reconstitution, given as a slow infusion or injection by a healthcare professional |
| Storage | Store the unreconstituted powder at room temperature between 15°C and 30°C, away from direct sunlight and moisture. After reconstitution, use the solution within the time recommended by the manufacturer, usually within a few hours if kept at room temperature or up to 24 hours if refrigerated. Do not freeze. Keep out of reach of children. |
| Shelf Life | The shelf life of the unreconstituted powder is typically 24 months from the date of manufacture, but you should always check the expiry date on the pack. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information for this specific combination product. Ceftriaxone is included in World Health Organization guidance for several infections, but the addition of sulbactam is not specifically addressed in all guidelines. |
| ICMR Guideline | Not established from the available information for this specific combination product. Indian Council of Medical Research guidance may recommend ceftriaxone for certain infections, but the combination with sulbactam should be used according to local hospital protocols and susceptibility data. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine combines two active ingredients. Ceftriaxone is a third-generation cephalosporin antibiotic that binds to penicillin-binding proteins in the bacterial cell wall and blocks the final step of peptidoglycan cross-linking. This weakens the bacterial cell wall, causing the bacteria to burst and die. Sulbactam is a beta-lactamase inhibitor that binds irreversibly to many beta-lactamase enzymes produced by bacteria. By blocking these enzymes, sulbactam protects ceftriaxone from being destroyed, allowing it to reach its target and kill bacteria that would otherwise be resistant. The combination is bactericidal against many gram-positive and gram-negative organisms, including some beta-lactamase-producing strains.
Mechanism Steps
💡 How to Take cefiton-s 1gm/500mg injection
Strength: This product is a powder for injection containing ceftriaxone 1 g and sulbactam 500 mg per vial, to be reconstituted and given intravenously.
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the type and severity of infection, the patient's kidney and liver function, and other factors. A common adult dose of ceftriaxone is 1 g to 2 g given intravenously once daily, with sulbactam added at a dose determined by the prescribed product. For severe infections such as meningitis, higher doses may be used. Treatment duration varies from a few days to several weeks depending on the infection. Dose must be individualized by a qualified clinician based on indication, age, weight, renal and hepatic function. |
| Pediatric Dosage | Pediatric dosing is not established from available information for this specific combination product. Ceftriaxone is used in children for many infections, but the dose depends on weight, age, and the type of infection, and sulbactam use in children is limited. Consult a pediatrician for appropriate dosing. |
| Elderly Dosage | Older adults may need a lower dose or longer dosing interval if kidney function is reduced. Kidney function should be checked before and during treatment, and the dose must be individualized by a qualified clinician. |
| Renal Impairment | In patients with kidney impairment, the dose of ceftriaxone usually does not need adjustment for mild to moderate impairment, but sulbactam may accumulate and require dose reduction. In severe kidney impairment, the dose and interval should be adjusted based on creatinine clearance, and kidney function should be monitored closely. Dose must be individualized by a qualified clinician. |
| Hepatic Impairment | In patients with liver impairment, ceftriaxone elimination may be prolonged, and the dose may need adjustment. Sulbactam is mainly excreted by the kidneys, so liver impairment alone may not require a change in sulbactam dose. Liver function should be monitored, and the dose must be individualized by a qualified clinician. |
| Maximum Daily Dose | The maximum daily dose depends on the infection being treated and the patient's kidney and liver function. For ceftriaxone, doses above 4 g per day are not usually recommended. Sulbactam maximum daily doses also depend on the product and patient factors. The exact maximum dose must be determined by a qualified clinician. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of cefiton-s 1gm/500mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Calcium-containing IV solutions | Major | |
| Warfarin | Major | |
| Aminoglycosides | Major | |
| Chloramphenicol | Major | |
| Loop diuretics | Moderate | |
| Probenecid | Moderate | |
| Oral contraceptives | Moderate | |
| Methotrexate | Moderate | |
| Antacids | Minor | |
| Iron supplements | Minor |
🚨 Major Interactions
- Calcium-containing intravenous solutions (for example, Ringer's lactate or Hartmann's solution)
- Warfarin and other vitamin K antagonists
- Aminoglycosides (for example, gentamicin or amikacin)
- Chloramphenicol
⚡ Moderate Interactions
- Loop diuretics (for example, furosemide)
- Probenecid
- Oral contraceptives
- Methotrexate
🍷 Alcohol Interaction
Alcohol does not directly interact with this medicine, but drinking alcohol while you have a serious infection can worsen dehydration, interfere with recovery, and increase the risk of liver strain. It is best to avoid alcohol until you have fully recovered and your doctor says it is safe.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known severe allergy to ceftriaxone, sulbactam, other cephalosporins, or penicillins","Previous severe allergic reaction to any beta-lactam antibiotic","Use in neonates with jaundice or who are receiving intravenous calcium-containing solutions","Use in patients with known severe kidney or liver impairment without appropriate dose adjustment and monitoring","Use in patients with a history of serious skin reactions to antibiotics"]
⚠️ Warnings & Precautions
["This medicine must only be given by a qualified healthcare professional in a setting where allergic reactions can be managed.","Do not mix this medicine with calcium-containing intravenous solutions in the same line because a precipitate can form.","Tell your doctor about all your allergies before receiving this medicine.","Use with caution in patients with kidney disease, liver disease, or a history of seizures.","Prolonged use may lead to overgrowth of non-susceptible organisms, including fungi, and may cause Clostridioides difficile-associated diarrhea.","This medicine may interact with blood thinners, so tell your doctor if you take warfarin or similar medicines.","Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding.","Do not stop treatment early even if you feel better, because the infection may return and resistance may develop."]
