Gestrone Injection: Complete Guide to Uses, Dosage, Side Effects, and Safety
Clinical Reference Standards: CDSCO (Central Drugs Standard Control Organisation), Indian Pharmacopoeia (IP) & WHO | Last Updated: September 2026
When to Call Your Doctor IMMEDIATELY
- Difficulty breathing or swelling of the face, lips, or throat
- Chest pain or sudden shortness of breath
- Severe headache with vision changes
- Pain, swelling, or redness in one leg
- Yellowing of the skin or eyes
- Severe abdominal pain
- Unusual vaginal bleeding
- Signs of infection at the injection site (increasing pain, redness, warmth, or pus)
If experiencing severe symptoms, call emergency services immediately.
What is awnagest 100mg injection used for?
This medicine is a progesterone injection used to support pregnancy, treat menstrual disorders, and assist in fertility treatments. It works by supplementing natural progesterone to prepare the uterus and maintain early pregnancy.
- Generic Name: Progesterone (50mg/ml)
- Manufacturer: Shawn & Co
- Form: Allopathy
- Pregnancy Category: Consult doctor
- Prescription Required: Yes
🇮🇳 awnagest 100mg injection के बारे में (Hindi Summary)
उपयोग: यह दवा प्रोजेस्टेरोन हार्मोन का इंजेक्शन है, जिसका उपयोग गर्भावस्था को सहारा देने, मासिक धर्म की समस्याओं के इलाज और प्रजनन उपचार में किया जाता है। यह शरीर में प्रोजेस्टेरोन की कमी को पूरा करती है, जिससे गर्भाशय की परत मजबूत होती है और गर्भावस्था बनी रहती है। यह दवा डॉक्टर द्वारा मांसपेशी में इंजेक्शन के रूप में दी जाती है।
साइड इफेक्ट्स: इस दवा के सामान्य दुष्प्रभावों में इंजेक्शन वाली जगह पर दर्द, लालिमा या सूजन, सिरदर्द, स्तनों में कोमलता, मूड में बदलाव, नींद आना और चक्कर आना शामिल हैं। कुछ महिलाओं को मतली, पेट फूलना या मासिक धर्म में बदलाव हो सकता है। गंभीर दुष्प्रभाव दुर्लभ हैं, लेकिन एलर्जी, खून के थक्के, या लीवर की समस्या हो सकती है। कोई भी असामान्य लक्षण दिखने पर तुरंत डॉक्टर से संपर्क करें।
सुरक्षा सलाह: यह दवा केवल डॉक्टर या प्रशिक्षित स्वास्थ्यकर्मी द्वारा ही दी जानी चाहिए। खुद से इंजेक्शन न लगाएं। अपने डॉक्टर को अपनी सभी स्वास्थ्य समस्याओं और दवाओं के बारे में बताएं। यदि आपको नींद या चक्कर आते हैं तो वाहन न चलाएं। सभी फॉलो-अप अपॉइंटमेंट पर जाएं। यदि कोई खुराक छूट जाए तो डॉक्टर से सलाह लें, दोहरी खुराक न लें। दवा को सही तापमान पर रखें और एक्सपायरी डेट का ध्यान रखें।
💊 awnagest 100mg injection Uses & Benefits
[{"condition":"Luteal phase support in assisted reproduction","description":"This medicine is used to support the luteal phase in women undergoing in vitro fertilization or other assisted reproductive techniques, helping to maintain the uterine lining and improve the chance of successful implantation and pregnancy.","evidence":"Well-established"},{"condition":"Threatened or recurrent miscarriage due to progesterone deficiency","description":"It is prescribed to women with a history of recurrent miscarriage or threatened miscarriage associated with low progesterone levels, to help sustain early pregnancy.","evidence":"Well-established"},{"condition":"Secondary amenorrhea","description":"This medicine can be used to induce bleeding in women who have missed periods due to progesterone deficiency, after other causes have been ruled out.","evidence":"Well-established"},{"condition":"Abnormal uterine bleeding due to hormonal imbalance","description":"It helps regulate the menstrual cycle and control abnormal bleeding caused by a lack of progesterone.","evidence":"Well-established"},{"condition":"Premenstrual syndrome (PMS)","description":"In some cases, this medicine may be used to relieve severe PMS symptoms, although it is not the first-line treatment.","evidence":"Limited"}]
Off-label uses: [{"condition":"Preterm birth prevention","description":"Progesterone injections have been studied for preventing preterm birth in women with a short cervix or a history of preterm delivery, but this use is not approved for all formulations and should only be considered under specialist care.","evidence":"Limited"},{"condition":"Endometrial hyperplasia","description":"Sometimes used off-label to treat endometrial hyperplasia, a condition where the uterine lining becomes too thick, but this is typically managed with other progestogens.","evidence":"Limited"}]
Primary treatment for: Progesterone deficiency
Also treats: Infertility, Recurrent miscarriage, Secondary amenorrhea, Abnormal uterine bleeding
📋 Drug Information
| Generic Name(s) | Progesterone (50mg/ml) |
| Brand Name | awnagest 100mg injection |
| Manufacturer | Shawn & Co |
| Packaging / Form | Varies by brand (Allopathy) |
| Therapeutic Class | GYNAECOLOGICAL |
| Action Class | Natural Progesterone |
| Route of Administration | Parenteral (intramuscular injection) |
| Storage | Store this medicine in its original packaging at room temperature, between 15°C and 30°C (59°F to 86°F). Protect it from light and do not freeze. Keep it out of reach of children. |
| Shelf Life | The shelf life of this medicine is typically 24 to 36 months from the date of manufacture, but refer to the expiry date printed on the packaging. Do not use after the expiry date. |
| WHO Guideline | Not established from the available information. |
| ICMR Guideline | Not established from the available information. |
👨⚕️ Doctor's Practical Tips
Evidence-based practical advice from experienced clinicians
🔍 Is This Medicine Right for Your Symptom?
Educational reference. Always consult a doctor for diagnosis.
🔬 How This Medicine Works (Pharmacology)
Pharmacokinetics
How It Works
This medicine works by delivering progesterone, a natural hormone that binds to and activates progesterone receptors in target tissues such as the endometrium, myometrium, breast, and brain. By binding to these receptors, it changes gene expression and protein synthesis, which helps to transform the uterine lining into a secretory state suitable for implantation, reduces uterine contractions to maintain pregnancy, and regulates the menstrual cycle. It also feedback-inhibits the release of gonadotropin-releasing hormone from the hypothalamus, which can suppress ovulation in certain situations.
Mechanism Steps
💡 How to Take awnagest 100mg injection
Strength: Progesterone 50 mg/mL injection (immediate release)
Dosage Information
| Adult Dosage | The dose of this medicine is individualized by a qualified clinician based on the indication, the patient's age, weight, renal and hepatic function, and response to treatment. For luteal support in assisted reproduction, a common dose is 50 mg to 100 mg intramuscularly daily, starting after ovulation or embryo transfer and continuing for several weeks. For threatened miscarriage, doses may range from 50 mg to 100 mg daily until symptoms resolve. For secondary amenorrhea, a typical regimen is 50 mg to 100 mg intramuscularly for 5 to 10 days. Always follow your doctor's prescription exactly and do not change the dose without consulting them. |
| Pediatric Dosage | Pediatric dosing is not established from available information. Consult a pediatrician. |
| Elderly Dosage | There is limited information on the use of this medicine in elderly women. It is not typically indicated for this age group unless for specific conditions. Dose should be individualized by a qualified clinician based on renal and hepatic function and overall health status. |
| Renal Impairment | No specific dose adjustment is provided for renal impairment in the available information. Use with caution in patients with severe kidney disease and consult a clinician for individualized dosing. |
| Hepatic Impairment | Progesterone is metabolized in the liver. In patients with mild to moderate liver impairment, no dose adjustment may be needed, but caution is advised. In severe liver disease, this medicine is contraindicated. Consult a clinician for individualized dosing. |
| Maximum Daily Dose | The maximum daily dose of this medicine is not established from the available information. Doses are individualized by a qualified clinician based on the indication and patient factors. Do not exceed the prescribed dose. |
Dosage Timeline
🍽️ Food Timing Guide
⏰ What to Do If You Miss a Dose
⚠️ Side Effects of awnagest 100mg injection
✅ Common Side Effects
🚨 Serious Side Effects
⚠️ Rare Side Effects
Consult your doctor if you experience any unusual symptoms.