🤱 Lactation Safety
Ceftriaxone and sulbactam pass into breast milk in small amounts. They are generally considered compatible with breastfeeding, but you should inform your doctor if you are breastfeeding. Watch the baby for diarrhea, thrush, or rash, and seek medical advice if these occur.
💊 Overdose Management
Overdose with this medicine is unlikely because it is given by a healthcare professional. If too much is given, treatment is supportive and focuses on monitoring vital signs, kidney function, liver function, and blood counts. There is no specific antidote. In case of accidental overdose, contact a doctor or poison control center immediately. Hemodialysis does not remove ceftriaxone effectively but may remove sulbactam.
⏰ Missed Dose
Because this medicine is given by a healthcare professional, missed doses are managed by the clinical team. If you miss an appointment for your dose, contact your doctor or clinic as soon as possible to reschedule. Do not try to take a double dose to make up for a missed one. Your doctor will decide the best way to continue your treatment schedule.
Additional Safety Advice
This medicine must only be given by a doctor or nurse in a clinic or hospital setting. Do not attempt to self-administer it at home. Before the first dose, tell your doctor about all your allergies, especially to penicillin or cephalosporin antibiotics, and about any previous reaction to an injection. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding. Tell your doctor about all other medicines you take, including blood thinners, pain relievers, and water pills, because some combinations can increase the risk of bleeding or kidney problems. Do not mix this medicine with calcium-containing intravenous fluids such as Ringer's lactate or Hartmann's solution in the same line, because a precipitate can form. If you have kidney disease, liver disease, or a history of seizures, your doctor may adjust the dose or monitor you more closely. Complete the full course prescribed even if you feel better after a few doses, because stopping early can allow the infection to return and can promote antibiotic resistance. Report any new diarrhea, rash, swelling, or difficulty breathing immediately. Keep all follow-up appointments so your doctor can check your response and adjust treatment if needed.
👴 Special Considerations for Elderly
💡 For Patients Above 65
Older adults are more likely to have reduced kidney function, which can affect how this medicine is cleared from the body. The dose may need to be adjusted, and kidney function should be monitored. Older adults may also be more prone to confusion, falls, or diarrhea during treatment. Close monitoring is advised.
🤰 Pregnancy Planning (TTC)
If you are planning pregnancy, tell your doctor before starting this medicine. Ceftriaxone and sulbactam are generally considered acceptable in pregnancy when needed, but the decision should be made with your doctor after weighing the benefits and risks. If you become pregnant during treatment, contact your doctor right away.
🏥 Post-Surgery Considerations
This medicine may be used after surgery to treat or prevent infection. If you have had surgery, your doctor will decide the dose and duration based on the type of surgery and your risk of infection. Follow your surgeon's instructions about wound care and follow-up.
🦷 Dental Procedures
Tell your dentist if you are receiving this medicine or have recently received it. In some cases, your dentist may need to coordinate with your doctor, especially if you are taking blood thinners or have a history of allergies to antibiotics. This medicine is not usually used for routine dental infections unless they are severe.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While you are recovering from a serious infection, avoid strenuous exercise until your doctor says it is safe. Light activity such as short walks may be helpful if you feel up to it. If you feel dizzy, short of breath, or very tired, stop and rest. Ask your doctor when you can return to your normal exercise routine.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine is given in a hospital or clinic, so you may need time off work during treatment. You may feel tired or dizzy, so avoid driving or operating heavy machinery until you know how the medicine affects you. Ask your doctor when you can return to work and normal activities.