🔬 Drug Interactions
| Drug | Severity | Effect |
|---|---|---|
| Warfarin | Major | |
| Carbamazepine | Major | |
| Rifampicin | Major | |
| Ketoconazole | Moderate | |
| St. John's wort | Moderate | |
| Bromocriptine | Moderate | |
| Paracetamol | Minor | |
| Ibuprofen | Minor |
🚨 Major Interactions
- Warfarin
- Carbamazepine
- Rifampicin
⚡ Moderate Interactions
- Ketoconazole
- St. John's wort
- Bromocriptine
🍷 Alcohol Interaction
Alcohol may increase drowsiness and dizziness caused by this medicine. It is best to avoid or limit alcohol while using this medicine, especially if you are pregnant.
🔎 Check Your Other Medicines
Educational tool. Always confirm with your doctor or pharmacist.
🛡️ Safety & Warnings
🚫 Contraindications
["Known hypersensitivity or allergy to progesterone or any ingredient in the formulation","Undiagnosed vaginal bleeding","Known or suspected breast cancer","Known or suspected progesterone-sensitive tumors","History of or current blood clots (deep vein thrombosis, pulmonary embolism)","Severe liver disease","Missed abortion"]
⚠️ Warnings & Precautions
["This medicine should only be administered by a healthcare professional.","Use with caution in women with a history of blood clots, liver disease, or heart disease.","May cause drowsiness; avoid driving or operating machinery until you know how it affects you.","Inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding.","Do not use if the solution is discolored or contains particles.","Keep out of reach of children.","Dispose of used needles and syringes safely."]
🤱 Lactation Safety
Progesterone is excreted in breast milk. While no harmful effects have been reported in breastfed infants, this medicine should be used during breastfeeding only if clearly needed and under medical supervision. Consult your doctor to weigh the benefits and risks.
💊 Overdose Management
Overdose with this medicine is unlikely due to its route of administration and medical supervision. If an overdose is suspected, seek immediate medical attention. Symptoms of overdose may include severe drowsiness, dizziness, or nausea. Treatment is supportive and symptomatic.
⏰ Missed Dose
If you miss a scheduled dose of this medicine, contact your healthcare provider as soon as possible for guidance. Do not try to double the dose to make up for the missed one. Your doctor will advise you on the best course of action based on your treatment plan.
Additional Safety Advice
This medicine must only be administered by a healthcare professional as an intramuscular injection. Do not attempt to self-inject unless you have been specifically trained and instructed to do so by your doctor. Inform your doctor about all your medical conditions, especially if you have a history of blood clots, liver disease, breast cancer, or undiagnosed vaginal bleeding. Tell your doctor about all other medicines, supplements, and herbal products you are taking, as some may interact with progesterone. Avoid driving or operating heavy machinery if you feel drowsy or dizzy after the injection. Keep all scheduled follow-up appointments so your doctor can monitor your response and adjust the dose if needed. If you miss a dose, contact your healthcare provider for guidance; do not try to catch up by taking extra doses. Store this medicine as directed by your pharmacist, and never use it if the solution is discolored or contains particles.
👴 Special Considerations for Elderly
💡 For Patients Above 65
This medicine is not typically used in elderly women unless for specific indications. Elderly patients may be more sensitive to the effects of progesterone, such as drowsiness and dizziness. Use with caution and under close medical supervision.
🤰 Pregnancy Planning (TTC)
If you are planning to become pregnant and have a history of progesterone deficiency or miscarriage, consult your doctor. This medicine may be prescribed to support early pregnancy. It is important to start treatment as advised by your doctor and follow the prescribed schedule.
🏥 Post-Surgery Considerations
If you are scheduled for surgery, inform your surgeon and anesthesiologist that you are using this medicine. Progesterone may affect blood clotting and interact with anesthetic agents. Your doctor may advise you to temporarily stop the injections before surgery.
🦷 Dental Procedures
Inform your dentist that you are using this medicine before any dental procedure. Progesterone may affect blood clotting, so your dentist may take extra precautions. No specific dose adjustment is usually needed, but consult your doctor if you have concerns.
💚 Lifestyle Tips for Better Results
🏋️ Exercise Considerations
While using this medicine, you can generally continue your normal exercise routine, but avoid strenuous activities if you feel dizzy or drowsy. If you are pregnant, consult your doctor about safe exercise during pregnancy. Avoid activities that carry a high risk of falls or injury, especially if you experience dizziness.
🥗 Diet Recommendations
💼 Impact on Daily Work & Life
This medicine may cause drowsiness or dizziness in some people. Avoid driving or operating heavy machinery until you know how it affects you. If your job requires mental alertness, discuss with your doctor about timing of injections. Most people can continue their normal daily activities, but listen to your body and rest when needed.
🛑 When to Stop This Medicine
Do not stop this medicine without consulting your doctor. The duration of treatment is determined by your condition and response. If you experience severe side effects or allergic reactions, seek immediate medical attention. Your doctor will advise you on when and how to safely stop the injections.
📅 Long-Term Use Effects
Long-term use of this medicine should be under regular medical supervision. Prolonged use may increase the risk of blood clots, liver problems, and fluid retention. Your doctor may monitor your liver function, blood clotting parameters, and clinical response. If you experience any unusual symptoms, report them to your doctor immediately. The duration of treatment depends on the underlying condition and your response to therapy.
🌿 Non-Medicine Approaches
These can complement medicine but do not replace prescribed treatment.
Micronized progesterone capsules can be taken orally, but they may cause more drowsiness and have variable absorption.
Evidence: Well-establishedVaginal suppositories or gels are an alternative route that delivers progesterone directly to the uterus with fewer systemic side effects.
Evidence: Well-establishedStress reduction, balanced diet, and regular exercise can help support hormonal balance, but they are not a substitute for medical treatment.
Evidence: Limited💉 Vaccination Considerations
💉 If You're Getting Vaccinated
There are no known interactions between this medicine and vaccines. However, always inform your healthcare provider about all medications you are taking before receiving any vaccine.
📦 Storage Guide
✅ DO
Store at room temperature (15-30°C)
❌ DON'T
Do not refrigerate unless specified
✅ DO
Keep in original container
❌ DON'T
Do not transfer to unmarked containers
✅ DO
Keep away from direct sunlight
❌ DON'T
Do not store in bathroom cabinet
✅ DO
Check expiry date before use
❌ DON'T
Do not use if expired or discolored
✈️ Traveling with This Medicine
When traveling with this medicine, carry it in its original packaging with the prescription label clearly visible. Bring a copy of your prescription and a doctor's letter explaining the medical need for the injection. Keep the medicine in a cool, dry place, and use a travel cooler if necessary to maintain the recommended temperature. If traveling across time zones, consult your doctor about adjusting the timing of your doses. Check the customs regulations of your destination country regarding injectable medications. Always carry enough supply for your entire trip and a little extra in case of delays.
💰 Cost Analysis & Savings
👥 Real Patient Stories
Educational, anonymized scenarios. Individual results may vary.
💬 Questions Patients Often Ask
A: The onset of action depends on the indication. For luteal support, effects on the endometrium may begin within hours to days. For maintaining pregnancy, the full effect develops over days to weeks of regular dosing.
A: This medicine is given as an intramuscular injection by a healthcare professional. Do not self-administer unless you have been specifically trained and instructed by your doctor.
A: Common side effects include injection site pain, headache, breast tenderness, mood swings, and drowsiness. These are usually mild and resolve on their own.
A: Yes, when used as indicated for luteal support or to maintain pregnancy, it is considered safe and beneficial. However, it should only be used under medical supervision.
A: Contact your healthcare provider as soon as possible for guidance. Do not try to double the dose to make up for the missed one.
🤔 Common Patient Concerns
🔄 Substitutes for awnagest 100mg injection
View AllAlternative brands with exact same active ingredient:
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gestone injectionFerring Pharmaceuticals ₹81.56 25.5% COSTLIER
-
weltime 200mg injectionAsterisk Laboratories India Pvt Ltd ₹166.00 155.4% COSTLIER
Medical Note: Always consult your doctor before switching medications.
🛑 Myths vs. Facts
- Myth: This medicine can be taken orally.
Fact: This medicine is an injection and must be given intramuscularly by a healthcare professional. - Myth: This medicine is safe for everyone.
Fact: It is contraindicated in certain conditions such as breast cancer, severe liver disease, and blood clotting disorders. - Myth: This medicine causes immediate weight gain.
Fact: Weight gain is not a common side effect; fluid retention may occur but is usually mild.
🔄 Alternative Options
Generic Alternatives
- Progesterone injection (generic)
Brand Alternatives
- Gestone
- Progesterone injection