🛑 When to Stop This Medicine
Do not stop this medicine on your own. Your doctor will decide when to stop based on your response to treatment, the type of infection, and your test results. If you develop serious side effects such as a severe allergic reaction, severe diarrhea, or signs of liver or kidney problems, your doctor may stop the medicine and change your treatment.
📅 Long-Term Use Effects
Long-term use of this medicine can increase the risk of antibiotic resistance, fungal infections, and Clostridioides difficile-associated diarrhea. Rarely, it can cause blood, liver, or kidney problems. If you need treatment for more than a few weeks, your doctor will monitor your blood counts, kidney function, and liver function regularly. Do not use this medicine for longer than prescribed without medical advice.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Once you improve, your doctor may switch you to oral antibiotics to complete the course.
Evidence: Well-establishedDepending on the bacteria and your allergies, other antibiotics such as piperacillin-tazobactam or cefepime may be used.
Evidence: Well-establishedRest, fluids, and fever control are important along with antibiotics.
Evidence: Well-established💉 Vaccination Considerations
💉 If You're Getting Vaccinated
This medicine does not interact with most vaccines, but if you are due for a live vaccine, tell your doctor. Antibiotics generally do not prevent you from receiving vaccines, but your doctor may advise timing based on your illness and treatment.
📦 Storage Guide
✅ DO
Store the unreconstituted powder at room temperature between 15°C and 30°C.
❌ DON'T
Do not freeze the powder or the reconstituted solution.
✅ DO
Keep the vial in its original carton to protect it from light and moisture.
❌ DON'T
Do not transfer the powder to another container.
✅ DO
Use the reconstituted solution within the time recommended by the manufacturer.
❌ DON'T
Do not use the solution if it is cloudy or contains particles.
✅ DO
Keep out of reach of children.
❌ DON'T
Do not store in a bathroom cabinet or near heat sources.
✈️ Traveling with This Medicine
This medicine is given in a hospital or clinic, so travel planning should be discussed with your doctor. If you need to travel while on treatment, carry a copy of your prescription and a letter from your doctor explaining the medicine and the reason for it. Keep the medicine in its original packaging and store it as directed. If you are traveling across time zones, ask your doctor how to adjust the timing of your doses. Check the laws of your destination country about carrying prescription injectable antibiotics, and carry them in your hand luggage with proper documentation. Do not skip doses during travel, and arrange for a clinic or hospital at your destination if you need ongoing treatment.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: You may start to feel better within 24 to 72 hours after starting treatment, but it can take longer depending on the infection. Complete the full course as prescribed.
A: No, this medicine is given intravenously by a healthcare professional in a clinic or hospital. It should not be self-administered at home.
A: Do not stop the medicine early. Complete the full course prescribed by your doctor to prevent the infection from returning and to reduce antibiotic resistance.
A: Tell your doctor if you are pregnant or planning pregnancy. This medicine may be used if needed, but only under medical supervision after weighing the benefits and risks.
A: Yes, it can interact with blood thinners, certain kidney medicines, and calcium-containing intravenous fluids. Tell your doctor about all medicines you take.
🤔 Common Patient Concerns
🔄 Substitutes for cefiton-s 1gm/500mg injection
View AllAlternative brands with exact same active ingredient:
-
cefinec-s injectionSolveig Lifesciences ₹58.62 43.4% CHEAPER
-
marxone injectionMRG Biotech Pvt Ltd ₹103.00 0.6% CHEAPER
-
awnacef sb 1gm/500mg injectionShawn & Co ₹107.81 4% COSTLIER
-
xetra-s 1gm/500mg injectionBaxton Pharmacia ₹142.00 37% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can cure any infection.
Fact: This medicine only works against certain bacteria. It does not treat viral infections such as colds or flu. - Myth: You can stop the medicine as soon as you feel better.
Fact: You must complete the full course prescribed by your doctor to prevent the infection from returning and to reduce antibiotic resistance. - Myth: This medicine is safe to take without a doctor's supervision.
Fact: This is a prescription injectable medicine and must only be given by a qualified healthcare professional. - Myth: This medicine weakens the immune system.
Fact: This medicine kills bacteria but does not weaken the immune system. It may rarely cause blood count changes that need monitoring.
🔄 Alternative Options
Generic Alternatives
- Ceftriaxone injection
- Ceftriaxone and sulbactam injection
Brand Alternatives
- Cefinec-S Injection